Susan Fernandes, Elvira Williams, Neil Finlayson, Hazel Stewart, Catharine Dhaliwal, David A Dorward, William A Wallace, Ahsan R Akram, James Stone, Kevin Dhaliwal, Gareth O S Williams
Lung cancer is the most common cause of cancer-related deaths worldwide. Early detection improves outcomes, however, existing sampling techniques are associated with suboptimal diagnostic yield and procedure-related complications. Autofluorescence-based fluorescence-lifetime imaging microscopy (FLIM), a technique which measures endogenous fluorophore decay rates, may aid identification of optimal biopsy sites in suspected lung cancer. Our fibre-based fluorescence-lifetime imaging system, utilising 488 nm excitation, which is deliverable via existing diagnostic platforms, enables real-time visualisation and lifetime analysis of distal alveolar lung structure...
February 29, 2024: Translational Lung Cancer Research