Tao-Hu Zhou, Xiu-Xiu Zhou, Jiong Ni, Yan-Qing Ma, Fang-Yi Xu, Bing Fan, Yu Guan, Xin-Ang Jiang, Xiao-Qing Lin, Jie Li, Yi Xia, Xiang Wang, Yun Wang, Wen-Jun Huang, Wen-Ting Tu, Peng Dong, Zhao-Bin Li, Shi-Yuan Liu, Li Fan
BACKGROUND: Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance of CT-based whole lung radiomic in discriminating COPD patients and non-COPD patients. METHODS: This retrospective study was performed on 2785 patients who underwent pulmonary function examination in 5 hospitals and were divided into non-COPD group and COPD group...
February 20, 2024: Military Medical Research
Ying-Ying Li, Shuai-Fei Ji, Xiao-Bing Fu, Yu-Feng Jiang, Xiao-Yan Sun
Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration, promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic transitions. The field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical properties...
February 18, 2024: Military Medical Research
Marcin M Kamiński
No abstract text is available yet for this article.
February 12, 2024: Military Medical Research
Qiang Cai, Quazi T H Shubhra
No abstract text is available yet for this article.
February 8, 2024: Military Medical Research
Shu-Yan Han, Zi-Xuan Zhao, Jun Wu
No abstract text is available yet for this article.
February 3, 2024: Military Medical Research
Mabel L Cummins, Grace Delmonte, Skylar Wechsler, Joseph J Schlesinger
No abstract text is available yet for this article.
February 1, 2024: Military Medical Research
Consolato M Sergi
No abstract text is available yet for this article.
January 25, 2024: Military Medical Research
Guang-Yu Liu, Dan Yu, Mei-Mei Fan, Xu Zhang, Ze-Yu Jin, Christoph Tang, Xiao-Fen Liu
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be developed. The discovery and introduction of novel antibiotics are time-consuming and expensive. According to WHO's report of antibacterial agents in clinical development, only 18 novel antibiotics have been approved since 2014. Therefore, novel antibiotics are critically needed. Artificial intelligence (AI) has been rapidly applied to drug development since its recent technical breakthrough and has dramatically improved the efficiency of the discovery of novel antibiotics...
January 23, 2024: Military Medical Research
Jia Zeng, Qi Li, Xiang Lu, Dan-Dan Liu, Rong-Guan Jiao, Yan-Qing Jiang, Yan-Bing Liu, Wan-Qing Xu, Jun Ma, Guo-Li Gu
No abstract text is available yet for this article.
January 22, 2024: Military Medical Research
Faith Nguyen, Ashok K Shetty
No abstract text is available yet for this article.
January 12, 2024: Military Medical Research
Leila Gobejishvili
No abstract text is available yet for this article.
January 8, 2024: Military Medical Research
Hiren Y Dandia, Mamatha M Pillai, Deepak Sharma, Meghna Suvarna, Neha Dalal, Ayush Madhok, Arvind Ingle, Shubhada V Chiplunkar, Sanjeev Galande, Prakriti Tayalia
BACKGROUND: Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological malignancies. However, its application to solid tumors presents significant challenges due to the limited accessibility and heterogeneity. Localized delivery of tumor-specific T-cells using biomaterials has shown promise, however, procedures required for genetic modification and generation of a sufficient number of tumor-specific T-cells ex vivo remain major obstacles due to cost and time constraints...
January 4, 2024: Military Medical Research
Stanislovas S Jankauskas, Fahimeh Varzideh, Pasquale Mone, Urna Kansakar, Francesco Di Lorenzo, Angela Lombardi, Gaetano Santulli
No abstract text is available yet for this article.
January 3, 2024: Military Medical Research
Esha Sultana, Nandan Shastry, Rishabh Kasarla, Jacob Hardy, Fanny Collado, Kristina Aenlle, Maria Abreu, Emily Sisson, Kimberly Sullivan, Nancy Klimas, Travis J A Craddock
BACKGROUND: One-third of veterans returning from the 1990-1991 Gulf War reported a myriad of symptoms including cognitive dysfunction, skin rashes, musculoskeletal discomfort, and fatigue. This symptom cluster is now referred to as Gulf War Illness (GWI). As the underlying mechanisms of GWI have yet to be fully elucidated, diagnosis and treatment are based on symptomatic presentation. One confounding factor tied to the illness is the high presence of post-traumatic stress disorder (PTSD)...
January 2, 2024: Military Medical Research
Hao-Jun Xiong, Hong-Qiang Yu, Jie Zhang, Lei Fang, Di Wu, Xiao-Tong Lin, Chuan-Ming Xie
BACKGROUND: Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether their activation requires ubiquitination. This study aimed to investigate whether and how F-box and leucine-rich repeat 6 (FBXL6) regulates KRAS and KRASG12D activity in hepatocellular carcinoma (HCC). METHODS: We constructed transgenic mouse strains LC (LSL-Fbxl6KI/+ ;Alb-Cre, n = 13), KC (LSL-KrasG12D/+ ;Alb-Cre, n = 10) and KLC (LSL-KrasG12D/+ ;LSL-Fbxl6KI/+ ;Alb-Cre, n = 12) mice, and then monitored HCC for 320 d...
December 20, 2023: Military Medical Research
Hao Zhang, Qing-Qi Zhou, He Chen, Xiao-Qing Hu, Wei-Guang Li, Yang Bai, Jun-Xia Han, Yao Wang, Zhen-Hu Liang, Dan Chen, Feng-Yu Cong, Jia-Qing Yan, Xiao-Li Li
Electroencephalography (EEG) is a non-invasive measurement method for brain activity. Due to its safety, high resolution, and hypersensitivity to dynamic changes in brain neural signals, EEG has aroused much interest in scientific research and medical fields. This article reviews the types of EEG signals, multiple EEG signal analysis methods, and the application of relevant methods in the neuroscience field and for diagnosing neurological diseases. First, three types of EEG signals, including time-invariant EEG, accurate event-related EEG, and random event-related EEG, are introduced...
December 19, 2023: Military Medical Research
Chang-Hong Du, Yi-Ding Wu, Ke Yang, Wei-Nian Liao, Li Ran, Chao-Nan Liu, Shu-Zhen Zhang, Kuan Yu, Jun Chen, Yong Quan, Mo Chen, Ming-Qiang Shen, Hong Tang, Shi-Lei Chen, Song Wang, Jing-Hong Zhao, Tian-Min Cheng, Jun-Ping Wang
BACKGROUND: The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological, physical and chemical origins, which could be suffered by military personnel and civilians during chemical, biological, radioactive, and nuclear events. Especially, thrombosis is considered a major cause of mortality from radiation injury-induced thrombocytopenia, while the underlying pathogenic mechanism remains elusive...
December 19, 2023: Military Medical Research
Xiao-Mei Tian, Wei Hu, Feng-Yong Liu
No abstract text is available yet for this article.
December 13, 2023: Military Medical Research
Hang Xu, Yi-Fan Li, Xian-Yan-Ling Yi, Xiao-Nan Zheng, Yang Yang, Yan Wang, Da-Zhou Liao, Jia-Peng Zhang, Ping Tan, Xing-Yu Xiong, Xi Jin, Li-Na Gong, Shi Qiu, De-Hong Cao, Hong Li, Qiang Wei, Lu Yang, Jian-Zhong Ai
BACKGROUND: Cell metabolism plays a pivotal role in tumor progression, and targeting cancer metabolism might effectively kill cancer cells. We aimed to investigate the role of hexokinases in prostate cancer (PCa) and identify a crucial target for PCa treatment. METHODS: The Cancer Genome Atlas (TCGA) database, online tools and clinical samples were used to assess the expression and prognostic role of ADP-dependent glucokinase (ADPGK) in PCa. The effect of ADPGK expression on PCa cell malignant phenotypes was validated in vitro and in vivo...
December 12, 2023: Military Medical Research
Meng-Yuan Jiang, Wan-Rong Man, Xue-Bin Zhang, Xiao-Hua Zhang, Yu Duan, Jie Lin, Yan Zhang, Yang Cao, De-Xi Wu, Xiao-Fei Shu, Lei Xin, Hao Wang, Xiao Zhang, Cong-Ye Li, Xiao-Ming Gu, Xuan Zhang, Dong-Dong Sun
BACKGROUND: Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, which impairs myocardial function. Adipsin may play an important protective role in the pathogenesis of DCM. The aim of this study is to investigate the regulatory effect of Adipsin on DCM lipotoxicity and its molecular mechanism. METHODS: A high-fat diet (HFD)-induced type 2 diabetes mellitus model was constructed in mice with adipose tissue-specific overexpression of Adipsin (Adipsin-Tg)...
December 11, 2023: Military Medical Research
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