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Biomaterials Research

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https://read.qxmd.com/read/30873291/correction-to-hypoxic-condition-enhances-chondrogenesis-in-synovium-derived-mesenchymal-stem-cells
#1
Hyun Cheol Bae, Hee Jung Park, Sun Young Wang, Ha Ru Yang, Myung Chul Lee, Hyuk-Soo Han
[This corrects the article DOI: 10.1186/s40824-018-0134-x.].
2019: Biomaterials Research
https://read.qxmd.com/read/30834142/ionic-silver-functionalized-ovine-forestomach-matrix-a-non-cytotoxic-antimicrobial-biomaterial-for-tissue-regeneration-applications
#2
Tanvi Karnik, Sandi G Dempsey, Micheal J Jerram, Arun Nagarajan, Ravindra Rajam, Barnaby C H May, Christopher H Miller
Background: Antimicrobial technologies, including silver-containing medical devices, are increasingly utilized in clinical regimens to mitigate risks of microbial colonization. Silver-functionalized resorbable biomaterials for use in wound management and tissue regeneration applications have a narrow therapeutic index where antimicrobial effectiveness may be outweighed by adverse cytotoxicity. We examined the effects of ionic silver functionalization of an extracellular matrix (ECM) biomaterial derived from ovine forestomach (OFM-Ag) in terms of material properties, antimicrobial effectiveness and cytotoxicity profile...
2019: Biomaterials Research
https://read.qxmd.com/read/30805200/preservation-of-allograft-bone-using-a-glycerol-solution-a-compilation-of-original-preclinical-research
#3
Brian Samsell, Davorka Softic, Xiaofei Qin, Julie McLean, Payal Sohoni, Katrina Gonzales, Mark A Moore
Background: Bone allografts are used in many orthopedic procedures to provide structural stability as well as an osteoconductive matrix for bone ingrowth and fusion. Traditionally, bone allografts have been preserved by either freezing or freeze-drying. Each of these preservation methods has some disadvantages: Frozen grafts require special shipping and storage conditions, and freeze-drying requires special lyophilization equipment and procedures that may impact biomechanical integrity...
2019: Biomaterials Research
https://read.qxmd.com/read/30788137/comparative-studies-on-thin-polycaprolactone-tricalcium-phosphate-composite-scaffolds-and-its-interaction-with-mesenchymal-stem-cells
#4
Gopinathan Janarthanan, In Gul Kim, Eun-Jae Chung, Insup Noh
Background: Hybrid scaffolds combining biodegradable polymers and ceramic particles for control of cell adhesion and proliferation are interesting materials for tissue engineering applications. Combinations of biodegradable polymers and ceramics are to provide higher beneficial functionalities to tissue engineering scaffolds with addition of different cell specific bio-factors. Many such hybrid combinations have been reported by several researchers around the world by using various methods and solvents as well as bioactive matrix polymers to fabricate such biomaterials...
2019: Biomaterials Research
https://read.qxmd.com/read/30774971/3d-printable-hyaluronic-acid-based-hydrogel-for-its-potential-application-as-a-bioink-in-tissue-engineering
#5
Insup Noh, Nahye Kim, Hao Nguyen Tran, Jaehoo Lee, Chibum Lee
Background: After recognition of 3D printing and injectable hydrogel as a critical issue in tissue/organ engineering and regenerative medicine society, many hydrogels as bioinks have been developed worldwide by using polymeric biomaterials such as gelatin, alginate, hyaluronic acid and others. Even though some gels have shown good performances in 3D bioprinting, still their performances do not meet the requirements enough to be used as a bioink in tissue engineering. Method: In this study, a hydrogel consisting of three biocompatible biomaterials such as hyaluronic acid (HA), hydroxyethyl acrylate (HEA) and gelatin-methacryloyl, i...
2019: Biomaterials Research
https://read.qxmd.com/read/30675377/bioactive-calcium-phosphate-materials-and-applications-in-bone-regeneration
#6
REVIEW
Jiwoon Jeong, Jung Hun Kim, Jung Hee Shim, Nathaniel S Hwang, Chan Yeong Heo
Background: Bone regeneration involves various complex biological processes. Many experiments have been performed using biomaterials in vivo and in vitro to promote and understand bone regeneration. Among the many biomaterials, calcium phosphates which exist in the natural bone have been conducted a number of studies because of its bone regenerative property. It can be directly contributed to bone regeneration process or assist in the use of other biomaterials. Therefore, it is widely used in many applications and has been continuously studied...
2019: Biomaterials Research
https://read.qxmd.com/read/30675376/cosmeceutical-activities-of-ethanol-extract-and-its-ethyl-acetate-fraction-from-coffee-silverskin
#7
Song Hua Xuan, Keon Soo Lee, Hyo Jin Jeong, Young Min Park, Ji Hoon Ha, Soo Nam Park
Background: Coffee silverskin is a thin film that covers the raw coffee bean. In general, coffee silverskin, which detaches during the coffee roasting process, is disposed as firelighters or dispatched to landfills and can cause serious environmental pollution. The aim of this study was to investigate the feasibility of using coffee silverskin as a functional material in cosmetics by evaluating its bioactive ingredients, antioxidative activity, cytoprotective effect, matrix metalloproteinase-1 (MMP-1)-inhibiting effect, and anti-melanogenesis effect...
2019: Biomaterials Research
https://read.qxmd.com/read/30619619/application-of-bonelike%C3%A2-as-synthetic-bone-graft-in-orthopaedic-and-oral-surgery-in-veterinary-clinical-cases
#8
José Miguel Campos, Ana Catarina Sousa, Pedro Olivério Pinto, Jorge Ribeiro, Miguel Lacueva França, Ana Rita Caseiro, Mariana Vieira Branquinho, Sílvia Santos Pedrosa, Carla Mendonça, Ana Brandão, José Domingos Santos, Américo Afonso, Luís Miguel Atayde, Ana Lúcia Luís, Ana Colette Maurício
Autologous bone remains the gold standard grafting substrate for bone fusions used for small gaps and critical defects. However, significant morbidity is associated with the harvesting of autologous bone grafts and, for that reason, alternative bone graft substitutes have been developed. In the present case series, a glass-reinforced hydroxyapatite synthetic bone substitute, with osteoinductive and osteoconductive proprieties, was applied. This synthetic bone substitute comprises the incorporation of P2 O5 -CaO glass-based system within a hydroxyapatite matrix, moulded into spherical pellets with 250-500 μm of diameter...
2018: Biomaterials Research
https://read.qxmd.com/read/30598837/silicone-breast-implant-modification-review-overcoming-capsular-contracture
#9
REVIEW
Byung Ho Shin, Byung Hwi Kim, Sujin Kim, Kangwon Lee, Young Bin Choy, Chan Yeong Heo
Background: Silicone implants are biomaterials that are frequently used in the medical industry due to their physiological inertness and low toxicity. However, capsular contracture remains a concern in long-term transplantation. To date, several studies have been conducted to overcome this problem. This review summarizes and explores these trends. Main body: First, we examined the overall foreign body response from initial inflammation to fibrosis capsule formation in detail and introduced various studies to overcome capsular contracture...
2018: Biomaterials Research
https://read.qxmd.com/read/30598836/recent-advances-in-stem-cell-therapeutics-and-tissue-engineering-strategies
#10
REVIEW
Seong Gyu Kwon, Yang Woo Kwon, Tae Wook Lee, Gyu Tae Park, Jae Ho Kim
Background: Tissue regeneration includes delivering specific types of cells or cell products to injured tissues or organs for restoration of tissue and organ function. Stem cell therapy has drawn considerable attention since transplantation of stem cells can overcome the limitations of autologous transplantation of patient's tissues; however, it is not perfect for treating diseases. To overcome the hurdles associated with stem cell therapy, tissue engineering techniques have been developed...
2018: Biomaterials Research
https://read.qxmd.com/read/30546914/calcium-release-and-physical-properties-of-modified-carbonate-apatite-cement-as-pulp-capping-agent-in-dental-application
#11
Myrna Nurlatifah Zakaria, Arief Cahyanto, Ahmed El-Ghannam
Background: Carbonate apatite (CO3 Ap) and silica-calcium phosphate composite (SCPC) are bone substitutes with good prospect for dental application. SCPC creates a hydroxyapatite surface layer and stimulate bone cell function while, CO3 Ap induce apatite crystal formation with good adaptation providing good seal between cement and the bone. Together, these materials will add favorable properties as a pulp capping material to stimulate mineral barrier and maintain pulp vitality. The aim of this study is to investigate modification of CO3 Ap cement combined with SCPC, later term as CO3 Ap-SCPC cement (CAS) in means of its chemical (Calcium release) and physical properties (setting time, DTS and pH value)...
2018: Biomaterials Research
https://read.qxmd.com/read/30534414/recent-updates-for-biomaterials-used-in-total-hip-arthroplasty
#12
REVIEW
Chang Yong Hu, Taek-Rim Yoon
Background: Total hip arthroplasty (THA) is probably one of the most successful surgical interventions performed in medicine. Through the revolution of hip arthroplasty by principles of low friction arthroplasty was introduced by Sir John Charnley in 1960s. Thereafter, new bearing materials, fixation methods, and new designs has been improved. The main concern regarding failure of THA has been the biological response to particulate polyethylene debris generated by conventional metal on polyethylene bearing surfaces leading to osteolysis and aseptic loosening of the prosthesis...
2018: Biomaterials Research
https://read.qxmd.com/read/30455977/mitochondria-targeting-theranostics
#13
REVIEW
Han Chang Kang
Background: Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing side effects, as well as the significance of theranostics for delivering therapeutics at the correct locations and doses for diseases throughout diagnosis. Among organelles, mitochondria have received substantial attention due to their significant controlling functions in cells...
2018: Biomaterials Research
https://read.qxmd.com/read/30323947/nanoengineered-cell-derived-extracellular-matrix-influences-ecm-related-gene-expression-of-mesenchymal-stem-cells
#14
Hatice O Ozguldez, Junghwa Cha, Yoonmi Hong, Ilkyoo Koh, Pilnam Kim
Background: Human mesenchymal stem cells (hMSCs) are, due to their pluripotency, useful sources of cells for stem cell therapy and tissue regeneration. The phenotypes of hMSCs are strongly influenced by their microenvironment, in particular the extracellular matrix (ECM), the composition and structure of which are important in regulating stem cell fate. In reciprocal manner, the properties of ECM are remodeled by the hMSCs, but the mechanism involved in ECM remodeling by hMSCs under topographical stimulus is unclear...
2018: Biomaterials Research
https://read.qxmd.com/read/30305920/application-of-black-phosphorus-nanodots-to-live-cell-imaging
#15
Yong Cheol Shin, Su-Jin Song, Yu Bin Lee, Moon Sung Kang, Hyun Uk Lee, Jin-Woo Oh, Dong-Wook Han
Background: Black phosphorus (BP) has emerged as a novel class of nanomaterials owing to its unique optical and electronic properties. BP, a two-dimensional (2D) nanomaterial, is a structure where phosphorenes are stacked together in layers by van der Waals interactions. However, although BP nanodots have many advantages, their biosafety and biological effect have not yet been elucidated as compared to the other nanomaterials. Therefore, it is particularly important to assess the cytotoxicity of BP nanodots for exploring their potentials as novel biomaterials...
2018: Biomaterials Research
https://read.qxmd.com/read/30275973/synthesis-and-characterization-of-thiolated-hexanoyl-glycol-chitosan-as-a-mucoadhesive-thermogelling-polymer
#16
Ik Sung Cho, Hye Min Oh, Myeong Ok Cho, Bo Seul Jang, Jung-Kyo Cho, Kyoung Hwan Park, Sun-Woong Kang, Kang Moo Huh
Background: Mucoadhesive polymers, which may increase the contact time between the polymer and the tissue, have been widely investigated for pharmaceutical formulations. In this study, we developed a new polysaccharide-based mucoadhesive polymer with thermogelling properties. Methods: Hexanoyl glycol chitosan (HGC), a new thermogelling polymer, was synthesized by the chemical modification of glycol chitosan using hexanoic anhydride. The HGC was further modified to include thiol groups to improve the mucoadhesive property of thermogelling HGC...
2018: Biomaterials Research
https://read.qxmd.com/read/30275972/layer-by-layer-assembled-polymeric-thin-films-as-prospective-drug-delivery-carriers-design-and-applications
#17
REVIEW
Sohyeon Park, Uiyoung Han, Daheui Choi, Jinkee Hong
Background: The main purpose of drug delivery systems is to deliver the drugs at the appropriate concentration to the precise target site. Recently, the application of a thin film in the field of drug delivery has gained increasing interest because of its ability to safely load drugs and to release the drug in a controlled manner, which improves drug efficacy. Drug loading by the thin film can be done in various ways, depending on type of the drug, the area of exposure, and the purpose of drug delivery...
2018: Biomaterials Research
https://read.qxmd.com/read/30275971/hypoxic-condition-enhances-chondrogenesis-in-synovium-derived-mesenchymal-stem-cells
#18
Hyun Cheol Bae, Hee Jung Park, Sun Young Wang, Ha Ru Yang, Myung Chul Lee, Hyuk-Soo Han
Background: The chondrogenic differentiation of mesenchymal stem cells (MSCs) is regulated by many factors, including oxygen tensions, growth factors, and cytokines. Evidences have suggested that low oxygen tension seems to be an important regulatory factor in the proliferation and chondrogenic differentiation in various MSCs. Recent studies report that synovium-derived mesenchymal stem cells (SDSCs) are a potential source of stem cells for the repair of articular cartilage defects. But, the effect of low oxygen tension on the proliferation and chondrogenic differentiation in SDSCs has not characterized...
2018: Biomaterials Research
https://read.qxmd.com/read/30275970/injectable-hydrogels-delivering-therapeutic-agents-for-disease-treatment-and-tissue-engineering
#19
REVIEW
Jin Hyun Lee
Background: Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and cancers and the repair and regeneration of tissues. It is because they have the injectability with minimal invasiveness and usability for irregularly shaped sites, in addition to typical advantages of conventional hydrogels such as biocompatibility, permeability to oxygen and nutrient, properties similar to the characteristics of the native extracellular matrix, and porous structure allowing therapeutic agents to be loaded...
2018: Biomaterials Research
https://read.qxmd.com/read/30275969/micro-ct-a-digital-3d-microstructural-voyage-into-scaffolds-a-systematic-review-of-the-reported-methods-and-results
#20
REVIEW
Ibrahim Fatih Cengiz, Joaquim Miguel Oliveira, Rui L Reis
Background: Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis, and differentiation is related to the design of the scaffolds. Thus, characterization of the scaffolds is highly required. Micro-computed tomography (micro-CT) provides a powerful platform to analyze, visualize, and explore any portion of interest in the scaffold in a 3D fashion without cutting or destroying it with the benefit of almost no sample preparation need...
2018: Biomaterials Research
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