journal
https://read.qxmd.com/read/38021073/long-non-coding-rna-pvt1-pvt1-affects-the-expression-of-ccnd1-and-promotes-doxorubicin-resistance-in-osteosarcoma-cells
#21
JOURNAL ARTICLE
Zi Li, Jia-Ming Tian, Yi Chu, Hong-Yi Zhu, Jun-Jie Wang, Jun Huang
BACKGROUND: Acquired drug-resistance is the major risk factor for poor prognosis and short-term survival in patients with osteosarcoma (OS). Accumulating evidence has revealed that long noncoding RNAs (lncRNAs), including plasmacytoma variant translocation 1 (PVT1), play potential regulatory roles in the malignant development of OS. Considering the subcellular distribution of PVT1 as both nuclear and cytoplasmic lncRNA, a thorough exploration of its extensive mechanisms becomes essential...
December 2023: Journal of Bone Oncology
https://read.qxmd.com/read/38021072/novel_circ_003686-regulates-the-osteogenic-differentiation-of-mscs-in-patients-with-myeloma-bone-disease-through-mir-142-5p-igf1-axis
#22
JOURNAL ARTICLE
Ling Qiu, Lei Ma, Dan Chen, Nan Zhang, Jiao Cai, Qian Zhang, Xiao Wang, Hai Yi, Hao Yao, Fang-Yi Fan
OBJECTIVES: Circ_003686 is a novel_circRNA with abnormally low expression found in the samples of multiple myeloma bone disease (MBD) patients. The current research intended to investigate the effects of novel_circ_003686 in osteogenesis-induced differentiation of bone marrow mesenchymal stem cells (BMSCs) in MBD. METHODS: BMSCs were extracted from MBD patients and normal participants, the pcDNA3.1 encoding the circ_003686 (ov-circ_003686), miR-142-5p-mimic/inhibitor and siRNA oligonucleotides targeting insulin like growth factor 1 (IGF1, si-IGF1) were applied to intervene circ_003686, miR-142-5p and IGF1 levels, respectively...
December 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37868617/the-low-and-disproportionate-utilization-of-antiresorptive-therapy-in-patients-with-osseous-metastasis
#23
JOURNAL ARTICLE
Amil R Agarwal, Christa L LiBrizzi, Lauren Wessel, Savyasachi C Thakkar, Adam S Levin
INTRODUCTION: Antiresorptive therapies are commonly utilized to mitigate and prevent skeletal-related-events in patients with metastatic osseous disease. However, limited data exists on the incidence or factors associated with prescription of antiresorptives or their effects on the incidence of pathologic fractures in patients with osseous metastatic disease. The aims of this study were to determine 1) the proportion of patients with osseous metastasis who receive antiresorptive therapy and sustain a pathologic fracture within 2-years of a new diagnosis, 2) factors associated with sustaining a pathologic fracture, and 3) factors are associated with the likelihood of receiving antiresorptive therapy...
December 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37868616/the-role-of-mitochondria-related-lncrnas-in-characterizing-the-immune-landscape-and-supervising-the-prognosis-of-osteosarcoma
#24
JOURNAL ARTICLE
Yiming Zhang, Nan Ru, Zhaowen Xue, Wenyi Gan, Ruilin Pan, Zelin Wu, Zihang Chen, Huajun Wang, Xiaofei Zheng
Mitochondrial damage is related to the functional properties of immune cells as well as to tumorigenesis and progression. Nevertheless, there is an absence concerning the systematic evaluation of mitochondria-associated lncRNAs (MALs) in the immune profile and tumor microenvironment of osteosarcoma patients. Based on transcriptomic and clinicopathological data from the TARGET database, MAL-related patterns were ascertained by consistent clustering, and gene set variation analysis of the different patterns was completed...
December 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37842554/immune-checkpoint-inhibitors-in-bone-metastasis-clinical-challenges-toxicities-and-mechanisms
#25
REVIEW
Gwenyth J Joseph, Douglas B Johnson, Rachelle W Johnson
Immune checkpoint inhibitors (ICIs) have revolutionized the field of anti-cancer therapy over the last decade; they provide durable clinical responses against tumors by inhibiting immune checkpoint proteins that canonically regulate the T cell-mediated immune response. Despite their success in many primary tumors and soft tissue metastases, ICIs function poorly in patients with bone metastases, and these patients do not have the same survival benefit as patients with the same primary tumor type (e.g., non-small cell lung cancer [NSCLC], urothelial, renal cell carcinoma [RCC], etc...
December 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37771750/what-to-choose-in-bone-tumour-resections-patient-specific-instrumentation-versus-surgical-navigation-a-systematic-review
#26
REVIEW
Alessandro Bruschi, Davide Maria Donati, Claudia Di Bella
Patient specific instrumentation (PSI) and intraoperative surgical navigation (SN) can significantly help in achieving wide oncological margins while sparing bone stock in bone tumour resections. This is a systematic review aimed to compare the two techniques on oncological and functional results, preoperative time for surgical planning, surgical intraoperative time, intraoperative technical complications and learning curve. The protocol was registered in PROSPERO database (CRD42023422065). 1613 papers were identified and 81 matched criteria for PRISMA inclusion and eligibility...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37766930/femurtumornet-bone-tumor-classification-in-the-proximal-femur-using-densenet-model-based-on-radiographs
#27
JOURNAL ARTICLE
Canyu Pan, Luoyu Lian, Jieyun Chen, Risheng Huang
BACKGROUND & PURPOSE: For the best possible outcomes from therapy, proximal femur bone cancers must be accurately classified. This work creates an artificial intelligence (AI) model based on plain radiographs to categorize bone tumor in the proximal femur. MATERIALS AND METHODS: A tertiary referral center's standard anteroposterior hip radiographs were employed. A dataset 538 images of the femur, including malignant, benign, and tumor-free cases, was employed for training the AI model...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37736418/bone-tumor-examination-based-on-fcnn-4s-and-crf-fine-segmentation-fusion-algorithm
#28
JOURNAL ARTICLE
Shiqiang Wu, Xiaoming Bai, Liquan Cai, Liangming Wang, XiaoLu Zhang, Qingfeng Ke, Jianlong Huang
BACKGROUND AND OBJECTIVE: Bone tumor is a kind of harmful orthopedic disease, there are benign and malignant points. Aiming at the problem that the accuracy of the existing machine learning algorithm for bone tumor image segmentation is not high, a bone tumor image segmentation algorithm based on improved full convolutional neural network which consists fully convolutional neural network (FCNN-4s) and conditional random field (CRF). METHODOLOGY: The improved fully convolutional neural network (FCNN-4s) was used to perform coarse segmentation on preprocessed images...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37701913/a-randomized-trial-comparing-ly01011-biosimilar-candidate-with-the-reference-product-denosumab-xgeva%C3%A2-in-healthy-chinese-subjects
#29
JOURNAL ARTICLE
Yanhua Ding, Yusi Liu, Changlin Dou, Shuren Guo
BACKGROUND: Complications of bone metastases such as skeletal-related events lead to the impaired functional status and quality of life including death in patients with bone metastasis from solid tumors. Denosumab (XGEVA®) is indicated for the prevention of skeletal-related events in bone metastasis patients with solid tumors. The biosimilar product LY01011, a fully human anti-receptor activator of nuclear factor kappa-B ligand monoclonal antibody, was developed to be compared with the reference product denosumab...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37670740/contrast-enhanced-magnetic-resonance-image-segmentation-based-on-improved-u-net-and-inception-resnet-in-the-diagnosis-of-spinal-metastases
#30
JOURNAL ARTICLE
Hai Wang, Shaohua Xu, Kai-Bin Fang, Zhang-Sheng Dai, Guo-Zhen Wei, Lu-Feng Chen
OBJECTIVE: The objective of this study was to investigate the use of contrast-enhanced magnetic resonance imaging (CE-MRI) combined with radiomics and deep learning technology for the identification of spinal metastases and primary malignant spinal bone tumor. METHODS: The region growing algorithm was utilized to segment the lesions, and two parameters were defined based on the region of interest (ROI). Deep learning algorithms were employed: improved U-Net, which utilized CE-MRI parameter maps as input, and used 10 layers of CE images as input...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37664160/a-global-bibliometric-and-visualized-analysis-of-the-status-and-trends-of-bone-metastasis-in-breast-cancer-research-from-2002-to-2021
#31
JOURNAL ARTICLE
Li Li, Nengbin Wan, Ying He, Yi Zhang, Xiao He, Lingli Lu
UNLABELLED: Bone metastasis of breast cancer considerably reduces not only overall survival but also health-related quality of life due to pain, fatigue, and skeletal-related events. OBJECTIVE: This study aims to analyze the research hotspots and trends of global research on bone metastasis of breast cancer in the past 20 years to provide a reference for relevant personnel in this field to carry out academic research. METHODS: The literature related to bone metastasis of breast cancer from 2002 to 2021 was retrieved from the Web of Science...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37664159/dxa-assessment-and-fracture-prevention-in-hormone-positive-breast-cancer-patients-after-treatment-initiation-with-aromatase-inhibitors-a-registry-based-cohort-study
#32
JOURNAL ARTICLE
Vanessa Rouach, Yona Greenman, Gabriel Chodick, Inbal Goldshtein
BACKGROUND: Several guidelines have been proposed to prevent aromatase inhibitors induced bone loss (AIBL), but there is scarce data on their endorsement in clinical practice. AIM: To assess bone health evaluation and fracture prevention in postmenopausal women with estrogen receptor (ER)-positive breast cancer after aromatase inhibitors (AI) initiation. METHODS: An historical cohort analysis based on data from the cancer and osteoporosis Maccabi Health Services (MHS) registries from Jan 1st 2009 to Dec 31st 2020...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37635708/implant-failure-and-revision-strategies-after-total-spondylectomy-for-spinal-tumors
#33
JOURNAL ARTICLE
Xianglin Hu, Sean M Barber, Yingzheng Ji, Hongwei Kou, Weiluo Cai, Mo Cheng, Hongjian Liu, Wending Huang, Wangjun Yan
BACKGROUND: Although there have been several risk factors reported for implant failure (IF), little consensus exists. Potential applicable measures to protect patients from IF are relatively few. This study aimed to discover new risk factors for IF and explore potential protective measures from IF after total spondylectomy for spinal tumors. METHODS: A total of 145 patients undergoing total spondylectomy for thoracic and lumbar spinal tumors between 2010 and 2021 were included from three tertiary university hospitals...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37589036/optimal-timing-for-local-ablative-treatment-of-bone-oligometastases-in-non-small-cell-lung-cancer
#34
REVIEW
Jayoung Lee, Jung A Kim, Tai Joon An, Hyochun Lee, Eun Ji Han, Young Jo Sa, Hyo Rim Kim, Chan Kwon Park, Tae-Jung Kim, Jeong Uk Lim
Oligometastases is a term commonly used to describe a disease state characterized by a limited number of distant metastases, and represents a transient phase between localized and widespread systemic diseases. This subgroup of stage IV cancer has increased in clinical importance due to the possibility of curative rather than palliative treatment. Among advanced lung cancer patients, 30-40% show bone metastases, and can show complications such as pathological fractures. Many prospective studies have shown efficacy of localized treatment in oligometastatic non-small cell lung cancer (NSCLC) in improving progression-free survival and overall survival...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37583441/cav3-2-t-type-calcium-channels-downregulation-attenuates-bone-cancer-pain-induced-by-inhibiting-igf-1-hif-1%C3%AE-signaling-pathway-in-the-rat-spinal-cord
#35
JOURNAL ARTICLE
Qingying Liu, Zhongyuan Lu, Huan Ren, Lijun Fu, Yueliang Wang, Huilian Bu, Minyu Ma, Letian Ma, Chen Huang, Jian Wang, Weidong Zang, Jing Cao, Xiaochong Fan
BACKGROUND: Bone cancer pain (BCP) is one of the most ubiquitous and refractory symptoms of cancer patients that needs to be urgently addressed. Substantial studies have revealed the pivotal role of Cav3.2 T-type calcium channels in chronic pain, however, its involvement in BCP and the specific molecular mechanism have not been fully elucidated. METHODS: The expression levels of Cav3.2, insulin-like growth factor 1(IGF-1), IGF-1 receptor (IGF-1R) and hypoxia-inducible factor-1α (HIF-1α) were detected by Western blot in tissues and cells...
October 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37601080/lncrna-satb2-as1-promotes-tumor-growth-and-metastasis-and-affects-the-tumor-immune-microenvironment-in-osteosarcoma-by-regulating-satb2
#36
JOURNAL ARTICLE
Peipei Wang, Jianwei Zhu, Qingqin Long, Yan Wang, Huihua Xu, Huimin Tao, Biwen Wu, Jiajun Li, Yong Wu, Sihong Liu
Our previous report has identified a lncRNA SATB2-AS1, which was significantly up-regulated in osteosarcoma tissue and promotes the proliferation of osteosarcoma cells in vitro . However, the mechanisms of SATB2-AS1 regulating the growth and metastasis of osteosarcoma cells in vivo and its role in the prognosis of osteosarcoma patients are still unclear. In this study, the transcriptome sequencing data of 87 patients with osteosarcoma from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and 7 patients from our clinical center (GZFPH) was used to evaluate the importance of SATB2-AS1 and SATB2 on the prognosis...
August 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37575527/linc00482-sponged-mir-2467-3p-to-promote-bone-metastasis-of-prostate-cancer-through-activating-wnt-%C3%AE-catenin-signaling-pathway
#37
JOURNAL ARTICLE
Shiyao Liao, Xuemei Fang, Kai Zhou, Tingxiao Zhao, Lichen Ji, Wei Zhang, Xugang Zhong, Fabo Feng, Jun Lv, Yao Kang, Danjie Zhu
This study was designed to investigate the biological functions of LINC00482 in prostate cancer (PCa) with bone metastasis. TCGA dataset of PCa was applied for LINC00482 expression analysis and real time PCR was used to verify the expression level of LINC00482 in PCa tissues as well as PCa bone metastatic tissues. To detect the biological functions of LINC00482 in vitro, various assays were used including CCK-8, EdU, colony formation and transwell assays. The biological functions of LINC00482 were also identified in vivo by inoculating PCa cells into the left cardiac ventricle of mice, followed by evaluating the osteolytic lesions and osteolytic score...
August 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37546383/imaging-evaluation-of-blood-supply-changes-after-chemotherapy-of-osteosarcoma-and-its-correlation-with-tumor-necrosis-rate
#38
JOURNAL ARTICLE
Yongkun Yang, Yuan Li, Xiaohui Niu, Weifeng Liu
BACKGROUND: Analysis of the tumour necrosis rate is an important method to evaluate the effect of neoadjuvant chemotherapy for osteosarcoma. However, at present, there is no specific imaging method to evaluate this effect. The purpose of this study was to evaluate the changes in blood supply after chemotherapy by measuring the CT enhancement rate and to analyse the correlation between the CT enhancement rate and the tumour necrosis rate. METHODS: Patients with primary osteosarcoma of the extremities treated in our institute from 2016 to 2017 were analysed retrospectively...
August 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37501717/analysis-of-intercellular-communication-in-the-osteosarcoma-microenvironment-based-on-single-cell-sequencing-data
#39
JOURNAL ARTICLE
Fangyi Chen, Jiao Liu, Ting Yang, Jianwei Sun, Xianwei He, Xinjie Fu, Shigang Qiao, Jianzhong An, Jiao Yang
Osteosarcoma (OS) is the most common primary bone cancer in children and young adults, patient survival rates have not improved in recent decades. To further understand the interrelationship between different cell types in the tumor microenvironment of osteosarcoma, we comprehensively analyzed single-cell sequencing data from six patients with untreated osteosarcoma. Nine major cell types were identified from a total of 46,046 cells based on unbiased clustering of gene expression profiles and canonical markers...
August 2023: Journal of Bone Oncology
https://read.qxmd.com/read/37457846/mat2a-inhibits-the-ferroptosis-in-osteosarcoma-progression-regulated-by-mir-26b-5p
#40
JOURNAL ARTICLE
Shuchi Xia, Yun Liang, Yuqing Shen, Wuxue Zhong, Yiqun Ma
Osteosarcoma (OS) is the most frequent primary malignant bone tumor. Ferroptosis, a form of regulated cell death, is a key tumor suppression mechanism. Although methionine adenosyltransferase II alpha (MAT2A) has been reported to inhibit several tumor cells, it is unclear whether inhibition of MAT2A in OS cells can reduce ferroptosis. CCK-8, flow cytometry, and Transwell assays were performed to evaluate cell viability, cell apoptosis/cycle, and cell migration, respectively. The levels of ferrous iron and glutathione (GSH) levels in cells were measured to evaluate the degree of cell ferroptosis...
August 2023: Journal of Bone Oncology
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