Pengcheng Tu, Yalan Pan, Lining Wang, Bin Li, Xiaoxian Sun, Zhongqing Liang, Mengmin Liu, Zitong Zhao, Chengjie Wu, Jianwei Wang, Zhifang Wang, Yu Song, Yafeng Zhang, Yong Ma, Yang Guo
Background: In the environment of cartilage injury, the activation of vascular endothelial cell (VEC), marked with excessive CD62E and reactive oxygen species (ROS), can affect the formation of hyaluronic cartilage. Therefore, we developed a CD62E- and ROS-responsive drug delivery system using E-selectin binding peptide, Thioketal, and silk fibroin (ETS) to achieve targeted delivery and controlled release of Clematis triterpenoid saponins (CS) against activated VEC, and thus promote cartilage regeneration. Methods: We prepared and characterized ETS/CS and verified their CD62E- and ROS-responsive properties in vitro...
2024: Biomaterials Research