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Journals Archives of Endocrinology and ...

Archives of Endocrinology and Metabolism

https://read.qxmd.com/read/38788147/efficacy-and-safety-of-burosumab-compared-with-conventional-therapy-in-patients-with-x-linked-hypophosphatemia-a-systematic-review
#1
COMPARATIVE STUDY
Manjunath Havalappa Dodamani, Samantha Cheryl Kumar, Samiksha Bhattacharjee, Rohit Barnabas, Sandeep Kumar, Anurag Ranjan Lila, Saba Samad Memon, Manjiri Karlekar, Virendra A Patil, Tushar R Bandgar
Burosumab, a monoclonal antibody directed against the fibroblast growth factor 23 (FGF23), has been approved for the treatment of X-linked hypophosphatemia (XLH). We conducted a systematic review to compare the efficacy and safety of burosumab versus conventional therapy (phosphorus and calcitriol) on XLH treatment. After a comprehensive literature search on MEDLINE/PubMed and Embase, we found nine studies for inclusion in the analysis. Risk of bias was assessed, and a random-effects model was used to determine the effect size...
May 17, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38788146/expression-of-somatostatin-receptors-in-hemangioblastomas-associated-with-von-hippel-lindau-disease-as-a-novel-diagnostic-therapeutic-and-follow-up-opportunity-a-case-report-and-literature-review
#2
REVIEW
Eloá Pereira Brabo, Sergio Altino de Almeida, Patrícia Piazza Rafful, Paulo Henrique Rosado-de-Castro, Leonardo Vieira Neto
Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors. Recent studies have shown the expression of somatostatin receptors in these types of hemangioblastomas. Notably, increased somatostatin receptor expression in a tumor, as determined by peptide-receptor radionuclide imaging, is a predictive factor of response to treatment with somatostatin analogs and peptide-receptor radionuclide therapy...
May 17, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38739525/associations-of-tsh-free-t3-free-t4-and-conversion-ratio-with-incident-hypertension-results-from-the-prospective-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#3
JOURNAL ARTICLE
Marina Gabriela Birck, Carolina C. P. S. Janovsky, Alessandra Carvalho Goulart, Vandrize Meneghini, Bianca de Almeida Pititto, José Augusto Sgarbi, Patrícia de Fátima dos Santos Teixeira, Isabela M Bensenor
OBJECTIVE: To evaluate the association of TSH, free T3 (FT3), free T4 (FT4), and conversion (FT3:FT4) ratio values with incident hypertension. MATERIALS AND METHODS: The study included data from participants of the ELSA-Brasil study without baseline hypertension. Serum TSH, FT4 and FT3 levels, and FT3:FT4 ratio values were assessed at baseline, and incident hypertension (defined by blood pressure levels ≥ 140/90 mmHg) was estimated over a median of 8.2 years of follow-up...
May 10, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38739524/podocytopathies-associated-with-familial-partial-lipodystrophy-due-to-lmna-variants-report-of-two-cases
#4
JOURNAL ARTICLE
Maria Julia Morguetti, Precil Diego Miranda de Menezes Neves, Ilana Korkes, Wallace Stwart Carvalho Padilha, Lectícia Barbosa Jorge, Andreia Watanabe, Elieser Hitoshi Watanabe, Denise Maria Avancini Costa Malheiros, de Lourdes Noronha Irene, Sergio Atala Dib, Luiz Fernando Onuchic, Regina S Moisés
Lipodystrophies are characterized by complete or selective loss of adipose tissue and can be acquired or inherited. Familial partial lipodystrophy (FPLD) is a hereditary lipodystrophy commonly caused by mutations in the LMNA gene. Herein, we report two cases of FPLD associated with podocytopathies. Patient 1 was diagnosed with FPLD associated with the heterozygous p.Arg482Trp variant in LMNA and had normal glucose tolerance and hyperinsulinemia. During follow-up, she developed nephroticrange proteinuria. Renal biopsy was consistent with minimal change disease...
May 10, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38739523/pulsatile-gonadotropin-releasing-hormone-therapy-for-spermatogenesis-in-congenital-hypogonadotropic-hypogonadism-patients-who-had-poor-response-to-combined-gonadotropin-therapy
#5
JOURNAL ARTICLE
Zhenxing Huang, Xi Wang, Bingqing Yu, Wanlu Ma, Pengyu Zhang, Xueyan Wu, Min Nie, Jiangfeng Mao
OBJECTIVE: Both pulsatile gonadotropin-releasing hormone (GnRH) and combined gonadotropin therapy are effective to induce spermatogenesis in men with congenital hypogonadotropic hypogonadism (CHH). This study aimed to evaluate the effect of pulsatile GnRH therapy on spermatogenesis in male patients with CHH who had poor response to combined gonadotropin therapy. MATERIALS AND METHODS: Patients who had poor response to combined gonadotropin therapy ≥ 6 months were recruited and shifted to pulsatile GnRH therapy...
May 10, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38739522/lncrna-xist-promotes-neovascularization-in-diabetic-retinopathy-by-regulating-mir-101-3p-vegfa
#6
JOURNAL ARTICLE
Weina Fu, Yunyan Ye, Feng Hu
OBJECTIVE: This study sought to investigate the regulation of long noncoding RNA (lncRNA) XIST on the microRNA (miR)-101-3p/vascular endothelial growth factor A (VEGFA) axis in neovascularization in diabetic retinopathy (DR). MATERIALS AND METHODS: Serum of patients with DR was extracted for the analysis of XIST, miR-101-3p, and VEGFA expression levels. High glucose (HG)-insulted HRMECs and DR model rats were treated with lentiviral vectors. MTT, transwell, and tube formation assays were performed to evaluate cell viability, migration, and angiogenesis, and ELISA was conducted to detect the levels of inflammatory cytokines...
May 10, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38709152/cervical-lymph-node-metastases-in-patients-with-differentiated-thyroid-cancer-a-new-and-more-relevant-indication-of-active-surveillance
#7
EDITORIAL
Jose Miguel Dora, Rafael Selbach Scheffel
No abstract text is available yet for this article.
May 6, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38709151/active-surveillance-is-a-feasible-and-safe-strategy-in-selected-patients-with-papillary-thyroid-cancer-and-suspicious-cervical-lymph-nodes-detected-after-thyroidectomy
#8
JOURNAL ARTICLE
Marlín Solórzano, Nicole Lustig, Lorena Mosso, Martín Espinoza, Roberto Santana, Hernan Gonzalez, Pablo H Montero, Francisco Cruz, Antonieta Solar, José Miguel Domínguez
OBJECTIVE: After initial treatment, up to 30% of patients with papillary thyroid cancer (PTC) have incomplete response, mainly cervical lymph node (LN) disease. Previous studies have suggested that active surveillance (AS) is a possible option for these patients. Our aim was to report the results of AS in patients with PTC and cervical LN disease. MATERIALS AND METHODS: In this retrospective observational study, we included adult patients treated and followed for PTC, who presented with cervical LN disease and were managed with AS...
May 6, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38709150/correlation-between-low-handgrip-strength-and-metabolic-syndrome-in-older-adults-a-systematic-review
#9
REVIEW
Joana da Costa d'Avila, Talel Georges Moreira El Nabbout, Hayfa Georges Moreira El Nabbout, Aline Dos Santos Silva, Antonio Carlos Barbosa Ramos Junior, Eliana Rosa da Fonseca, Aluana Santana Carlos, Rodrigo de Azeredo Siqueira
Muscle weakness has been associated to insulin resistance and metabolic syndrome in the general population. However, it is still unclear whether this association is maintained in older adults. This study investigated correlations between low handgrip strength (HGS) and metabolic syndrome, or some of its components, in older adults through a systematic review of the literature. Searches were conducted in the Virtual Health Library Regional Portal, Scopus, Cochrane, Embase, MEDLINE/ PubMed, SciELO, and Web of Science databases for relevant studiesinvestigating muscle weakness (measured by hand dynamometer) and metabolic syndrome or its components in older adult populations, published up to September 2023...
May 6, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38709149/epidemiological-profile-of-neuroendocrine-tumors-in-adults-in-brazil
#10
JOURNAL ARTICLE
Priscilla Brunelli Pujatti, Verônica Paim, Rinaldo Gonçalves, Bruno Vilhena, Anke Bergmann, Luiz Cláudio Santos Thuler, Daniel Bulzico
OBJECTIVE: Neuroendocrine tumors (NETs) are a set of diseases that originate from neuroendocrine cells, which comprises a diffuse endocrine system present in various organs of the body. These tumors are more frequent in the gastrointestinal tract (70%) and the bronchopulmonary system (20%-30%). A NET incidence rate of 1-5 per 100,000 inhabitants has been estimated for several European countries and the USA employing 20 years of data. However, no comprehensive studies on this rare neoplasm are available in Brazil...
May 6, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38709148/impact-of-sustained-virologic-response-on-glucose-parameters-among-patients-with-chronic-hepatitis-c-treated-with-direct-acting-antivirals
#11
JOURNAL ARTICLE
Fábia Benetti, Alexandre de Araújo, Italo de Maman Júnior, Cristina Coelho Borges Cheinquer, Fernando Herz Wolff, Hugo Cheinquer
OBJECTIVE: The aim of this study was to evaluate the glycated hemoglobin (HbA1c) levels before and after sustained virologic response (SVR) and investigate the baseline characteristics associated with improved glycemic control in patients with chronic hepatitis C (CHC) achieving SVR after directacting antivirals (DAA) therapy. MATERIALS AND METHODS: Consecutive adult patients with CHC who achieved SVR after DAA treatment between January 2016 and December 2017 at Hospital de Clínicas de Porto Alegre (RS, Brazil) were prospectively included...
May 6, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38652701/raas-in-diabetic-retinopathy-mechanisms-and-therapies
#12
REVIEW
Xin Li, Yu-Hong Fu, Xue-Wei Tong, Yi-Tong Zhang, Yong-Yan Shan, Yu-Xin Xu, Sheng-Dan Pu, Xin-Yuan Gao
Diabetic retinopathy (DR) is a complication of diabetes with a complex pathophysiology and multiple factors involved. Recently, it has been found that the upregulation of the renin-angiotensin-aldosterone system (RAAS) leads to overexpression of angiotensin II (Ang II), which induces oxidative stress, inflammation, and angiogenesis in the retina. Therefore, RAAS may be a promising therapeutic target in DR. Notably, RAAS inhibitors are often used in the treatment of hypertension. Still, the potential role and mechanism of DR must be further studied...
April 19, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38652700/a-rare-case-of-bilateral-frontal-lobe-lesions-due-to-thyroid-storm
#13
JOURNAL ARTICLE
Zhang Delong, Wang Fugui, Hu Xin, Lu Houqing
Thyroid storm is a rare but well-known life-threatening complication that occurs due to acute exacerbation of thyrotoxicosis with the increased levels of circulating thyroid hormones. Reports of metabolic encephalopathy associated with thyroid storm are scarce. We describe the case of a 23-year-old male patient with no previous history of abnormal thyroid function who had consumed excessive amounts of alcohol before disease onset. The patient was found unconscious and febrile on a roadside by a passerby and was admitted to our hospital's emergency department...
April 19, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38602747/efficacy-of-the-hybrid-closedloop-insulin-delivery-system-in-children-and-adolescents-with-type-1-diabetes-a-meta-analysis-with-trial-sequential-analysis
#14
JOURNAL ARTICLE
Rafael Oliva Morgado Ferreira, Talita Trevisan, Eric Pasqualotto, Pedro Schmidt, Matheus Pedrotti Chavez, Janine Midori Figueiredo Watanabe, Simone van de Sande-Lee
The aim of this study was to assess the efficacy and safety of hybrid closed-loop (HCL) systems for insulin delivery in children and adolescents with type 1 diabetes (T1D). We searched Embase, PubMed, and Cochrane Library for randomized controlled trials (RCTs) published until March 2023 comparing the HCL therapy with control therapies for children and adolescents with T1D. We computed weighted mean differences (WMDs) for continuous outcomes and risk ratios (RRs) with 95% confidence intervals (CIs) for binary endpoints...
April 11, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38602746/correlation-of-18-f-sodium-fluoride-uptake-and-radiodensity-in-extraosseous-metastases-of-medullary-thyroid-carcinoma
#15
JOURNAL ARTICLE
Cristina Emiko Ueda, Laís Flausino Dias, Camila de Godoi Carneiro, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel, Paulo Schiavom Duarte
OBJECTIVE: Although 18 F-sodium fluoride (18 F-NaF) uptake is frequently observed in extraosseous metastases of medullary thyroid carcinoma (MTC) with calcification, itcan also occur in metastatic sites without visible calcium deposition, leading to the hypothesis that visually undetectable calcium accumulation may be responsible for this uptake. The aim of this study was to indirectly support this hypothesis by analyzing the correlation between the degree of 18 F-NaF uptake and radiodensity in extraosseous MTC metastases, since calcium deposition can increase attenuation even when not visually detectable...
April 11, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38578473/treatment-of-hyperprolactinemia-in-women-a-position-statement-from-the-brazilian-federation-of-gynecology-and-obstetrics-associations-febrasgo-and-the-brazilian-society-of-endocrinology-and-metabolism-sbem
#16
JOURNAL ARTICLE
Cristina Laguna Benetti-Pinto, Andrea Prestes Nácul, Ana Carolina Japur de Sá Rosa-E-Silva, Gustavo Arantes Rosa Maciel, Vania Dos Santos Nunes Nogueira, Paula Condé Lamparelli Elias, Manoel Martins, Leandro Kasuki, Heraldo Mendes Garmes, Andrea Glezer
Dopamine agonists are the first line of treatment for patients with symptomatic hyperprolactinemia due to prolactinomas and in those with idiopathic hyperprolactinemia. Treatment with these agents is effective in 80%-90% of the cases. Infertility treatment of patients with hyperprolactinemia is also carried out with dopamine agonists, aiming for the normalization of prolactin levels. The risk of symptomatic growth of prolactinomas during pregnancy is dependent on the tumor's size, duration of previous treatments, and prolactin levels...
April 5, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38578472/diagnosis-of-hyperprolactinemia-in-women-a-position-statement-from-the-brazilian-federation-of-gynecology-and-obstetrics-associations-febrasgo-and-the-brazilian-society-of-endocrinology-and-metabolism-sbem
#17
JOURNAL ARTICLE
Andrea Glezer, Heraldo Mendes Garmes, Leandro Kasuki, Manoel Martins, Paula Condé Lamparelli Elias, Vania Dos Santos Nunes Nogueira, Ana Carolina Japur de Sá Rosa-E-Silva, Gustavo Arantes Rosa Maciel, Cristina Laguna Benetti-Pinto, Andrea Prestes Nácul
Hyperprolactinemia is a frequent cause of menstrual irregularity, galactorrhea, hypogonadism, and infertility. The most common etiologies of hyperprolactinemia can be classified as physiological, pharmacological, and pathological. Among pathological conditions, it is essential to distinguish prolactinomas from other tumors and pituitary lesions presenting with hyperprolactinemia due to pituitary stalk disconnection. Proper investigation considering clinical data, laboratory tests, and, if necessary, imaging evaluation, is important to identify the correctcause of hyperprolactinemia and manage the patient properly...
April 5, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38578437/coronary-calcium-score-in-patients-with-post-surgical-hypoparathyroidism
#18
JOURNAL ARTICLE
Jhenifer Franco de Souza Sartori, Maria Luiza Dos Santos, Aline Stollmeier, Rodrigo Julio Cerci, Carolina Aguiar Moreira, Victoria Zeghbi Cochenski Borba
OBJECTIVE: This study aimed to evaluate the cardiovascular risk of patients with post-surgical hypoparathyroidism through coronary calcium score (CACS) evaluation andcardiovascular risk calculators. SUBJECTS AND METHODS: Patients with post-surgical hypoparathyroidism (HG = 29) were compared to a control group (CG = 29), matched by sex and age. Demographic and clinical data were captured by a questionnaire or patient files. Both groups performed a thoracic-computed tomography to evaluate the CACS and the cardiovascular risk was calculated by two risk calculators...
April 4, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38578436/predictors-of-recurrence-after-total-thyroidectomy-in-1-611-patients-with-papillary-thyroid-carcinoma-postoperative-stimulated-serum-thyroglobulin-and-ata-initial-and-dynamic-risk-assessment
#19
JOURNAL ARTICLE
Andre Ywata de Carvalho, Hugo Fontan Kohler, Camila C G Ywata de Carvalho, Jose Guilherme Vartanian, Luiz Paulo Kowalski
OBJECTIVE: Despite a favorable prognosis, some patients with papillary thyroid carcinoma (PTC) develop recurrence. The objective of this study was to examine the impact of the combination of initial American Thyroid Association (ATA) risk stratification with serum level of postoperative stimulated thyroglobulin (s-Tg) in predicting recurrence in patients with PTC and compare the results with an assessment of response to initial therapy (dynamic risk stratification). SUBJECTS AND METHODS: We retrospectively analyzed 1,611 patients who had undergone total thyroidectomy for PTC, followed in most cases (87...
April 4, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38557479/the-risk-of-covid-19-in-cushing-s-disease-is-independently-related-to-disease-activity-hypercortisolism-and-obesity
#20
JOURNAL ARTICLE
Bruna M G Mascarenhas-Nakano, Silvia R Correa-Silva, Silvia M R Fracacio, Paola W Brock, Rossella F Dias, Eduarda S S Binda, Pedro F Santos-Neto, Luiz H C Portari, Adriana Sanudo, Julio Abucham
OBJECTIVE: To evaluate the cumulative incidence, risk factors, and outcomes of COVID-19 in patients with Cushing's disease (CD). SUBJECTS AND METHODS: In all, 60 patients with CD following up in our outpatient clinic answered via phone interview a questionnaire about the occurrence of COVID-19 infection documented by RT-PCR (including the diagnosis date and clinical outcome) and vaccination status. Clinical and biochemical data on disease activity (hypercortisolism) and comorbidities (obesity, diabetes mellitus, and hypertension) were obtained from the patients' electronic medical records...
March 27, 2024: Archives of Endocrinology and Metabolism
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