David Tougeron, Laetitia Dahan, Ludovic Evesque, Karine Le Malicot, Farid El Hajbi, Thomas Aparicio, Olivier Bouché, Nathalie Bonichon Lamichhane, Benoist Chibaudel, Antoine Angelergues, Anaïs Bodere, Jean-Marc Phelip, May Mabro, Laure Kaluzinski, Caroline Petorin, Gilles Breysacher, Yves Rinaldi, Aziz Zaanan, Denis Smith, Marie-Claude Gouttebel, Clément Perret, Nicolas Etchepare, Jean-François Emile, Ivan Sanfourche, Frédéric Di Fiore, Côme Lepage, Pascal Artru, Christophe Louvet
IMPORTANCE: Efficacy of second-line chemotherapy in advanced gastric or gastrooesphageal junction (GEJ) adenocarcinoma remains limited. OJECTIVES: To determine the efficacy of 1 or 2 immune checkpoint inhibitors combined with FOLFIRI (leucovorin [folinic acid], fluorouracil, and irinotecan) in the treatment of advanced gastric/GEJ adenocarcinoma. DESIGN, SETTING, AND PARTICIPANTS: The PRODIGE 59-FFCD 1707-DURIGAST trial is a randomized, multicenter, noncomparative, phase 2 trial, conducted from August 27, 2020, and June 4, 2021, at 37 centers in France that included patients with advanced gastric/GEJ adenocarcinoma who had disease progression after platinum-based first-line chemotherapy...
April 4, 2024: JAMA Oncology