Journals Intensive Care Medicine Experi...

Intensive Care Medicine Experimental
Johannes Zipperle, Johannes Oesterreicher, Matthias Hackl, Teresa Lara Krammer, Helena Thumfart, Madhusudhan Reddy Bobbili, Marion Wiegele, Johannes Grillari, Marcin F Osuchowski, Herbert Schöchl, Wolfgang Holnthoner, Christoph J Schlimp, Judith Schiefer, Marco Valerio Pesce, Stefan Ulbing, Johannes Gratz
Extracellular vesicles (EVs) represent nanometer-sized, subcellular spheres, that are released from almost any cell type and carry a wide variety of biologically relevant cargo. In severe cases of coronavirus disease 2019 (COVID-19) and other states of systemic pro-inflammatory activation, EVs, and their cargo can serve as conveyors and indicators for disease severity and progression. This information may help distinguish individuals with a less severe manifestation of the disease from patients who exhibit severe acute respiratory distress syndrome (ARDS) and require intensive care measures...
November 30, 2023: Intensive Care Medicine Experimental
Raghavan Murugan, Kianoush Kashani, Paul M Palevsky
No abstract text is available yet for this article.
November 28, 2023: Intensive Care Medicine Experimental
Caroline Lauwers, Lauren De Bruyn, Lies Langouche
Critical illness is characterized by a hypercatabolic response encompassing endocrine and metabolic alterations. Not only the uptake, synthesis and metabolism of glucose and amino acids is majorly affected, but also the homeostasis of lipids and cholesterol is altered during acute and prolonged critical illness. Patients who suffer from critically ill conditions such as sepsis, major trauma, surgery or burn wounds display an immediate and sustained reduction in low plasma LDL-, HDL- and total cholesterol concentrations, together with a, less pronounced, increase in plasma free fatty acids...
November 28, 2023: Intensive Care Medicine Experimental
Pedro Leme Silva, Martin Scharffenberg, Patricia Rieken Macedo Rocco
Mechanical ventilation is a life-saving therapy in several clinical situations, promoting gas exchange and providing rest to the respiratory muscles. However, mechanical ventilation may cause hemodynamic instability and pulmonary structural damage, which is known as ventilator-induced lung injury (VILI). The four main injury mechanisms associated with VILI are as follows: barotrauma/volutrauma caused by overstretching the lung tissues; atelectrauma, caused by repeated opening and closing of the alveoli resulting in shear stress; and biotrauma, the resulting biological response to tissue damage, which leads to lung and multi-organ failure...
November 27, 2023: Intensive Care Medicine Experimental
Katja Mohnke, Philipp Conzelmann, Miriam Renz, Julian Riedel, René Rissel, Andrea Urmann, Johanna Hain, Bastian Duenges, Alexander Ziebart, Robert Ruemmler
OBJECTIVE: This study aimed to determine whether ultra-low tidal volume ventilation (ULTVV) applied during cardiopulmonary resuscitation (CPR) compared with standard ventilation (intermittent positive pressure ventilation, IPPV) can reduce pulmonary end-organ damage in the post-resuscitation period. METHODS: A prospective, randomized trial was conducted using a porcine model (n = 45). The animals were divided into three groups: IPPV, ULTVV, and a sham control group...
November 25, 2023: Intensive Care Medicine Experimental
Matthias Jörg, Malin Öster, Jens Wretborn, Daniel B Wilhelms
BACKGROUND: Venous blood gas sampling has replaced arterial sampling in many critically ill patients, though interpretation of venous pCO2 still remains a challenge. Lemoël et al., Farkas and Zeserson et al. have proposed models to estimate arterial pCO2 based on venous pCO2 . Our objective was to externally validate these models with a new dataset. This was a prospective cross-sectional study of consecutive adult patients with a clinical indication for blood gas analysis in an academic emergency department in Sweden...
November 21, 2023: Intensive Care Medicine Experimental
Tianfeng Hua, Yuqian Chu, Minjie Wang, Yijun Zhang, Wei Shi, Qihui Huang, Liangliang Zhang, Min Yang
BACKGROUND: Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some patients may eventually progress to multiple organ failure. There is evidence that heart failure is the terminal stage in the development of various cardiovascular diseases. Although the cardio-protective effect of canagliflozin (CANA) has been confirmed in large clinical studies and recommended in domestic and international heart failure-related guidelines, the effectiveness of CANA after resuscitation remains unclear...
November 15, 2023: Intensive Care Medicine Experimental
Jantine Wisse, Annemijn H Jonkman
No abstract text is available yet for this article.
November 15, 2023: Intensive Care Medicine Experimental
Tommaso Tonetti, Alberto Zanella, David Pérez-Torres, Giacomo Grasselli, V Marco Ranieri
Extracorporeal life support (ECLS) for acute respiratory failure encompasses veno-venous extracorporeal membrane oxygenation (V-V ECMO) and extracorporeal carbon dioxide removal (ECCO2 R). V-V ECMO is primarily used to treat severe acute respiratory distress syndrome (ARDS), characterized by life-threatening hypoxemia or ventilatory insufficiency with conventional protective settings. It employs an artificial lung with high blood flows, and allows improvement in gas exchange, correction of hypoxemia, and reduction of the workload on the native lung...
November 14, 2023: Intensive Care Medicine Experimental
Sole Lindvåg Lie, Jonny Hisdal, Marius Rehn, Lars Øivind Høiseth
BACKGROUND: Trauma patients frequently receive supplemental oxygen, but its hemodynamic effects in blood loss are poorly understood. We studied the effects of oxygen on the hemodynamic response and tolerance to simulated blood loss in healthy volunteers. METHODS: Fifteen healthy volunteers were exposed to simulated blood loss by lower body negative pressure (LBNP) on two separate visits at least 24 h apart. They were randomized to inhale 100% oxygen or medical air on visit 1, while inhaling the other on visit 2...
November 10, 2023: Intensive Care Medicine Experimental
Johan Mälberg, Silvia Marchesi, Douglas Spangler, Nermin Hadziosmanovic, David Smekal, Sten Rubertsson
BACKGROUND: Ventilation during cardiopulmonary resuscitation (CPR) has long been a part of the standard treatment during cardiac arrests. Ventilation is usually given either during continuous chest compressions (CCC) or during a short pause after every 30 chest compressions (30:2). There is limited knowledge of how ventilation is delivered if it effects the hemodynamics and if it plays a role in the occurrence of lung injuries. The aim of this study was to compare ventilation parameters, hemodynamics, blood gases and lung injuries during experimental CPR given with CCC and 30:2 in a porcine model...
November 8, 2023: Intensive Care Medicine Experimental
Tobias Wengenmayer, Eike Tigges, Dawid L Staudacher
No abstract text is available yet for this article.
October 30, 2023: Intensive Care Medicine Experimental
Matthijs L Janssen, Annemijn H Jonkman, Myrte Wennen, Evert-Jan Wils, Henrik Endeman, Leo Heunks
There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with adverse clinical outcome. However, quantification of tidal volume in non-intubated patients is challenging. In this proof-of-concept study, we evaluated whether ultrasound measurements of diaphragm excursion could be a valid surrogate for tidal volume in patients with respiratory failure. Diaphragm excursions and tidal volumes were simultaneously measured in invasively ventilated patients (N = 21) and healthy volunteers (N = 20)...
October 27, 2023: Intensive Care Medicine Experimental
(no author information available yet)
No abstract text is available yet for this article.
October 24, 2023: Intensive Care Medicine Experimental
Salil R Rajayer, Stephen M Smith
BACKGROUND: Neurological manifestations of severe coronavirus infections, including SARS-CoV-2, are wide-ranging and may persist following virus clearance. Detailed understanding of the underlying changes in brain function may facilitate the identification of therapeutic targets. We directly tested how neocortical function is impacted by the specific panel of cytokines that occur in coronavirus brain infection. Using the whole-cell patch-clamp technique, we determined how the five cytokines (TNFα, IL-1β, IL-6, IL-12p40 and IL-15 for 22-28-h) at concentrations matched to those elicited by MHV-A59 coronavirus brain infection, affected neuronal function in cultured primary mouse neocortical neurons...
October 14, 2023: Intensive Care Medicine Experimental
Anthony S Bonavia, Abigail Samuelsen, Menglu Liang, Jodi Hanson, Daniel McKeone, Zissis C Chroneos, E Scott Halstead
BACKGROUND: Sepsis is characterized by highly heterogeneous immune responses associated with a spectrum of disease severity. Methods that rapidly and sensitively profile these immune responses can potentially personalize immune-adjuvant therapies for sepsis. We hypothesized that the ELLA microfluidic approach to measure cytokine production from the whole blood of septic and critically ill patients would deliver faster, more precise results than the existing optic-driven ELISpot quantification...
October 13, 2023: Intensive Care Medicine Experimental
Nazlıhan Boyacı Dündar, David Sarphie, Kenan Yüce, Ümmügülsüm Gaygısız, O Tolga Kaskatı, Melda Türkoğlu, Gülbin Aygencel Bıkmaz, Lale Karabıyık, Kayhan Çağlar, Gülendam Bozdayı, Rubina Mian, Paul Moss, Mustafa Necmi İlhan
PURPOSE: A prompt and effective immune response is required for clearance of pathogens but exaggerated states of inflammation can cause extensive collateral damage to the host. We have previously used a rapid near-patient assay that measures the functional capacity of neutrophils to produce reactive oxygen species (ROS) to show that values are elevated in patients with severe COVID-19 or sepsis. Here, we assess the utility of longitudinal ROS measurements to monitor and predict mortality outcome for patients with COVID-19 infection being treated in an ICU setting...
October 6, 2023: Intensive Care Medicine Experimental
Klaus Stahl, Sascha David
No abstract text is available yet for this article.
September 30, 2023: Intensive Care Medicine Experimental
Emmanuel Novy, Mathieu Esposito, Julien Birckener, Adeline Germain, Marie-Reine Losser, Marie-Claire Machouart, Philippe Guerci
BACKGROUND: The understanding of high mortality associated with intra-abdominal candidiasis (IAC) remains limited. While Candida is considered a harmless colonizer in the digestive tract, its role as a true pathogen in IAC is still debated. Evidence regarding Candida virulence in the human peritoneal fluid are lacking. We hypothesized that during IAC, Candida albicans develops virulence factors to survive to new environmental conditions. The objective of this observational exploratory monocentric study is to investigate the influence of peritoneal fluid (PF) on the expression of C...
September 30, 2023: Intensive Care Medicine Experimental
Theodor Sievert, Ingrid Didriksson, Martin Spångfors, Gisela Lilja, Kaj Blennow, Henrik Zetterberg, Attila Frigyesi, Hans Friberg
BACKGROUND: Neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and total-tau protein (tau) are novel blood biomarkers of neurological injury, and may be used to predict outcomes in critical COVID-19. METHODS: A prospective multicentre cohort study of 117 consecutive and critically ill COVID-19 patients in six intensive care units (ICUs) in southern Sweden between May and November 2020. Serial NfL, GFAP and tau were analysed in relation to mortality, the Glasgow Outcome Scale Extended (GOSE) and the physical (PCS) and mental (MCS) components of health-related quality of life at one year...
September 28, 2023: Intensive Care Medicine Experimental
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