Touraj Mahmoudi, Shadi Nouri, Fatemeh Zarei, Zeinab Nourmohammadi Najafabadi, Maryam Sanei, Shiva Sayedsalehi, Gholamreza Rezamand, Asadollah Asadi, Reza Dabiri, Hossein Nobakht, Hamid Farahani, Seidamir Pasha Tabaeian, Mohammad Reza Zali
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease and a growing global epidemic. In NAFLD, liver fat surpasses 5% of hepatocytes without the secondary causes of lipid accumulation or excessive alcohol consumption. Given the link between NAFLD and insulin resistance, the possible association between the rs2854744 (-202 G>T) promoter polymorphism of insulin-like growth factor binding protein 3 ( IGFBP3 ) gene and NAFLD was investigated in this study. MATERIALS AND METHODS: In this genetic case-control association study, the IGFBP3 rs2854744 genotypes of 315 unrelated individuals, including 156 patients with biopsy-proven NAFLD and 159 controls, were determined using polymerase chain reaction/restriction fragment length polymorphism analyses...
November 10, 2023: Archives of Endocrinology and Metabolism