journal
https://read.qxmd.com/read/38792861/identifying-mortality-predictors-in-hospitalized-covid-19-patients-insights-from-a-single-center-retrospective-study-at-a-university-hospital
#1
JOURNAL ARTICLE
Ondrej Zahornacky, Alena Rovnakova, Maria Surimova, Stefan Porubcin, Pavol Jarcuska
INTRODUCTION: The pandemic instigated by the SARS-CoV-2 virus has led to over 7 million deaths globally, primarily attributable to viral pneumonia. Identifying fundamental markers associated with an elevated risk of mortality can aid in the early identification of patients prone to disease progression to a severe state, enabling prompt intervention. METHODS: This was a single-center, retrospective study. RESULTS: In this study, we examined 299 patients admitted to the Department of Infectology and Travel Medicine in Košice, Slovakia, with PCR-confirmed COVID-19 pneumonia...
May 20, 2024: Microorganisms
https://read.qxmd.com/read/38792860/expanding-the-spectrum-of-diseases-and-disease-associations-caused-by-edwardsiella-tarda-and-related-species
#2
REVIEW
J Michael Janda, Muhammed Duman
The genus Edwardsiella , previously residing in the family Enterobacteriaceae and now a member of the family Hafniaceae , is currently composed of five species, although the taxonomy of this genus is still unsettled. The genus can primarily be divided into two pathogenic groups: E. tarda strains are responsible for almost all human infections, and two other species ( E. ictaluri , E. piscicida ) cause diseases in fish. Human infections predominate in subtropical habitats of the world and in specific geospatial regions with gastrointestinal disease, bloodborne infections, and wound infections, the most common clinical presentations in decreasing order...
May 20, 2024: Microorganisms
https://read.qxmd.com/read/38792859/characteristics-of-vaginal-microbiota-of-women-of-reproductive-age-with-infections
#3
JOURNAL ARTICLE
Wanting Dong, Siyi Wang, Xi Wang, Guojin Xu, Qiuying Liu, Zheng Li, Na Lv, Yuanlong Pan, Qian Xiong, Donglai Liu, Baoli Zhu
The vaginal microbiota can be classified into five major community state types (CSTs) based on the bacterial content. However, the link between different CST subtypes and vaginal infection remains unclear. Here, we analyzed 2017 vaginal microbiota samples from women of a reproductive age with vaginal infections that were published in the last decade. We found that L. iners was the most dominant in 34.8% of the vaginal samples, followed by L. crispatus (21.2%). CST I was common in healthy individuals, whereas CST III and IV were associated with dysbiosis and infection...
May 20, 2024: Microorganisms
https://read.qxmd.com/read/38792858/selective-isolation-and-identification-of-microorganisms-with-dual-capabilities-leather-biodegradation-and-heavy-metal-resistance-for-industrial-applications
#4
JOURNAL ARTICLE
Manuela Bonilla-Espadas, Basilio Zafrilla, Irene Lifante-Martínez, Mónica Camacho, Elena Orgilés-Calpena, Francisca Arán-Aís, Marcelo Bertazzo, María-José Bonete
Tanning, crucial for leather production, relies heavily on chromium yet poses risks due to chromium's oxidative conversion, leading to significant wastewater and solid waste generation. Physico-chemical methods are typically used for heavy metal removal, but they have drawbacks, prompting interest in eco-friendly biological remediation techniques like biosorption, bioaccumulation, and biotransformation. The EU Directive (2018/850) mandates alternatives to landfilling or incineration for industrial textile waste management, highlighting the importance of environmentally conscious practices for leather products' end-of-life management, with composting being the most researched and viable option...
May 20, 2024: Microorganisms
https://read.qxmd.com/read/38792857/exploring-the-frozen-armory-antiphage-defense-systems-in-cold-adapted-bacteria-with-a-focus-on-crispr-cas-systems
#5
JOURNAL ARTICLE
Greta Daae Sandsdalen, Animesh Kumar, Erik Hjerde
Our understanding of the antiphage defense system arsenal in bacteria is rapidly expanding, but little is known about its occurrence in cold-adapted bacteria. In this study, we aim to shed light on the prevalence and distribution of antiphage defense systems in cold-adapted bacteria, with a focus on CRISPR-Cas systems. Using bioinformatics tools, Prokaryotic Antiviral Defense LOCator (PADLOC) and CRISPRCasTyper, we mapped the presence and diversity of antiphage defense systems in 938 available genomes of cold-adapted bacteria from diverse habitats...
May 20, 2024: Microorganisms
https://read.qxmd.com/read/38792856/transcriptome-analysis-reveals-candidate-genes-for-light-regulation-of-elsinochrome-biosynthesis-in-elsino%C3%A3-arachidis
#6
JOURNAL ARTICLE
Dan Liu, Jingzi Piao, Yang Li, Haiwen Guan, Jingwen Hao, Rujun Zhou
Light regulation is critical in fungal growth, development, morphogenesis, secondary metabolism, and the biological clock. The fungus Elsinoë arachidis is known to produce the mycotoxin Elsinochrome (ESC), a key factor contributing to its pathogenicity, under light conditions. Although previous studies have predominantly focused on the light-induced production of ESC and its biosynthetic pathways, the detailed mechanisms underlying this process remain largely unexplored. This study explores the influence of light on ESC production and gene expression in E...
May 19, 2024: Microorganisms
https://read.qxmd.com/read/38792855/a-review-of-the-mechanisms-of-bacterial-colonization-of-the-mammal-gut
#7
REVIEW
Qingjie Lin, Shiying Lin, Zitao Fan, Jing Liu, Dingcheng Ye, Pingting Guo
A healthy animal intestine hosts a diverse population of bacteria in a symbiotic relationship. These bacteria utilize nutrients in the host's intestinal environment for growth and reproduction. In return, they assist the host in digesting and metabolizing nutrients, fortifying the intestinal barrier, defending against potential pathogens, and maintaining gut health. Bacterial colonization is a crucial aspect of this interaction between bacteria and the intestine and involves the attachment of bacteria to intestinal mucus or epithelial cells through nonspecific or specific interactions...
May 19, 2024: Microorganisms
https://read.qxmd.com/read/38792854/insights-into-the-impact-of-physicochemical-and-microbiological-parameters-on-the-safety-performance-of-deep-geological-repositories
#8
REVIEW
Mar Morales-Hidalgo, Cristina Povedano-Priego, Marcos F Martinez-Moreno, Miguel A Ruiz-Fresneda, Margarita Lopez-Fernandez, Fadwa Jroundi, Mohamed L Merroun
Currently, the production of radioactive waste from nuclear industries is increasing, leading to the development of reliable containment strategies. The deep geological repository (DGR) concept has emerged as a suitable storage solution, involving the underground emplacement of nuclear waste within stable geological formations. Bentonite clay, known for its exceptional properties, serves as a critical artificial barrier in the DGR system. Recent studies have suggested the stability of bentonite within DGR relevant conditions, indicating its potential to enhance the long-term safety performance of the repository...
May 19, 2024: Microorganisms
https://read.qxmd.com/read/38792853/reference-genes-for-expression-analyses-by-qrt-pcr-in-enterobacter-cancerogenus
#9
JOURNAL ARTICLE
Yang Pan, Yue Zhao, Hua-Rui Zeng, Jia-Qi Wu, Ying-Ying Song, Ya-Hao Rao, Guo-Qing Li, Lin Jin
The Enterobacter cancerogenus strain EcHa1 was isolated from the dead larvae of Helicoverpa armigera , and has the potential for biocontrol of some Lepidoptera insects. In order to screen insecticidal-related genes by qRT-PCR, stable endogenous reference genes used for normalizing qRT-PCR data were selected and evaluated from 13 housekeeping genes (HKGs). The expression levels of the HKGs were determined using qRT-PCR under different experimental conditions, including two culture temperatures and three bacterial OD values...
May 19, 2024: Microorganisms
https://read.qxmd.com/read/38792852/interplay-of-demographic-influences-clinical-manifestations-and-longitudinal-profile-of-laboratory-parameters-in-the-progression-of-sars-cov-2-infection-insights-from-the-saudi-population
#10
JOURNAL ARTICLE
Sarah Al-Hassinah, Sooad Al-Daihan, Mashael Alahmadi, Sara Alghamdi, Rawabi Almulhim, Dalia Obeid, Yaseen Arabi, Abdulrahman Alswaji, Marwh Aldriwesh, Majed Alghoribi
Understanding the factors driving SARS-CoV-2 infection progression and severity is complex due to the dynamic nature of human physiology. Therefore, we aimed to explore the severity risk indicators of SARS-CoV-2 through demographic data, clinical manifestations, and the profile of laboratory parameters. The study included 175 patients either hospitalized at King Abdulaziz Medical City-Riyadh or placed in quarantine at designated hotels in Riyadh, Saudi Arabia, from June 2020 to April 2021. Hospitalized patients were followed up through the first week of admission...
May 18, 2024: Microorganisms
https://read.qxmd.com/read/38792851/customized-16s-23s-rdna-its-amplicon-metagenomics-for-acetic-acid-bacteria-species-identification-in-vinegars-and-kombuchas
#11
JOURNAL ARTICLE
Alja Ribič, Janja Trček
Acetic acid bacteria (AAB) are involved in food and beverage production bioprocesses, like those in vinegar and kombucha. They oxidize sugars and alcohols into various metabolites, resulting in the final products' pleasant taste and aroma. The 16S rDNA amplicon metagenomics using Illumina technology is usually used to follow the microbiological development of these processes. However, the 16S rRNA gene sequences among different species of AAB are very similar, thus not enabling a reliable identification down to the species level but only to the genus...
May 18, 2024: Microorganisms
https://read.qxmd.com/read/38792850/facial-skin-microbiome-composition-and-functional-shift-with-aging
#12
JOURNAL ARTICLE
Allison Garlet, Valerie Andre-Frei, Nicolas Del Bene, Hunter James Cameron, Anita Samuga, Vimal Rawat, Philipp Ternes, Sabrina Leoty-Okombi
The change in the skin microbiome as individuals age is only partially known. To provide a better understanding of the impact of aging, whole-genome sequencing analysis was performed on facial skin swabs of 100 healthy female Caucasian volunteers grouped by age and wrinkle grade. Volunteers' metadata were collected through questionnaires and non-invasive biophysical measurements. A simple model and a biological statistical model were used to show the difference in skin microbiota composition between the two age groups...
May 18, 2024: Microorganisms
https://read.qxmd.com/read/38792849/role-of-probiotics-in-gut-microbiome-and-metabolome-in-non-alcoholic-fatty-liver-disease-mouse-model-a-comparative-study
#13
JOURNAL ARTICLE
Tian Wu, Zheng Zeng, Yanyan Yu
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver condition worldwide. Numerous studies conducted recently have demonstrated a connection between the dysbiosis of the development of NAFLD and gut microbiota. Rebuilding a healthy gut ecology has been proposed as a strategy involving the use of probiotics. The purpose of this work is to investigate and compare the function of probiotics Akkermansia muciniphila ( A. muciniphila ) and VSL#3 in NAFLD mice. Rodent NAFLD was modeled using a methionine choline-deficient diet (MCD) with/without oral probiotic delivery...
May 17, 2024: Microorganisms
https://read.qxmd.com/read/38792848/efficiency-of-virucidal-disinfectants-on-wood-surfaces-in-animal-husbandry
#14
JOURNAL ARTICLE
Martin J Oettler, Franz J Conraths, Uwe Roesler, Sven Reiche, Timo Homeier-Bachmann, Nicolai Denzin
The aim of this study was to test the inactivation of viruses on germ carriers of different types of wood using a disinfectant in order to assess the biosafety of wood as a building material in animal husbandry. The laboratory disinfectant efficacy tests were based on German testing guidelines and current European standards. Five different types of wood germ carriers, i.e., spruce ( Picea abies ), pine ( Pinus sylvestris ), poplar ( Populus sp.), beech ( Fagus sylvatica ) and Douglas fir ( Pseudotsuga menziesii ), were inoculated with enveloped or non-enveloped viruses and then treated with one of three different disinfectants...
May 17, 2024: Microorganisms
https://read.qxmd.com/read/38792847/rapid-identification-of-brucella-genus-and-species-in-silico-and-on-site-using-novel-probes-with-crispr-cas12a
#15
JOURNAL ARTICLE
Yan Zhang, Yufei Lyu, Dongshu Wang, Meijie Feng, Sicheng Shen, Li Zhu, Chao Pan, Xiaodong Zai, Shuyi Wang, Yan Guo, Shujuan Yu, Xiaowei Gong, Qiwei Chen, Hengliang Wang, Yuanzhi Wang, Xiankai Liu
Human brucellosis caused by Brucella is a widespread zoonosis that is prevalent in many countries globally. The high homology between members of the Brucella genus and Ochrobactrum spp. often complicates the determination of disease etiology in patients. The efficient and reliable identification and distinction of Brucella are of primary interest for both medical surveillance and outbreak purposes. A large amount of genomic data for the Brucella genus was analyzed to uncover novel probes containing single-nucleotide polymorphisms (SNPs)...
May 17, 2024: Microorganisms
https://read.qxmd.com/read/38792846/sodium-polyoxotungstate-inhibits-the-replication-of-influenza-virus-by-blocking-the-nuclear-import-of-vrnp
#16
JOURNAL ARTICLE
Zhuogang Li, Yuanyuan Duan, Yang Yu, Yue Su, Mingxin Zhang, Yarou Gao, Lefang Jiang, Haonan Zhang, Xiaoqin Lian, Xingjian Zhu, Jiaxin Ke, Qun Peng, Xulin Chen
Both pandemic and seasonal influenza are major health concerns, causing significant mortality and morbidity. Current influenza drugs primarily target viral neuraminidase and RNA polymerase, which are prone to drug resistance. Polyoxometalates (POMs) are metal cation clusters bridged by oxide anions. They have exhibited potent anti-tumor, antiviral, and antibacterial effects. They have remarkable activity against various DNA and RNA viruses, including human immunodeficiency virus, herpes simplex virus, hepatitis B and C viruses, dengue virus, and influenza virus...
May 17, 2024: Microorganisms
https://read.qxmd.com/read/38792845/divergence-within-the-taxon-candidatus-phytoplasma-asteris-confirmed-by-comparative-genome-analysis-of-carrot-strains
#17
JOURNAL ARTICLE
Rafael Toth, Anna-Marie Ilic, Bruno Huettel, Bojan Duduk, Michael Kube
Phytoplasmas are linked to diseases in hundreds of economically important crops, including carrots. In carrots, phytoplasmosis is associated with leaf chlorosis and necrosis, coupled with inhibited root system development, ultimately leading to significant economic losses. During a field study conducted in Baden-Württemberg (Germany), two strains of the provisional taxon ' Candidatus Phytoplasma asteris' were identified within a carrot plot. For further analysis, strains M8 and M33 underwent shotgun sequencing, utilising single-molecule-real-time (SMRT) long-read sequencing and sequencing-by-synthesis (SBS) paired-end short-read sequencing techniques...
May 17, 2024: Microorganisms
https://read.qxmd.com/read/38792844/exploring-gut-microbiota-alterations-with-trimethoprim-sulfamethoxazole-and-dexamethasone-in-a-humanized-microbiome-mouse-model
#18
JOURNAL ARTICLE
George B H Green, Alexis N Cox-Holmes, Olivia Backan, Olivia Valbak, Anna Claire E Potier, Dongquan Chen, Casey D Morrow, Christopher D Willey, Braden C McFarland
Along with the standard therapies for glioblastoma, patients are commonly prescribed trimethoprim-sulfamethoxazole (TMP-SMX) and dexamethasone for preventing infections and reducing cerebral edema, respectively. Because the gut microbiota impacts the efficacy of cancer therapies, it is important to understand how these medications impact the gut microbiota of patients. Using mice that have been colonized with human microbiota, this study sought to examine how TMP-SMX and dexamethasone affect the gut microbiome...
May 17, 2024: Microorganisms
https://read.qxmd.com/read/38792843/probiotics-in-the-new-era-of-human-milk-oligosaccharides-hmos-hmo-utilization-and-beneficial-effects-of-bifidobacterium-longum-subsp-infantis-m-63-on-infant-health
#19
REVIEW
Chyn Boon Wong, Huidong Huang, Yibing Ning, Jinzhong Xiao
A healthy gut microbiome is crucial for the immune system and overall development of infants. Bifidobacterium has been known to be a predominant species in the infant gut; however, an emerging concern is the apparent loss of this genus, in particular, Bifidobacterium longum subsp. infantis ( B. infantis ) in the gut microbiome of infants in industrialized nations, underscoring the importance of restoring this beneficial bacterium. With the growing understanding of the gut microbiome, probiotics, especially infant-type human-residential bifidobacteria (HRB) strains like B...
May 17, 2024: Microorganisms
https://read.qxmd.com/read/38792842/a-review-microbes-and-their-effect-on-growth-performance-of-litopenaeus-vannamei-white-leg-shrimps-during-culture-in-biofloc-technology-system
#20
REVIEW
Bilal Raza, Zhongming Zheng, Jinyong Zhu, Wen Yang
In the modern era of Aquaculture, biofloc technology (BFT) systems have attained crucial attention. This technology is used to reduce water renewal with the removal of nitrogen and to provide additional feed. In BFT, microorganisms play a crucial role due to their complex metabolic properties. Pathogens can be controlled through multiple mechanisms using probiotics, which can promote host development and enhance the quality of the culture environment. During culturing in a biofloc technology system, the supplementation of microalgae and its accompanying bacteria plays a beneficial role in reducing nitrogenous compounds...
May 17, 2024: Microorganisms
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