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Archives of Endocrinology and Metabolism

Mariella Zaiden Rezende Reis, Virgínia Oliveira Fernandes, Eveline Gadelha Pereira Fontenele, Ana Paula Abreu Martins Sales, Renan Magalhães Montenegro Junior, Ana Rosa Pinto Quidute
Insulin autoimmune syndrome (IAS, Hirata's disease) is a rare hypoglycemic disorder characterized by spontaneous hypoglycemia associated with extremely high circulating insulin levels and positive anti-insulin antibody results. Thus far, most cases have been reported in Asian countries, notably Japan, with few cases reported in western countries. As a possible cause, it is associated with the use of drugs containing sulfhydryl radicals, such as captopril. This report refers to a 63-year-old female Brazilian patient with a history of postprandial hypoglycemia...
October 2018: Archives of Endocrinology and Metabolism
Francisco Sousa-Santos, Helder Simões, Lidia Castro-Feijóo, Paloma Cabanas Rodríguez, Ana Fernández-Marmiesse, Rebeca Saborido Fiaño, Teresa Rego, Ángel Carracedo, Jesús Barreiro Conde
Congenital hyperinsulinism (CHI) is a heterogenous disease caused by insulin secretion regulatory defects, being ABCC8/KCNJ11 the most commonly affected genes. Therapeutic options include diazoxide, somatostatin analogues and surgery, which is curative in focal CHI. We report the case of two siblings (born two years apart) that presented themselves with hypoketotic hyperinsulinemic persistent hypoglycemias during neonatal period. The diagnosis of diffuse CHI due to an ABCC8 compound mutation (c.3576delG and c...
October 2018: Archives of Endocrinology and Metabolism
Mariana Veronez Borgo, Marcelo Perim Baldo, Rafael de Oliveira Alvim, Divanei Zaniqueli, Daniel Pires Capingana, Pedro Magalhães, Amilcar Bernardo da Silva, Polyana Romano Oliosa, Carmem Luiza Sartório, José Geraldo Mill
OBJECTIVE: Angola is a sub-Saharan African country where the population has scarce access to lipidlowering medication. We sought to determine the frequency of lipid disorders among Angolan nonusers of lipid-lowering medication. MATERIAL AND METHODS: A cross-sectional descriptive study was carried out in a sample of 604 workers from the public sector. Blood pressure and anthropometric data were measured along with biochemical parameters including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)...
October 2018: Archives of Endocrinology and Metabolism
Bruna Karoline Lima Piazera, Diego Viana Gomes, Patrícia Vigário, Verônica P Salerno, Mário Vaisman
OBJECTIVE: Evaluate the relationship between exogenous subclinical hyperthyroidism and oxidative stress through the analysis of the redox profile of patients with subclinical hyperthyroidism exogenous (SCH) grade I (TSH = 0.1 to 0.4 IU/mL) and grade II (TSH < 0.1 IU/mL). SUBJECTS AND METHODS: We analyzed 46 patients with SCH due to the use of TSH suppressive therapy with LT4 after total thyroidectomy along with 6 control euthyroid individuals (3M and 3W). Patients were divided into two groups, G1 with TSH ≥ 0...
October 2018: Archives of Endocrinology and Metabolism
Carolina Castro Porto Silva Janovsky, Marcio Sommer Bittencourt, Maykon Anderson Pires de Novais, Rui M B Maciel, Rosa Paula M Biscolla, Paola Zucchi
OBJECTIVE: Recent data indicates an increasing incidence of thyroid cancer not accompanied by a proportional increase in mortality, suggesting overdiagnosis, which may represent a big public health problem, particularly where resources are scarce. This article aims to describe and evaluate the procedures related to investigation of thyroid nodules and treatment and follow-up of thyroid cancer and the costs for the Brazilian public health system between 2008 and 2015. MATERIALS AND METHODS: Data on procedures related to investigation of thyroid nodules and treatment/follow-up of thyroid cancer between 2008 and 2015 in Brazil were collected from the Department of Informatics of the Brazilian Unified Health System (Datasus) website...
October 2018: Archives of Endocrinology and Metabolism
Francisco Zacaron Werneck, Emerson Filipino Coelho, Saulo Peters Almas, Marília Mendes do Nascimento Garcia, Heloina Lamha Machado Bonfante, Jorge Roberto Perrout de Lima, Patrícia Dos Santos Vigário, Míriam Raquel Meira Mainenti, Patrícia de Fátima Dos Santos Teixeira, Mário Vaisman
OBJECTIVE: The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training. SUBJECTS AND METHODS: In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL...
October 2018: Archives of Endocrinology and Metabolism
Kai Wu, Sen He, Yi Zheng, Xiaoping Chen
OBJECTIVE: Recently, a new obesity index (A Body Shape Index, ABSI) based on waist circumference (WC) was developed, and high ABSI corresponds to a more central concentration of body volume. It is well known that central obesity is closely linked with insulin resistance (IR). Therefore, our study aimed to examine the discriminatory power of ABSI for IR in Chinese adults and elderly without diabetes. SUBJECTS AND METHODS: In 2007, a cross-sectional study was made...
October 2018: Archives of Endocrinology and Metabolism
Denise P Momesso, Rubens Carmo Costa Filho, João Luiz Ferreira Costa, Felipe Saddy, Ayla Mesquita, Marcela Calomeni, Claudia Dos Santos Silva, Jacqueline Farret, Mariana Leon Vasques, Aline G Santos, Ana Paula Vieira Cabral, Dayane Ribeiro, Luciana Reis, Maria de Fátima M Muino, Roberta Santiago Vitorino, Claudio Amorim Monteiro, Evandro Tinoco, Andre Volschan
OBJECTIVE: Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate the impact of the implementation of an inpatient multidisciplinary glucose control management program on glucose control in hospitalized patients. MATERIALS AND METHODS: Retrospective analysis of medical records and glucose monitoring data obtained by point- of-care testing (POCT) in hospitalized patients before (May 2014) and after (June 2015 and May 2017) the implementation of the program...
October 2018: Archives of Endocrinology and Metabolism
Dilek Tuzun, Ayten Oguz, Muhammet Naci Aydin, Ergul Belge Kurutas, Onder Ercan, Murat Sahin, Velid Ünsal, Imran Ceren, Ahmet Akçay, Kamile Gul
OBJECTIVE: Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone and plays a role in the pathogenesis of myocardial hypertrophy. The aim of this study was to evaluate the association of FGF-23 levels with echocardiographic parameters and insulin resistance (IR) in patients with gestational diabetes. SUBJECTS AND METHODS: Fifty-four pregnant patients with gestational diabetes mellitus (GDM) (age, 31.12 ± 5.72 years) and 33 healthy pregnant women (age, 29...
October 2018: Archives of Endocrinology and Metabolism
Leila Aghaghazvini, Pirouz Pirouzi, Hashem Sharifian, Nasrin Yazdani, Soheil Kooraki, Afsoon Ghadiri, Majid Assadi
OBJECTIVE: Magnetic resonance spectroscopy (MRS) is a powerful tool for structural studies of chemical compounds and biomolecules and also documented promising findings as a potential imaging technology in thyroid oncology. This prospective study was to ascertain the clinical significance of 3 Tesla MRS in the evaluation of patients with thyroid nodules (TNs) as an ancillary diagnostic technique for thyroid carcinoma. MATERIALS AND METHODS: Magnetic resonance spectroscopy at 3T at echo- times (TEs) 136 and 270 ms was carried out on 15 patients with total number of 32 TNs larger than 1 cm3, which all were surgically resected...
October 2018: Archives of Endocrinology and Metabolism
Ethem Turgay Cerit, Mehmet Muhittin Yalçin, Çiğdem Ӧzkan, Müjde Aktürk, Alev Eroğlu Altinova, Ümit Ӧzgür Akdemir, Murat Akin, Emre Arslan, Ayhan Karakoç, Ali Riza Çimen, Nuri Çakir
OBJECTIVE: Our aim was to present our experiences related to performing neck surgery using the guided intraoperative scintigraphic tumor targeting (GOSTT) procedure for patients who had locally recurrent or persistent differentiated thyroid cancer (DTC) and who had undergone previous thyroid surgery. SUBJECTS AND METHODS: We retrospectively evaluated 11 patients who had locally recurrent or persistent DTC, who had undergone previous surgery, and for whom reoperation was planned for metastatic cervical lymph nodes (LNs)...
October 2018: Archives of Endocrinology and Metabolism
Regina Lúcia Elia Gomes, Eloísa M M Santiago Gebrim
No abstract text is available yet for this article.
October 2018: Archives of Endocrinology and Metabolism
Marcelo Tatit Sapienza
No abstract text is available yet for this article.
October 2018: Archives of Endocrinology and Metabolism
Thais Pereira Costa Magalhães, Rodrigo Bastos Fóscolo, Aleida Nazareth Soares, Janice Sepúlveda Reis
OBJECTIVE: To evaluate the introduction of coaching in the interdisciplinary care of individuals with type 1 diabetes mellitus in the public health care system. SUBJECTS AND METHODS: Ten patients routinely attending a public health care service and with a glycated hemoglobin (HbA1c) level above 75% participated in eight coaching sessions. This study evaluated the patients' self-management of the disease and personal behavior. The participants were assessed at the beginning of the program and on two occasions after the intervention, with evaluation of biochemical and anthropometric data, and frequency of self-monitoring of blood glucose (SMBG)...
August 2018: Archives of Endocrinology and Metabolism
Karla Simone Costa de Souza, Marcela Abbott Galvão Ururahy, Yonara Monique da Costa Oliveira, Melina Bezerra Loureiro, Heglayne Pereira Vital da Silva, Raul Hernandes Bortolin, André Ducati Luchessi, Ricardo Fernando Arrais, Rosário Dominguez Crespo Hirata, Maria das Graças Almeida, Mário Hiroyuki Hirata, Adriana Augusto de Rezende
OBJECTIVE: The present study has investigated the association between low-density lipoprotein receptor-related protein 5 (LRP5) 4037C>T polymorphism and type 1 diabetes mellitus (T1DM) susceptibility in a Brazilian population. SUBJECTS AND METHODS: A total number of 134 T1DM patients and 180 normoglycemic individuals (NG) aged 6-20 years were studied. Glycated hemoglobin and glucose levels were determined. Genotyping of LRP5 4037C>T (rs3736228) was performed...
August 2018: Archives of Endocrinology and Metabolism
Fernanda Gaspar do Amaral, José Cipolla-Neto
Melatonin is a ubiquitous molecule in nature, being locally synthesized in several cells and tissues, besides being a hormone that is centrally produced in the pineal gland of vertebrates, particularly in mammals. Its pineal synthesis is timed by the suprachiasmatic nucleus, that is synchronized to the light-dark cycle via the retinohypothalamic tract, placing melatonin synthesis at night, provided its dark. This unique trait turns melatonin into an internal synchronizer that adequately times the organism's physiology to the daily and seasonal demands...
August 2018: Archives of Endocrinology and Metabolism
Taíse Lima de Oliveira Cerqueira, Yanne Rocha Ramos, Giorgia Bruna Strappa, Mariana Souza de Jesus, Jailciele Gonzaga Santos, Camila Sousa, Gildásio Carvalho, Vladimir Fernandes, Ney Boa-Sorte, Tatiana Amorim, Thiago Magalhães Silva, Ana Marice Teixeira Ladeia, Angelina Xavier Acosta, Helton Estrela Ramos
OBJECTIVE: To evaluate the candidate genes PAX-8, NKX2-5, TSH-R and HES-1 in 63 confirmed cases of thyroid dysgenesis. SUBJECTS AND METHODS: Characterization of patients with congenital hypothyroidism into specific subtypes of thyroid dysgenesis with hormone levels (TT4 and TSH), thyroid ultrasound and scintigraphy. DNA was extracted from peripheral blood leukocytes and the genetic analysis was realized by investigating the presence of mutations in the transcription factor genes involved in thyroid development...
August 2018: Archives of Endocrinology and Metabolism
Filiz Eksi Haydardedeoglu, Gulay Simsek Bagir, Nese Torun, Emrah Kocer, Mehmet Reyhan, Melek Eda Ertorer
OBJECTIVES: Detection rate of thyroid nodules is increasing with the use of new imaging modalities, especially in screening for malignancies. Positron emission tomography/computed tomography (PET/ CT)-positive thyroid nodules should be differentiated for malignancy to avoid unnecessary operations and further follow-up. Most trials evaluate the role of SUVmax, but there is no definitive information about the utility of Hounsfield unit (HU) values for prediction of malignancy. This study aimed to evaluate the HU values beside SUVmax for detecting malignancy risk of PET/CT-positive thyroid nodules...
August 2018: Archives of Endocrinology and Metabolism
Arunkumar Karthikayan, Sathasivam Sureshkumar, Dharanipragada Kadambari, Chellappa Vijayakumar
OBJECTIVE: This study was conducted to assess the serum 25-hydroxy (OH) vitamin D levels in patients with breast cancer compared to healthy controls and to identify its association with aggressive breast cancer phenotypes. MATERIALS AND METHODS: Serum 25-OH vitamin D levels of 78 breast cancer patients and 78 matched healthy controls were estimated using ELISA. The cases and controls were matched with respect to age, menopausal status, parity, weight, height and co-morbidities...
August 2018: Archives of Endocrinology and Metabolism
Leila C B Zanatta, Cesar L Boguszewski, Victoria Z C Borba, Carolina A Moreira
OBJECTIVE: Osteocalcin has been associated with several effects on energy and glucose metabolism. However, the physiological role of undercarboxylated osteocalcin (U-osc; the hormonally active isoform of osteocalcin) is still controversial. To correlate the serum levels of U-osc with bone mineral density (BMD) values and metabolic parameters in postmenopausal women. SUBJECTS AND METHODS: Cross-sectional study including 105 postmenopausal women (age 56.5 ± 6.1 years, body mass index [BMI] 28...
August 2018: Archives of Endocrinology and Metabolism
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