journal
https://read.qxmd.com/read/38545260/human-extracellular-matrix-ecm-like-collagen-and-its-bioactivity
#1
JOURNAL ARTICLE
Hui Zhou, Wenwei Li, Lixin Pan, Tianci Zhu, Teng Zhou, E Xiao, Qiang Wei
Collagen, the most abundant structural protein in the human extracellular matrix (ECM), provides essential support for tissues and guides tissue development. Despite its widespread use in tissue engineering, there remains uncertainty regarding the optimal selection of collagen sources. Animal-derived sources pose challenges such as immunogenicity, while the recombinant system is hindered by diminished bioactivity. In this study, we hypothesized that human ECM-like collagen (hCol) could offer an alternative for tissue engineering...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38529352/fabrication-of-a-3d-bioprinting-model-for-posterior-capsule-opacification-using-gelma-and-plma-hydrogel-coated-resin
#2
JOURNAL ARTICLE
Xin Liu, Jiale Li, Shuyu Liu, Yan Long, Ching Kang, Chen Zhao, Ling Wei, Shaoqi Huang, Yi Luo, Bo Dai, Xiangjia Zhu
Posterior capsule opacification (PCO) remains the predominant complication following cataract surgery, significantly impairing visual function restoration. In this study, we developed a PCO model that closely mimics the anatomical structure of the crystalline lens capsule post-surgery. The model incorporated a threaded structure for accurate positioning and observation, allowing for opening and closing. Utilizing 3D printing technology, a stable external support system was created using resin material consisting of a rigid, hollow base and cover...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38525327/mri-guided-photothermal-photodynamic-immune-activation-combined-with-pd-1-inhibitor-for-the-multimodal-combination-therapy-of-melanoma-and-metastases
#3
JOURNAL ARTICLE
Changqiang Wu, Wei Chen, Shuang Yan, Jie Zhong, Liang Du, Chenwu Yang, Yu Pu, Yang Li, Jiafu Lin, Mei Zeng, Xiaoming Zhang
Non-invasive image-guided precise photothermal/photodynamic therapy (PTT/PDT) has been proven to be an effective local treatment modality but incompetent against metastases. Hence, the combination of local PTT/PDT and systemic immunotherapy would be a promising strategy for tumor eradication. Herein, a magnetic resonance imaging (MRI)-visualized PTT/PDT agent (SIDP NMs) was constructed, and the efficacy of its multimodal combination with a programmed cell death 1 (PD-1) inhibitor in the treatment of melanoma and metastases was studied...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38525326/role-of-integrin-%C3%AE-1-and-tenascin-c-mediate-tgf-smad2-3-signaling-in-chondrogenic-differentiation-of-bmscs-induced-by-type-i-collagen-hydrogel
#4
JOURNAL ARTICLE
Yuanjun Huang, Miao Sun, Zhenhui Lu, Qiuling Zhong, Manli Tan, Qingjun Wei, Li Zheng
Cartilage defects may lead to severe degenerative joint diseases. Tissue engineering based on type I collagen hydrogel that has chondrogenic potential is ideal for cartilage repair. However, the underlying mechanisms of chondrogenic differentiation driven by type I collagen hydrogel have not been fully clarified. Herein, we explored potential collagen receptors and chondrogenic signaling pathways through bioinformatical analysis to investigate the mechanism of collagen-induced chondrogenesis. Results showed that the super enhancer-related genes induced by collagen hydrogel were significantly enriched in the TGF-β signaling pathway, and integrin-β1 (ITGB1), a receptor of collagen, was highly expressed in bone marrow mesenchymal stem cells (BMSCs)...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38525325/polyethylenimine-modified-graphene-quantum-dots-promote-endothelial-cell-proliferation
#5
JOURNAL ARTICLE
Qirong Xu, Chen Li, Xiangyan Meng, Xinghong Duo, Yakai Feng
Endothelial cell proliferation plays an important role in angiogenesis and treatment of related diseases. The aim of this study was to evaluate the effect of polyethylenimine (PEI)-modified graphene quantum dots (GQDs) gene vectors on endothelial cell proliferation. The GQDs-cationic polymer gene vectors were synthesized by amidation reaction, and used to deliver pZNF580 gene to Human umbilical vein endothelial cells (HUVECs) for promoting their proliferation. The chemical modification of GQDs can adjust gene vectors' surface properties and charge distribution, thereby enhancing their interaction with gene molecules, which could effectively compress the pZNF580 gene...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38525324/one-step-biofabrication-of-liquid-core-gelma-shell-microbeads-for-in-situ-hollow-cell-ball-self-assembly
#6
JOURNAL ARTICLE
Jianwei Chen, Zeyang Liu, Zixian Wang, Xiuxiu Zhang, Yi Zhang, Zhen Zhan, Xiaohua Gong, Tao Xu
There are many instances of hollow-structure morphogenesis in the development of tissues. Thus, the fabrication of hollow structures in a simple, high-throughput and homogeneous manner with proper natural biomaterial combination is valuable for developmental studies and tissue engineering, while it is a significant challenge in biofabrication field. We present a novel method for the fabrication of a hollow cell module using a coaxial co-flow capillary microfluidic device. Sacrificial gelatin laden with cells in the inner layer and GelMa in the outer layer are used via a coaxial co-flow capillary microfluidic device to produce homogenous micro-beads...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38487713/a-transferrin-receptor-targeting-dual-modal-mr-nir-fluorescent-imaging-probe-for-glioblastoma-diagnosis
#7
JOURNAL ARTICLE
Jiaqi Hao, Huawei Cai, Lei Gu, Yiqi Ma, Yan Li, Beibei Liu, Hongyan Zhu, Fanxin Zeng, Min Wu
The prognosis of glioblastoma (GBM) remains challenging, primarily due to the lack of a precise, effective imaging technique for comprehensively characterization. Addressing GBM diagnostic challenges, our study introduces an innovative dual-modal imaging that merges near-infrared (NIR) fluorescent imaging with magnetic resonance imaging (MRI). This method employs superparamagnetic iron oxide nanoparticles coated with NIR fluorescent dyes, specifically Cyanine 7, and targeted peptides. This synthetic probe facilitates MRI functionality through superparamagnetic iron oxide nanoparticles, provides NIR imaging capability via Cyanine 7 and enhances tumor targeting trough peptide interactions, offering a comprehensive diagnostic tool for GBM...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38487712/macrophage-exosomes-modified-by-mir-365-2-5p-promoted-osteoblast-osteogenic-differentiation-by-targeting-olfml1
#8
JOURNAL ARTICLE
Caiyao Hou, Yujue Zhang, Zhaoyong Lv, Yurun Luan, Jun Li, Chunxiu Meng, Kun Liu, Xin Luo, Liyu Chen, Fengzhen Liu
In the bone immune microenvironment, immune cells can regulate osteoblasts through a complex communication network. Macrophages play a central role in mediating immune osteogenesis, exosomes derived from them have osteogenic regulation and can be used as carriers in bone tissue engineering. However, there are problems with exosomal therapy alone, such as poor targeting, and the content of loaded molecules cannot reach the therapeutic concentration. In this study, macrophage-derived exosomes modified with miR-365-2-5p were developed to accelerate bone healing...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38476678/cancer-cell-response-to-extrinsic-and-intrinsic-mechanical-cue-opportunities-for-tumor-apoptosis-strategies
#9
REVIEW
Jun Shu, Huan Deng, Yu Zhang, Fang Wu, Jing He
Increasing studies have revealed the importance of mechanical cues in tumor progression, invasiveness and drug resistance. During malignant transformation, changes manifest in either the mechanical properties of the tissue or the cellular ability to sense and respond to mechanical signals. The major focus of the review is the subtle correlation between mechanical cues and apoptosis in tumor cells from a mechanobiology perspective. To begin, we focus on the intracellular force, examining the mechanical properties of the cell interior, and outlining the role that the cytoskeleton and intracellular organelle-mediated intracellular forces play in tumor cell apoptosis...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38454966/3d-printing-sequentially-strengthening-high-strength-natural-polymer-hydrogel-bilayer-scaffold-for-cornea-regeneration
#10
JOURNAL ARTICLE
Xiongfeng Nie, Yong Tang, Tengling Wu, Xinrui Zhao, Ziyang Xu, Rong Yang, Yage Sun, Bin Wu, Quanhong Han, Jingwen Hui, Wenguang Liu
3D printing of high-strength natural polymer biodegradable hydrogel scaffolds simultaneously resembling the biomechanics of corneal tissue and facilitating tissue regeneration remains a huge challenge due to the inherent brittleness of natural polymer hydrogels and the demanding requirements of printing. Herein, concentrated aqueous solutions of gelatin and carbohydrazide-modified alginate (Gel/Alg-CDH) are blended to form a natural polymer hydrogel ink, where the hydrazides in Alg-CDH are found to form strong hydrogen bonds with the gelatin...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38435376/biofouling-on-titanium-implants-a-novel-formulation-of-poloxamer-and-peroxide-for-in-situ-removal-of-pellicle-and-multi-species-oral-biofilm
#11
JOURNAL ARTICLE
Badra Hussain, Roger Simm, Jaime Bueno, Savvas Giannettou, Ali-Oddin Naemi, Ståle Petter Lyngstadaas, Håvard Jostein Haugen
Eradicating biofouling from implant surfaces is essential in treating peri-implant infections, as it directly addresses the microbial source for infection and inflammation around dental implants. This controlled laboratory study examines the effectiveness of the four commercially available debridement solutions '(EDTA (Prefgel® ), NaOCl (Perisolv® ), H2 O2 (Sigma-Aldrich) and Chlorhexidine (GUM® Paroex® ))' in removing the acquired pellicle, preventing pellicle re-formation and removing of a multi-species oral biofilm growing on a titanium implant surface, and compare the results with the effect of a novel formulation of a peroxide-activated 'Poloxamer gel (Nubone® Clean)'...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38426010/facile-synthesis-of-nanoparticles-stacked-co-3-o-4-nanoflakes-with-catalase-like-activity-for-accelerating-wound-healing
#12
JOURNAL ARTICLE
Yanan Huang, Wanyi Liao, Wenxuan Wang, Tingting Zhang, Yan Zhang, Lei Lu
Delayed wound healing caused by excessive reactive oxygen species (ROS) remains a considerable challenge. In recent years, metal oxide nanozymes have gained significant attention in biomedical research. However, a comprehensive investigation of Co3 O4 -based nanozymes for enhancing wound healing and tissue regeneration is lacking. This study focuses on developing a facile synthesis method to produce high-stability and cost-effective Co3 O4 nanoflakes (NFs) with promising catalase (CAT)-like activity to regulate the oxidative microenvironment and accelerate wound healing...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38420353/application-of-metal-organic-frameworks-based-functional-composite-scaffolds-in-tissue-engineering
#13
REVIEW
Xinlei Yao, Xinran Chen, Yu Sun, Pengxiang Yang, Xiaosong Gu, Xiu Dai
With the rapid development of materials science and tissue engineering, a variety of biomaterials have been used to construct tissue engineering scaffolds. Due to the performance limitations of single materials, functional composite biomaterials have attracted great attention as tools to improve the effectiveness of biological scaffolds for tissue repair. In recent years, metal-organic frameworks (MOFs) have shown great promise for application in tissue engineering because of their high specific surface area, high porosity, high biocompatibility, appropriate environmental sensitivities and other advantages...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38414799/microbiome-friendly-ps-pvp-electrospun-fibrous-membrane-with-antibiofilm-properties-for-dental-engineering
#14
JOURNAL ARTICLE
Jiamin Chen, Jia Guo, Xueyun Lu, Derong Yin, Cuisong Zhou, Yuqing Li, Xuedong Zhou
Dental caries is one of the most prevalent and biofilm-associated oral diseases in humans. Streptococcus mutans , with a high ability to form biofilms by adhering to hard surfaces, has been established as an important etiological agent for dental caries. Therefore, it is crucial to find a way to prevent the formation of cariogenic biofilm. Here, we report an electrospun fibrous membrane that could inhibit the adhesion and biofilm formation of S. mutans . Also, the polystyrene (PS)/polyvinyl pyrrolidone (PVP) electrospun fibrous membrane altered the 3D biofilm architecture and decreased water-insoluble extracellular polysaccharide production...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38414798/antioxidant-and-anti-inflammatory-injectable-hydrogel-microspheres-for-in-situ-treatment-of-tendinopathy
#15
JOURNAL ARTICLE
Qibin Han, Lang Bai, Yinhua Qian, Xiaoyu Zhang, Juan Wang, Jing Zhou, Wenguo Cui, Yuefeng Hao, Xing Yang
Tendinopathy is a common disorder that causes local dysfunction and reduces quality of life. Recent research has indicated that alterations in the inflammatory microenvironment play a vital role in the pathogenesis of tendinopathy. Herein, injectable methacrylate gelatin (GelMA) microspheres (GM) were fabricated and loaded with heparin-dopamine conjugate (HDC) and hepatocyte growth factor (HGF). GM@HDC@HGF were designed to balance the inflammatory microenvironment by inhibiting oxidative stress and inflammation, thereby regulating extracellular matrix (ECM) metabolism and halting tendon degeneration...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38414797/anisotropic-microtopography-surface-of-chitosan-scaffold-regulating-skin-precursor-derived-schwann-cells-towards-repair-phenotype-promotes-neural-regeneration
#16
JOURNAL ARTICLE
Meng Cong, Xia Wu, Lingjie Zhu, Guohao Gu, Fei Ding, Guicai Li, Haiyan Shi
For repairing peripheral nerve and spinal cord defects, biomaterial scaffold-based cell-therapy was emerged as an effective strategy, requiring the positive response of seed cells to biomaterial substrate and environment signals. Previous work highlighted that the imposed surface properties of scaffold could provide important guidance cues to adhered cells for polarization. However, the insufficiency of native Schwann cells and unclear cellular response mechanisms remained to be addressed. Given that, this study aimed to illuminate the micropatterned chitosan-film action on the rat skin precursor-derived Schwann cells (SKP-SCs)...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38414796/a-strategy-for-mechanically-integrating-robust-hydrogel-tissue-hybrid-to-promote-the-anti-calcification-and-endothelialization-of-bioprosthetic-heart-valve
#17
JOURNAL ARTICLE
Haoshuang Wu, Nuoya Chen, Tiantian Zheng, Li Li, Mengyue Hu, Yumei Qin, Gaoyang Guo, Li Yang, Yunbing Wang
Bioprosthetic heart valve (BHV) replacement has been the predominant treatment for severe heart valve diseases over decades. Most clinically available BHVs are crosslinked by glutaraldehyde (GLUT), while the high toxicity of residual GLUT could initiate calcification, severe thrombosis, and delayed endothelialization. Here, we construed a mechanically integrating robust hydrogel-tissue hybrid to improve the performance of BHVs. In particular, recombinant humanized collagen type III (rhCOLIII), which was precisely customized with anti-coagulant and pro-endothelialization bioactivity, was first incorporated into the polyvinyl alcohol (PVA)-based hydrogel via hydrogen bond interactions...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38414795/enhancing-cartilage-regeneration-and-repair-through-bioactive-and-biomechanical-modification-of-3d-acellular-dermal-matrix
#18
JOURNAL ARTICLE
Wei Gao, Tan Cheng, Zhengya Tang, Wenqiang Zhang, Yong Xu, Min Han, Guangdong Zhou, Chunsheng Tao, Ning Xu, Huitang Xia, Weijie Sun
Acellular dermal matrix (ADM) shows promise for cartilage regeneration and repair. However, an effective decellularization technique that removes cellular components while preserving the extracellular matrix, the transformation of 2D-ADM into a suitable 3D scaffold with porosity and the enhancement of bioactive and biomechanical properties in the 3D-ADM scaffold are yet to be fully addressed. In this study, we present an innovative decellularization method involving 0.125% trypsin and 0.5% SDS and a 1% Triton X-100 solution for preparing ADM and converting 2D-ADM into 3D-ADM scaffolds...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38404619/fe-zn-alloy-a-new-biodegradable-material-capable-of-reducing-ros-and-inhibiting-oxidative-stress
#19
JOURNAL ARTICLE
Shuaikang Yang, Weiqiang Wang, Yanan Xu, Yonghui Yuan, Shengzhi Hao
Fe-based biodegradable materials have attracted significant attention due to their exceptional mechanical properties and favorable biocompatibility. Currently, research on Fe-based materials mainly focuses on regulating the degradation rate. However, excessive release of Fe ions during material degradation will induce the generation of reactive oxygen species (ROS), leading to oxidative stress and ferroptosis. Therefore, the control of ROS release and the improvement of biocompatibility for Fe-based materials are very important...
2024: Regenerative Biomaterials
https://read.qxmd.com/read/38404618/mild-synthesis-of-ultra-bright-carbon-dots-with-solvatochromism-for-rapid-lipid-droplet-monitoring-in-varied-physiological-processes
#20
JOURNAL ARTICLE
Borui Su, Dong Gao, Nini Xin, Kai Wu, Mei Yang, Shichao Jiang, Yusheng Zhang, Jie Ding, Chengheng Wu, Jing Sun, Dan Wei, Hongsong Fan, Zhenzhen Guo
Lipid droplets (LDs) participating in various cellular activities and are increasingly being emphasized. Fluorescence imaging provides powerful tool for dynamic tracking of LDs, however, most current LDs probes remain inconsistent performance such as low Photoluminescence Quantum Yield (PLQY), poor photostability and tedious washing procedures. Herein, a novel yellow-emissive carbon dot (OT-CD) has been synthesized conveniently with high PLQY up to 90%. Besides, OT-CD exhibits remarkable amphiphilicity and solvatochromic property with lipid-water partition coefficient higher than 2, which is much higher than most LDs probes...
2024: Regenerative Biomaterials
journal
journal
50058
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.