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Journal of Cardiovascular Development and Disease

Michael G Katz, Anthony S Fargnoli, Sarah M Gubara, Kenneth Fish, Thomas Weber, Charles R Bridges, Roger J Hajjar, Kiyotake Ishikawa
Advances in DNA- and RNA-based technologies have made gene therapy suitable for many lung diseases, especially those that are hereditary. The main objective of gene therapy is to deliver an adequate amount of gene construct to the intended target cell, achieve stable transduction in target cells, and to produce a clinically therapeutic effect. This review focuses on the cellular organization in the normal lung and how gene therapy targets the specific cell types that are affected by pulmonary disorders caused by genetic mutations...
February 15, 2019: Journal of Cardiovascular Development and Disease
Ayumi Aurea Miyakawa, Vinícius Bassaneze, Nubia Esteban Duarte, Thais Girão-Silva, Monica Nunes Bizerra, Julliana Carvalho Campos, Jose Eduardo Krieger
The global expression profile of the arterialized rat jugular vein was established to identify candidate genes and cellular pathways underlying the remodeling process. The arterialized jugular vein was analyzed on days 3 and 28 post-surgery and compared with the normal jugular vein and carotid artery. A gene array platform detected 9846 genes in all samples. A heatmap analysis uncovered patterns of gene expression showing that the arterialized vein underwent a partial transition from vein to artery from day 3 to 28 post-surgery...
February 2, 2019: Journal of Cardiovascular Development and Disease
Nicholas A Battista, Dylan R Douglas, Andrea N Lane, Leigh Ann Samsa, Jiandong Liu, Laura A Miller
Proper heart morphogenesis requires a delicate balance between hemodynamic forces, myocardial activity, morphogen gradients, and epigenetic signaling, all of which are coupled with genetic regulatory networks. Recently both in vivo and in silico studies have tried to better understand hemodynamics at varying stages of veretebrate cardiogenesis. In particular, the intracardial hemodynamics during the onset of trabeculation is notably complex-the inertial and viscous fluid forces are approximately equal at this stage and small perturbations in morphology, scale, and steadiness of the flow can lead to significant changes in bulk flow structures, shear stress distributions, and chemical morphogen gradients...
January 22, 2019: Journal of Cardiovascular Development and Disease
Adriana M Rodriguez, Viravuth P Yin
Stimulating cardiomyocyte regeneration after an acute injury remains the central goal in cardiovascular regenerative biology. While adult mammals respond to cardiac damage with deposition of rigid scar tissue, adult zebrafish and salamander unleash a regenerative program that culminates in new cardiomyocyte formation, resolution of scar tissue, and recovery of heart function. Recent studies have shown that immune cells are key to regulating pro-inflammatory and pro-regenerative signals that shift the injury microenvironment toward regeneration...
January 15, 2019: Journal of Cardiovascular Development and Disease
Yingxi Cao, Jingli Cao
The epicardium, a mesothelial layer that envelops vertebrate hearts, has become a therapeutic target in cardiac repair strategies because of its vital role in heart development and cardiac injury response. Epicardial cells serve as a progenitor cell source and signaling center during both heart development and regeneration. The importance of the epicardium in cardiac repair strategies has been reemphasized by recent progress regarding its requirement for heart regeneration in zebrafish, and by the ability of patches with epicardial factors to restore cardiac function following myocardial infarction in mammals...
December 24, 2018: Journal of Cardiovascular Development and Disease
Ian J Begeman, Junsu Kang
The heart plays the vital role of propelling blood to the entire body, which is essential to life. While maintaining heart function is critical, adult mammalian hearts poorly regenerate damaged cardiac tissue upon injury and form scar tissue instead. Unlike adult mammals, adult zebrafish can regenerate injured hearts with no sign of scarring, making zebrafish an ideal model system with which to study the molecular mechanisms underlying heart regeneration. Investigation of heart regeneration in zebrafish together with mice has revealed multiple cardiac regeneration genes that are induced by injury to facilitate heart regeneration...
December 22, 2018: Journal of Cardiovascular Development and Disease
Marco Cirillo
I was disappointed by Anderson's comment on my recent review, a comment that I think derives from a too quick reading of the article. [...].
December 20, 2018: Journal of Cardiovascular Development and Disease
Robert H Anderson
In his recent review for the Journal of Cardiovascular Development and Disease, Cirillo offers a concept for "cardiac memory" based on the notion that the ventricular cone can be unwrapped to show a myocardial band extending from the pulmonary to the aortic root. The concept of the myocardial band was itself developed by Torrent Guasp, and has subsequently been championed by Buckberg. Neither Torrent Guasp, when formulating his initial concept, nor Buckberg in his subsequent endorsements, have validated the results of dissection using histological or other techniques that would reveal the boundaries of the alleged band...
December 19, 2018: Journal of Cardiovascular Development and Disease
Subir Kapuria, Tyler Yoshida, Ching-Ling Lien
Functional coronary circulation is essential for a healthy heart in warm-blooded vertebrates, and coronary diseases can have a fatal consequence. Despite the growing interest, the knowledge about the coronary vessel development and the roles of new coronary vessel formation during heart regeneration is still limited. It is demonstrated that early revascularization is required for efficient heart regeneration. In this comprehensive review, we first describe the coronary vessel formation from an evolutionary perspective...
December 17, 2018: Journal of Cardiovascular Development and Disease
Wolfgang J Weninger, Barbara Maurer-Gesek, Lukas F Reissig, Fabrice Prin, Robert Wilson, Antonella Galli, David J Adams, Jacqueline K White, Timothy J Mohun, Stefan H Geyer
The article will briefly introduce the high-resolution episcopic microscopy (HREM) technique and will focus on its potential for researching cardiovascular development and remodelling in embryos of biomedical model organisms. It will demonstrate the capacity of HREM for analysing the cardiovascular system of normally developed and genetically or experimentally malformed zebrafish, frog, chick and mouse embryos in the context of the whole specimen and will exemplarily show the possibilities HREM offers for comprehensive visualisation of the vasculature of adult human skin...
December 15, 2018: Journal of Cardiovascular Development and Disease
Xiaojun Zhu, Chenglu Xiao, Jing-Wei Xiong
The zebrafish is broadly used for investigating de novo organ regeneration, because of its strong regenerative potential. Over the past two decades of intense study, significant advances have been made in identifying both the regenerative cell sources and molecular signaling pathways in a variety of organs in adult zebrafish. Epigenetic regulation has gradually moved into the center-stage of this research area, aided by comprehensive work demonstrating that DNA methylation, histone modifications, chromatin remodeling complexes, and microRNAs are essential for organ regeneration...
December 14, 2018: Journal of Cardiovascular Development and Disease
Cristina E Fernandez, Melanie Bakovic, Ravi Karra
Studies over the past two decades have shown heart regeneration in zebrafish to be a dynamic process, choreographed by multiple cell types. In particular, recent work has identified revascularization of the wound to be a sentinel event during heart regeneration. The cardiac endothelium has emerged as a key orchestrator of heart regeneration, influencing cardiomyocyte hyperplasia and tissue morphogenesis. Here, we review how the coronary vasculature regenerates after injury, how signaling pathways link the cardiac endothelium to heart regeneration, and how understanding these signaling dynamics can lead to targeted therapies for heart regeneration...
December 11, 2018: Journal of Cardiovascular Development and Disease
Marco Cirillo
The embryological development of the heart is one of the most fascinating phenomena in nature and so is its final structure and function. The various ontogenetic passages form the evolutive basis of the final configuration of the heart. Each key step can be recognized in the final features, as the heart maintains a kind of "memory" of these passages. We can identify the major lines of development of the heart and trace these lines up to the mature organ. The aim of this review is to identify these key parameters of cardiac structure and function as essential elements of the heart's proper functioning and bases for its treatment...
November 11, 2018: Journal of Cardiovascular Development and Disease
Robert E Poelmann, Adriana C Gittenberger-de Groot
The beating heart is subject to intrinsic mechanical factors, exerted by contraction of the myocardium (stretch and strain) and fluid forces of the enclosed blood (wall shear stress). The earliest contractions of the heart occur already in the 10-somite stage in the tubular as yet unsegmented heart. With development, the looping heart becomes asymmetric providing varying diameters and curvatures resulting in unequal flow profiles. These flow profiles exert various wall shear stresses and as a consequence different expression patterns of shear responsive genes...
November 6, 2018: Journal of Cardiovascular Development and Disease
Alex I Gavino, Vivian Isaac, Craig S McLachlan
Hypertension is the most frequently managed condition by Australian general practitioners (GP). Knowledge of hypertension and blood pressure (BP) values may motivate individuals to seek GP management. Our study aims to determine the associations of knowledge of BP values, BP perception, GP health seeking, and self-rated health (SRH) in a rural population. Two-hundred and seventy-eight (278) residents responded to the health survey on socio-demographic profile, medical history, BP knowledge and perception, SRH, and GP visit frequency...
November 6, 2018: Journal of Cardiovascular Development and Disease
Agata Puzzovivo, Francesco Monitillo, Pietro Guida, Marta Leone, Caterina Rizzo, Dario Grande, Marco Matteo Ciccone, Massimo Iacoviello
AIM OF THE STUDY: In chronic heart failure (CHF) patients, renal congestion plays a key role in determining the progression of renal dysfunction and a worse prognosis. The aim of this study was to define the role of Doppler venous patterns reflecting renal congestion that predict heart failure progression. METHODS: We enrolled outpatients affected by CHF, in stable clinical conditions and in conventional therapy. All patients underwent a clinical evaluation, routine chemistry, an echocardiogram and a renal echo-Doppler...
November 3, 2018: Journal of Cardiovascular Development and Disease
Dima Kreidieh, Leila Itani, Dana El Masri, Hana Tannir, Roberto Citarella, Marwan El Ghoch
The last decade has seen a new condition that describes the coexistence of obesity and sarcopenia, termed sarcopenic obesity (SO). We aimed to assess the prevalence of SO in overweight and obese treatment-seeking adult women and the association with type 2 diabetes, hypertension, and dyslipidemia. A body composition assessment was conducted with an InBody bioimpedance analyser in 154 overweight and obese women referred to the Outpatient Clinic in the Department of Nutrition and Dietetics at Beirut Arab University (BAU) in Lebanon, and 30 normal-weight participants of similar age...
October 20, 2018: Journal of Cardiovascular Development and Disease
Melad Farraha, Saurabh Kumar, James Chong, Hee Cheol Cho, Eddy Kizana
Bradycardia arising from pacemaker dysfunction can be debilitating and life threatening. Electronic pacemakers serve as effective treatment options for pacemaker dysfunction. They however present their own limitations and complications. This has motivated research into discovering more effective and innovative ways to treat pacemaker dysfunction. Gene therapy is being explored for its potential to treat various cardiac conditions including cardiac arrhythmias. Gene transfer vectors with increasing transduction efficiency and biosafety have been developed and trialed for cardiovascular disease treatment...
October 19, 2018: Journal of Cardiovascular Development and Disease
Amélie Calmont, Naomi Anderson, Jenifer P Suntharalingham, Richard Ang, Andrew Tinker, Peter J Scambler
Haploinsufficiency of the T-box transcription factor TBX1 is responsible for many features of 22q11.2 deletion syndrome. Tbx1 is expressed dynamically in the pharyngeal apparatus during mouse development and Tbx1 homozygous mutants display numerous severe defects including abnormal cranial ganglion formation and neural crest cell defects. These abnormalities prompted us to investigate whether parasympathetic (vagal) innervation of the heart was affected in Tbx1 mutant embryos. In this report, we used an allelic series of Tbx1 mouse mutants, embryo tissue explants and cardiac electrophysiology to characterise, in detail, the function of Tbx1 in vagal innervation of the heart...
September 23, 2018: Journal of Cardiovascular Development and Disease
Nur Ilyana Jaafar, Ramachandran Vasudevan, Patimah Ismail, Ahmad Fazli Abdul Aziz, Nur Afiqah Mohamad, Geetha Kandavello, Raja Nurzatul Effah Raja Adnan, Vinod Balasubramaniam
Genetic polymorphisms are variations in DNA sequences which can influence either disease susceptibility, severity, or prognosis. Pulmonary arterial hypertension (PAH) is one of the complications that occurs in certain patients who have atrial septal defect (ASD). This study seeks to determine the association of gene polymorphisms with the pathogenesis of PAH in ASD patients. This study was conducted on 30 ASD patients with PAH, and 50 ASD patients who were not diagnosed with PAH. All respondents were Malay...
September 18, 2018: Journal of Cardiovascular Development and Disease
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