journal
https://read.qxmd.com/read/38421587/a-case-of-non-lupus-full-house-nephropathy-diagnosed-by-kidney-biopsy-but-observed-iga-nephropathy-on-second-biopsy
#1
JOURNAL ARTICLE
Yoichi Iwafuchi, Tetsuo Morioka, Yuko Oyama, Ichiei Narita
We describe a case of full-house nephropathy without any underlying disease, including systemic lupus erythematosus. A 40-year-old woman was referred to our hospital with mild proteinuria and microscopic hematuria. The patient was diagnosed with immune complex-mediated glomerulonephritis with a predominant mesangioproliferative pattern based on renal histopathological results using full-house immunofluorescence staining. She showed no clinical criteria for the diagnosis of systemic lupus erythematosus, except for kidney disorders, and tested negative for antinuclear antibodies throughout her clinical course...
February 29, 2024: CEN Case Reports
https://read.qxmd.com/read/38416371/renal-dysfunction-caused-by-severe-hypothyroidism-diagnosed-by-renal-biopsy-a-case-report
#2
JOURNAL ARTICLE
Hiroki Tani, Shuma Hirashio, Akihiro Tsuda, Yoshiro Tachiyama, Shigeo Hara, Takao Masaki
There is a close relationship between thyroid dysfunction and renal dysfunction. However, thyroid dysfunction can unfortunately result in inaccurate measurements of serum creatinine and cystatin C levels. The chronic decrease in cardiac output due to hypothyroidism can reduce renal plasma flow (RPF) resulting in renal dysfunction. We report the case of a 36-year-old male in whom renal dysfunction detected during a company health check-up was found to be caused by severe hypothyroidism. His serum creatinine levels showed poor results, but serum cystatin C levels were within the normal range...
February 28, 2024: CEN Case Reports
https://read.qxmd.com/read/38416370/multilocular-cystic-nephroma-in-an-adult-a-diagnostic-quandary
#3
JOURNAL ARTICLE
Ritu Verma, Jyoti Verma, Neelima Gupta
Multilocular cystic nephroma (MLCN) is an unusual, benign slow-growing renal cystic neoplasm which mimics other cystic renal lesions and has such clinical, radiological, and morphological features that causes diagnostic dilemma. MLCN lies in the spectrum of mixed epithelial and stromal tumor (MEST) family of kidney. According to World Health Organization (WHO 2016 classification), MEST encompasses spectrum of tumors ranging from predominantly cystic tumors, adult cystic nephroma (ACN) to tumors that are variably solid (MEST), thus creating diagnostic dilemma...
February 28, 2024: CEN Case Reports
https://read.qxmd.com/read/38411894/a-child-with-tsc2-pkd1-contiguous-gene-deletion-syndrome-successfully-treated-with-tolvaptan-for-rapidly-enlarging-renal-cysts
#4
JOURNAL ARTICLE
Chika Muroga, Hiroki Yokoyama, Ryo Kinoshita, Daisuke Fujimori, Yuko Yamada, Tohru Okanishi, Naoya Morisada, Kandai Nozu, Noriyuki Namba
Tolvaptan, a vasopressin receptor antagonist, has been shown to be effective in the treatment of renal cysts in ADPKD. However, tolvaptan is not indicated for pediatric patients, and reports of its use are rare, making its efficacy and adverse reactions unclear. Herein, we present the case of an 11-year-old girl who had vitiligo from birth. She was diagnosed with West syndrome at 6 months of age and tuberous sclerosis at 2 years of age. At the age of 6 years, an abdominal magnetic resonance imaging (MRI) revealed multiple bilateral renal cysts, and she was diagnosed with ADPKD...
February 27, 2024: CEN Case Reports
https://read.qxmd.com/read/38367183/a-case-of-late-onset-organizing-pneumonia-following-covid-19-infection-in-a-post-kidney-transplant-patient
#5
JOURNAL ARTICLE
Kumiko Fujieda, Shoji Saito, Akihito Tanaka, Kazuhiro Furuhashi, Yosinari Yasuda, Yuta Sano, Masashi Kato, Shoichi Maruyama
A 50-year-old man who had undergone a living-donor kidney transplant 12 years prior for chronic renal failure due to autosomal dominant polycystic kidney disease contracted coronavirus disease 19 (COVID-19). He had a positive antigen test, mild symptoms, sore throat, and fever of 37.9 ℃. The patient was treated with molnupiravir for 5 days, and the symptoms disappeared 5 days after onset. However, 10 days after onset, he developed a fever of approximately 37 ℃ and a non-productive cough; 27 days after onset, the patient was hospitalized for anorexia and a worsening respiratory condition...
February 17, 2024: CEN Case Reports
https://read.qxmd.com/read/38337109/hemodialysis-treatment-of-vancomycin-induced-drug-reaction-with-eosinophilia-and-systemic-symptoms-drug-induced-hypersensitivity-syndrome-in-a-patient-undergoing-peritoneal-dialysis
#6
JOURNAL ARTICLE
Ryunosuke Mitsuno, Takashin Nakayama, Kiyotaka Uchiyama, Norifumi Yoshimoto, Ei Kusahana, Kohkichi Morimoto, Jun Yoshino, Tadashi Yoshida, Takeshi Kanda, Shintaro Yamaguchi, Kaori Hayashi
Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe drug-induced hypersensitivity reaction with 10% mortality. To date, there is insufficient evidence regarding the association between DRESS/DIHS and serum levels of vancomycin (VCM). Here, we report the case of a 46-year-old woman undergoing peritoneal dialysis who developed VCM-induced DRESS/DIHS. She was hospitalized for peritonitis with abdominal pain and treated with VCM...
February 10, 2024: CEN Case Reports
https://read.qxmd.com/read/38308744/a-novel-homozygous-slc12a3-mutation-causing-gitelman-syndrome-with-co-existent-autoimmune-thyroiditis-a-case-report-and-review-of-the-literature
#7
JOURNAL ARTICLE
Oguzhan Koca, Mustafa Tarık Alay, Ahmet Murt, Aysel Kalayci Yigin, Mehmet Seven, Isil Bavunoglu
Gitelman syndrome is a rare, autosomal recessively inherited tubulopathy manifesting with hypokalemia, hypomagnesemia, hypocalciuria, and metabolic alkalosis. Common symptoms include fatigue, myalgia, reduced performance capacity, tetany, paresthesia, and delayed growth. However, as reported in the literature, diagnosis in some patients is prompted by an incidental finding of hypokalemia. GS develops due to mutations in the SLC12A3 gene, which encodes the thiazide-sensitive Na-Cl cotransporter. Many variants in the SLC12A3 gene causing GS have been reported in literature...
February 3, 2024: CEN Case Reports
https://read.qxmd.com/read/38306007/a-case-of-pseudo-bartter-gitelman-syndrome-caused-by-long-term-laxative-abuse-leading-to-end-stage-kidney-disease
#8
JOURNAL ARTICLE
Atsushi Kondo, Kunihiko Yoshiya, Nana Sakakibara, China Nagano, Tomoko Horinouchi, Kandai Nozu
Pseudo-Bartter/Gitelman syndrome (PBS/PGS) is a disorder that presents with hypokalemia and metabolic alkalosis resembling Gitelman syndrome (GS) due to secondary factors, such as lifestyle and /or medicines. Notably, PBS/PGS is more likely to cause renal dysfunction than GS. We report the first case of PBS/PGS due to long-term laxative abuse leading to end-stage kidney disease (ESKD). The patient was a 49-year-old woman with a history of constipation since school, who had used excessive doses of laxatives on her own judgment for nine years at least from 22 years of age...
February 2, 2024: CEN Case Reports
https://read.qxmd.com/read/38280123/lupus-like-membranous-nephropathy-during-the-postpartum-period-expressing-glomerular-antigens-exostosin-1-exostosin-2-and-phospholipase-a2-receptor-a-case-report
#9
JOURNAL ARTICLE
Ryoma Miyasaka, Yukihiro Wada, Kazuhiro Takeuchi, Tetsuya Abe, Ryota Uchitsubo, Sayumi Kawamura, Shun Sakurabayashi, Shokichi Naito, Togo Aoyama, Akira Shimizu, Yasuo Takeuchi
Recently, several target antigens of membranous nephropathy (MN), such as phospholipase A2 receptor (PLA2R) and exostosin 1/exostosin 2 (EXT1/2), have been discovered. A 30-year-old woman was referred to our hospital with nephrotic range proteinuria and microscopic hematuria. She was first noted to have proteinuria before pregnancy, and her proteinuria worsened in the postpartum period. A renal biopsy showed MN. Immunofluorescence microscopy showed IgG, IgA, IgM, C3, C4, and C1q depositions in the mesangial area and glomerular capillary walls (GCWs)...
January 27, 2024: CEN Case Reports
https://read.qxmd.com/read/38277067/hypereosinophilia-associated-acute-intradialytic-hypotension-a-report-of-three-cases-and-literature-review
#10
JOURNAL ARTICLE
Awaisshafiq Fukumi, Mari Tanaka, Akane Sugae, Yuki Ishida, Hiroko Yamamoto, Tomoka Watanabe, Chiho Fukushima, Miho Miyauchi, Mariko Teragaki, Kotaro Maeda, Yohtaro Takami, Sachio Iwanari, Masaki Ikeda, Hiroya Takeoka
Occasionally, patients undergoing dialysis develop acute severe hypotension that requires interruption of dialysis within minutes of initiating every dialysis session. Although the underlying causes of recurrent intradialytic hypotension are evaluated extensively, including dialysis-associated allergic reactions or other possible causes, the definitive cause is sometimes missed. Dialysis is a life-sustaining procedure; therefore, prompt identification and management of the underlying cause of dialysis intolerance are crucial...
January 26, 2024: CEN Case Reports
https://read.qxmd.com/read/38189897/an-unusual-cause-of-renal-vein-thrombosis-in-a-newborn-covid-19
#11
JOURNAL ARTICLE
Nihan Öztürk, Zühre Kaya, Öznur Boyunağa, Oğuz Söylemezoğlu
There is no information on renal vein thrombosis induced by COVID-19 infection in a neonate. Few cases of renal vein thrombosis caused by COVID-19 infection have been reported in predominantly adult patients. On day 25 after birth, a newborn whose mother was infected with COVID-19 had renal vein thrombosis. We believed that our patient's renal vein thrombosis was caused by postnatal transmission of the COVID-19 infection that the mother had acquired during birth. The clinical and radiologic findings of these unusual renal complications in a neonate, as well as treatment options, are presented...
January 8, 2024: CEN Case Reports
https://read.qxmd.com/read/38151624/correction-to-functional-changes-in-the-heart-after-sacubitril-valsartan-use-in-5-hemodialysis-patients-with-hypertension-case-report
#12
Noriko Kuwae
No abstract text is available yet for this article.
December 28, 2023: CEN Case Reports
https://read.qxmd.com/read/38145434/concurrent-glomerular-pcdh7-deposits-in-pla2r-associated-membranous-nephropathy
#13
JOURNAL ARTICLE
NaNa Fu, Shuang Yuan, Guang Yang, Hang Li, Tao Wang
The understanding of membranous nephropathy (MN) has undergone impressive advancements in the last 5 years, particularly due to identification of novel antigenic targets. M-type phospholipase A2 receptor (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A) account for approximately 70% and 1-5% of the target antigens in primary MN, respectively. Recently, more novel/putative antigens have been identified in the remaining cases of MN that include exostosin 1/exostosin 2 (EXT1/EXT2), neural epidermal growth factor-like 1 protein (NELL-1), semaphorin 3B (SEMA3B) and protocadherin 7 (PCDH7)...
December 25, 2023: CEN Case Reports
https://read.qxmd.com/read/38135868/effects-of-switching-from-agalsidase-%C3%AE-to-agalsidase-%C3%AE-on-biomarkers-renal-and-cardiac-parameters-and-disease-severity-in-fabry-disease-forming-neutralizing-antidrug-antibodies-a-case-report
#14
JOURNAL ARTICLE
Hisato Shima, Takahiro Tsukimura, Tomoko Shiga, Tadayasu Togawa, Hitoshi Sakuraba, Toshio Doi, Yuka Ikeda, Takuya Okamoto, Yukari Yoshikawa, Takehiko Kimura, Takashi Iwase, Tomoko Inoue, Manabu Tashiro, Kazuyoshi Okada, Jun Minakuchi
Fabry disease is an X-linked hereditary disorder caused by deficient α-galactosidase A (GLA) activity. Patients with Fabry disease are often treated with enzyme replacement therapy (ERT). However, ERT often induces the formation of neutralizing antidrug antibodies (ADAs), which may impair the therapeutic efficacy. Here, we report the case of a 32-year-old man with Fabry disease and resultant neutralizing ADAs who was treated by switching from agalsidase-α to agalsidase-β. We monitored biomarkers, such as plasma globotriaosylsphingosine (lyso-Gb3), urinary globotriaosylceramide (Gb3), urinary mulberry bodies, renal and cardiac parameters, and disease severity during the treatment period...
December 22, 2023: CEN Case Reports
https://read.qxmd.com/read/38117458/dapagliflozin-administration-for-1%C3%A2-year-promoted-kidney-enlargement-in-patient-with-adpkd
#15
JOURNAL ARTICLE
Shinya Nakatani, Fumiyuki Morioka, Hideki Uedono, Akihiro Tsuda, Katsuhito Mori, Masanori Emoto
To date, there is insufficient evidence regarding use of sodium-glucose cotransporter-2 (SGLT2) inhibitors for patients with autosomal-dominant polycystic kidney disease (ADPKD), as such cases have been excluded from previous clinical trials exploring the kidney protection effects of such medications. Here, findings of an ADPKD patient who received dapagliflozin, a selective SGLT2 inhibitor, for 1 year are presented. A 38-year-old woman with a family history of ADPKD wished for treatment with dapagliflozin...
December 20, 2023: CEN Case Reports
https://read.qxmd.com/read/38093149/early-transition-to-avacopan-from-glucocorticoids-applied-during-induction-therapy-for-microscopic-polyangiitis-with-rapidly-progressive-glomerulonephritis
#16
JOURNAL ARTICLE
Hiromasa Miyake, Katsuyuki Tanabe, Shuhei Yamaji, Takashi Kihara
Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a systemic autoimmune disease characterized by necrotizing inflammation of small blood vessels. Glucocorticoids (GC) in combination with rituximab or cyclophosphamide can reduce AAV-related mortality and rescue renal function. However, several side effects associated with these agents, including GC toxicity, are concerning. Avacopan, an inhibitor of the C5a receptor, is now available for AAV treatment and is expected to mitigate GC toxicity...
December 13, 2023: CEN Case Reports
https://read.qxmd.com/read/38066231/the-successful-treatment-of-microscopic-polyangiitis-associated-with-non-tuberculous-mycobacterial-pulmonary-disease
#17
JOURNAL ARTICLE
Ryuichi Yoshii, Kengo Kajiwara, Naomichi Uemura, Koki Matsushita, Tomohumi Nakamura, Masao Tomita, Masashi Mukoyama
While the incidence and prevalence of non-tuberculous mycobacterial-pulmonary disease (NTM-PD) are increasing and microscopic polyangiitis (MPA) is common in East Asian countries, case reports of MPA associated with NTM-PD are limited. A 72-year-old male receiving treatment for NTM-PD with antibiotics was referred to our hospital with fever and arthralgia that developed a few months previously. A blood test revealed the presence of the myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) and renal impairment...
December 9, 2023: CEN Case Reports
https://read.qxmd.com/read/38055184/a-case-of-bullous-pemphigoid-and-renal-disease-after-dipeptidyl-peptidase-4-inhibitor-administration
#18
JOURNAL ARTICLE
Atsuhiko Suenaga, Naoki Sawa, Yuki Oba, Daisuke Ikuma, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Hiroki Mizuno, Tatsuya Suwabe, Nobukazu Hayashi, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Motoaki Miyazono, Yutaka Yamaguchi, Yoshifumi Ubara
A 62-year-old man with type 2 diabetes was admitted because of a decrease in estimated glomerular filtration rate from 72 to 17.5 mL/min/1.73 m2 in 10 years and development of widespread bullous skin lesions. His hemoglobin A1c level had been maintained at 6.0-7.0% for 10 years with a dipeptidyl peptidase (DPP)-4 inhibitor. Skin biopsy showed typical bullous pemphigoid, and kidney biopsy showed tubulointerstitial nephritis with eosinophilic infiltration and glomerular endothelial cell proliferation...
December 6, 2023: CEN Case Reports
https://read.qxmd.com/read/38038886/lamb2-gene-broad-clinical-spectrum-in-pierson-syndrome
#19
JOURNAL ARTICLE
Emre Leventoğlu, Emine Dönmez, Bahriye Uzun Kenan, Burcu Yazıcıoğlu, Bahar Büyükkaragöz, Kibriya Fidan, Sevcan A Bakkaloğlu, Oğuz Söylemezoğlu
Pierson syndrome (PS) is a rare autosomal recessive disease, characterized by congenital nephrotic syndrome (CNS), and ocular and neurologic abnormalities. In affected cases, there is abnormal b-2 laminin which is compound of the several basement membranes caused by inherited mutations in the LAMB2 gene. Although patients have mutations in the same gene, the phenotype is highly variable. In this case series, the relationship between genotype and phenotype is emphasized, and information about the clinical follow-up of the patients is presented...
December 1, 2023: CEN Case Reports
https://read.qxmd.com/read/38032436/active-flare-of-iga-nephropathy-during-long-term-therapy-with-anti-tumor-necrosis-factor-%C3%AE-antibody-drugs-for-crohn-s-disease-three-case-reports-and-literature-review
#20
JOURNAL ARTICLE
Akihiro Shimizu, Nobuo Tsuboi, Kotaro Haruhara, Izumi Shirai, Kyohei Ogawa, Akane Miura, Kentaro Oshiro, Hiroyuki Ueda, Shinya Yokote, Masahiro Okabe, Takaya Sasaki, Masato Ikeda, Takashi Yokoo
In recent years, increasing numbers of reports have described new onset or active disease flare of IgA nephropathy (IgAN) during administration of TNF-α inhibitor (TNFi) therapy for chronic inflammatory diseases. Crohn's disease (CD) is the most common indication for TNFi therapy in this clinical setting, but the underlying etiology of IgAN in such patients remains unclear. We report our experience with three patients who developed acute worsening of preexisting urinalysis abnormalities and kidney dysfunction approximately 2 to 6 years after TNFi administration for CD...
November 30, 2023: CEN Case Reports
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