Alicia D Henn, Kunal Mitra, Joshua Hunsberger, Xiuzhi Susan Sun, Mark Nardone, Ramon Montero, Sita Somara, Gary Green, Alan Blanchard, Yu Shrike Zhang, Carl G Simon, Randy Yerden
PURPOSE OF REVIEW: Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encountered over time. Currently, routine cell culture practices subject cell and tissue products to highly variable and non-physiologic conditions. This article defines five cytocentric principles that place the conditions for cells at the core of what we do for better reproducibility in Regenerative Medicine. RECENT FINDINGS: There is a rising awareness of the cell environment as a neglected, but critical variable...
2022: Current Stem Cell Reports