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Regenerative Biomaterials

J M Campos, A C Sousa, A R Caseiro, S S Pedrosa, P O Pinto, M V Branquinho, I Amorim, J D Santos, T Pereira, C M Mendonça, A Afonso, L M Atayde, A C Maurício
Development of synthetic bone substitutes has arisen as a major research interest in the need to find an alternative to autologous bone grafts. Using an ovine model, the present pre-clinical study presents a synthetic bone graft (Bonelike® ) in combination with a cellular system as an alternative for the regeneration of non-critical defects. The association of biomaterials and cell-based therapies is a promising strategy for bone tissue engineering. Mesenchymal stem cells (MSCs) from human dental pulp have demonstrated both in vitro and in vivo to interact with diverse biomaterial systems and promote mineral deposition, aiming at the reconstruction of osseous defects...
February 2019: Regenerative Biomaterials
Wensen Jiang, Jiajia Lin, Alex H Chen, Jianwei Pan, Huinan Liu
A portable device was designed and constructed for studying the properties of biomaterials in physiologically relevant fluids under controllable flow conditions that closely simulate fluid flow inside the body. The device can fit entirely inside a cell incubator; and, thus, it can be used directly under standard cell culture conditions. An impedance-driven pump was built in the sterile flow loop to control the flow rates of fluids, which made the device small and portable for easy deployment in the incubator...
February 2019: Regenerative Biomaterials
James K Carrow, Andrea Di Luca, Alireza Dolatshahi-Pirouz, Lorenzo Moroni, Akhilesh K Gaharwar
Additive manufacturing (AM) has shown promise in designing 3D scaffold for regenerative medicine. However, many synthetic biomaterials used for AM are bioinert. Here, we report synthesis of bioactive nanocomposites from a poly(ethylene oxide terephthalate) (PEOT)/poly(butylene terephthalate) (PBT) (PEOT/PBT) copolymer and 2D nanosilicates for fabricating 3D scaffolds for bone tissue engineering. PEOT/PBT have been shown to support calcification and bone bonding ability in vivo , while 2D nanosilicates induce osteogenic differentiation of human mesenchymal stem cells (hMSCs) in absence of osteoinductive agents...
February 2019: Regenerative Biomaterials
M Putzu, F Causa, Manuel Parente, Israel González de Torre, J C Rodriguez-Cabello, P A Netti
In the field of tissue engineering the choice of materials is of great importance given the possibility to use biocompatible polymers produced by means of biotechnology. A large number of synthetic and natural materials have been used to this purpose and processed into scaffolds using Electrospinning technique. Among materials that could be used for the fabrication of scaffold and degradable membranes, natural polymers such as collagen, elastin or fibroin offer the possibility to design structures strictly similar to the extracellular matrix (ECM)...
February 2019: Regenerative Biomaterials
Dan Meng, Limin Dong, Yafei Yuan, Qingsong Jiang
Calcium phosphate cements (CPCs) have been widely used as bone graft substitutes for many years. The aim of this study was to evaluate the biocompatibility of two novel injectable, bioactive cements: β-tricalcium phosphate (β-TCP)/CPC and chitosan microsphere/CPC in vitro and in vivo. This was accomplished by culturing mouse pre-osteoblastic cells (MC3T3-E1) on discs and pastes of CPCs. Cell growth, adhesion, proliferation and differentiation were assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and alkaline phosphatase assays as well as by scanning electron microscopy and fluorescence...
February 2019: Regenerative Biomaterials
Heidi F Oldenkamp, Julia E Vela Ramirez, Nicholas A Peppas
No abstract text is available yet for this article.
February 2019: Regenerative Biomaterials
Muhammad Shafiq, Yue Zhang, Dashuai Zhu, Zongxian Zhao, Dong-Hwee Kim, Soo Hyun Kim, Deling Kong
Cardiovascular diseases cause huge socio-economic burden worldwide. Although a mammalian myocardium has its own limited healing capability, scaffold materials capable of releasing stem cell recruiting/engrafting factors may facilitate the regeneration of the infarcted myocardium. The aim of this research was to develop cardiac patches capable of simultaneously eluting substance P (SP) and insulin-like growth factor-1C (IGF-1C) peptide. Polycaprolactone/collagen type 1-based patches with or without SP and IGF-1C peptide were fabricated by co-electrospinning, which exhibited nanofibrous morphology...
October 2018: Regenerative Biomaterials
Georgia Kaklamani, Diana Kazaryan, James Bowen, Fabrice Iacovella, Spiros H Anastasiadis, George Deligeorgis
Hydrogels have been extensively used in the field of biomedical applications, offering customizable natural, synthetic or hybrid materials, particularly relevant in the field of tissue engineering. In the bioelectronics discipline, hydrogels are promising mainly as sensing platforms with or without encapsulated cells, showing great potential in healthcare and medicine. However, to date there is little data in the literature which characterizes the electrical properties of tissue engineering materials which are relevant to bioelectronics...
October 2018: Regenerative Biomaterials
Shuo Wang, Zhijun Zhao, Yongdong Yang, Antonios G Mikos, Zhiye Qiu, Tianxi Song, Fuzhai Cui, Xiumei Wang, Chunyang Zhang
Large-sized cranial bone defect repair presents a great challenge in the clinic. The ideal cranioplasty materials to realize the functional and cosmetic recovery of the defect must have sufficient mechanical support, excellent biocompatibility, good osseointegration and biodegradability as well. In this study, a high-strength mineralized collagen (MC) bone scaffold was developed with biomimetic composition, microstructure and mechanical properties for the repair of sheep large-sized cranial bone defects in comparison with two traditional cranioplasty materials, polymethyl methacrylate and titanium mesh...
October 2018: Regenerative Biomaterials
Jingsheng Huang, Yun Chen, Pengxiang Zhao, Yunlong Yu, Shiyong Zhang, Zhongwei Gu
We report that the co-solvent polarity can precisely control the TPE-buried amphiphile 1 to self-assemble into nanoparticles (NPs) in water with size range from ∼21-32 nm to 55-68 nm to 95-106 nm. Excepted for size, these TPE-buried amphiphile fabricated NPs hold identical physical properties such as spherical shape, surface charge, and luminescent properties, and moreover, after covalent capture of the acrylate hydrophilic heads, the resulting cross-linked NPs (cNPs I-III) own excellent in vivo stability, which thus would be an ideal platform for investigating the size effects on tumor accumulation and penetration...
October 2018: Regenerative Biomaterials
Xiaoying Lü, Heng Zhang, Yan Huang, Yiwen Zhang
The aim of this article is to apply proteomics in the comparison of the molecular mechanisms of PC12 cell adhesion and growth mediated by the adsorbed serum proteins on the surfaces of chitosan and collagen/chitosan films. First, the chitosan and the collagen/chitosan films were prepared by spin coating; and their surface morphologies were characterized by scanning electron microscopy, X-ray energy dispersive spectroscopy, contact angle measurement and Fourier transform infrared spectroscopy. Subsequently, cell proliferation experiments on two materials were performed and the dynamic curves of protein adsorption on their surfaces were measured...
October 2018: Regenerative Biomaterials
Shuang Cai, Bin Luo, Xiaohui Zhan, Xiaoxi Zhou, Fang Lan, Qiangying Yi, Yao Wu
The strategy of using Fe3 O4 amphiphilic Janus nanoparticles (Fe3 O4 @AJNPs) bearing β-cyclodextrin (β-CD) and aminopyridine (APD) functionalized polymethyl methacrylate (PGMA) to construct pH-stimuli responsive co-assemblies through host-guest interactions between β-CD and APD was proposed. The spherical co-assemblies with an average diameter about 210 nm were excellent magnetic responsive and quite stable even up to 2 months in deionized water. The pH-liable capability of these co-assemblies was revealed by disassembly of the formed superstructures with destruction of the built inclusion complexes...
October 2018: Regenerative Biomaterials
Jiayuan Tang, Jinlin Chen, Jing Guo, Qingrong Wei, Hongsong Fan
Konjac glucomannan (KGM) is recognized as a safe material for its health-promoting benefits and thus widely used in various fields including pharmaceutical industry. In recent decades, the combination of collagen and KGM attracts more attentions for biomedical purpose, especially the hybrid films of collagen-KGM or collagen-KGM-polysaccharide. In this study, to further and deeply develop the intrinsic values of both collagen and KGM as biomaterials, a novel kind of composite hydrogel comprising collagen and KGM at a certain ratio was fabricated under mild conditions via fibrillogenesis process of the aqueous blends of collagen and KGM that experienced deacetylation simultaneously...
August 2018: Regenerative Biomaterials
Xing Yang, Yuanyuan Li, Xujie Liu, Qianli Huang, Ranran Zhang, Qingling Feng
The development of bone tissue engineering scaffolds still remains a challenging field, although various biomaterials have been developed for this purpose. Electrospinning is a promising approach to fabricate nanofibers with an interconnected porous structure, which can support cell adhesion, guide cell proliferation and regulate cell differentiation. The aim of this study is to fabricate composite fibers composed of poly(lactic-co-glycolic acid) (PLGA) and silica nanoparticles (NPs) via electrospinning and investigate the effect of PLGA/SiO2 composite fibers on the cellular response of osteoblast-like cells (SaOS-2 cells)...
August 2018: Regenerative Biomaterials
Jia Wei, Hufei Qian, Yu Liu, Jiangang Liu, Rui Zhao, Xiao Yang, Xiangdong Zhu, Ruoping Chen, Xingdong Zhang
This work aimed at investigating the possibility and effectiveness of osteoinductive calcium phosphate (CaP) ceramics to close the drilled skull holes and prevent the postoperative cerebrospinal fluid (CSF) leaking in children's endoscopic neurosurgery. Five children patients (four boys and one girl, 3- to 8-years old) underwent the surgery, in which the endoscopic third ventriculostomy (ETV) was operated in four cases of hydrocephalus, and biopsy and ETV were both performed in one case of pineal tumor. The drilled skull holes were filled with the commercial osteoinductive CaP ceramics...
August 2018: Regenerative Biomaterials
Jing Zhang, Yang Chen, Jing Xu, Jingjing Wang, Chengzhang Li, Liyan Wang
The purposes of this study were to construct a novel tissue engineered bone composed of 3D-printed bioactive glass block/chitosan nanoparticles (BD/CSn) composites loaded with Nel-like Type I molecular-1 DNA (pDNA-NELL1) and/or bone marrow mesenchymal stem cells (BMSCs), and study their osteogenic activities by repairing bone defects in rhesus monkeys. CSn with NELL1 gene plasmid and rhesus monkey BMSCs were composited with a BD scaffold to prepare the tissue-engineered bone. Four adult female rhesus monkeys with 10- to 12-years old and 5-7 kg in weight were used in animal experiments...
August 2018: Regenerative Biomaterials
Tinke-Marie De Witte, Lidy E Fratila-Apachitei, Amir A Zadpoor, Nicholas A Peppas
In recent years, bone tissue engineering has emerged as a promising solution to the limitations of current gold standard treatment options for bone related-disorders such as bone grafts. Bone tissue engineering provides a scaffold design that mimics the extracellular matrix, providing an architecture that guides the natural bone regeneration process. During this period, a new generation of bone tissue engineering scaffolds has been designed and characterized that explores the incorporation of signaling molecules in order to enhance cell recruitment and ingress into the scaffold, as well as osteogenic differentiation and angiogenesis, each of which is crucial to successful bone regeneration...
August 2018: Regenerative Biomaterials
Ioannis V Yannas
This is a historical account of the steps, both serendipitous and rational, that led my group of students and colleagues at MIT and Harvard Medical School to discover induced organ regeneration. Our research led to methods for growing back in adult mammals three heavily injured organs, skin, peripheral nerves and the conjunctiva. We conclude that regeneration in adults is induced by a modification of normal wound healing.
August 2018: Regenerative Biomaterials
Ying Chen, Jing Wang, Xiangdong Zhu, Xuening Chen, Xiao Yang, Kai Zhang, Yujiang Fan, Xingdong Zhang
Osteoinductivity of porous calcium phosphate (CaP) ceramics has been widely investigated and confirmed, and it might be attributed to the rapid formation of the vascular networks after in vivo implantation of the ceramics. In this study, to explore the vascularization mechanism within the CaP ceramics, the migration and differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) under the stimulation of porous biphasic calcium phosphate (BCP) ceramic with excellent osteoinductivity were systematically investigated...
June 2018: Regenerative Biomaterials
Samad Ahadian, Ali Khademhosseini
Recent advances in biofabrication technologies and chemical synthesis approaches have enabled the fabrication of smart scaffolds that aim to mimic the dynamic nature of the native extracellular matrix. These scaffolds have paved the way for tissue regeneration in a dynamic and controllable manner.
June 2018: Regenerative Biomaterials
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