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Journals ACS Biomaterials Science & Eng...

ACS Biomaterials Science & Engineering

https://read.qxmd.com/read/38537162/advancing-bone-targeted-drug-delivery-leveraging-biological-factors-and-nanoparticle-designs-to-improve-therapeutic-efficacy
#1
JOURNAL ARTICLE
Baixue Xiao, Marian A Ackun-Farmmer, Emmanuela Adjei-Sowah, Yuxuan Liu, Indika Chandrasiri, Danielle S W Benoit
Designing targeted drug delivery systems to effectively treat bone diseases ranging from osteoporosis to nonunion bone defects remains a significant challenge. Previously, nanoparticles (NPs) self-assembled from diblock copolymers of poly(styrene- alt -maleic anhydride)- b -poly(styrene) (PSMA- b -PS) delivering a Wnt agonist were shown to effectively target bone and improve healing via the introduction of a peptide with high affinity to tartrate-resistant acid phosphatase (TRAP), an enzyme deposited by the osteoclasts during bone remodeling...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#2
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38531866/noninvasive-assessment-of-hipsc-differentiation-toward-cardiomyocytes-using-pretrained-convolutional-neural-networks-and-the-channel-pruning-algorithm
#3
JOURNAL ARTICLE
Yujie Duan, Kaitong He, Wei Lan, Yuli Luo, Hao Fan, Peiran Lin, Wenlong Wang, Yadong Tang
Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes (hiPSC-CMs) offer versatile applications in tissue engineering and drug screening. To facilitate the monitoring of hiPSC cardiac differentiation, a noninvasive approach using convolutional neural networks (CNNs) was explored. HiPSCs were differentiated into cardiomyocytes and analyzed using the quantitative real-time polymerase chain reaction (qRT-PCR). The bright-field images of the cells at different time points were captured to create the dataset...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38531043/microrna-200c-release-from-gelatin-coated-3d-printed-pcl-scaffolds-enhances-bone-regeneration
#4
JOURNAL ARTICLE
Matthew T Remy, Chawin Upara, Qiong J Ding, Jacob M Miszuk, Hongli Sun, Liu Hong
The fabrication of clinically relevant synthetic bone grafts relies on combining multiple biodegradable biomaterials to create a structure that supports the regeneration of defects while delivering osteogenic biomolecules that enhance regeneration. MicroRNA-200c ( miR-200c ) functions as a potent osteoinductive biomolecule to enhance osteogenic differentiation and bone formation; however, synthetic tissue-engineered bone grafts that sustain the delivery of miR-200c for bone regeneration have not yet been evaluated...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38530973/soft-and-hard-tissue-integration-around-percutaneous-bone-anchored-titanium-prostheses-toward-achieving-holistic-biointegration
#5
REVIEW
Sangeeta Shrivas, Harshita Samaur, Vinod Yadav, Sunil Kumar Boda
A holistic biointegration of percutaneous bone-anchored metallic prostheses with both hard and soft tissues dictates their longevity in the human body. While titanium (Ti) has nearly solved osseointegration, soft tissue integration of percutaneous metallic prostheses is a perennial problem. Unlike the firm soft tissue sealing in biological percutaneous structures (fingernails and teeth), foreign body response of the skin to titanium (Ti) leads to inflammation, epidermal downgrowth and inferior peri-implant soft tissue sealing...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38530812/microplate-based-cryopreservation-of-adherent-cultured-human-cell-lines-using-amino-acids-and-proteins
#6
JOURNAL ARTICLE
Kenta Morita, Tomoko Yashiro, Takashi Aoi, Ryutaro Imamura, Tomoyuki Ohtake, Norihiro Yoshizaki, Tatsuo Maruyama
With the progression of regenerative medicine and cell therapy, the importance of cryopreservation techniques for cultured cells continues to rise. Traditional cryoprotectants, such as dimethyl sulfoxide and glycerol, are effective in cryopreserving suspended cells, but they do not demonstrate sufficient efficacy for two-dimensional (2D)-cultured cells. In the past decade, small molecules and polymers have been studied as cryoprotectants. Some L-amino acids have been reported to be natural and biocompatible cryoprotectants...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38529792/milk-extracellular-vesicles-natural-nanoparticles-for-enhancing-oral-drug-delivery-against-bacterial-infections
#7
REVIEW
Cunchun Dai, Qingjun Xu, Lin Li, Ying Liu, Shaoqi Qu
Oral drug delivery is typically preferred as a therapeutic intervention due to the complexities and expenses associated with intravenous administration. However, some drugs are poorly absorbed orally, requiring intravenous administration to bypass the gastrointestinal tract and deliver the drug directly into the bloodstream. Thus, there is an urgent need to develop novel drug delivery platforms to overcome the challenges of oral drug delivery with low solubility, low permeability, oral degradation, and low bioavailability...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38529538/carboxyethylsilanetriol-coated-magnetic-nanoparticles-as-an-ultrasensitive-immunoplatform-for-electrochemical-magnetosensing-of-cotinine
#8
JOURNAL ARTICLE
Muhammet Aydın, Elif Burcu Aydın, Mustafa Kemal Sezgintürk
In the present study, an innovative and simple electrochemical magneto biosensor based on carboxyethylsilanetriol-modified iron oxide (Fe3 O4 ) magnetic nanoparticles was designed for ultrasensitive and specific analysis of cotinine, an important marker of smoking. Anticotinine antibodies were covalently immobilized on carboxylic acid-modified magnetic nanoparticles, and the cotinine-specific magnetic nanoparticles created a specific surface on the working electrode surface. The use of magnetic nanoparticles as an immobilization platform for antibodies provided a large surface area for antibody attachment and increased sensitivity...
March 26, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38526450/a-supramolecular-assembly-of-egcg-for-long-term-treatment-of-allergic-rhinitis
#9
JOURNAL ARTICLE
Fu Zhong Zhang, Min Tan, Jing Zeng, Xu-Wei Qi, Ye-Tao Zhang, Yu-Ting Che, Sheng Zhang, Bang-Jing Li
Allergic rhinitis (AR) is a type-I hypersensitivity disease mediated by immunoglobulin E (IgE). Although antihistamines, glucocorticoids, leukotriene receptor antagonists, and other drugs are widely used to treat AR, the various adverse side effects of long-term use of these drugs should not be ignored. Therefore, more effective and safe natural alternative strategies are urgently needed. To this end, this study designed a nanosupramolecular delivery system composed of β-cyclodextrin supramolecular polymer (PCD), thiolated chitosan (TCS), and natural polyphenol epigallocatechin gallate (EGCG) for intranasal topical continuous treatment of AR...
March 25, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38526408/peptide-based-flavivirus-biosensors-from-cell-structure-to-virological-and-serological-detection-methods
#10
REVIEW
Atqiya Muslihati, Ni Luh Wulan Septiani, Gilang Gumilar, Nugraha Nugraha, Hutomo Suryo Wasisto, Brian Yuliarto
In tropical and developing countries, mosquito-borne diseases by flaviviruses pose a serious threat to public health. Early detection is critical for preventing their spread, but conventional methods are time-consuming and require skilled technicians. Biosensors have been developed to address this issue, but cross-reactivity with other flaviviruses remains a challenge. Peptides are essentially biomaterials used in diagnostics that allow virological and serological techniques to identify flavivirus selectively...
March 25, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38525821/a-predictive-toxicokinetic-model-for-nickel-leaching-from-vascular-stents
#11
JOURNAL ARTICLE
Matheos Giakoumi, Pavlos S Stephanou, Despoina Kokkinidou, Chara Papastefanou, Andreas Anayiotos, Konstantinos Kapnisis
In vitro testing methods offer valuable insights into the corrosion vulnerability of metal implants and enable prompt comparison between devices. However, they fall short in predicting the extent of leaching and the biodistribution of implant byproducts under in vivo conditions. Physiologically based toxicokinetic (PBTK) models are capable of quantitatively establishing such correlations and therefore provide a powerful tool in advancing nonclinical methods to test medical implants and assess patient exposure to implant debris...
March 25, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38520335/multifunctional-inorganic-organic-composite-carriers-for-synergistic-dual-therapy-of-melanoma
#12
JOURNAL ARTICLE
Kseniya A Mitusova, Darya R Akhmetova, Anna Rogova, Timofey E Karpov, Yulia A Tishchenko, Daler R Dadadzhanov, Anna O Matyushevskaya, Nina V Gavrilova, Evgeny E Priakhin, Alexander S Timin
Many methods for cancer treatment have been developed. Among them photothermal therapy (PTT) has drawn the most significant attention due to its noninvasiveness, remote control activation, and low side effects. However, a limited depth of light penetration of PTT is the main drawback. To improve the therapeutic efficiency, the development of combined PTT with other therapeutic agents is highly desirable. In this work, we have designed multifunctional composite carriers based on polylactic acid ( PLA ) particles decorated with gold nanorods ( Au NRs ) as nanoheaters and selenium nanoparticles ( Se NPs ) for reactive oxygen species (ROS) production in order to perform a combined PTT against B16-F10 melanoma...
March 23, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38517700/lactic-acid-induced-colloidal-microrheology-of-synovial-fluids
#13
JOURNAL ARTICLE
Nayanjyoti Kakati, Dileep Ahari, Prathu Raja Parmar, Omkar Suresh Deshmukh, Dipankar Bandyopadhyay
The presence of colloidal scaffolds composed of proteins and hyaluronic acid engenders unique viscous and elastic properties to the synovial fluid (SF). While the elastic resistance of SF due to the presence of such nanoscale structures provides the load-bearing capacity, the viscous nature enables fluidity of the joints during the movements to minimize the wear and tear of the adjacent muscle, cartilage, or bone tissues. It is well-known that the hypoxic conditions at the bone joints often increase the lactic acid (LA) concentration due to the occurrence of excess anaerobic respiration during either hyperactivity or arthritic conditions...
March 22, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38506625/potential-application-prospects-of-biomolecule-modified-two-dimensional-chiral-nanomaterials-in-biomedicine
#14
REVIEW
Ling-Xiao Zhao, Li-Lin Chen, Di Cheng, Ting-Yao Wu, Yong-Gang Fan, Zhan-You Wang
Chirality, one of the most fundamental properties of natural molecules, plays a significant role in biochemical reactions. Nanomaterials with chiral characteristics have superior properties, such as catalytic properties, optoelectronic properties, and photothermal properties, which have significant potential for specific applications in nanomedicine. Biomolecular modifications such as nucleic acids, peptides, proteins, and polysaccharides are sources of chirality for nanomaterials with great potential for application in addition to intrinsic chirality, artificial macromolecules, and metals...
March 20, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38502729/influence-of-ultrasound-on-the-characteristics-of-cap-coatings-generated-via-the-micro-arc-oxidation-process-in-relation-to-biomedical-engineering
#15
JOURNAL ARTICLE
Balbina Makurat-Kasprolewicz, Marcin Wekwejt, Anna Ronowska, Grzegorz Gajowiec, Marlena Grodzicka, Stefan Dzionk, Agnieszka Ossowska
Over the past decade, bone tissue engineering has been at the core of attention because of an increasing number of implant surgeries. The purpose of this study was to obtain coatings on titanium (Ti) implants with improved properties in terms of biomedical applications and to investigate the effect of ultrasound (US) on these properties during the micro-arc oxidation (MAO) process. The influence of various process parameters, such as time and current density, as well as US mode, on the properties of such coatings was evaluated...
March 19, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38498674/fabrication-of-novel-3-d-nanocomposites-of-hap-tic-h-bn-zro-2-enhanced-mechanical-performances-and-in-vivo-toxicity-study-for-biomedical-applications
#16
JOURNAL ARTICLE
Sarvesh Kumar Avinashi, Shweta, Bhavna Bohra, Rajat Kumar Mishra, Savita Kumari, Zaireen Fatima, Ajaz Hussain, Bhagawati Saxena, Saurabh Kumar, Monisha Banerjee, Chandki Ram Gautam
Due to excellent biocompatibility, bioactivities, and osteoconductivity, hydroxyapatite (HAp) is considered as one of the most suitable biomaterials for numerous biomedical applications. Herein, HAp was fabricated using a bottom-up approach, i.e., a wet chemical method, and its composites with TiC, h-BN, and ZrO2 were fabricated by a solid-state reaction method with enhanced mechanical and biological performances. Structural, surface morphology, and mechanical behavior of the fabricated composites were characterized using various characterization techniques...
March 18, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38489227/three-dimensional-printed-spherical-hollow-structural-scaffolds-for-guiding-critical-sized-bone-regeneration
#17
JOURNAL ARTICLE
Xiao Liu, Jianpeng Gao, Jianheng Liu, Junyao Cheng, Zhenchuan Han, Zijian Li, Zhengyang Chang, Licheng Zhang, Ming Li, Peifu Tang
The treatment of bone tissue defects continues to be a complex medical issue. Recently, three-dimensional (3D)-printed scaffold technology for bone tissue engineering (BTE) has emerged as an important therapeutic approach for bone defect repair. Despite the potential of BTE scaffolds to contribute to long-term bone reconstruction, there are certain challenges associated with it including the impediment of bone growth within the scaffolds and vascular infiltration. These difficulties can be resolved by using scaffold structural modification strategies that can effectively guide bone regeneration...
March 15, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38487853/multichannel-conduits-with-fascicular-complementation-significance-in-long-segmental-peripheral-nerve-injury
#18
REVIEW
Preethy Amruthavarshini Ramesh, Swaminathan Sethuraman, Anuradha Subramanian
Despite the advances in tissue engineering approaches, reconstruction of long segmental peripheral nerve defects remains unsatisfactory. Although autologous grafts with proper fascicular complementation have shown meaningful functional recovery according to the Medical Research Council Classification (MRCC), the lack of donor nerve for such larger defect sizes (>30 mm) has been a serious clinical issue. Further clinical use of hollow nerve conduits is limited to bridging smaller segmental defects of denuded nerve ends (<30 mm)...
March 15, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38483467/formation-pattern-analysis-of-spheroids-formed-by-a-droplet-based-microfluidic-system-for-predicting-the-aggressiveness-of-tumor-cells
#19
JOURNAL ARTICLE
Sunghan Lee, Chang Jae Woo, Hyo-Il Jung, Ki Chang Nam, Ji Seok Lim, Bong Seop Kwak
Examining tumor heterogeneity is essential for selecting an appropriate anticancer treatment for an individual. This study aimed to distinguish low- and high-aggressive tumor cells by analyzing the formation patterns of spheroids. The droplet-based microfluidic system was employed for the formation of each spheroid from four different subtypes of breast tumor cells. Additionally, heterotypic spheroids with T lymphocytes and cancer-associated fibroblasts (CAFs) were produced, and distinctions between low- and high-aggressive tumor cells were explored through the analysis of formation patterns using circularity, convexity, and cell distributions...
March 14, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38480510/novel-bioresorbable-drug-eluting-mesh-scaffold-for-therapy-of-muscle-injury
#20
JOURNAL ARTICLE
Ying-Chao Chou, Yung-Heng Hsu, Demei Lee, Jheng-Wei Yang, Yi-Hsun Yu, Err-Cheng Chan, Shih-Jung Liu
A novel bioresorbable drug-eluting polycaprolactone (PCL) mesh scaffold was developed, utilizing a solvent-cast additive manufacturing technique, to promote therapy of muscle injury. The degradation rate and mechanical properties strength of the PCL mesh were characterized after immersion in a buffer solution for different times. The in vitro release characteristics of vancomycin, ceftazidime, and lidocaine from the prepared mesh were evaluated using a high-performance liquid chromatography (HPLC) assay. In addition, the in vivo efficacy of PCL meshes for the repair of muscle injury was investigated on a rat model with histological examinations...
March 13, 2024: ACS Biomaterials Science & Engineering
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