journal
https://read.qxmd.com/read/38988690/ido-endothelial-cells-in-glomeruli-of-kidney-transplantation-patients-with-glomerulitis
#1
JOURNAL ARTICLE
Sanne H Hendriks, Sebastiaan Heidt, Juliette Krop, Marieke E IJsselsteijn, Jeroen Eggermont, Jesper Kers, Marlies E J Reinders, Frits Koning, Cees van Kooten
BACKGROUND: Kidney transplantation is the preferred treatment option for patients with end-stage renal disease. However, long-term graft survival remains a challenge. The enzyme indoleamine 2,3 dioxygenase (IDO) has been reported to have immunomodulatory effects with IDO transcripts being elevated in both antibody-mediated rejection and T cell-mediated rejection. METHODS: A metal-conjugated antibody panel for the staining of kidney biopsies was developed, allowing the visualization of 41 structural and immune markers on a single tissue slide to gain in-depth insight into the composition and localization of the immune cell compartment...
August 2024: Transplantation Direct
https://read.qxmd.com/read/38988689/optimizing-dcd-liver-grafts-with-prolonged-warm-ischemic-time-using-stabilized-plasmin-in-a-static-cold-storage-orthotopic-rat-liver-transplant-model
#2
JOURNAL ARTICLE
Riley Kahan, Nader Abraham, Min Zhang, Valery Novokhatny, Isaac Alderete, Paul Cray, Fengming Chen, Qimeng Gao, Greta Cywinska, Ryan Neill, Kentaro Nakata, Ahmed Hassan, Caroline Rush, Jude Penaflor, Justin J Pollara, Matthew G Hartwig, Benjamin Hughes, Andrew S Barbas
BACKGROUND: The clinical success of liver transplantation has led to increased demand, requiring further expansion of the donor pool. Therapeutic interventions to optimize organs from donation after circulatory death (DCD) have significant potential to mitigate the organ shortage. Dysfunction in DCD liver grafts is mediated by microvascular thrombosis during the warm ischemic period, and strategies that reduce this thrombotic burden may improve graft function. We hypothesized that the administration of the fibrinolytic enzyme plasmin to the donor organ during the cold storage period would reduce the thrombotic burden and improve DCD liver graft function...
August 2024: Transplantation Direct
https://read.qxmd.com/read/38988688/use-of-machine-perfusion-to-increase-the-number-of-expanded-criteria-deceased-donor-kidney-transplants-a-pharmacoeconomic-analysis
#3
JOURNAL ARTICLE
Helio Tedesco Silva, Teresa Raquel de Moraes Ramos, Deise De Boni Monteiro de Carvalho, Gustavo Fernandes Ferreira, João Marcelo Medeiros de Andrade, Luis Gustavo Modelli de Andrade, Mario Abbud-Filho, Renato Demarchi Foresto, Roberto Ceratti Manfro, Ronaldo de Matos Esmeraldo, Tainá Veras de Sandes Freitas, Valter Duro Garcia, José Medina Pestana, Marcelo Cunio Machado Fonseca
BACKGROUND: The discard of expanded criteria donor (ECD) kidneys is unacceptably high, considering the growing demand for transplantation. Using machine perfusion may reduce the discard rate, increase the number of transplants, and reduce mortality on the waiting list. METHODS: We developed a 5-y Markov model to simulate incorporating the pulsatile perfusion machine into the current government-funded healthcare system. The model compared the universal use of static cold storage for all kidneys with the selective use of machine perfusion for ECD kidneys...
August 2024: Transplantation Direct
https://read.qxmd.com/read/38988687/normothermic-machine-perfusion-is-associated-with-improvement-in-mortality-and-graft-failure-in-donation-after-cardiac-death-liver-transplant-recipients-in-the-united-states
#4
JOURNAL ARTICLE
Kenji Okumura, Abhay Dhand, Ryosuke Misawa, Hiroshi Sogawa, Gregory Veillette, Seigo Nishida
BACKGROUND: Use of normothermic machine perfusion (NMP) may help to expand the liver transplantation (LT) donor pool by potentially increasing the utilization of donation after circulatory death (DCD) organs. The aim of this study was to assess the impact of NMP on LT from DCD organs. METHODS: Data among DCD adult LT recipients in the United Network for Organ Sharing between January 2016 and December 2022 were analyzed. Outcomes were compared between 2 groups: NMP versus non-MP using propensity score matching...
August 2024: Transplantation Direct
https://read.qxmd.com/read/38988686/belatacept-removal-by-plasmapheresis-dose-adjustments-and-clinical-recommendations
#5
JOURNAL ARTICLE
Nicole K Wilson, Simon Tremblay, Adele R Shields, E Steve Woodle, Rita R Alloway, Alexander A Vinks, Bradley Miyagawa, Tomoyuki Mizuno
No abstract text is available yet for this article.
August 2024: Transplantation Direct
https://read.qxmd.com/read/38953041/the-risk-of-microbial-transmission-in-recipients-of-donor-livers-that-underwent-hypothermic-or-normothermic-machine-perfusion
#6
JOURNAL ARTICLE
Chikako Endo, Bianca Lascaris, Isabel M A Brüggenwirth, Jan Roggeveld, Hans Blokzijl, Vincent E de Meijer, M H Edwina Doting, Robert J Porte
BACKGROUND: Ex situ machine perfusion is increasingly used to preserve and assess donor livers before transplantation. Compared with traditional static cold storage (SCS), machine perfusion exposes livers to an additional risk of microbial contamination. However, information on the risk of microbial transmission during machine perfusion is lacking. METHODS: All livers that underwent either hypothermic oxygenated machine perfusion (HOPE) or normothermic machine perfusion (NMP) in our center between September 2021 and September 2023, and during which samples were taken from SCS fluid and/or machine perfusion solution for microbiological examination, were included in this retrospective, observational clinical study...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38953040/comparison-of-covid-19-hospitalization-and-death-between-solid-organ-transplant-recipients-and-the-general-population-in-canada-2020-2022
#7
JOURNAL ARTICLE
Kyla L Naylor, Gregory A Knoll, Darin Treleaven, Yuguang Kang, Amit X Garg, Kathryn Stirling, S Joseph Kim
BACKGROUND: Solid organ transplant recipients have a high risk of severe outcomes from SARS-CoV-2 infection. A comprehensive understanding of the impact of the COVID-19 pandemic across multiple waves in the solid organ transplant population and how this compares to the general population is limited. We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada to answer this question. METHODS: We included 15 306 solid organ transplant recipients and 12 160 904 individuals from the general population...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38953039/baseline-lung-allograft-dysfunction-after-bilateral-lung-transplantation-is-associated-with-an-increased-risk-of-death-results-from-a-multicenter-cohort-study
#8
JOURNAL ARTICLE
Michael B Keller, Junfeng Sun, Muhtadi Alnababteh, Lucia Ponor, Pali D Shah, Joby Mathew, Hyesik Kong, Ananth Charya, Helen Luikart, Shambhu Aryal, Steven D Nathan, Jonathan B Orens, Kiran K Khush, Moon Kyoo Jang, Sean Agbor-Enoh
BACKGROUND: A prior single-center, retrospective cohort study identified baseline lung allograft dysfunction (BLAD) as a risk factor for death in bilateral lung transplant recipients. In this multicenter prospective cohort study, we test the association of BLAD with death in bilateral lung transplant recipients, identify clinical risk factors for BLAD, and assess its association with allograft injury on the molecular level. METHODS: This multicenter, prospective cohort study included 173 bilateral lung transplant recipients that underwent serial pulmonary function testing and plasma collection for donor-derived cell-free DNA at prespecified time points...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38953038/randomized-controlled-trial-of-enhanced-recovery-after-surgery-protocols-in-live-kidney-donors-eraskt-study
#9
JOURNAL ARTICLE
Jacob Saks, Uzung Yoon, Natalie Neiswinter, Eric S Schwenk, Stephen Goldberg, Linh Nguyen, Marc C Torjman, Elia Elia, Ashesh Shah
BACKGROUND: Enhanced recovery after surgery (ERAS) pathways represent a comprehensive approach to optimizing perioperative management and reducing hospital stay and cost. In living donor kidney transplantation, key impediments to postoperative discharge include pain, and opioid associated complications such as nausea, vomiting, and the return of gastrointestinal function. METHODS: In this randomized controlled trial, living kidney transplantation donors were assigned to either the ERAS or control group...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911278/the-cascade-of-care-in-management-of-solid-organ-transplant-candidates-with-latent-tuberculosis-infection
#10
JOURNAL ARTICLE
Chia-Yu Chiu, Maryam Mahmood, Lisa M Brumble, Holenarasipur R Vikram, Elitza S Theel, Elena Beam
BACKGROUND: Solid organ transplant (SOT) candidates should be screened and treated for latent tuberculosis infection (LTBI) to prevent tuberculosis (TB) reactivation after transplantation. We aimed to assess the steps from positive QuantiFERON (QFT) through LTBI treatment (cascade of care) in the SOT population. METHODS: We conducted a retrospective study of SOT recipients older than 18 y with a positive QFT during pretransplant evaluation at the Mayo Clinic from January 2010 to June 2023...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911277/hla-genotype-imputation-results-in-largely-accurate-epitope-mismatch-risk-categorization-across-racial-groups
#11
JOURNAL ARTICLE
Gregory S Cohen, Alison J Gareau, Melissa A Kallarakal, Tayyiaba Farooq, Maria P Bettinotti, H Cliff Sullivan, Abeer Madbouly, Scott M Krummey
BACKGROUND: Biomarkers that predict posttransplant alloimmunity could lead to improved long-term graft survival. Evaluation of the number of mismatched epitopes between donor and recipient HLA proteins, termed molecular mismatch analysis, has emerged as an approach to classify transplant recipients as having high, intermediate, or low risk of graft rejection. When high-resolution genotypes are unavailable, molecular mismatch analysis requires algorithmic assignment, or imputation, of a high-resolution genotyping...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911276/long-term-outcomes-after-kidney-transplantation-from-dbd-donors-aged-70-y-and-older
#12
JOURNAL ARTICLE
Jørn Petter Lindahl, Anders Åsberg, Kristian Heldal, Trond Jenssen, Christina Dörje, Morten Skauby, Karsten Midtvedt
BACKGROUND: Transplantation of kidneys from elderly donations after brain death (DBD) donors has increased owing to organ shortages. We aimed to assess the impact on long-term kidney transplant outcomes from DBD donors aged 70 y and older compared with kidneys from younger donors. METHODS: From 2007 to 2022, 2274 first single kidney transplantations from DBD donors were performed at our center. Data from 1417 kidney transplant recipients receiving a DBD organ were included and categorized into 3 groups according to donor age: 70 y and older (n = 444, median age 74 y), 60-69 y (n = 527, median age 64 y), and a reference group consisting of donors aged 45-54 y (n = 446, median age 50 y)...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911275/the-impact-of-donor-body-mass-index-on-safety-and-outcomes-in-living-donor-liver-transplantation-an-analysis-of-the-national-united-states-database
#13
JOURNAL ARTICLE
Amay Banker, Claire Cywes, Nicolas Muñoz, Raeda Taj, Therese Bittermann, Peter Abt, Samir Abu Gazala
BACKGROUND: The prevalence of obesity is rising in the general population. Donor obesity (body mass index ≥30 kg/m2 ) may potentially reduce the donor pool and impact outcomes in living donor liver transplantation (LDLT). METHODS: We utilized the national transplant database to investigate the impact of donor obesity on donor and recipient outcomes. This was a retrospective cohort study of all LDLTs performed in the United States between January 2010 and June 2023...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911274/evaluating-islet-cell-isolation-and-transplantation-from-donors-following-medical-assistance-in-dying
#14
JOURNAL ARTICLE
Alessandro Parente, Kevin Verhoeff, Tatsuya Kin, Joshua Hefler, Braulio A Marfil-Garza, Norberto Sanchez-Fernandez, Anna Lam, James Lyon, Doug O'Gorman, Khaled Z Dajani, Blaire L Anderson, David L Bigam, Patrick E MacDonald, A M James Shapiro
BACKGROUND: Limited information is available regarding outcomes of islet cell isolation (ICI) and transplantation (ITx) using medical assistance in dying (MAiD) donors. We aimed to assess the feasibility and outcomes of ICI and ITx in MAiD donors. METHODS: ICI and ITx from MAiD were compared with donation after circulatory death (DCD) type III between 2016 and 2023. Differences of isolated islet equivalents (IEQs), numeric viability and other quantitative in vitro metabolic measures were assessed...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911273/hernia-correction-after-liver-transplantation-using-nonvascularized-fascia
#15
JOURNAL ARTICLE
Iago Justo, Oscar Caso, Alberto Marcacuzco, Yolanda Rodríguez-Gil, Carlos Jiménez-Romero
BACKGROUND: Liver transplantation is an increasingly frequent surgical procedure, with elevated rates of postoperative incisional hernias ranging from 5% to 46%. There are numerous known risk factors for incisional hernia, including the type of incision, patient sex, and presence of comorbidities such as diabetes, ascites, older age, and the use of steroids. Most studies on the treatment of incisional hernias in patients who have undergone liver transplantation have shown consistently high rates of complications...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911272/sex-based-disparities-in-liver-transplantation-for-hepatocellular-carcinoma-and-the-impact-of-the-growing-burden-of-nash
#16
JOURNAL ARTICLE
Jia Hong Koh, Douglas Chee, Cheng Han Ng, Karn Wijarnpreecha, Mark Muthiah, Darren Jun Hao Tan, Wen Hui Lim, Rebecca Wenling Zeng, Benjamin Koh, Eunice Tan Xiang Xuan, Glenn Bonney, Shridhar Iyer, Dan Yock Young, Toru Nakamura, Hirokazu Takahashi, Mazen Noureddin, Mohammad Shadab Siddiqui, Tracey G Simon, Rohit Loomba, Daniel Q Huang
BACKGROUND: The cause of liver disease is changing, but its impact on liver transplantation (LT) for hepatocellular carcinoma (HCC) in women and men is unclear. We performed a nationwide study to assess the prevalence and posttransplant survival outcomes of the various causes of liver disease in women and men with HCC. METHODS: Data were obtained from the United Network for Organ Sharing database from 2000 to 2022. Data related to the listing, transplant, waitlist mortality, and posttransplant mortality for HCC were extracted...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38911271/pharmacodynamic-effect-of-mtor-inhibition-based-immunosuppressive-therapy-on-t-and-b-cell-subsets-after-renal-transplantation
#17
JOURNAL ARTICLE
Xinyi Wei, Sabine Weber, Decheng Yin, Ida Allabauer, Tilman Jobst-Schwan, Michael Wiesener, Mario Schiffer, Diana Dudziak, Christian H K Lehmann, Joachim Woelfle, Andre Hoerning
BACKGROUND: The mammalian target of rapamycin inhibitor (mTORi) therapy after kidney transplantation is solely monitored pharmacokinetically, not necessarily reflecting PI3K-Akt-mTOR pathway blockade efficacy leading to potential under-or overimmunosuppression. METHODS: In this cross-sectional study, phosphoflow cytometry was used to determine the efficacy of mTOR inhibition in peripheral T- and B-lymphocyte subsets by assessing p70S6 kinase (p70S6K) phosphorylation in renal transplant recipients upon treatment with a combination of either mTORi and calcineurin inhibitors (n = 18), or mTORi with mycophenolic acid (n = 9)...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38881747/immunologic-benefits-of-0-antigen-mismatched-transplants-no-added-boost-for-racial-and-ethnic-minorities
#18
JOURNAL ARTICLE
Jillian S Caldwell, Gomathy Parvathinathan, Margaret R Stedman, Patrick Ahearn, Jane C Tan, Xingxing S Cheng
BACKGROUND: Systemic barriers to posttransplant care, including access to immunosuppressant medications, contribute to higher rates of kidney transplant failure in racial minorities. Matching donor and recipient HLA alleles reduce allorecognition, easing reliance on immunosuppression. We hypothesize that 0-antigen mismatch transplants may provide stronger protection against graft loss in racial minorities. METHODS: We compared adult, single-organ, deceased-donor kidney transplants in the United States from 2007 to 2016 by degree of HLA mismatch (0- versus ≥1-antigen mismatch)...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38881746/mesangial-expansion-by-morphometry-at-5-y-after-kidney-transplantation-incidence-risk-factors-and-association-with-graft-loss
#19
JOURNAL ARTICLE
Aleksandar Denic, Alessia Buglioni, Sandor Turkevi-Nagy, Mateo Velasquez Mejia, Byron H Smith, Walter D Park, Rashmi Subramani, Aleksandra Kukla, Tayyab S Diwan, Joseph P Grande, Mark D Stegall
BACKGROUND: Mesangial expansion (ME) is an understudied histologic lesion in renal allografts. The current Banff mm score is not reproducible and may miss important ME features. The study aimed to improve the quantification of ME using morphometry, assess changes over time, and determine its association with allograft loss. METHODS: We studied ME in 1-y and 5-y surveillance biopsies in 835 kidney transplants performed between January 2000 and December 2013. ME was assessed using the Banff mm score by a central pathologist and by morphometry...
July 2024: Transplantation Direct
https://read.qxmd.com/read/38881745/mycophenolate-dose-reduction-in-tacrolimus-based-regimens-and-long-term-kidney-transplant-outcomes-in-australia-and-new-zealand
#20
JOURNAL ARTICLE
Darren Lee, Kevan R Polkinghorne, Helen Pilmore, William R Mulley
BACKGROUND: Mycophenolate dose reduction (MDR) is associated with acute rejection and transplant failure in kidney transplant recipients (KTRs). The optimal dose to prevent rejection and reduce complications remains poorly defined in tacrolimus-based regimens. METHODS: We assessed adult KTRs from 2005 to 2017 initiated on mycophenolate mofetil 2 g/d, tacrolimus, and prednisolone from the Australia and New Zealand Dialysis and Transplant Registry. KTRs with rejection within the first 30 d posttransplant were excluded...
July 2024: Transplantation Direct
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