journal
Journals Drug Metabolism and Personaliz...

Drug Metabolism and Personalized Therapy

https://read.qxmd.com/read/37216433/-crhr1-polymorphism-at-rs242941-rs242940-and-rs72834580-association-of-symptoms-improvement-with-intranasal-corticosteroids-in-allergic-rhinitis-jordanian-patients
#21
JOURNAL ARTICLE
Malek Zihlif, Osama H Abusara, Walid Al-Qerem, Mahmood Al-Ibadah, Tareq M Mahafza, Fatima M Al-Akhras, Naseem T Mahafza
OBJECTIVES: Rhinitis is classified into several types with allergic rhinitis (AR) being the most common. AR is among the inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), in which corticosteroids are administered to overcome the decrease in cortisol production. The treatment options available for AR vary with 1st line treatment being intranasal corticosteroids (INCS). The responsiveness to corticosteroids is due to their binding to corticotropin-releasing hormone receptor-1 (CRHR1)...
May 22, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/37201212/pharmacogenetic-predictors-of-development-of-secondary-to-enalapril-dry-cough-in-hypertensive-patients
#22
JOURNAL ARTICLE
Ivan V Sychev, Natalia P Denisenko, Anastasiya A Kachanova, Anna V Lapshtaeva, Ludmila N Goncharova, Karin B Mirzaev, Dmitry A Sychev
OBJECTIVES: Development of the secondary to ACEI cough leads to discontinuation of the drugs of this group. Assessing the safety of the ACEIs with further development of customized approaches for their administration is a major scientific and practical problem. The objective of this study was to assess the association of the genetic markers with the development of the adverse drug reaction in the form of secondary to enalapril dry cough in the patients with essential arterial hypertension...
May 19, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/37155924/pharmacogenetics-and-ethnicity-dr-jos%C3%A3-mar%C3%A3-a-cant%C3%A3%C2%BA-award-announcement
#23
EDITORIAL
Ingrid Fricke-Galindo, Adrián LLerena
No abstract text is available yet for this article.
May 8, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/37098129/safety-immunogenecity-and-effectiveness-of-chadox1-ncov-19-vaccine-during-the-second-wave-of-pandemic-in-india-a-real-world-study
#24
JOURNAL ARTICLE
Preeti Chavan, Rajashree Dey, Renita Castelino, Akshay Kamble, Pratik Poladia, Rajani Bagal, Monica Jadhav, Aditi Shirsat, Ashish Chavan, Sachin Dhumal, Sharath Kumar, Manjunath Nookala Krishnamurty, Vivek Bhat, Atanu Bhattacharjee, Vikram Gota
OBJECTIVES: This real-world study was conducted to assess the adverse effects following immunization (AEFI) and immunogenicity of ChAdO×1 nCoV-19 vaccine in terms of neutralising antibody titers and to study the effects of covariates such as age, sex, comorbidities and prior COVID status on these outcomes. Also, the effectiveness of the vaccine based on interval between the two doses was also investigated. METHODS: A total of 512 participants (M/F=274/238) aged 35(18-87) years comprising a mixed population of healthcare workers, other frontline workers and general public were enrolled between March and May 2021...
April 26, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/37075481/development-and-validation-wise-assessment-of-genotype-guided-warfarin-dosing-algorithm-in-indian-population
#25
JOURNAL ARTICLE
Aishwarya Anand, Rupesh Kumar, Swati Sharma, Ankur Gupta, Rajesh Vijayvergiya, Saurabh Mehrotra, Basant Kumar, Deepesh Lad, Amol N Patil, Nusrat Shafiq, Samir Malhotra
OBJECTIVES: A study was conducted to develop and validate the warfarin pharmacogenetic dose optimization algorithm considering the clinical pharmacogenetic implementation consortium (CPIC) recommendations for the Asian ethnicity population. METHODS: The present prospective observational study recruited warfarin-receiving patients. We collected a three ml blood sample for VKORC1, CYP2C9*2, CYP2C9*3, and CYP4F2 polymorphism assessment during the follow-up visits. Clinical history, sociodemographic and warfarin dose details were noted...
April 19, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/37062805/ayurvedic-medicines-in-alleviating-the-symptoms-of-sars-cov-2-omicron-variant-in-north-indian-population-a-regional-genomic-study
#26
LETTER
Konduru Rama Chandra Reddy, Chetan Sahni, Royana Singh, Hari Chandana, Rohit Sharma
No abstract text is available yet for this article.
April 17, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/37012894/evaluation-of-the-efficacy-of-topical-terminalia-chebula-retz-with-vinegar-in-the-treatment-of-tinea-corporis-a-non-inferiority-randomized-controlled-trial
#27
JOURNAL ARTICLE
Sumayya Tasneem Parapur, Nazim Husain, Mohd Khalid, Saba Abdul Razzaq Mamdapur, Khan Ameer Kauser Khan
OBJECTIVES: Unani physicians have suggested a wide range of anti-dermatophytic remedies, although the scientific evidence is scarce. Thus, the efficacy and safety of Terminalia chebula Retz. fruit powder mixed with vinegar was compared with terbinafine hydrochloride 1% cream in the treatment of tinea corporis in order to establish the non-inferiority of test drugs. METHODS: The primary outcome measures were change in the presence or absence of hyphae on KOH mount test, change in pruritus severity assessed on 100 mm VAS and change in physician's global assessment...
April 4, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36930739/histomorphological-study-of-hepatic-lobules-of-adult-wistar-rats-administered-with-aqueous-extracts-of-leaves-of-cassia-singueana
#28
JOURNAL ARTICLE
Jemila Alley, Adam N Jibril, Sagir M Saleh, Mikail Umar, Mujittapha U Sirajo
OBJECTIVES: Cassia singueana is widely used in northern Nigeria as an herb for the treatment of enamors ailments. Nevertheless the toxicity of the herb on liver architecture; the hepatic lobule and body weight is yet to be authenticated. METHODS: A total of 24 male Wistar rats with an average weight of 150 g were randomly placed into four groups. Each group consisted of 6 rats. Group A served as the control group while groups B, C and D were given 150, 300, and 450 mg of Cassia singueana leaves extract respectively for 14 days...
March 20, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36919284/impact-of-fcgr2a-r131h-fcgr3a-f158v-and-fcgr3b-na1-na2-polymorphisms-on-response-to-fc-containing-tnf-inhibitors-in-tunisian-rheumatoid-arthritis-patients
#29
JOURNAL ARTICLE
Mahmoud Ines, Moalla Myriam, Ben Tekaya Aicha, Bouden Selma, Rouached Leila, Tekaya Rawdha, Saidane Olfa, Gorji Yousr, Elleuch Mohamed, Laatar Ahmed, Hamdi Wafa, Abdelmoula Leila, Sfar Imen
OBJECTIVES: Single nucleotid polymorphisms (SNPs) of Fc-gamma receptors (FcgRs), by inducing a variation of their affinity to the Fc-region of immunoglobulins, might influence the efficacy of Fc-containing biologics prescribed in rheumatoid arthritis (RA). Our aim was to investigate associations of FCGR2A , FCGR3A and FCGR3B SNPs with TNF-inhibitors (TNFi)' response in Tunisian RA patients. METHODS: A cross-sectional, observational and analytic multicentric cohort study was conducted in a group of 47 Tunisian RA patients treated with (etanercept [ETA], adalimumab [ADL] and infliximab [IFX])...
March 16, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36919259/exploratory-quasi-experimental-study-of-anti-arthritic-activity-of-ayurvedic-polyherbal-formulation-abha-guggulu-in-osteoarthritis-patients
#30
JOURNAL ARTICLE
Mrinmayee Hedaoo, Trupti Patil-Bhole, Rohit Sharma, Madhavi Mahajan
OBJECTIVES: Abha Guggulu (AG) is a traditional Ayurvedic herbal formulation used for treating joint disorders and bone fractures. Individually, the ingredients are known for their promising anti-inflammatory and rejuvenating actions. The present study attempts to explore the anti-arthritic potential of AG through an exploratory clinical trial. METHODS: The study was conducted using a quasi-experimental model. The clinical trial has been registered in Clinical Trials Registry of India (registration number: CTRI/2019/09/021354)...
March 16, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36913309/lack-of-exposure-to-pharmacogenomics-education-among-the-health-care-providing-students-in-the-west-bank-of-palestine
#31
JOURNAL ARTICLE
Yazun Jarrar, Rami Musleh, Anas Hamdan, Mustafa Ghanim, Malik Alqub, Sara Abudahab
OBJECTIVES: Evaluating the knowledge in pharmacogenomics (PGx) is the first step toward the implementation of PGx testing in clinical practice. This survey aimed to evaluate the knowledge of PGx testing among healthcare providing students at the top-ranked university in the West Bank of Palestine. METHODS: First an online questionnaire consisting of 30 questions regarding the demographic, knowledge, and attitude toward pharmacogenomics testing was structured and validated...
March 13, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36883753/cathine-and-cathinone-disposition-kinetics-and-neurotransmitter-profile-in-several-organs-of-rats-exposed-to-a-single-dose-of-catha-edulis-vahl-forssk-ex-endl-extract
#32
JOURNAL ARTICLE
Ahmad M Alamir, Mohammed A Jeraiby, Hesham M Korashy, Emad Sayed Shaheen, Mohammad A Attafi, Magbool E Oraiby, Ahmed M Hakami, Mohammed Y Albeishy, Ibrahim A Khardali, Ismail A Juraybi, Abeer A Alobaida, Ibraheem M Attafi
OBJECTIVES: Catha edulis (Vahl) Forssk. ex Endl. (Khat) is a stimulant plant that contains cathine and cathinone, which its abuses induce euphoria, alertness, and motor activity. Since the toxicokinetics of these substances remain unclear, this study was carried out to investigate the disposition kinetics of cathine and cathinone, the neurotransmitter profile, following a single dose of C. edulis extract in rats. METHODS: Twenty-four adult male Wistar albino rats (250-300 g) were randomly selected and divided into six groups of four rats each...
March 9, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36854045/a-review-of-pharmacogenetic-studies-in-the-bangladeshi-population
#33
REVIEW
Md Shaki Mostaid, Md Abdul Aziz, Jeba Atkia Maisha, Mohammad Safiqul Islam, Abdullah Al Maruf
Pharmacogenetics (PGx)-guided prescribing is an evidence-based precision medicine strategy. Although the past two decades have reported significant advancements in both the quality and quantity of PGx research studies, they are seldom done in developing countries like Bangladesh. This review identified and summarized PGx studies conducted in the Bangladeshi population by searching PubMed and Google Scholar. Additionally, a quality evaluation of the identified studies was also carried out. Eleven PGx studies were identified that looked at the effects of genetic variants on blood thinners ( CYP2C9 , VKORC1 , and ITGB3 ), cancer drugs ( TPMT , MTHFR , DPYD , ERCC1 , GSTP1 , XPC , XRCC1 , TP53 , XPD , and ABCC4 ), statins ( COQ2 , CYP2D6 , and CYP3A5 ), and prednisolone ( ABCB1 , CYP3A5 , and NR3C1 ) in the Bangladeshi population...
March 1, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36853909/influence-of-ephx1-c-337%C3%A2-t-c-and-ugt2b7-2-genetic-polymorphisms-on-the-requirement-of-carbamazepine-maintenance-dose-in-person-with-epilepsy-pwe-of-southern-part-of-india-a-cross-sectional-genetic-association-study
#34
JOURNAL ARTICLE
Shravan Venkatraman, Kesavan Ramasamy, Pradeep P Nair, Priyadharsini Rajendran
OBJECTIVES: Carbamazepine (CBZ) is a first-line antiseizure drug used for focal onset seizures. It exhibits inter-individual variability in plasma carbamazepine levels and there are both genetic and non-genetic factors having a role in the requirement of CBZ maintenance dose. The aim was to study the influence of EPHX1 c.337 T>C and UGT2B7*2 genetic polymorphisms on CBZ maintenance dose requirement in persons with epilepsy. METHODS: Persons with epilepsy (PWE) of both gender of age 15-65 years on carbamazepine monotherapy who had been taking same maintenance dose for one year were eligible...
March 1, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/35998916/therapeutic-drug-monitoring-of-teriflunomide-do-plasma-concentrations-predict-response-to-leflunomide-in-patients-with-rheumatoid-arthritis
#35
JOURNAL ARTICLE
Tekaya Rawdha, Ben Tekaya Aicha, Ben Ammar Lobna, Salouaje Issam, Ben Sassi Mouna, Saidane Olfa, Bouden Selma, Ben Brahim Takoua, Ben Abdelghani Kawther, Metoui Leila, Sahli Hana, Mahmoud Ines, Abdelmoula Leila
OBJECTIVES: Leflunomide is a commonly used treatment for rheumatoid arthritis. It acts by inhibiting dihydroorotate dehydrogenase through its active metabolite teriflunomide. The objective of the study was to investigate the relation between plasma-concentration of teriflunomide and disease-activity in rheumatoid arthritis. METHODS: Data were collected from patients with rheumatoid arthritis on a stable leflunomide dose for at least 2 months. Socio-demographic data, disease characteristics and DAS28 score were recorded...
March 1, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/35751549/the-efficacy-and-safety-of-dry-cupping-in-cervical-spondylosis-with-optimization-of-cup-application-time%C3%A2-a-randomized-clinical-trial
#36
RANDOMIZED CONTROLLED TRIAL
Ayesha Tehseen, Hamid Ali, Nazim Husain, Hina Kouser Varda
OBJECTIVES: Dry cupping therapy (DCT) is considered beneficial in the amelioration of cervical spondylosis (CS) symptoms in Unani medicine. Therefore, the focus of this study was to ascertain the efficacy of DCT and optimal cup application time duration for CS. METHODS: It was a randomized clinical trial involving 45 participants with clinically diagnosed CS. The eligible subjects were randomly categorized into three groups, each having 15 participants. Each of the three groups, i...
March 1, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36803453/news-in-dmpt-leaders-in-pharmacogenetics-section
#37
EDITORIAL
Ingrid Fricke-Galindo, Adrián LLerena
No abstract text is available yet for this article.
February 20, 2023: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36580432/-cyp2c9-gene-polymorphisms-influence-on-antihypertensive-effectiveness-and-hypouricemic-effect-of-losartan-among-patients-with-arterial-hypertension-an-observational-study
#38
JOURNAL ARTICLE
Irina I Sinitsina, Alexey V Boyarko, Ilyas I Temirbulatov, Dmitry A Sychev, Kristina A Akmalova, Zhannet A Sozaeva, Elena A Grishina, Karin B Mirzaev, Anastasiia V Asoskova, Vladimir P Fisenko
OBJECTIVES: CYP2C9 gene polymorphic variants can decrease the effects of losartan, reducing active metabolite (E-3174) formation. Study aims to determine the influence of *2 (+430C>T; rs799853) and *3 (+1075A>C; rs1057910) CYP2C9 gene polymorphic variants on the hypotensive and uricosuric effect of losartan on patients with arterial hypertension. METHODS: Eighty one patients with stage 1-2 arterial hypertension newly diagnosed with ABMP were enrolled in the study...
December 29, 2022: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36577508/quantitative-assessment-of-antioxidant-potential-of-selected-homeopathic-preparations-in-clinical-practice
#39
JOURNAL ARTICLE
Arun Kumar, Suneel Prajapati, Mahima Sharma, Tejveer Singh, Neha Choudhary, Alok C Bharti, Rohit Sharma, Pankaj Gupta
OBJECTIVES: Antioxidant property like radical scavenging is a primary target to elucidate the efficacy mechanism of a drug against diseases linked to oxidative stress such as cancer, metabolic disorders, rheumatoid arthritis, etc. In alternative therapies, homeopathy is one of the preferred choices by patients and clinicians due to its potential to cure chronic and complex illnesses. However, the efficacy of homeopathic preparations at high diluted potencies attracts rational criticism due to insufficient scientific knowledge supporting the mechanism of action...
December 29, 2022: Drug Metabolism and Personalized Therapy
https://read.qxmd.com/read/36563403/actionable-mutations-in-non-small-cell-lung-cancer-in-patients-at-hospital-de-especialidades-eugenio-espejo-ecuador-2017-2020
#40
JOURNAL ARTICLE
Miguel Ángel Fernández Freire, Gabriela Isabel Gálvez Salazar, Mariana Meira Scudeler, Fernanda Rodrigues-Sores, Gabriela Fernanda Jaramillo Koupermann, Andrea Paola Moreno Ocampo
OBJECTIVES: Determine the frequency of actionable mutations in non-small cell lung cancer (NSCLC) and their correlation with overall survival (OS) and the site of metastases. METHODS: We performed a descriptive cross-sectional study at the Hospital de Especialidades Eugenio Espejo, Ecuador, between 2017 and 2020. Demographic, pathological, and molecular alterations in epidermal growth factor (EGFR), Anaplastic lymphoma kinase (ALK), ROS proto-oncogene 1 (ROS1), Programmed death-ligand 1 (PD-L1) expression, and clinical data detailed in patients' medical records with metastatic NSCLC were collected and analyzed...
December 26, 2022: Drug Metabolism and Personalized Therapy
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