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Gynecologic Oncology Reports

Martha E Stewart, Anne T Knisely, Mackenzie W Sullivan, Kari L Ring, Susan C Modesitt
The objectives of this study were to determine both surgical and subsequent cancer outcomes for high-risk women from the University of Virginia's High-Risk Breast/Ovarian Cancer clinic undergoing ovarian cancer risk-reducing surgery. Retrospective review identified high risk women who had ovarian risk reducing surgery over the past decade and surgical outcomes, pathology, pre-operative screening results, and pre-/post-operative cancer diagnoses were evaluated. One hundred and eighty-three high-risk women had risk reducing surgery at a mean age of 50...
May 2019: Gynecologic Oncology Reports
E Cochrane, A Menzies, K Sweeney, W Burke
•Serous endometrial carcinomas rarely involve the renal system.•Stage IVB serous endometrial carcinoma with confirmed renal metastasis.•Paclitaxel/carboplatin treating serous endometrial carcinoma with renal metastasis.
May 2019: Gynecologic Oncology Reports
Blerina Salman, Amir Momeni-Boroujeni, Margaux Kanis, Yi-Chun Lee
•Cervical rhabdomyosarcoma does not always present as a cervical mass with vesicles.•Treatment regimens studied in the pediatric population can be used in adults with rhabdomyosarcoma.•More data is needed on outcomes of adult patients treated for rhabdomyosarcoma.
May 2019: Gynecologic Oncology Reports
Elizabeth K Lee, Neal I Lindeman, Ursula A Matulonis, Panagiotis A Konstantinopoulos
We report an extraordinary case of a woman, exposed to diethylstilbestrol in utero, who developed clear cell adenocarcinoma of the cervix with a concurrent polymerase-Ɛ ( POLE ) somatic mutation. The tumor exhibited the classic phenotypic characteristics of POLE -mutated tumors originating from other organs (e.g. the uterus or the colon) including increased tumor infiltrating lymphocytes and high PD-L1 expression and has remained in remission since completion of primary therapy for >4 years. This case highlights the importance of next generation sequencing in unraveling the biology of rare tumors and supports that the presence of a POLE mutation and the associated ultramutated state confers a unique phenotype of higher immunogenicity and possibly improved prognosis in a tissue-agnostic manner, i...
May 2019: Gynecologic Oncology Reports
Robert Neff, Robert Collins, Floor Backes
•Biopsies of a large mass are prone to sampling errors and may lead to an incorrect diagnosis.•MRI imaging of vulvar tumors can aid in surgical planning.•Large sarcomas of the vulva require a multi-disciplinary approach.
May 2019: Gynecologic Oncology Reports
James C Cripe, Tommy R Buchanan, Leping Wan, Andrea R Hagemann, Carolyn K McCourt, L Stewart Massad, Katherine C Fuh, David G Mutch, Mathew A Powell, Premal H Thaker, Lindsay M Kuroki
We aim to describe survival outcomes of gynecologic oncology inpatients treated with intravenous bisphosphonates for hypercalcemia and develop a risk stratification model that predicts decreased survival to aid with goals of care discussion. In a single-center, retrospective cohort study of gynecologic oncology patients admitted for bisphosphonate therapy for hypercalcemia. Survival from hypercalcemia to death was assessed by Kaplan-Meier method and log-rank test. Univariate log-rank test and Cox proportional hazards modeling were used to develop a risk stratification model...
May 2019: Gynecologic Oncology Reports
Rajmohan Murali, Robert A Soslow
No abstract text is available yet for this article.
February 2019: Gynecologic Oncology Reports
C Blake Gilks, Naveena Singh
No abstract text is available yet for this article.
February 2019: Gynecologic Oncology Reports
Lauren Montemorano, Stacy A Smrz, Anahita D Jalilvand, Sabrena F Noria, Ritu Salani
•Extreme obesity may preclude patients from primary surgical management of endometrial cancer.•Bariatric surgery is a safe and effective method of rapid weight loss in patients with extreme obesity.•Delayed hysterectomy, after weight loss from bariatric surgery, is an option in select patients with endometrial cancer.
February 2019: Gynecologic Oncology Reports
Krista S Pfaendler, Leslie M Randall
Undifferentiated endometrial carcinoma, a rare histopathologic diagnosis, has a poor prognosis with high risk of progression during or shortly after completion of adjuvant treatment. We present two cases of undifferentiated endometrial carcinoma: one in a postmenopausal female who experienced recurrent disease immediately after completion of adjuvant treatment and one in a premenopausal female who experienced disease progression while receiving adjuvant treatment. These cases exemplify the aggressive behavior of undifferentiated endometrial carcinoma and suggest the need for a more effective treatment in the upfront setting than the current standard of care for endometrioid endometrial adenocarcinoma...
February 2019: Gynecologic Oncology Reports
Janhvi Sookram, Brooke Levin, Julieta Barroeta, Kathy Kenley, Pallav Mehta, Lauren S Krill
Ovarian endometrioid adenocarcinoma with yolk sac component has been reported in fewer than twenty cases in the literature. A majority of the diagnoses are described in postmenopausal women without specific reference to germline genetic testing. We describe, to our knowledge, the first case in the English literature of a premenopausal woman that presented with an ovarian endometrioid adenocarcinoma with focal yolk sac component and was subsequently found to have a germline MSH2 mutation confirming a diagnosis of Lynch syndrome...
February 2019: Gynecologic Oncology Reports
Soumyajit Roy, Jenny J Ko, Gaurav Bahl
Objectives: To describe the patient characteristics, patterns of treatment, and outcome of patients with small cell carcinoma of Cervix (SmCC) treated with radical radiotherapy from a provincial cancer registry database. Methods: Overall 25 patients with SmCC were treated with radical radiotherapy (with or without chemotherapy) from January 1, 1994 to December 31, 2013. Nineteen patients had pure SmCC while 6 had additional neuroendocrine component. Patients were treated with combined chemo-radiotherapy using multi-agent chemotherapy with pelvic or combined pelvic and para-aortic radiotherapy...
February 2019: Gynecologic Oncology Reports
R Gotlieb, J Abitbol, J A How, I Ben-Brith, H A Abenhaim, S K Lau, M Basik, Z Rosberger, N Geva, W H Gotlieb, A Mintz
There is an absence of information on how physicians make surgical decisions, and on the effect of gender on the processing of information. A novel web based decision-matrix software was designed to trace experimentally the process of decision making in medical situations. The scenarios included a crisis and non-crisis simulation for endometrial cancer surgery. Gynecologic oncologists, fellows, and residents (42 male and 42 female) in Canada participated in this experiment. Overall, male physicians used more heuristics, whereas female physicians were more comprehensive in accessing clinical information (p < 0...
February 2019: Gynecologic Oncology Reports
Odinaka Mogor, Emily Hargrave, Demarreta Rush, Kenneth Hatch
Mucinous adenocarcinoma of the endometrium (MACE) is a rare subtype of endometrial adenocarcinoma that often presents a significant diagnostic challenge due to its variation from the conventional morphologic appearance of endometrioid epithelium. This case report is of a woman who has survived 4 years after pelvic exenteration and subsequent vulvectomy for recurrent MACE.
February 2019: Gynecologic Oncology Reports
Takashi Uehara, Hiroshi Yoshida, Keisei Tate, Tomoyasu Kato
A solitary pelvic tumor after treating a primary endometriosis-related neoplasm is usually considered a recurrence but may actually be a primary endometriosis-related peritoneal neoplasm. A Japanese woman in her late 60s was referred to our hospital for a solitary pelvic tumor. The tumor was suspected as a recurrence of a previously treated stage IA ovarian clear-cell carcinoma, and resected. Pathological analysis revealed that the tumor was a peritoneal seromucinous carcinoma associated with pelvic endometriosis...
February 2019: Gynecologic Oncology Reports
Dalia Khalife, Alaa El Housheimi, Ali Khalil, Salim Saba C, Muhieddine Seoud, Rayan Rammal, Ibrahim Elias Abdallah, Reem Abdallah
A 43-year-old woman treated with radical hysterectomy 1 year ago for cervical cancer presented with a suprapubic abdominal mass. A 15 cm necrotic mass from the abdominal wall along with 2 small bowel loops and the dome of the bladder were resected. The peritoneal defect was reconstructed with a pedicled anterolateral thigh and Vastus Lateralis muscle composite flap. Pathology showed invasive non-keratinizing moderately differentiated squamous cell carcinoma, consistent with metastatic cervical cancer, involving urinary bladder, bowel and soft tissue...
February 2019: Gynecologic Oncology Reports
Sue Li, Melissa Schwartz, Sedef Everest, Stephanie V Blank
•Breast cancer originating from the vulva is extremely rare.•There are no guidelines for the treatment of such cancers.•More research is needed to uncover a possible genetic predisposition.
February 2019: Gynecologic Oncology Reports
Sarah P Huepenbecker, Leping Wan, Andrea Leon, Diane Rosen, John Hoff, Lindsay M Kuroki, Katherine C Fuh, Matthew A Powell, David G Mutch, Graham A Colditz, Andrea R Hagemann
To determine how obstetricians and gynecologists (OB/GYNs) perceive the gynecologic health effects of obesity and to identify perceived obstacles to counseling. OB/GYNs with 3 St. Louis health systems were emailed a 46-question survey regarding physicians' role in counseling women on the health risks of obesity and barriers faced in achieving this counseling. Differences between respondents' gender, age, practice type, years in practice, and body mass index were assessed using Chi-square or Fisher's exact tests as appropriate...
February 2019: Gynecologic Oncology Reports
Koen De Decker, Henk G Ter Brugge, Joost Bart, Roy F P M Kruitwagen, Hans W Nijman, Arnold-Jan Kruse
Objectives: Discordance between frozen section diagnosis and the definite histopathological diagnosis and the fact that the frozen section result is not always unambiguous, may contribute to differences in clinical practice regarding perioperative treatment and follow-up of borderline ovarian tumours (BOTs) patients amongst gynaecologic oncologists, which may lead to over- and undertreatment. The aim of the study was to map the Dutch gynaecologists' preferred treatment and follow-up strategy in case of BOTs...
February 2019: Gynecologic Oncology Reports
Timothy N Dunn, Kamyar Khazaeian, Donna M Coffey, Jan Rohozinski, Ertug Kovanci, Creighton L Edwards, Celestine S Tung
Yolk-sac tumors account for about 20% of ovarian germ cell tumors and occur predominantly in women below 35 years of age. Modern evidence-based treatment strategies have ensured long term post-treatment survival, but with increased survival, attention has been turned to an urgent need for developing fertility sparing treatment strategies. In this report we describe the successful treatment of a young woman who was able to conceive and deliver two children, in spite of the loss of one ovary two years prior to being diagnosed with an ovarian yolk-sac tumor on the remaining ovary...
February 2019: Gynecologic Oncology Reports
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