journal
Journals Alzheimer's & Dementia : Trans...

Alzheimer's & Dementia : Translational Research & Clinical Interventions

https://read.qxmd.com/read/38389855/bayesian-meta-analysis-of-phase-3-results-of-aducanumab-lecanemab-donanemab-and-high-dose-gantenerumab-in-prodromal-and-mild-alzheimer-s-disease
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JOURNAL ARTICLE
Stefan J Teipel, Anna G M Temp, Michael W Lutz
INTRODUCTION: Phase 3 trials using the anti-amyloid antibodies aducanumab, lecanemab, donanemab, and high-dose gantenerumab in prodromal and mild Alzheimer's disease dementia were heterogeneous in respect to statistical significance of effects. However, heterogeneity of results has not yet directly be quantified. METHODS: We used Bayesian random effects meta-analysis to quantify evidence for or against a treatment effect, and assessed the size of the effect and its heterogeneity...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356481/evaluation-of-racial-and-ethnic-heterogeneity-in-the-associations-of-sleep-quality-and-sleep-apnea-risk-with-cognitive-function-and-cognitive-decline
#2
JOURNAL ARTICLE
Ruijia Chen, Jingxuan Wang, Annie M Pederson, Aric A Prather, Andrew K Hirst, Sarah Ackley, Emily Hokett, Kristen M George, Dan Mungas, Elizabeth Rose Mayeda, Paola Gilsanz, Sebastien Haneuse, Rachel A Whitmer, M Maria Glymour
INTRODUCTION: The prevalence of poor sleep quality and sleep apnea differs by race and ethnicity and may contribute to racial disparities in cognitive aging. We investigated whether sleep quality and sleep apnea risk were associated with cognitive function and decline and whether the associations differed by race/ethnicity. METHODS: Participants from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE; N = 1690; mean age: 75.7 years) study, a cohort of Asian, Black, Latino, and White participants, completed a modified Pittsburgh Sleep Quality Index assessing subjective sleep quality, latency, duration, disturbances, sleep medication use, and daytime dysfunction...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356480/the-functional-role-of-the-pulvinar-in-discriminating-between-objective-and-subjective-cognitive-impairment-in-major-depressive-disorder
#3
JOURNAL ARTICLE
Burak Yulug, Sevilay Ayyildiz, Dila Sayman, Ramazan Karaca, Lutfiye Ipek, Seyda Cankaya, Ali Behram Salar, Behcet Ayyildiz, Christian Mikuta, Nilay Yagci, Ece Ozdemir Oktem, Ahmet Ozsimsek, Halil Aziz Velioglu, Lutfu Hanoglu
INTRODUCTION: Emotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients' descriptions of their cognitive symptoms. METHODS: We compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as "amnestic" or "nonamnestic," based on the members' subjective reports concerning their forgetfulness...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356479/building-digital-solutions-to-support-brain-health-prescribing-in-primary-care-where-to-begin
#4
JOURNAL ARTICLE
Joyce Siette, Patrick J Adam
National and international policy goals on healthy ageing and dementia risk reduction are yet to be fully realised in community healthcare settings. Disease modification strategies through lifestyle and social interventions are viable, evidence-based solutions to reduce age-related disease burden. However, prescribing lifestyle interventions targeting dementia risk in primary care remains deficient. Using digital technologies to support older individuals and healthcare professionals through formal health checks and lifestyle management is likely to enable shared understanding and consequences of personalized care and treatment options...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356478/factors-associated-with-attitudes-toward-research-mri-in-older-asian-americans
#5
JOURNAL ARTICLE
Karthik J Kota, Alice Dawson, Julia Papas, Victor Sotelo, Guibin Su, Mei-Ling Li, Woowon Lee, Jaunis Estervil, Melissa Marquez, Shromona Sarkar, Lisa Lanza Lopez, William T Hu
INTRODUCTION: South Asian (SA) and East Asian (EA) older adults represent the fastest-growing racial/ethnic groups of Americans at risk for dementia. While recruiting older SA adults into a brain health study, we encountered unexpected hesitancy toward structural brain magnetic resonance imaging (MRI) analysis and stigmatizing attitudes related to internal locus of control (LoC) for future dementia risks. We hypothesized that support for MRI-related research was influenced by these attitudes as well as personal MRI experience, perceived MRI safety, and concerns for personal risk for future dementia/stroke...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356477/longitudinal-associations-of-apathy-and-regional-tau-in-mild-cognitive-impairment-and-dementia-findings-from-the-alzheimer-s-disease-neuroimaging-initiative
#6
JOURNAL ARTICLE
Pranitha Y Premnath, Joseph J Locascio, Kayden J Mimmack, Christopher Gonzalez, Michael J Properzi, Onyinye Udeogu, Paul B Rosenberg, Gad A Marshall, Jennifer R Gatchel
INTRODUCTION: It is important to study apathy in Alzheimer's disease (AD) to better understand its underlying neurobiology and develop effective interventions. In the current study, we sought to examine the relationships between longitudinal apathy and regional tau burden in cognitively impaired older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. METHODS: Three hundred and nineteen ADNI participants with mild cognitive impairment (MCI) or AD dementia underwent flortaucipir (FTP) tau positron emission tomography (PET) imaging and clinical assessment with the Neuropsychiatric Inventory (NPI) annually...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356476/differentiating-mci-from-depression-through-verbal-memory-scores
#7
JOURNAL ARTICLE
Seyda Cankaya, Betul Yalciner, Melek Kandemir Yilmaz, Burak Yulug
INTRODUCTION: The present study aims to assess the differences between major depressive disorder (MDD) and mild cognitive impairment (MCI) in terms of verbal learning profile together with structural changes in the brain on magnetic resonance imaging (MRI) and to reveal predictive factors for MCI. METHODS: Fifty-six patients with MDD and 31 MCI subjects were assessed using the Turkish Verbal Memory Processes Test (VMPT). Brain MRI was used to evaluate sulcal atrophy (SA), ventricular atrophy, periventricular white matter hyperintensity (WMH), subcortical WMH, basal ganglia infarct, medial temporal lobe atrophy, and infratentorial infarct scores based on the Modified Visual MRI Rating Scale (MVMRS)...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356475/the-hope4mci-study-a-randomized-double-blind-assessment-of-agb101-for-the-treatment-of-mci-due-to-ad
#8
JOURNAL ARTICLE
Richard Mohs, Arnold Bakker, Sharon Rosenzweig-Lipson, Michael Rosenblum, Russell L Barton, Marilyn S Albert, Sharon Cohen, Scott Zeger, Michela Gallagher
INTRODUCTION: In addition to the accumulation of amyloid plaques and neurofibrillary tangles, the presence of excess neural activity is a pathological hallmark of Alzheimer's disease (AD) and a prognostic indicator for progression of AD pathology and clinical/cognitive worsening in mild cognitive impairment due to Alzheimer's disease (MCI due to AD). The HOPE4MCI clinical study tested the efficacy of a therapeutic with demonstrated ability to normalize heightened neural activity in the hippocampus in a randomized controlled trial of 78 weeks duration in patients with MCI due to AD...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356474/phase-1-study-of-latozinemab-in-progranulin-associated-frontotemporal-dementia
#9
JOURNAL ARTICLE
Michael Ward, Lawrence P Carter, Julie Y Huang, Daniel Maslyar, Balasubrahmanyam Budda, Robert Paul, Arnon Rosenthal
INTRODUCTION: Heterozygous mutations in the GRN gene lead to reduced progranulin (PGRN) levels in plasma and cerebrospinal fluid (CSF) and are causative of frontotemporal dementia (FTD) with > 90% penetrance. Latozinemab is a human monoclonal immunoglobulin G1 antibody that is being developed to increase PGRN levels in individuals with FTD caused by heterozygous loss-of-function GRN mutations. METHODS: A first-in-human phase 1 study was conducted to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of multiple-dose intravenous administration of latozinemab in eight symptomatic participants with FTD caused by a heterozygous loss-of-function GRN mutation (FTD- GRN )...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356473/commentary-on-greenberg-et%C3%A2-al-prescribing-anti-amyloid-immunotherapies-to-treat-alzheimer-s-disease-fully-informing-patient-decisions-alzheimer-s-dement-2023-9-4-e12426-doi-org-10-1002-trc2-12426
#10
JOURNAL ARTICLE
Carl V Hill, Joanne Pike
No abstract text is available yet for this article.
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356472/association-of-region-specific-hippocampal-reduction-of-neurogranin-with-inflammasome-proteins-in-post-mortem-brains-of-alzheimer-s-disease
#11
JOURNAL ARTICLE
Regina T Vontell, Ryan Gober, Julian Dallmeier, Daniel Brzostowicki, Ayled Barreda, Kaj Blennow, Henrik Zetterberg, Hlin Kvartsberg, Sakir Humayun Gultekin, Juan Pablo de Rivero Vaccari, Helen M Bramlett, W Dalton Dietrich, Robert W Keane, David A Davis, Tatjana Rundek, Xiaoyan Sun
INTRODUCTION: Neurogranin (Ng) is considered a biomarker for synaptic dysfunction in Alzheimer's disease (AD). In contrast, the inflammasome complex has been shown to exacerbate AD pathology. METHODS: We investigated the protein expression, morphological differences of Ng, and correlated Ng to hyperphosphorylated tau in the post mortem brains of 17 AD cases and 17 age- and sex-matched controls. In addition, we correlated the Ng expression with two different epitopes of apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356471/cerebrospinal-fluid-biomarker-profiling-of-diverse-pathophysiological-domains-in-alzheimer-s-disease
#12
JOURNAL ARTICLE
Bianca A Trombetta, Chao-Yi Wu, Evan Kuo, Matthijs B de Geus, Hiroko H Dodge, Becky C Carlyle, Pia Kivisäkk, Steven E Arnold
INTRODUCTION: While Alzheimer's disease (AD) is defined by amyloid-β plaques and tau tangles in the brain, it is evident that many other pathophysiological processes such as inflammation, neurovascular dysfunction, oxidative stress, and metabolic derangements also contribute to the disease process and that varying contributions of these pathways may reflect the heterogeneity of AD. Here, we used a previously validated panel of cerebrospinal fluid (CSF) biomarkers to explore the degree to which different pathophysiological domains are dysregulated in AD and how they relate to each other...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38356470/recruitment-and-baseline-data-of-the-aging-and-cognitive-health-evaluation-in-elders-achieve-study-a-randomized-trial-of-a-hearing-loss-intervention-for-reducing-cognitive-decline
#13
JOURNAL ARTICLE
Nicholas S Reed, Lisa Gravens-Mueller, Alison R Huang, Adele M Goman, Christine M Mitchell, Michelle L Arnold, Spencer Bolton, Sheila Burgard, Theresa H Chisolm, David Couper, Jennifer A Deal, Joshua Evans, Sarah Faucette, Nancy W Glynn, Theresa Gmelin, Kathleen M Hayden, Elizabeth Miller, Melissa Minotti, Thomas Mosley, Stacee Naylor, James S Pankow, James Russell Pike, Victoria A Sanchez, Jennifer A Schrack, Josef Coresh, Frank R Lin
INTRODUCTION: Hearing loss is highly prevalent among older adults and independently associated with cognitive decline. The Aging and Cognitive Health Evaluation in Elders (ACHIEVE) study is a multicenter randomized control trial (partially nested within the infrastructure of an observational cohort study, the Atherosclerosis Risk in Communities [ARIC] study) to determine the efficacy of best-practice hearing treatment to reduce cognitive decline over 3 years. The goal of this paper is to describe the recruitment process and baseline results...
2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38188606/participant-completion-of-longitudinal-assessments-in-an-online-cognitive-aging-registry-the-role-of-medical-conditions
#14
JOURNAL ARTICLE
Miriam T Ashford, Chengshi Jin, John Neuhaus, Adam Diaz, Anna Aaronson, Rachana Tank, Joseph Eichenbaum, Monica R Camacho, Juliet Fockler, Aaron Ulbricht, Derek Flenniken, Diana Truran, Robert Scott Mackin, Michael W Weiner, Monica Rivera Mindt, Rachel L Nosheny
INTRODUCTION: This study aimed to understand whether older adults' longitudinal completion of assessments in an online Alzheimer's disease and related dementias (ADRD)-related registry is influenced by self-reported medical conditions. METHODS: Brain Health Registry (BHR) is an online cognitive aging and ADRD-related research registry that includes longitudinal health and cognitive assessments. Using logistic regressions, we examined associations between longitudinal registry completion outcomes and self-reported (1) number of medical conditions and (2) eight defined medical condition groups (cardiovascular, metabolic, immune system, ADRD, current psychiatric, substance use/abuse, acquired, other specified conditions) in adults aged 55+ ( N = 23,888)...
January 2024: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38093736/effects-of-informant-replacement-in-alzheimer-s-disease-clinical-trials
#15
JOURNAL ARTICLE
Mikaela K Nishida, Michelle M Nuño, Joshua D Grill, Daniel L Gillen
INTRODUCTION: Alzheimer's disease (AD) trials require enrollment with an informant. METHODS: We assessed relationships between informant replacement and Alzheimer's Disease Cooperative Study Activities of Daily Living (ADCS-ADL) scores across four AD trials. Using generalized estimating equations, we examined associations between replacement and change in ADCS-ADL between successive visits. We used analysis of covariance to estimate the association between replacement and 18-month change from baseline, and an F- test to compare the variance of this change...
2023: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38053753/atrophy-of-specific-amygdala-subfields-in-subjects-converting-to-mild-cognitive-impairment
#16
JOURNAL ARTICLE
Caterina Padulo, Carlo Sestieri, Miriam Punzi, Eleonora Picerni, Piero Chiacchiaretta, Maria Giulia Tullo, Alberto Granzotto, Antonello Baldassarre, Marco Onofrj, Antonio Ferretti, Stefano Delli Pizzi, Stefano L Sensi
INTRODUCTION: Accumulating evidence indicates that the amygdala exhibits early signs of Alzheimer's disease (AD) pathology. However, it is still unknown whether the atrophy of distinct subfields of the amygdala also participates in the transition from healthy cognition to mild cognitive impairment (MCI). METHODS: Our sample was derived from the AD Neuroimaging Initiative 3 and consisted of 97 cognitively healthy (HC) individuals, sorted into two groups based on their clinical follow-up: 75 who remained stable (s-HC) and 22 who converted to MCI within 48 months (c-HC)...
2023: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38023622/ship1-therapeutic-target-enablement-identification-and-evaluation-of-inhibitors-for-the-treatment-of-late-onset-alzheimer-s-disease
#17
JOURNAL ARTICLE
Cynthia D Jesudason, Emily R Mason, Shaoyou Chu, Adrian L Oblak, June Javens-Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E Beck, Jiajun Dong, Ovini Amarasinghe, Zhong-Yin Zhang, Adam K Hamdani, Kratika Singhal, Andrew D Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M Soni, Murugesh Kandasamy, Andrea R Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J Sukoff Rizzo, Bruce T Lamb, Alan D Palkowitz, Timothy I Richardson
INTRODUCTION: The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate-5-phosphatase ( INPP5D ), which encodes Src homology 2 (SH2) domain-containing inositol polyphosphate 5-phosphatase 1 (SHIP1), is a risk gene expressed in microglia. Because SHIP1 binds receptor immunoreceptor tyrosine-based inhibitory motifs (ITIMs), competes with kinases, and converts PI(3,4,5)P3 to PI(3,4)P2 , it is a negative regulator of microglia function...
2023: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38023621/one-step-forward-to-personalized-medicine
#18
EDITORIAL
Hiroko H Dodge, Steven E Arnold
No abstract text is available yet for this article.
2023: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38023620/operationalizing-selection-criteria-for-clinical-trials-in-alzheimer-s-disease-biomarker-and-clinical-considerations
#19
JOURNAL ARTICLE
Ronald C Petersen, Ana Graf, Chris Brady, Susan De Santi, Hana Florian, Jaren Landen, Mike Pontecorvo, Christopher Randolph, Kaycee M Sink, Maria C Carrillo, Christopher J Weber
Alzheimer's disease (AD) staging criteria lack standardized, empirical description. Well-defined AD staging criteria are an important consideration in protocol design, influencing a more standardized inclusion/exclusion criteria and defining what constitutes meaningful differentiation among the stages. However, many trials are being designed on the basis of biomarker features and the two need to be coordinated. The Alzheimer's Association Research Roundtable (AARR) Spring 2021 meeting discussed the implementation of preclinical AD staging criteria, and provided recommendations for how they may best be incorporated into clinical trials research...
2023: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://read.qxmd.com/read/38023619/open-peer-commentary-on-prescribing-anti-amyloid-immunotherapies-to-treat-alzheimer-s-disease-fully-informing-patient-decisions
#20
JOURNAL ARTICLE
Sam Gandy
No abstract text is available yet for this article.
2023: Alzheimer's & Dementia: Translational Research & Clinical Interventions
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