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Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

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https://read.qxmd.com/read/30723775/heritability-in-frontotemporal-tauopathies
#1
Shelley L Forrest, Glenda M Halliday, Heather McCann, Andrew B McGeachie, Ciara V McGinley, John R Hodges, Olivier Piguet, John B Kwok, Maria G Spillantini, Jillian J Kril
Introduction: Exploring the degree of heritability in a large cohort of frontotemporal lobar degeneration with tau-immunopositive inclusions (FTLD-tau) and determining if different FTLD-tau subtypes are associated with stronger heritability will provide important insight into disease pathogenesis. Methods: Using modified Goldman pedigree classifications, heritability was examined in pathologically proven FTLD-tau cases with dementia at any time (n = 124) from the Sydney-Cambridge collection...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30723774/quantifying-memory-deficits-in-amnestic-mild-cognitive-impairment
#2
Pilar Andrés, Helena Vico, Aina Yáñez, Antònia Siquier, Guillermo Amer Ferrer
Introduction: In the present study, we use the item-specific deficit approach (ISDA), a method for characterizing memory deficits in list-learning, to portray the memory deficits in amnestic mild cognitive impairment (aMCI). Methods: We applied the ISDA to compare memory performance of patients with aMCI and healthy controls in encoding, consolidation, and retrieval using the Free and Cued Selective Reminding Test. Results: The results revealed clear differences in recall performance between patients with aMCI and controls...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30723773/structural-connectivity-centrality-changes-mark-the-path-toward-alzheimer-s-disease
#3
Luis R Peraza, Antonio Díaz-Parra, Oliver Kennion, David Moratal, John-Paul Taylor, Marcus Kaiser, Roman Bauer
Introduction: The pathophysiological process of Alzheimer's disease is thought to begin years before clinical decline, with evidence suggesting prion-like spreading processes of neurofibrillary tangles and amyloid plaques. Methods: Using diffusion magnetic resonance imaging data from the Alzheimer's Disease Neuroimaging Initiative database, we first identified relevant features for dementia diagnosis. We then created dynamic models with the Nathan Kline Institute-Rockland Sample database to estimate the earliest detectable stage associated with dementia in the simulated disease progression...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30671532/serum-levels-of-proteins-involved-in-amyloid-%C3%AE-clearance-are-related-to-cognitive-decline-and-neuroimaging-changes-in-mild-cognitive-impairment
#4
Shan Liu, Hideaki Suzuki, Hitomi Ito, Tatsumi Korenaga, Hiroyasu Akatsu, Kohji Meno, Kazuhiko Uchida
Introduction: Amyloid-β (Aβ) clearance is important for damage prevention in Alzheimer's disease. We investigated the utility of Aβ clearance proteins as biomarkers for mild cognitive impairment (MCI). Methods: Serum apolipoprotein (apo) A-I, compliment protein C3 (C3), transthyretin, and cholesterol levels were measured in 273 subjects, and we analyzed the relationship between these levels and brain atrophy and cerebral blood flow in 63 clinically diagnosed mild cognitive impairment, Alzheimer's disease, and nondemented disease control subjects...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30671531/brain-imaging-working-group-summaries-for-the-european-joint-programme-for-neurodegenerative-disease-research
#5
EDITORIAL
Giovanni B Frisoni, Jorge Jovicich
No abstract text is available yet for this article.
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30623019/development-and-validation-of-a-salivary-tau-biomarker-in-alzheimer-s-disease
#6
Heather Pekeles, Hamid Y Qureshi, Hemant K Paudel, Hyman M Schipper, Mervyn Gornistky, Howard Chertkow
Introduction: Total tau (t-tau) and phosphorylated tau (p-tau) are abnormally elevated in the brain and cerebrospinal fluid of individuals with Alzheimer's disease (AD). Tau is also present in the salivary gland tissue and saliva, and salivary measures might produce an accurate, accessible, and inexpensive biomarker. Methods: Using unstimulated saliva and Western blot analysis, we quantified the p-tau/t-tau ratio at different phosphorylation sites. Results: We found that for one phosphorylation site, S396, p-tau/t-tau ratio was significantly elevated in patients with AD compared with normal elderly control subjects...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30623018/the-social-functioning-in-dementia-scale-sf-dem-exploratory-factor-analysis-and-psychometric-properties-in-mild-moderate-and-severe-dementia
#7
Jessica Budgett, Anna Brown, Stephanie Daley, Thomas E Page, Sube Banerjee, Gill Livingston, Andrew Sommerlad
Introduction: The psychometric properties of the social functioning in dementia scale over different dementia severities are unknown. Methods: We interviewed 299 family carers of people with mild, moderate, or severe dementia from two UK research sites; examined acceptability (completion rates); conducted exploratory factor analysis; and tested each factor's internal consistency and construct validity. Results: Of 299, 285 (95.3%) carers completed questionnaires...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30623017/normative-data-from-linear-and-nonlinear-quantile-regression-in-cantab-cognition-in-mid-to-late-life-in-an-epidemiological-sample
#8
Rosemary A Abbott, Caroline Skirrow, Martha Jokisch, Maarten Timmers, Johannes Streffer, Luc van Nueten, Michael Krams, Angela Winkler, Noreen Pundt, Pradeep J Nathan, Philippa Rock, Francesca K Cormack, Christian Weimar
Introduction: Normative cognitive data can help to distinguish pathological decline from normal aging. This study presents normative data from the Cambridge Neuropsychological Test Automated Battery, using linear regression and nonlinear quantile regression approaches. Methods: Heinz Nixdorf Recall study participants completed Cambridge Neuropsychological Test Automated Battery tests: paired-associate learning, spatial working memory, and reaction time. Data were available for 1349-1529 healthy adults aged 57-84 years...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30581973/white-matter-and-its-relationship-with-cognition-in-subjective-cognitive-decline
#9
Lisa Ohlhauser, Ashleigh F Parker, Colette M Smart, Jodie R Gawryluk
Introduction: Subjective cognitive decline (SCD) is the earliest stage on the continuum toward Alzheimer's disease. This study examined (1) differences in white matter integrity between individuals with SCD and healthy control subjects and (2) how white matter integrity related to memory and executive function. Methods: Diffusion tensor imaging and neuropsychological assessment data were retrieved from the Alzheimer's Disease Neuroimaging Initiative database for 30 individuals with SCD and 44 control subjects...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30581972/retinal-ganglion-cell-inner-plexiform-layer-thickness-is-nonlinearly-associated-with-cognitive-impairment-in-the-community-dwelling-elderly
#10
Yao-Lin Liu, Yi-Ting Hsieh, Ta-Fu Chen, Jeng-Min Chiou, Min-Kuang Tsai, Jen-Hau Chen, Yen-Ching Chen
Introduction: Thinning of optical coherence tomography-measured retinal nerve fiber layer thickness and ganglion cell-inner plexiform layer (GC-IPL) thickness has been found in patients with Alzheimer's disease. However, the association of these retinal markers and cognition in nondemented elders may not be linear. Methods: This cross-sectional study included 227 community-dwelling elders (age 65+ years). Multivariable regression analyses were performed to investigate the association between retinal nerve fiber layer/GC-IPL and global/domain-specific cognition...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30581971/apolipoprotein-e-particle-size-is-increased-in-alzheimer-s-disease
#11
Thomas J Nelson, Abhik Sen
Introduction: Apolipoprotein E4 (apoE4) is the predominant risk factor for late-onset Alzheimer's disease (AD), but the question of which structural differences might explain its effect remains unclear. Methods: We compared high-density lipoprotein-like apoE particles from 12 AD and 10 control patients using size-exclusion chromatography. Results: ApoE particles from patients genotyped as ε4/ε4 were 2.2 ± 0.3 times as massive as particles from ε3/ε3 control subjects and 1...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30569013/decision-tree-supports-the-interpretation-of-csf-biomarkers-in-alzheimer-s-disease
#12
Rosha Babapour Mofrad, Niki S M Schoonenboom, Betty M Tijms, Philip Scheltens, Pieter Jelle Visser, Wiesje M van der Flier, Charlotte E Teunissen
Introduction: We developed and validated a clinically applicable decision tree for the use of cerebrospinal fluid biomarkers in the diagnosis of Alzheimer's disease (AD). Methods: Subjects with probable AD ( n  = 1004) and controls ( n =  442) were included. A decision tree was modeled using Classification And Regression Tree analysis in a training cohort (AD n =  221; controls n =  221) and validated in an independent cohort (AD n  = 783; controls n  = 221)...
December 2019: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30619929/computer-assisted-prediction-of-clinical-progression-in-the-earliest-stages-of-ad
#13
Hanneke F M Rhodius-Meester, Hilkka Liedes, Juha Koikkalainen, Steffen Wolfsgruber, Nina Coll-Padros, Johannes Kornhuber, Oliver Peters, Frank Jessen, Luca Kleineidam, José Luis Molinuevo, Lorena Rami, Charlotte E Teunissen, Frederik Barkhof, Sietske A M Sikkes, Linda M P Wesselman, Rosalinde E R Slot, Sander C J Verfaillie, Philip Scheltens, Betty M Tijms, Jyrki Lötjönen, Wiesje M van der Flier
Introduction: Individuals with subjective cognitive decline (SCD) are at increased risk for clinical progression. We studied how combining different diagnostic tests can help to identify individuals who are likely to show clinical progression. Methods: We included 674 patients with SCD (46% female, 64 ± 9 years, Mini-Mental State Examination 28 ± 2) from three memory clinic cohorts. A multivariate model based on the Disease State Index classifier incorporated the available baseline tests to predict progression to MCI or dementia over time...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30581970/validation-into-arabic-versions-of-dementia-rating-scales-dementia-caregivers-scales-and-dementia-research-instruments
#14
Georges Elie Karam, Mohannad Nawaf Khandakji, Nayri Sarkis Sahakian, Jessica Christian Dandan, Elie Georges Karam
Introduction: This study aimed to examine the validity and internal consistency of Arabic versions of the eight-item Alzheimer's Dementia, Alzheimer Questionnaire, and Clinical Dementia Rating scales and to assess the Arabic version of Katz Activities of Daily Living, and Neuropsychiatric Inventory. Methods: One hundred fifty participants were recruited from different settings; they underwent clinical interviews and filled the aforementioned scales. Results: In our sample, 56...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30581969/validation-of-geriatric-depression-and-anxiety-rating-scales-into-arabic
#15
Georges Elie Karam, Mohannad Nawaf Khandakji, Nayri Sarkis Sahakian, Jessica Christian Dandan, Elie Georges Karam
Introduction: This study aimed to examine the validity and internal consistency of Arabic version of the Cornell Scale for Depression in Dementia (A-CSDD) and compare it to the Geriatric Depression and Hospital Anxiety and Depression Scales. Methods: Hundred fifty individuals were recruited; they underwent a clinical interview and filled the A-CSDD, Geriatric Depression Scale, and Hospital Anxiety and Depression Scale. The depression rating scales were validated against the Structured Clinical Interview for Diagnostic and Statistical Manual disorders...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30555890/csf-total-tau-levels-are-associated-with-hippocampal-novelty-irrespective-of-hippocampal-volume
#16
Emrah Düzel, David Berron, Hartmut Schütze, Arturo Cardenas-Blanco, Coraline Metzger, Matthew Betts, Gabriel Ziegler, Yi Chen, Laura Dobisch, Daniel Bittner, Wenzel Glanz, Martin Reuter, Annika Spottke, Janna Rudolph, Frederic Brosseron, Katharina Buerger, Daniel Janowitz, Klaus Fliessbach, Michael Heneka, Christoph Laske, Martina Buchmann, Peter Nestor, Oliver Peters, Dominik Diesing, Siyao Li, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Alfredo Ramirez, Anja Schneider, Barbara Kofler, Oliver Speck, Stefan Teipel, Ingo Kilimann, Martin Dyrba, Jens Wiltfang, Claudia Bartels, Steffen Wolfsgruber, Michael Wagner, Frank Jessen
Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age. Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment)...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30511009/amnestic-mild-cognitive-impairment-individuals-with-dissimilar-pathologic-origins-show-common-regional-vulnerability-in-the-default-mode-network
#17
Swati Rane, Manus J Donahue, Daniel O Claassen
Introduction: Alzheimer's and Parkinson's disease (AD and PD) are distinct disorders but share similar biomarker profiles. The regions of the default mode network are implicated in these diseases and are associated with amnestic symptoms. The role of apolipoprotein-ε4 (APOE-ε4), which is associated with cognitive function, is unclear in PD. Methods: In this work, we evaluated cortical thickness of default mode network regions that are likely affected in both early AD and PD individuals, that is, with amnestic mild cognitive impairment...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30511008/do-2-year-changes-in-superior-frontal-gyrus-and-global-brain-atrophy-affect-cognition
#18
Maria Del C Valdés Hernández, Stuart Reid, Shadia Mikhael, Cyril Pernet
Introduction: Metabolic alterations to the superior frontal gyrus (SFG) have been linked to cognitive decline. Whether these indicate structural atrophy, which could be screened for at a larger scale using noninvasive structural imaging, is unknown. Methods: We assessed annual structural magnetic resonance imaging scans and cognitive data from 3 consecutive years from 204 participants from the AD Neuroimaging Initiative database (mean age 72.24 [8.175] years). We evaluated associations between brain structural changes and performance in the Montreal Cognitive Assessment, Everyday Cognition Visuospatial subtest (ECog Visuospatial), and Functional Assessment Questionnaire...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30505927/optimal-cutoffs-for-the-montreal-cognitive-assessment-vary-by-race-and-ethnicity
#19
Sadaf Arefi Milani, Michael Marsiske, Linda B Cottler, Xinguang Chen, Catherine W Striley
Introduction: The Montreal Cognitive Assessment (MoCA), scored from 0 to 30, is used as a screening tool for mild cognitive impairment (MCI). The current cutoff (26) may not be optimal among minorities. Methods: Data from the National Alzheimer's Coordinating Center Uniform Data Set March 2018 data freeze was used to calculate optimal cutoffs for detection of MCI and dementia by race/ethnic group and education. Results: Of the 3895 individuals included, 80...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/30505926/utility-of-the-nih-toolbox-for-assessment-of-prodromal-alzheimer-s-disease-and-dementia
#20
Katherine Hackett, Robert Krikorian, Tania Giovannetti, Josefina Melendez-Cabrero, Aneela Rahman, Emily E Caesar, Jaclyn L Chen, Hollie Hristov, Alon Seifan, Lisa Mosconi, Richard S Isaacson
Introduction: The NIH Toolbox Cognition Battery (NIHTB-CB) is a computer-based protocol not yet validated for clinical assessment. Methods: We administered the NIHTB-CB and traditional neuropsychological tests to 247 Memory Disorders and Alzheimer's Prevention Clinic patients with subjective cognitive decline, mild cognitive impairment, mild dementia due to Alzheimer's disease, and normal cognition. Principal component analysis, partial correlations, and univariate general linear model tests were performed to assess construct validity...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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