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ACS Biomaterials Science & Engineering

Sören B Gutekunst, Katharina Siemsen, Steven Huth, Anneke Möhring, Britta Hesseler, Michael Timmermann, Ingo Paulowicz, Yogendra Kumar Mishra, Leonard Siebert, Rainer Adelung, Christine Selhuber-Unkel
Porous hydrogel scaffolds are ideal candidates for mimicking cellular microenvironments, regarding both structural and mechanical aspects. We present a novel strategy to use uniquely designed ceramic networks as templates for generating hydrogels with a network of interconnected pores in the form of microchannels. The advantages of this new approach are the high and guaranteed interconnectivity of the microchannels, as well as the possibility to produce channels with diameters smaller than 7 μm. Neither of these assets can be ensured with other established techniques...
April 8, 2019: ACS Biomaterials Science & Engineering
Nicholas J Kaiser, Rajeev J Kant, Alicia J Minor, Kareen L K Coulombe
Natural polymer hydrogels are used ubiquitously as scaffold materials for cardiac tissue engineering as well as for soft tissue engineering more broadly because of FDA approval, minimal immunogenicity, and well-defined physiological clearance pathways. However, the relationships between natural polymer hydrogels and resident cell populations in directing the development of engineered tissues are poorly defined. This interaction is of particular concern for tissues prepared with iPSC-derived cell populations, in which population purity and batch-to-batch variability become additional critical factors to consider...
February 11, 2019: ACS Biomaterials Science & Engineering
Henk J Busscher, Volker Alt, Henny C van der Mei, Paul H Fagette, Werner Zimmerli, T Fintan Moriarty, Javad Parvizi, Gerhard Schmidmaier, Michael J Raschke, Thorsten Gehrke, Roger Bayston, Larry M Baddour, Lynn C Winterton, Rabih O Darouiche, David W Grainger
Current regulatory requirements impede clinical translation and market introduction of many new antimicrobial combination implants and devices, causing unnecessary patient suffering, doctor frustration, and costs to healthcare payers. Regulatory requirements of antimicrobial combination implants and devices should be thoroughly revisited and their approval allowed based on enrichment of benefit demonstrations from high-risk patient groups and populations or device components to facilitate their clinical translation...
February 11, 2019: ACS Biomaterials Science & Engineering
Rebecca A Hortensius, Jill H Ebens, Marley J Dewey, Brendan A C Harley
Tendon injuries often require surgical intervention and even then result in poor outcomes due to scar formation and repeated failure. Biomaterial implants offer the potential to address multiple underlying concerns preventing improved tendon repair. Here, we describe modifications to the composition of an anisotropic collagen-glycosaminoglycan (CG) scaffold biomaterial, incorporating amniotic membrane (AM)-derived matrix to alter the inflammatory response and establish conditions for improved regenerative repair...
December 10, 2018: ACS Biomaterials Science & Engineering
A D Thilanga Liyanage, Alexander J Chen, David A Puleo
Simvastatin was previously converted to a polymeric prodrug with higher drug loading, but the hydrophobic nature of the poly(simvastatin) component of the block copolymer led to slow release of the drug in vitro . In this study, we hypothesized that degradation could be accelerated by chemically modifying the polymer backbone by introducing glycolide and lactide comonomers. Copolymers were formed by ring-opening polymerization using 5 kDa monomethyl ether poly(ethylene glycol) as the microinitiator in presence of triazabicyclodecene catalyst...
December 10, 2018: ACS Biomaterials Science & Engineering
Hyun-Soo Shin, Hye Jin Hong, Won-Gun Koh, Jae-Yol Lim
The self-organizing properties of stem cells have been exploited to generate organoids, organ-specific, cell-containing, three-dimensional (3D) structures. The present study aimed to introduce a novel bioengineering technique for driving the effective organization of adult tissue stem cells via niche-independent 3D microwell culture. Microwells were fabricated by photopatterning poly(ethylene glycol) hydrogel in the presence of an electrospun polycaprolactone nanofibrous scaffold. Human single clonal salivary gland stem cells (SGSCs) were cultured in nanofibrous microwells through two simple steps, priming and differentiation...
December 10, 2018: ACS Biomaterials Science & Engineering
Rongquan Duan, Davide Barbieri, Florence de Groot, Joost D de Bruijn, Huipin Yuan
Tricalcium phosphate (TCP) ceramics are used as bone void fillers because of their bioactivity and resorbability, while their performance in bone regeneration and material resorption vary with their physical properties (e.g., the dimension of the crystal grain). Herein, three TCP ceramic bone substitutes (TCP-S, TCP-M, and TCP-L) with gradient crystal grain size (0.77 ± 0.21 μm for TCP-S, 1.21 ± 0.35 μm for TCP-M and 4.87 ± 1.90 μm for TCP-L), were evaluated in a well-established rabbit lateral condylar defect model (validated with sham) with respect to bone formation and material resorption up to 26 weeks...
September 10, 2018: ACS Biomaterials Science & Engineering
Marije Sloff, Heinz P Janke, Paul K J D de Jonge, Dorien M Tiemessen, Barbara B M Kortmann, Silvia M Mihaila, Paul J Geutjes, Wout F J Feitz, Egbert Oosterwijk
Clinical implementation of novel products for tissue engineering and regenerative medicine requires a validated sterilization method. In this study, we investigated the effect of γ-irradiation and EtO degassing on material characteristics in vitro and the effect on template remodeling of hybrid tubular constructs in a large animal model. Hybrid tubular templates were prepared from type I collagen and Vicryl polymers and sterilized by 25 kGray of γ-irradiation or EtO degassing. The in vitro characteristics were extensively studied, including tensile strength analysis and degradation studies...
September 10, 2018: ACS Biomaterials Science & Engineering
Erik R Johnston, Yu Miyagi, Jo-Ann Chuah, Keiji Numata, Monica A Serban
Bombyx mori -derived silk fibroin (SF) is a well-characterized protein employed in numerous biomedical applications. Structurally, SF consists of a heavy chain (HC) and a light chain (LC), connected via a single disulfide bond. The HC sequence is organized into 12 crystalline domains interspersed with amorphous regions that can transition between random coil/alpha helix and beta-sheet configurations, giving silk its hallmark properties. SF has been reported to have adhesive properties and shows promise for development of medical adhesives; however, the mechanism of these interactions and the interplay between SF's structure and adhesion is not understood...
August 13, 2018: ACS Biomaterials Science & Engineering
Chen Zhao, Zongyue Zeng, Nader Taheri Qazvini, Xinyi Yu, Ruyi Zhang, Shujuan Yan, Yi Shu, Yunxiao Zhu, Chongwen Duan, Elliot Bishop, Jiayan Lei, Wenwen Zhang, Chao Yang, Ke Wu, Ying Wu, Liping An, Shifeng Huang, Xiaojuan Ji, Cheng Gong, Chengfu Yuan, Linghuan Zhang, Wei Liu, Bo Huang, Yixiao Feng, Bo Zhang, Zhengyu Dai, Yi Shen, Xi Wang, Wenping Luo, Leonardo Oliveira, Aravind Athiviraham, Michael J Lee, Jennifer Moriatis Wolf, Guillermo A Ameer, Russell R Reid, Tong-Chuan He, Wei Huang
Effective bone tissue engineering is important to overcome the unmet clinical challenges as more than 1.6 million bone grafts are done annually in the United States. Successful bone tissue engineering needs minimally three critical constituents: osteoprogenitor cells, osteogenic factors, and osteoinductive/osteoconductive scaffolds. Osteogenic progenitors are derived from multipotent mesenchymal stem cells (MSCs), which can be prepared from numerous tissue sources, including adipose tissue. We previously showed that BMP9 is the most osteogenic BMP and induces robust bone formation of immortalized mouse adipose-derived MSCs entrapped in a citrate-based thermoresponsive hydrogel referred to as PPCNg...
August 13, 2018: ACS Biomaterials Science & Engineering
Yipin Qi, Zhou Ye, Alex Fok, Brian N Holmes, Monsterrat Espanol, Maria-Pau Ginebra, Conrado Aparicio
Inspired by nature, poly(acrylic acid) (PAA) and other polyelectrolytes have been used as noncollagenous proteins (NCPs) surrogates for biomimetic intrafibrillar mineralization of collagen fibrils and thus, to model the ultrastructure of bone, to study the mechanism of bone mineralization and, more scarcely to fabricate scaffolds for hard tissue engineering. The objective of this study was to systematically investigate the effect of the molecular weight (MW) and the concentration of PAA on the rate and pattern of biomineralization of collagen matrices...
August 13, 2018: ACS Biomaterials Science & Engineering
Julie Bejoy, Liqing Song, Zhe Wang, Qing-Xiang Sang, Yi Zhou, Yan Li
Extracellular matrix (ECM) components of the brain play complex roles in neurodegenerative diseases. The study of microenvironment of brain tissues with Alzheimer's disease revealed colocalized expression of different ECM molecules such as heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), matrix metal-loproteinases (MMPs), and hyaluronic acid. In this study, both cortical and hippocampal populations were generated from human-induced pluripotent stem cell-derived neural spheroids...
August 13, 2018: ACS Biomaterials Science & Engineering
Zhenghuan Zhao, Harini Kantamneni, Shuqing He, Sandra Pelka, Aiyer Sandhya Venkataraman, Mijung Kwon, Steven K Libutti, Mark Pierce, Prabhas V Moghe, Vidya Ganapathy, Mei Chee Tan
Gene therapy is emerging as the next generation of therapeutic modality with United States Food and Drug Administration approved gene-engineered therapy for cancer and a rare eye-related disorder, but the challenge of real-time monitoring of on-target therapy response remains. In this study, we have designed a theranostic nanoparticle composed of shortwave-infrared-emitting rare-earth-doped nanoparticles (RENPs) capable of delivering genetic cargo and of real-time response monitoring. We showed that the cationic coating of RENPs with branched polyethylenimine (PEI) does not have a significant impact on cellular toxicity, which can be further reduced by selectively modifying the surface characteristics of the PEI coating using counter-ions and expanding their potential applications in photothermal therapy...
July 9, 2018: ACS Biomaterials Science & Engineering
Dongfei Liu, Katriina Lipponen, Peng Quan, Xiaocao Wan, Hongbo Zhang, Ermei Mäkilä, Jarno Salonen, Risto Kostiainen, Jouni Hirvonen, Tapio Kotiaho, Hélder A Santos
By exploiting its porous structure and high loading capacity, porous silicon (PSi) is a promising biomaterial to fabricate protocells and biomimetic reactors. Here, we have evaluated the impact of physicochemical properties of PSi particles [thermally oxidized PSi, TOPSi; annealed TOPSi, AnnTOPSi; (3-aminopropyl) triethoxysilane functionalized thermally carbonized PSi, APTES-TCPSi; and thermally hydrocarbonized PSi, THCPSi] on their surface interactions with different phospholipids. All of the four phospholipids were similarly adsorbed by the surface of PSi particles, except for TOPSi...
July 9, 2018: ACS Biomaterials Science & Engineering
Tania T Emi, Tanner Barnes, Emma Orton, Anne Reisch, Anita E Tolouei, S Zahra M Madani, Stephen M Kennedy
Pulsatile chemotherapeutic delivery profiles may provide a number advantages by maximizing the anticancer toxicity of chemotherapeutics, reducing off-target side effects, and combating adaptive resistance. While these temporally dynamic deliveries have shown some promise, they have yet to be clinically deployed from implantable hydrogels, whose localized deliveries could further enhance therapeutic outcomes. Here, several pulsatile chemotherapeutic delivery profiles were tested on melanoma cell survival in vitro and compared to constant (flatline) delivery profiles of the same integrated dose...
July 9, 2018: ACS Biomaterials Science & Engineering
Ohan S Manoukian, Aja Aravamudhan, Paul Lee, Michael R Arul, Xiaojun Yu, Swetha Rudraiah, Sangamesh G Kumbar
This Article reports the fabrication and characterization of composite micro-nanostructured spiral scaffolds functionalized with nanofibers and hydroxyapatite (HA) for bone regeneration. The spiral poly(lactic acid- co -glycolic acid) (PLGA) porous microstructure was coated with sparsely spaced PLGA nanofibers and HA to enhance surface area and bioactivity. Polyelectrolyte-based HA coating in a layer-by-layer (LBL) fashion allowed 10-70 μ M Ca2+ /mm2 incorporation. These scaffolds provided a controlled release of Ca2+ ions up to 60 days with varied release kinetics accounting up to 10-50 μ g...
June 11, 2018: ACS Biomaterials Science & Engineering
Tadas Kasputis, Daniel Clough, Fallon Noto, Kevin Rychel, Briana Dye, Lonnie D Shea
Type I diabetes mellitus, which affects an estimated 1.5 million Americans, is caused by autoimmune destruction of the pancreatic beta cells that results in the need for life-long insulin therapy. Allogeneic islet transplantation for the treatment of type I diabetes is a therapy in which donor islets are infused intrahepatically, which has led to the transient reversal of diabetes. However, therapeutic limitations of allogeneic transplantation, which include a shortage of donor islets, long-term immunosuppression, and high risk of tissue rejection, have led to the investigation of embryonic or induced pluripotent stem cells as an unlimited source of functional beta-cells...
May 14, 2018: ACS Biomaterials Science & Engineering
Jekaterina Kazantseva, Roman Ivanov, Michael Gasik, Toomas Neuman, Irina Hussainova
Three-dimensional (3D) customized scaffolds are anticipated to provide new frontiers in cell manipulation and advanced therapy methods. Here, we demonstrate the application of hybrid 3D porous scaffolds, representing networks of highly aligned self-assembled ceramic nanofibers, for culturing four types of cancer cells. Ultrahigh aspect ratio (∼107 ) of graphene augmented fibers of tailored nanotopology is shown as an alternative tool to substantially affect cancerous gene expression, eventually due to differences in local biomechanical features of the cell-matrix interactions...
May 14, 2018: ACS Biomaterials Science & Engineering
Mohammed Al-Jarsha, Vladimíra Moulisová, Aldo Leal-Egaña, Andrew Connell, Kurt B Naudi, Ashraf F Ayoub, Matthew J Dalby, Manuel Salmerón-Sánchez
The ongoing research to improve the clinical outcome of titanium implants has resulted in the implemetation of multiple approches to deliver osteogenic growth factors accelerating and sustaining osseointegration. Here we show the presentation of human bone morphogenetic protein 7 (BMP-7) adsorbed to titanium discs coated with poly(ethyl acrylate) (PEA). We have previously shown that PEA promotes fibronectin organization into nanonetworks exposing integrin- and growth-factor-binding domains, allowing a synergistic interaction at the integrin/growth factor receptor level...
May 14, 2018: ACS Biomaterials Science & Engineering
Kristin P O'Grady, Taylor E Kavanaugh, Hongsik Cho, Hanrong Ye, Mukesh K Gupta, Megan C Madonna, Jinjoo Lee, Christine M O'Brien, Melissa C Skala, Karen A Hasty, Craig L Duvall
The inherent antioxidant function of poly(propylene sulfide) (PPS) microspheres (MS) was dissected for different reactive oxygen species (ROS), and therapeutic benefits of PPS-MS were explored in models of diabetic peripheral arterial disease (PAD) and mechanically induced post-traumatic osteoarthritis (PTOA). PPS-MS (∼1 μ m diameter) significantly scavenged hydrogen peroxide (H2 O2 ), hypochlorite, and peroxynitrite but not superoxide in vitro in cell-free and cell-based assays. Elevated ROS levels (specifically H2 O2 ) were confirmed in both a mouse model of diabetic PAD and in a mouse model of PTOA, with greater than 5- and 2-fold increases in H2 O2 , respectively...
April 9, 2018: ACS Biomaterials Science & Engineering
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