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Journal of Pathology and Translational Medicine

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https://read.qxmd.com/read/30646673/guanabenz-acetate-induces-endoplasmic-reticulum-stress-related-cell-death-in-hepatocellular-carcinoma-cells
#1
Hyo Jeong Kang, Hyang Sook Seol, Sang Eun Lee, Young-Ah Suh, Jihun Kim, Se Jin Jang, Eunsil Yu
Background: Development of chemotherapeutics for the treatment of advanced hepatocellular carcinoma (HCC) has been lagging. Screening of candidate therapeutic agents by using patient-derived preclinical models may facilitate drug discovery for HCC patients. Materials and Methods: Four primary cultured HCC cells from surgically resected tumor tissues and six HCC cell lines were used for high-throughput screening of 252 drugs from the Prestwick Chemical Library®...
January 16, 2019: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30646672/metastatic-insulinoma-presenting-as-a-liver-cyst
#2
Hua Li, Tony El Jabbour, Ankesh Nigam, Hwajeong Lee
No abstract text is available yet for this article.
January 16, 2019: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30646671/primary-necrobiotic-xanthogranulomatous-sialadenitis-with-submandibular-gland-localization-without-skin-involvement-a-case-report-and-review
#3
Myunghee Kang, Na Rae Kim, Dong Hae Chung, Jae Yeon Seok, Dong Young Kim
Necrobiotic xanthogranulomatous reaction is a multiorgan, non-Langerhans cell histiocytosis with an unknown etiology. Occurrence in the salivary gland is extremely rare. We recently identified a case of necrobiotic xanthogranulomatous sialadenitis in a 73-year-old Korean woman who presented with a painless palpable lesion in the chin. There was no accompanying cutaneous lesion. Partial resection and subsequent wide excision with neck dissection were performed. Pathologically, examination showed a severe inflammatory lesion that included foamy macrophages centrally admixed with neutrophils, eosinophils, lymphocytes, plasma cells, and scattered giant cells, as well as necrobiosis...
January 16, 2019: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30636391/intraoperative-frozen-cytology-of-central-nervous-system-neoplasms-an-ancillary-tool-for-frozen-diagnosis
#4
Myunghee Kang, Dong Hae Chung, Na Rae Kim, Hyun Yee Cho, Seung Yeon Ha, Sangho Lee, Jungsuk An, Jae Yeon Seok, Gie-Taek Yie, Chan Jong Yoo, Sang Gu Lee, Eun Young Kim, Woo Kyung Kim, Sung Son, Sun Jin Sym, Dong Bok Shin, Hee Young Hwang, Eung Yeop Kim, Kyu Chan Lee
Background: Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the diagnostic accuracy for CNS neoplasms. Here, we evaluate the diagnostic value of cytology in frozen diagnoses of CNS neoplasms. Materials and methods: Cases were selected from patients undergoing both frozen cytology and frozen sections...
January 14, 2019: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30636390/human-leukocyte-antigen-class-i-and-programmed-death-ligand-1-co-expression-is-an-independent-poor-prognostic-factor-in-adenocarcinoma-of-the-lung
#5
Yeon Bi Han, Hyun Jung Kwon, Soo Young Park, Eun-Sun Kim, Hyojin Kim, Jin-Haeng Chung
Background: Both human leukocyte antigen (HLA) class I and programmed death-ligand 1 (PD-L1) molecules are known to play important roles in cancer immunity. In this study, we evaluated HLA class I expression in resected adenocarcinoma of the lung, and investigated its prognostic impact in correlation with PD-L1 expression. Materials and Methods: HLA class I and PD-L1 expression was evaluated by immunohistochemistry in a total of 403 resected lung adenocarcinomas using tissue microarray...
January 14, 2019: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30636389/encapsulated-papillary-thyroid-tumor-with-delicate-nuclear-changes-and-a-kras-mutation-as-a-possible-novel-subtype-of-borderline-tumor
#6
Kenji Ohba, Norisato Mitsutake, Michiko Matsuse, Tatiana Rogounovitch, Nobuhiko Nishino, Yutaka Oki, Yoshie Goto, Kennichi Kakudo
Although papillary thyroid carcinoma (PTC)-type nuclear changes are the most reliable morphological feature in the diagnosis of PTC, the nuclear assessment used to identify these changes is highly subjective. Here, we report a noninvasive encapsulated thyroid tumor with a papillary growth pattern measuring 23 mm at its largest diameter with a nuclear score of 2 in a 26-year-old man. After undergoing left lobectomy, the patient was diagnosed with an encapsulated PTC. However, a second opinion consultation suggested an alternative diagnosis of follicular adenoma with papillary hyperplasia...
January 14, 2019: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30599506/artificial-intelligence-in-pathology
#7
Hye Yoon Chang, Chan Kwon Jung, Junwoo Isaac Woo, Sanghun Lee, Joonyoung Cho, Sun Woo Kim, Tae-Yeong Kwak
As in other domains, artificial intelligence is becoming increasingly important in medicine. In particular, deep learning-based pattern recognition methods can advance the field of pathology by incorporating clinical, radiologic and genomic data to accurately diagnose diseases and predict patient prognoses. In this review, we present an overview of artificial intelligence, the brief history of artificial intelligence in the medical domain, recent advances in artificial intelligence applied to pathology, and future prospects of pathology driven by artificial intelligence...
December 28, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30599505/cytopathologic-features-of-secretory-carcinoma-of-salivary-gland-report-of-two-cases
#8
Young Ah Kim, Jae Won Joung, Sun-Jae Lee, Hoon-Kyu Oh, Chang Ho Cho, Woo Jung Sung
Secretory carcinoma of the salivary gland (SC) is a newly introduced rare salivary gland tumor that shares histological, immunohistochemical, and genetic characteristics with secretory carcinoma of the breast. Here, we report the cytologic features of two cases of SC confirmed by surgical resection. In these two cases, SC was incidentally detected in a 64-year-old female and a 56-year-old male. Fine needle aspiration cytology revealed nests of tumor cells with a papillary or glandular structure floating in mucinous secretions...
December 28, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30599504/endocervical-adenocarcinoma-in-situ-phenotype-with-ovarian-metastasis
#9
Hyun-Soo Kim, Yeon Seung Chung, Moon Sik Kim, Hyang Joo Ryu, Ji Hee Lee
No abstract text is available yet for this article.
December 28, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30586952/prognostic-impact-of-fusobacterium-nucleatum-depends-on-combined-tumor-location-and-microsatellite-instability-status-in-stage-ii-iii-colorectal-cancers-treated-with-adjuvant-chemotherapy
#10
Hyeon Jeong Oh, Jung Ho Kim, Jeong Mo Bae, Hyun Jung Kim, Nam-Yun Cho, Gyeong Hoon Kang
Background: This study aimed to investigate the prognostic impact of intratumoral Fusobacterium nucleatum in colorectal cancer (CRC) treated with adjuvant chemotherapy. Materials and Methods: F. nucleatum DNA was quantitatively measured in a total of 593 CRC tissues retrospectively collected from surgically resected specimens of stage III or high-risk stage II CRC patients who had received curative surgery and subsequent oxaliplatin-based adjuvant chemotherapy (either FOLFOX or CAPOX)...
December 26, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30586951/quilty-lesions-in-the-endomyocardial-biopsies-after-heart-transplantation
#11
Haeyon Cho, Jin-Oh Choi, Eun-Seok Jeon, Jung-Sun Kim
Background: The aim of this study was to investigate the clinical significance of Quilty lesions in endomyocardial biopsies (EMBs) of cardiac transplantation patients. Materials and Methods: A total of 1190 EMBs from 117 cardiac transplantation patients were evaluated histologically for Quilty lesions, acute cellular rejection, and antibody-mediated rejection. Cardiac allograft vasculopathy was diagnosed by computed tomography coronary angiography. Clinical information, including the patients' survival was retrieved by a review of medical records...
December 26, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30558398/uterine-malignant-mixed-m%C3%A3-llerian-tumors-following-treatment-with-selective-estrogen-receptor-modulators-in-patients-with-breast-cancer-a-report-of-13-cases-and-their-clinicopathologic-characteristics
#12
Byung-Kwan Jeong, Chang O Sung, Kyu-Rae Kim
Background: Breast cancer treatment with selective estrogen receptor modulators (SERMs) increases the incidence of uterine malignant mixed Müllerian tumors (uMMMTs). We examine clinicopathologic characteristics and prognosis of SERM-associated uMMMTs (S-uMMMTs) and discuss possible pathogenetic mechanisms. Materials and Methods: Among 28,104 patients with breast cancer, clinicopathologic features and incidence of uMMMT were compared between patients who underwent SERM treatment and those who did not...
December 18, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30472817/adrenal-cortical-neoplasm-with-uncertain-malignant-potential-arising-in-the-heterotopic-adrenal-cortex-in-the-liver-of-a-patient-with-beckwith-wiedemann-syndrome-a-case-rteport
#13
Eun Na Kim, Dong Eun Song, Hee Mang Yoon, Beom Hee Lee, Chong Jai Kim
Patients with Beckwith-Wiedemann syndrome (BWS) are predisposed to developing embryonal tumors, with hepatoblastoma being the most common type. Our patient showed hemihypertrophy, macroglossia, and paternal uniparental disomy in chromosome 11 and was diagnosed with BWS. When the patient was nine months old, a 2.5×1.5 cm oval hypoechoic exophytic mass was detected in the inferior tip of his right liver. Preoperative imaging identified it as hepatoblastoma; however, histologic, immunohistochemistry and electron microscopic findings were compatible with adrenal cortical neoplasm with uncertain malignant potential...
November 26, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30472816/prognostic-role-of-s100a8-and-s100a9-protein-expressions-in-non-small-cell-carcinoma-of-the-lung
#14
Hyun Min Koh, Hyo Jung An, Gyung Hyuck Ko, Jeong Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Sung Hwan Kim, Kyung Nyeo Jeon, Gyeong-Won Lee, Se Min Jang, Dae Hyun Song
Background: S100A8 and S100A9 have been gaining recognition for modulating tumor growth and metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 in non-small cell lung cancer (NSCLC). Materials and Methods: We analyzed the relationship between S100A8 and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumor cells and peritumoral inflammatory cells. Results: The positive staining in tumor cells for S100A8 was significantly increased in male (p < ...
November 26, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30472815/primary-malignant-melanoma-of-the-breast-a-report-of-two-cases
#15
Jiwon Koh, Jihyeon Lee, So Youn Jung, Han Sung Kang, Tak Yun, Youngmee Kwon
Primary malignant melanoma of the breast (PMMB) is a rare tumor with only a few case reports available in the literature. We report two cases of PMMB, one with tumor derived from breast parenchyma and the other from breast skin. The first case consisted of atypical epithelioid cells without overt melanocytic differentiation. The tumor cells showed diffuse positivity for S100 protein, tyrosinase, and BRAF (V600E). However, the tumor cells were negative for cytokeratin, epithelial membrane antigen, and HMB-45...
November 26, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30424592/plag1-sox10-and-myb-expression-in-benign-and-malignant-salivary-gland-neoplasms
#16
Ji Hyun Lee, Hye Ju Kang, Chong Woo Yoo, Weon Seo Park, Jun Sun Ryu, Yuh-Seog Jung, Sung Weon Choi, Joo Yong Park, Nayoung Han
Background: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues. Materials and Methods: A total of 113 cases of surgically resected salivary gland neoplasms at the National Cancer Center from January 2007 to March 2017 were identified. Immunohistochemical staining of PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays...
November 14, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30424591/loss-of-human-leukocyte-antigen-class-i-expression-is-associated-with-poor-prognosis-in-patients-with-advanced-breast-cancer
#17
Hong Sik Park, Uiju Cho, So Young Im, Chang Young Yoo, Ji Han Jung, Oung Jin Suh, Hyun Joo Choi
Background: Human leukocyte antigen class I (HLA-I) molecules play important roles in regulating immune responses. Loss or reduction of HLA-I expression has been shown to be associated with prognosis in several cancers. Regulatory T-cells (Tregs) also play critical functions in immune response regulation. Evaluation of HLA-I expression status by the EMR8-5 antibody and its clinical impact in breast cancer have not been well studied, and its relationship with Tregs remains unclear. Materials and Methods: We evaluated HLA-I expression and Treg infiltration by immunohistochemistry in 465 surgically resected breast cancer samples...
November 14, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30424590/wharton-jelly-hair-in-a-case-of-umbilical-cord-stricture-and-fetal-death
#18
Eun Na Kim, Jae-Yoon Shim, Chong Jai Kim
No abstract text is available yet for this article.
November 14, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30424589/coexisting-mucinous-cystic-neoplasm-of-the-pancreas-and-type-1-autoimmune-pancreatitis
#19
Mee-Jeong Kim, Tae Jun Song, Hyoung Jung Kim, Song-Cheol Kim, Myung-Hwan Kim, Seung-Mo Hong
Type 1 autoimmune pancreatitis (AIP1) is an IgG4-related systemic disease that mimics tumors. We report a rare case of AIP1 accompanied by mucinous cystic neoplasm (MCN). A pancreatic lesion was incidentally detected in a woman in her 60s. After 6 years of follow-up, the lesion abruptly increased in size. Computed tomography showed a 3.5-cm unilocular cyst in the tail of the pancreas and distal pancreatectomy was performed. On microscopic examination, the cyst was lined by mucinous and non-mucinous epithelial cells with mild cytologic atypia...
November 14, 2018: Journal of Pathology and Translational Medicine
https://read.qxmd.com/read/30458607/multiplicity-of-advanced-t-category-tumors-is-a-risk-factor-for-survival-in-patients-with-colorectal-carcinoma
#20
Hye Eun Park, Seungyeon Yoo, Jeong Mo Bae, Seorin Jeong, Nam-Yun Cho, Gyeong Hoon Kang
BACKGROUND: Previous studies on synchronous colorectal carcinoma (SCRC) have reported inconsistent results about its clinicopathologic and molecular features and prognostic significance. METHODS: Forty-six patients with multiple advanced tumors (T2 or higher category) who did not receive neoadjuvant chemotherapy and/or radiotherapy and who are not associated with familial adenomatous polyposis were selected and 99 tumors from them were subjected to clinicopathologic and molecular analysis...
November 2018: Journal of Pathology and Translational Medicine
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