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Journals Intensive Care Medicine Experi...

Intensive Care Medicine Experimental

https://read.qxmd.com/read/38332384/mesenchymal-stem-cells-based-therapies-for-severe-ards-with-ecmo-a-review
#21
REVIEW
Jing-Ke Cao, Xiao-Yang Hong, Zhi-Chun Feng, Qiu-Ping Li
Acute respiratory distress syndrome (ARDS) is the primary cause of respiratory failure in critically ill patients. Despite remarkable therapeutic advances in recent years, ARDS remains a life-threatening clinical complication with high morbidity and mortality, especially during the global spread of the coronavirus disease 2019 (COVID-19) pandemic. Previous studies have demonstrated that mesenchymal stem cell (MSC)-based therapy is a potential alternative strategy for the treatment of refractory respiratory diseases including ARDS, while extracorporeal membrane oxygenation (ECMO) as the last resort treatment to sustain life can help improve the survival of ARDS patients...
February 9, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38311676/positive-end-expiratory-pressure-limits-inspiratory-effort-through-modulation-of-the-effort-to-drive-ratio-an-experimental-crossover-study
#22
JOURNAL ARTICLE
Hannes Widing, Mariangela Pellegrini, Elena Chiodaroli, Per Persson, Katarina Hallén, Gaetano Perchiazzi
BACKGROUND: How assisted spontaneous breathing should be used during acute respiratory distress syndrome is questioned. Recent evidence suggests that high positive end-expiratory pressure (PEEP) may limit the risk of patient self-inflicted lung injury (P-SILI). The aim of this study was to assess the effects of PEEP on esophageal pressure swings, inspiratory drive, and the neuromuscular efficiency of ventilation. We hypothesized that high PEEP would reduce esophageal pressure swings, regardless of inspiratory drive changes, by modulating the effort-to-drive ratio (EDR)...
February 5, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38302808/validation-of-a-low-cost-continuous-renal-replacement-therapy-dialysate-fluid-controller-for-experimental-purposes
#23
JOURNAL ARTICLE
Yuri de Albuquerque Pessoa Dos Santos, Viviane Flor Park, Luis Carlos Maia Cardozo Junior, Bruno Adler Maccagnan Pinheiro Besen, Pedro Vitale Mendes, Marcelo Park
BACKGROUND: Continuous renal replacement therapy (CRRT) support is crucial for critically ill patients and it is underexplored in specific situations. Experimental CRRT offers a means to gain insights into these scenarios, but the prohibitive cost of CRRT machines limits their accessibility. This study aimed to develop and validate a low-cost and precise dialysate controller for experimental CRRT. RESULTS: Our results demonstrate a commendable level of precision in affluent flow control, with a robust correlation (R2  = 0...
February 2, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38291192/understanding-the-pathophysiology-of-acute-critical-illness-translational-lessons-from-zebrafish-models
#24
REVIEW
Kensuke Fujii, Kazuma Yamakawa, Yuriko Takeda, Natsuko Okuda, Akira Takasu, Fumihito Ono
The models used to investigate the pathophysiological mechanisms of acute critical illness are not limited to mammalian species. The zebrafish (Danio rerio) is a popular model organism for studying diseases due to its transparency and rapid development. The genes and signaling pathways involved in acute critical illness appear highly conserved among zebrafish and humans. Forward genetics such as random mutagenesis by a chemical mutagen or reverse genetics methods represented by CRISPR/Cas9 allowed researchers to reveal multiple novel aspects of pathological processes in areas including infection, immunity, and regeneration...
January 31, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38282162/recombinant-antithrombin-attenuates-acute-kidney-injury-associated-with-rhabdomyolysis-an-in-vivo-animal-study
#25
JOURNAL ARTICLE
Tomotaka Miura, Tomoki Okuda, Kodai Suzuki, Hideshi Okada, Hiroyuki Tomita, Chihiro Takada, Kosuke Mori, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Yohei Fukuda, Hirotsugu Fukuda, Ayane Nishio, Yuki Kawasaki, Ayumi Kuroda, Keiko Suzuki, Ryo Kamidani, Haruka Okamoto, Tetsuya Fukuta, Yuichiro Kitagawa, Takahito Miyake, Keita Nakane, Akio Suzuki, Takahiro Yoshida, Nobuyuki Tetsuka, Shozo Yoshida, Takuya Koie, Shinji Ogura
BACKGROUND: Rhabdomyolysis is characterized by the destruction and necrosis of skeletal muscle tissue, resulting in acute kidney injury (AKI). Recombinant antithrombin (rAT) has DNA repair and vascular endothelial-protection properties. Herein, we investigated whether rAT therapy has beneficial effects against rhabdomyolysis-induced AKI. Ten-week-old male B6 mice were injected with 5 mL/kg of 50% glycerol intramuscularly in the left thigh after 24 h of fasting to create a rhabdomyolysis mouse model...
January 29, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38273120/estimation-of-normal-lung-weight-index-in-healthy-female-domestic-pigs
#26
JOURNAL ARTICLE
Antonio Fioccola, Rosmery Valentina Nicolardi, Tommaso Pozzi, Isabella Fratti, Federica Romitti, Francesca Collino, Verena Reupke, Gianluigi Li Bassi, Alessandro Protti, Alessandro Santini, Massimo Cressoni, Mattia Busana, Onnen Moerer, Luigi Camporota, Luciano Gattinoni
INTRODUCTION: Lung weight is an important study endpoint to assess lung edema in porcine experiments on acute respiratory distress syndrome and ventilatory induced lung injury. Evidence on the relationship between lung-body weight relationship is lacking in the literature. The aim of this work is to provide a reference equation between normal lung and body weight in female domestic piglets. MATERIALS AND METHODS: 177 healthy female domestic piglets from previous studies were included in the analysis...
January 26, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38270695/validation-of-an-alternative-technique-for-rq-estimation-in-anesthetized-pigs
#27
JOURNAL ARTICLE
Jacob Karlsson, Anders Svedmyr, Mats Wallin, Magnus Hallbäck, Per-Arne Lönnqvist
BACKGROUND: Respiratory quotient (RQ) is an important variable when assessing metabolic status in intensive care patients. However, analysis of RQ requires cumbersome technical equipment. The aim of the current study was to examine a simplified blood gas-based method of RQ assessment, using Douglas bag measurement of RQ (Douglas-RQ) as reference in a laboratory porcine model under metabolic steady state. In addition, we aimed at establishing reference values for RQ in the same population, thereby generating data to facilitate further research...
January 25, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38238627/current-clinical-practice-in-using-adjunctive-extracorporeal-blood-purification-in-sepsis-and-septic-shock-results-from-the-esicm-exploration-survey
#28
JOURNAL ARTICLE
Klaus Stahl, Christian Bode, Benjamin Seeliger, Pedro David Wendel-Garcia, Sascha David
BACKGROUND: Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis and believes in both efficacy and level of evidence are very heterogeneous. METHODS: The "EXPLORATION" (Current Clinical Practice in using adjunctive extracorporeal blood purification in septic shock), a web-based survey endorsed by the European Society of Intensive Care Medicine (ESICM), questioned both the current local clinical practices as well as future perspectives of EBP in sepsis and septic shock...
January 19, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38224398/estimating-the-change-in-pleural-pressure-using-the-change-in-central-venous-pressure-in-various-clinical-scenarios-a-pig-model-study
#29
JOURNAL ARTICLE
Miyako Kyogoku, Soichi Mizuguchi, Taku Miyasho, Yusuke Endo, Yu Inata, Kazuya Tachibana, Yuji Fujino, Kazuto Yamashita, Muneyuki Takeuchi
BACKGROUND: We have previously reported a simple correction method for estimating pleural pressure (Ppl) using central venous pressure (CVP). However, it remains unclear whether this method is applicable to patients with varying levels of intravascular volumes and/or chest wall compliance. This study aimed to investigate the accuracy of our method under different conditions of intravascular volume and chest wall compliance. RESULTS: Ten anesthetized and paralyzed pigs (43...
January 15, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38206543/immunophenotyping-patients-with-sepsis-and-underlying-haematological-malignancy-reveals-defects-in-monocyte-and-lymphocyte-function
#30
LETTER
Timothy Arthur Chandos Snow, Aimee Serisier, David Brealey, Mervyn Singer, Nishkantha Arulkumaran
No abstract text is available yet for this article.
January 11, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38194181/doxycycline-reduces-liver-and-kidney-injuries-in-a-rat-hemorrhagic-shock-model
#31
JOURNAL ARTICLE
Regina Sordi, Luana Bojko, Filipe R M B Oliveira, Thiele Osvaldt Rosales, Camila Fernandes Souza, Lucas Wenceslau Moreno, Gustavo Ferreira Alves, José Carlos Rebuglio Vellosa, Daniel Fernandes, Jose Rosa Gomes
BACKGROUND: Hemorrhagic shock (HS), which causes insufficient tissue perfusion, can result in multiple organ failure (MOF) and death. This study aimed to evaluate whether doxycycline (DOX) protects cardiovascular, kidney, and liver tissue from damage in a rat model of HS. Immediately before the resuscitation, DOX (10 mg/kg; i.v.) was administered, and its protective effects were assessed 24 h later. Mean arterial pressure, renal blood flow, heart rate, vasoactive drug response, and blood markers such as urea, creatinine, AST, ALT, CPK, CPR, and NOx levels were determined...
January 9, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38182945/mastering-the-brain-in-critical-conditions-an-update
#32
JOURNAL ARTICLE
Chiara Robba, Elisa R Zanier, Carmen Lopez Soto, Soojin Park, Romain Sonneville, Raimund Helbolk, Aarti Sarwal, Virginia F J Newcombe, Mathieu van der Jagt, Jan Gunst, Tobias Gauss, Samy Figueiredo, Jacques Duranteau, Markus B Skrifvars, Carolina Iaquaniello, Susanne Muehlschlegel, Victoria Metaxa, Claudio Sandroni, Giuseppe Citerio, Geert Meyfroidt
Acute brain injuries, such as traumatic brain injury and ischemic and hemorragic stroke, are a leading cause of death and disability worldwide. While characterized by clearly distict primary events-vascular damage in strokes and biomechanical damage in traumatic brain injuries-they share common secondary injury mechanisms influencing long-term outcomes. Growing evidence suggests that a more personalized approach to optimize energy substrate delivery to the injured brain and prognosticate towards families could be beneficial...
January 5, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38127207/metabolic-disturbances-potentially-attributable-to-clogging-during-continuous-renal-replacement-therapy
#33
JOURNAL ARTICLE
Mattia M Müller, Larina Caspar, Onur Sazpinar, Daniel A Hofmaenner, Rolf Erlebach, Rea Andermatt, Christoph C Ganter, Reto A Schuepbach, Pedro D Wendel-Garcia, Sascha David
BACKGROUND: Clogging is characterized by a progressive impairment of transmembrane patency in renal replacement devices and occurs due to obstruction of pores by unknown molecules. If citrate-based anti-coagulation is used, clogging can manifest as a metabolic alkalosis accompanied by hypernatremia and hypercalcemia, primarily a consequence of Na3 Citrate infusion. An increased incidence of clogging has been observed during the COVID-19 pandemic. However, precise factors contributing to the formation remain uncertain...
December 21, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38117435/capillary-leak-and-endothelial-permeability-in-critically-ill-patients-a-current-overview
#34
REVIEW
Babak Saravi, Ulrich Goebel, Lars O Hassenzahl, Christian Jung, Sascha David, Aarne Feldheiser, Matthias Stopfkuchen-Evans, Jakob Wollborn
Capillary leak syndrome (CLS) represents a phenotype of increased fluid extravasation, resulting in intravascular hypovolemia, extravascular edema formation and ultimately hypoperfusion. While endothelial permeability is an evolutionary preserved physiological process needed to sustain life, excessive fluid leak-often caused by systemic inflammation-can have detrimental effects on patients' outcomes. This article delves into the current understanding of CLS pathophysiology, diagnosis and potential treatments...
December 20, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38117345/the-effect-of-inspiratory-rise-time-on-mechanical-power-calculations-in-pressure-control-ventilation-dynamic-approach
#35
JOURNAL ARTICLE
Özlem Acicbe, Canan Yazıcı Özgür, Payam Rahimi, Emral Canan, Sinan Aşar, Zafer Çukurova
BACKGROUND: Mechanical power may serve as a valuable parameter for predicting ventilation-induced injury in mechanically ventilated patients. Over time, several equations have been developed to calculate power in both volume control ventilation (VCV) and pressure control ventilation (PCV). Among these equations, the linear model mechanical power equation (MPLM ) closely approximates the reference method when applied in PCV. The dynamic mechanical power equation (MPdyn ) computes power by utilizing the ventilatory work of breathing parameter (WOBv ), which is automatically measured by the mechanical ventilator...
December 20, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38117344/a-model-of-hemodialysis-after-acute-kidney-injury-in-rats
#36
JOURNAL ARTICLE
J Mallet, P-A Billiet, M Scarton, N Benichou, M Bobot, K Chaibi, A Hertig, J Hadchouel, D Dreyfuss, S Gaudry, S Placier
BACKGROUND: Acute kidney injury (AKI) is frequent among critically ill patients. Renal replacement therapy (RRT) is often required to deal with severe complications of AKI. This technique is however associated with side effects such as hemodynamic instability and delayed renal recovery. In this study, we aimed to describe a novel model of hemodialysis in rats with AKI and depict a dialysis membrane performance. METHODS: Eighteen Sprague-Dawley rats received 0.75% adenine-rich diet to induce AKI...
December 20, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38110829/publisher-correction-esicm-lives-2023
#37
(no author information available yet)
No abstract text is available yet for this article.
December 18, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38109016/phrenic-nerve-stimulation-to-prevent-diaphragmatic-dysfunction-and-ventilator-induced-lung-injury
#38
REVIEW
Alessandro Panelli, Michael A Verfuß, Martin Dres, Laurent Brochard, Stefan J Schaller
Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur frequently in critically ill patients. Phrenic nerve stimulation (PNS) has been a valuable tool for diagnosing VIDD by assessing respiratory muscle strength in response to magnetic PNS. The detection of pathophysiologically reduced respiratory muscle strength is correlated with weaning failure, longer mechanical ventilation time, and mortality. Non-invasive electromagnetic PNS designed for diagnostic use is a reference technique that allows clinicians to measure transdiaphragm pressure as a surrogate parameter for diaphragm strength and functionality...
December 18, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38102452/pressure-support-compared-with-pressure-controlled-ventilation-mitigates-lung-and-brain-injury-in-experimental-acute-ischemic-stroke-in-rats
#39
JOURNAL ARTICLE
Adriana L da Silva, Camila M Bessa, Nazareth N Rocha, Eduardo B Carvalho, Raquel F Magalhaes, Vera L Capelozzi, Chiara Robba, Paolo Pelosi, Cynthia S Samary, Patricia R M Rocco, Pedro L Silva
BACKGROUND: We aimed to evaluate the pulmonary and cerebral effects of low-tidal volume ventilation in pressure-support (PSV) and pressure-controlled (PCV) modes at two PEEP levels in acute ischemic stroke (AIS). METHODS: In this randomized experimental study, AIS was induced by thermocoagulation in 30 healthy male Wistar rats. After 24 h, AIS animals were randomly assigned to PSV or PCV with VT  = 6 mL/kg and PEEP = 2 cmH2 O (PSV-PEEP2 and PCV-PEEP2) or PEEP = 5 cmH2 O (PSV-PEEP5 and PCV-PEEP5) for 2 h...
December 15, 2023: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38095819/time-spent-above-optimal-cerebral-perfusion-pressure-is-not-associated-with-failure-to-improve-in-outcome-in-traumatic-brain-injury
#40
JOURNAL ARTICLE
Kevin Y Stein, Logan Froese, Alwyn Gomez, Amanjyot Singh Sainbhi, Nuray Vakitbilir, Younis Ibrahim, Abrar Islam, Izabella Marquez, Fiorella Amenta, Tobias Bergmann, Frederick A Zeiler
BACKGROUND: Optimal cerebral perfusion pressure (CPPopt) has emerged as a promising personalized medicine approach to the management of moderate-to-severe traumatic brain injury (TBI). Though literature demonstrating its association with poor outcomes exists, there is yet to be work done on its association with outcome transition due to a lack of serial outcome data analysis. In this study we investigate the association between various metrics of CPPopt and failure to improve in outcome over time...
December 14, 2023: Intensive Care Medicine Experimental
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