journal
Journals Archives of Endocrinology and ...

Archives of Endocrinology and Metabolism

https://read.qxmd.com/read/37948568/insulin-like-growth-factor-binding-protein-3-promoter-variant-rs2854744-is-associated-with-nonalcoholic-fatty-liver-disease
#21
JOURNAL ARTICLE
Touraj Mahmoudi, Shadi Nouri, Fatemeh Zarei, Zeinab Nourmohammadi Najafabadi, Maryam Sanei, Shiva Sayedsalehi, Gholamreza Rezamand, Asadollah Asadi, Reza Dabiri, Hossein Nobakht, Hamid Farahani, Seidamir Pasha Tabaeian, Mohammad Reza Zali
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease and a growing global epidemic. In NAFLD, liver fat surpasses 5% of hepatocytes without the secondary causes of lipid accumulation or excessive alcohol consumption. Given the link between NAFLD and insulin resistance, the possible association between the rs2854744 (-202 G>T) promoter polymorphism of insulin-like growth factor binding protein 3 ( IGFBP3 ) gene and NAFLD was investigated in this study. MATERIALS AND METHODS: In this genetic case-control association study, the IGFBP3 rs2854744 genotypes of 315 unrelated individuals, including 156 patients with biopsy-proven NAFLD and 159 controls, were determined using polymerase chain reaction/restriction fragment length polymorphism analyses...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37948567/diagnostic-value-of-a-computer-assisted-diagnosis-system-for-the-ultrasound-features-in-thyroid-nodules
#22
JOURNAL ARTICLE
Yiwei Wang, Ming Yu, Minliang He, Ganjun Zhang, Libo Zhang, Bo Zhang
OBJECTIVE: To explore the diagnostic value of the TUIAS (SW_TH01/II) computer-aided diagnosis (CAD) software system for the ultrasound Thyroid Imaging Reporting and Data System (TI-RADS) features in thyroid nodules. MATERIALS AND METHODS: This retrospective study enrolled patients with thyroid nodules in Shanghai East Hospital between January 2017 and October 2021. The novel CAD software (SW_TH01/II) and three sonographers performed a qualitative analysis of the ultrasound TI-RADS features in aspect ratio, margin irregularity, margin smoothness, calcification, and echogenicity of the thyroid nodules...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37948566/use-of-fgf21-analogs-for-the-treatment-of-metabolic-disorders-a-systematic-review-and-meta-analysis
#23
REVIEW
Maria Paula Carbonetti, Fernanda Almeida-Oliveira, David Majerowicz
FGF21 is a hormone produced primarily by the liver with several metabolic functions, such as induction of heat production, control of glucose homeostasis, and regulation of blood lipid levels. Due to these actions, several laboratories have developed FGF21 analogs to treat patients with metabolic disorders such as obesity and diabetes. Here, we performed a systematic review and meta-analysis of randomized controlled trials that used FGF21 analogs and analyzed metabolic outcomes. Our search yielded 236 articles, and we included eight randomized clinical trials in the meta-analysis...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37948565/long-term-consequences-of-osteoporosis-therapy-with-bisphosphonates
#24
REVIEW
Bárbara Gehrke, Maria Caroline Alves Coelho, Catarina Brasil d'Alva, Miguel Madeira
Bisphosphonates (BPs) are medications widely used in clinical practice to treat osteoporosis and reduce fragility fractures. Its beneficial effects on bone tissue have been consolidated in the literature for the last decades. They have a high affinity for bone hydroxyapatite crystals, and most bisphosphonates remain on the bone surface for a long period of time. Benefits of long-term use of BPs: Large and important trials (Fracture Intervention Trial Long-term Extension and Health Outcomes and Reduced Incidence with Zoledronic acid Once Yearly-Pivotal Fracture Trial) with extended use of alendronate (up to 10 years) and zoledronate (up to 6 years) evidenced significant gain of bone mineral density (BMD) and vertebral fracture risk reduction...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37948564/genetic-diagnosis-of-congenital-hypopituitarism-in-turkish-patients-by-a-target-gene-panel-novel-pathogenic-variants-in-ghrhr-gli2-lhx4-and-pou1f1-genes
#25
JOURNAL ARTICLE
Tarık Kırkgöz, Semra Gürsoy, Sezer Acar, Özlem Nalbantoğlu, Beyhan Özkaya, Hüseyin Anıl Korkmaz, Filiz Hazan, Behzat Özkan
OBJECTIVE: Congenital hypopituitarism (CH) is a rare disease characterized by one or more hormone deficiencies of the pituitary gland. To date, many genes have been associated with CH. In this study, we identified the allelic variant spectrum of 11 causative genes in Turkish patients with CH. MATERIALS AND METHODS: This study included 47 patients [21 girls (44.6%) and 26 boys (55.4%)] from 45 families. To identify the genetic etiology, we screened 11 candidate genes associated with CH using next-generation sequencing...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37948563/evaluation-of-the-hypothalamo-pituitary-adrenal-axis-during-the-post-covid-19-period-in-patients-treated-with-steroids-during-the-illness
#26
JOURNAL ARTICLE
Shyam Sundar C M, Jayanthy Ramesh
OBJECTIVE: COVID-19 is a multisystem immunoinflammatory disorder, and the hypothalamo-pituitary-adrenal (HPA) axis may be affected by SARS-CoV-2 as well as by steroid treatment during the illness. Information on the HPA axis after recovering from COVID-19, especially in those treated with steroids, is sparse. Hence, this study was performed to evaluate the hypothalamo-pituitary-adrenal axis during the post-COVID-19 period in patients treated with steroids during the illness. SUBJECT AND METHODS: This prospective study involved 60 patients aged 18-60 years who had recovered from moderate or severe COVID-19 and had received steroid treatment during the illness...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37948562/histological-findings-and-nafld-nash-status-in-liver-biopsies-of-patients-subjected-to-bariatric-surgery
#27
JOURNAL ARTICLE
Marielle Malucelli, Rodrigo Strobel, Claudia Ivantes, Danielle Sakamoto, Márcio Luís Duarte, Maria Lucia Alves Pedroso
OBJECTIVE: To investigate nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and hepatic fibrosis in biopsies of people with obesity who underwent bariatric surgery and examine the possible association of different variables with a diagnosis of NAFLD and NASH. MATERIALS AND METHODS: Epidemiological, clinical and laboratory data from 574 individuals with obesity of both genders seen by the same physician between 2003 and 2009 who had a liver biopsy during bariatric surgery were examined...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37948561/genetic-polymorphisms-in-the-angiotensin-converting-enzyme-actinin-3-and-paraoxonase-1-genes-in-women-with-diabetes-and-hypertension
#28
JOURNAL ARTICLE
Gabrielle Gaspar Arejano, Laura Vargas Hoffmann, Linoska Ferreira Wyse, Poliana Espíndola Correia, Simone Pieniz, Fabiana Torma Botelho, Augusto Schneider, Ines Schadock, Carlos Castilho Barros
OBJECTIVE: To study associations between polymorphisms in the angiotensin converting enzyme (ACE I/D), actinin 3 (ACTN3 R577X) and paraoxonase 1 (PON1 T(-107)C) genes and chronic diseases (diabetes and hypertension) in women. MATERIALS AND METHODS: Genomic DNA was extracted from saliva samples of 78 women between 18 and 59 years old used for genetic polymorphism screening. Biochemical data were collected from the medical records in Basic Health Units from Southern Brazil...
November 10, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37856706/a-portrait-of-gestational-diabetes-mellitus-in-brazil-a-systematic-review-and-meta-analysis
#29
REVIEW
Betine Pinto Moehlecke Iser, Caroline Stein, Luisia Feichas Alves, Morgana Lourenço de Souza Carvalho, Sergio Angelo Rojas Espinoza, Maria Inês Schmidt
The diagnostic criteria for gestational diabetes mellitus (GDM), a transient hyperglycemic state during pregnancy, has varied remarkably over time, resulting in a diversity of prevalence rates. The aim of this systematic literature review was to provide estimates of prevalence rates of GDM in Brazil according to different diagnostic criteria. We identified, reviewed, and extracted data from the scientific literature on studies estimating the prevalence of diabetes in pregnant women living in Brazil. The databases searched were PubMed, LILACS, SciELO, Embase, Web of Science, and Cochrane Library...
October 18, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37738467/cardiorespiratory-fitness-in-individuals-with-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#30
JOURNAL ARTICLE
Aline Chagastelles Pinto de Macedo, Camila Wohlgemuth Schaan, Patricia Martins Bock, Mariana Brutto de Pinto, Cintia Ehlers Botton, Daniel Umpierre, Beatriz D Schaan
OBJECTIVE: To conduct a systematic review and meta-analysis assessing the cardiorespiratory fitness (CRF) among individuals with and without type 2 diabetes. MATERIALS AND METHODS: The current review was registered in PROSPERO under the number CRD42018082718. MEDLINE, EMBASE, and Cochrane Library databases were searched from inception through February 2022. Eligibility criteria consisted of observational or interventional studies that evaluated CRF through cardiopulmonary exercise testing or six-minute walk test in individuals with type 2 diabetes compared with individuals without type 2 diabetes...
September 25, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37738466/lower-25-hydroxyvitamin-d-25ohd-levels-diabetes-and-age-are-associated-with-foot-and-ankle-fracture-treatment-complications
#31
JOURNAL ARTICLE
Hallan Douglas Bertelli, José Luis Braga de Aquino, VÂnia Aparecida Leandro-Merhi
OBJECTIVE: This study investigated the nutritional status, 25-hydroxyvitamin D (25OHD), albumin and risk factors associated with complications in patients with foot and ankle fragility fractures. SUBJECTS AND METHODS: Prospective study, developed with patients who suffered fractures due to fragility of the foot and ankle (n = 108); the type of fractured bone, fracture mechanisms and classification were studied and also pseudoarthrosis, treatment, surgical dehiscence, anthropometry, 25OHD and albumin...
September 25, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37585688/-anti-obesity-medications-or-medications-to-treat-obesity-instead-of-weight-loss-drugs-why-language-matters-an-official-statement-of-the-brazilian-association-for-the-study-of-obesity-and-metabolic-syndrome-abeso-and-the-brazilian-society-of-endocrinology-and
#32
Bruno Halpern, Marcio C Mancini, Simone van de Sande-Lee, Paulo Augusto Carvalho Miranda
Obesity is largely undertreated, in part because of the stigma surrounding the disease and its treatment. The use of the term "weight loss drugs" to refer to medications for the treatment of obesity may contribute to this stigma, leading to the idea that anyone who wants to lose weight could use them and that short-term use, only in the active weight loss phase would be enough. On the contrary, the use of terms such as "medications to treat obesity" or "anti-obesity medications" conveys the idea that the treatment is directed at the disease rather than the symptom...
August 16, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364157/reference-intervals-for-serum-tsh-concentrations-of-healthy-children-from-the-central-region-of-brazil
#33
JOURNAL ARTICLE
Tula Beatriz Brandão Caldas Meirelles-Cardoso, Natasha Slhessarenko, Cor Jesus Fernandes Fontes
OBJECTIVE: The objective of this study was to determine the serum thyroid-stimulating hormone (TSH) concentration reference intervals (RIs) of healthy children aged 1 to 10 years of both sexes, living in the Central Region of Brazil. SUBJECTS AND METHODS: 1,735 children [869 (50.1%) female; 866 (49.9%) male] enrolled in the morning shift of 47 pre- and 83 public elementary schools in the municipality of Cuiabá, Mato Grosso, were studied by gathering anthropometric and social data and their medical history...
June 19, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364156/neoadjuvant-therapy-with-anlotinib-in-a-locally-advanced-and-pulmonary-metastasis-ptc-patient-harboring-tert-promoter-and-braf-v600e-mutations-a-case-report
#34
Yan-Jun Su, Shao-Hao Cheng, Jun Qian, Ming Zhang, Wen Liu, Xiang-Xiang Zhan, Zhu-Quan Wang, Hai-Dan Liu, Xing-Wei Zhong, Ruo-Chuan Cheng
A 71-year-old woman with recurrent papillary thyroid carcinoma (PTC) was referred to our hospital. A computed tomography scan revealed extensive recurrence in the neck, invading sternocleidomastoid muscle, internal jugular vein, sternal end of the clavicle, strap muscle and skin; and lateral compartment and subclavian lymph nodes were also involved. Multiple pulmonary micrometastases also noticed. The tumor was considered unresectable; however, the patient was unwilling to accept highly invasive surgery. Therefore, we initiated neoadjuvant therapy with anlotinib, 12mg p...
June 19, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364155/treatment-of-graves-disease-in-brazil-results-of-a-survey-among-endocrinologists
#35
JOURNAL ARTICLE
Danilo Villagelin, Glaucia M F S Mazeto, Cléo Otaviano Mesa, Helton Estrela Ramos, Rafael Selbach Scheffel, Maria Izabel Chiamolera, Nicolas Perini, Thiago Luis Ronconi, Patricia Texeira
OBJECTIVE: The objective of the study was to determine how physicians in Brazil manage Graves' disease in different scenarios including extrathyroidal manifestations. MATERIALS AND METHODS: This study was conducted via a digital survey. The respondents (n = 573) answered multiple-choice questions based on a clinical case and variations of the case regarding laboratory and imaging evaluation, treatment choice, and follow-up. RESULTS: The preferred initial treatment chosen by 95% of the respondents was ATD with a preferred treatment duration of 18-24 months...
June 19, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364154/references-values-and-predictive-factors-for-thyroid-volume-in-pregnant-women
#36
JOURNAL ARTICLE
Lisette Leal Curí, María de Las Mercedes Rubén Quesada, Daysi Antonia Navarro Despaigne, Esther Jequín Savariego, Lisandro Chávez González, Drissa Bina Konaré, Erick Robles Torres
OBJECTIVE: Thyroid volume varies within each population according to different clinical and biochemical factors and can change during pregnancy. The present investigation was aimed to determine the reference values for thyroid volume in pregnant women and their predictive factors. MATERIALS AND METHODS: A cross-sectional study was carried out with 360 healthy pregnant women. The following variables were examined: maternal age, gestational age, skin color, current smoking status, parity, use of iodinated supplements, body mass index, thyrotropin, total and free thyroid hormones, thyroglobulin, antithyroid antibodies, chorionic gonadotropin, cholesterol and triglycerides...
June 19, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364153/immune-checkpoint-inhibitor-induced-endocrinopathies-a-possible-indicator-of-improved-survival
#37
JOURNAL ARTICLE
Mariana Ornelas, Marta Borges-Canha, Pedro Gouveia, Margarida Ferreira, Eduarda Resende, Maritza Sá, Silvestre Abreu
OBJECTIVE: To evaluate the association between the patients' characteristics and the development of endocrine toxicity and to assess the association between endocrine-related adverse effects (ERAE) development and mortality. SUBJECTS AND METHODS: A retrospective observational study was conducted in 98 patients submitted to immunotherapy in our centre since its introduction in 2015 until March 2021. We excluded patients for which data regarding the corticotroph axis evaluation was missing...
June 19, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364152/endoscopic-endonasal-approach-for-acromegaly-surgical-outcomes-using-2018-consensus-criteria-for-remission
#38
JOURNAL ARTICLE
Rodrigo Alves de Carvalho Cavalcante, Luiz Alves Vieira, Luís Felipe Araújo Peres, Alice Jardim Zaccariotti, Helioenai de Sousa Alencar, Estela Muszkat Jatene, Leandro Azevedo Camargo, Monike Lourenço Dias Rodrigues
OBJECTIVE: The primary aim is to analyze the endoscopic endonasal surgical results in short-term and two-year follow-ups according to the 11th Acromegaly Consensus statement (2018). Indeed, prognostic factors and complications were analyzed. SUBJECTS AND METHODS: 40 patients who underwent endoscopic endonasal surgery by acromegaly between 2013 to 2020 was analyzed. Patients were considered in remission if an upper limit of normal (ULN) IGF-1 was less than 1.0 at the six-month and two-year follow-ups...
June 19, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364151/is-elevated-blood-glucose-at-admission-associated-with-poor-outcomes-in-hospitalized-covid-19-patients
#39
JOURNAL ARTICLE
Mariana Barbosa, Juliana Marques-Sá, Carla Carvalho, Vera Fernandes
OBJECTIVE: Hyperglycemia has been suggested as a risk factor for poor outcomes in coronavirus disease 2019 (COVID-19). The aim of our work was to evaluate the association between blood glucose levels at admission (BGA) and disease outcomes in hospitalized COVID-19 patients. SUBJECTS AND METHODS: Retrospective study including all adult COVID-19 patients admitted to a Portuguese hospital from March to August 2020 with BGA measurement. Subjects were categorized into two groups: BGA < 140 mg/dL and ≥ 140 mg/dL...
June 19, 2023: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/37364150/knowledge-about-diabetes-and-its-association-with-adherence-to-self-care-and-glycemic-control-in-patients-with-type-1-diabetes-in-southern-brazil
#40
JOURNAL ARTICLE
Luciana Foppa, Betina Nemetz, Rosimeri De Matos, Josiane Schneiders, Gabriela Heiden Telo, Beatriz D Schaan
OBJECTIVE: To evaluate the association between knowledge about the disease, adherence to self-care, and glycemic control in people diagnosed with type 1 diabetes mellitus. SUBJECTS AND METHODS: A cross-sectional study of patients aged over 18 years diagnosed with type 1 diabetes mellitus, treated at an outpatient clinic of a Brazilian university hospital. Participants with other types of diabetes, cognitive impairment, pregnancy, and outpatient discharge were excluded...
June 19, 2023: Archives of Endocrinology and Metabolism
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