Aude Christelle Ka'e, Maria Mercedes Santoro, Leonardo Duca, Collins Ambe Chenwi, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Naomi-Karell Etame, Willy Leroi Togna Pabo, Grace Beloumou, Marie Laure Mpouel, Sandrine Djupsa, Desire Takou, Samuel Martin Sosso, Hyppolite K Tchidjou, Vittorio Colizzi, Gregory-Edie Halle-Ekane, Carlo-Federico Perno, Sharon Lewin, R Brad Jones, Caroline T Tiemessen, Francesca Ceccherini-Silberstein, Joseph Fokam
BACKGROUND: With the advent of antiretroviral therapy (ART), most children living with HIV in sub-Saharan Africa (SSA) are growing toward adolescence, with scarcity of evidence on the size of viral reservoirs to enhance paediatric cure research strategies. This study aims to compare HIV-1 proviral DNA levels according to virological response among adolescents living with perinatally acquired HIV-1 (ALPHIV) and identify associated-factors in the Cameroonian context. METHODS: In this observational cohort study, HIV-1 RNA viremia and CD4+ T-cell count were assessed through RT-PCR and flow cytometry respectively at three time-points over 18 months of observation...
March 2024: Journal of Virus Eradication