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Journal of Bone Oncology

Charles Meares, Alexander Badran, David Dewar
Background: Operative fixation for femoral metastatic bone disease is based on the principles of reducing pain and restoring function. Recent literature has proposed a number of prognostic models for appendicular metastatic bone disease. The aim of this study was to compare the accuracy of proposed soring systems in the setting of femoral metastatic bone disease in order to provide surgeons with information to determine the most appropriate scoring system in this setting. Methods: A retrospective cohort analysis of patients who underwent surgical management of femoral metastatic bone disease at a single institution were included...
April 2019: Journal of Bone Oncology
Qiang Zhou, Zong-Yi Wu, Zhong-Qin Lin
Objective: This study was designed to develop a nomogram for assessing the survival of patients with Ewing sarcoma (ES). Methods: Data from patients diagnosed with ES between 2004 and 2013 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Based on patient registration, the primary cohort was divided into a training set ( n  = 479, data from 17 cancer registries) and a validation set ( n  = 137, data from 1 cancer registry)...
April 2019: Journal of Bone Oncology
Yurday Ozdemir, Nese Torun, Ozan Cem Guler, Berna Akkus Yildirim, Ali A Besen, Aylin Gunesli Yetisken, H Cem Onal, Erkan Topkan
Purpose: We aimed to retrospectively assess the incidence of vertebral compression fractures (VCF), examine clinicopathologic factors potentially associated with VCF, and evaluate treatment response in patients who received stereotactic body radiotherapy (SBRT) for spine metastases (spMets). Methods and Materials: We identified 78 patients with 125 spMets at baseline and subsequent assessments. Patients received SBRT doses of 16 or 18 Gy. Patients with pre-existing VCF and co-existing local progression were excluded...
April 2019: Journal of Bone Oncology
Pichaya Thanindratarn, Dylan C Dean, Scott D Nelson, Francis J Hornicek, Zhenfeng Duan
Bone sarcomas are a collection of sporadic malignancies of mesenchymal origin. The most common subtypes include osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma. Despite the use of aggressive treatment protocols consisting of extensive surgical resection, chemotherapy, and radiotherapy, outcomes have not significantly improved over the past few decades for osteosarcoma or Ewing sarcoma patients. In addition, chondrosarcoma and chordoma are resistant to both chemotherapy and radiation therapy. There is, therefore, an urgent need to elucidate which novel new therapies may affect bone sarcomas...
April 2019: Journal of Bone Oncology
Ruben D Addie, Yvonne de Jong, Gaia Alberti, Alwine B Kruisselbrink, Ivo Que, Hans Baelde, Judith V M G Bovée
Background: Chondrosarcomas are malignant cartilage-producing tumors showing mutations and changes in gene expression in metabolism related genes. In this study, we aimed to explore the metabolome and identify targetable metabolic vulnerabilities in chondrosarcoma. Methods: A custom-designed metabolic compound screen containing 39 compounds targeting different metabolic pathways was performed in chondrosarcoma cell lines JJ012, SW1353 and CH2879. Based on the anti-proliferative activity, six compounds were selected for validation using real-time metabolic profiling...
April 2019: Journal of Bone Oncology
Mingyu Zhu, Xin Liu, Yuan Qu, Silong Hu, Yingjian Zhang, Wentao Li, Xiaoyan Zhou, Huijuan Yang, Liangping Zhou, Qifeng Wang, Yifeng Hou, Yong Chen, Yanli Wang, Yaohui Wang, Zhongwu Lu, Zhiguo Luo, Xichun Hu
Background: Bone metastasis of cancer can be a result from systemic blood spreading or vertebral venous plexus spreading. Systemic blood pathway induced bone metastasis can happen in any bone in the body since the spreading is considered to be random. However, it remains unknown whether there is any pattern of vertebral venous plexus related bone metastasis. In this study, we explored bone metastasis patterns in patients whose primary tumors had been well identified. Methods: We included 290 consecutive cancer patients with bone metastases but no visceral metastases, out of 2559 patients whose bone metastases were diagnosed by positron emission tomography/computed tomography, between Jan 2015 and Oct 2017 at the Fudan University Shanghai Cancer Center...
April 2019: Journal of Bone Oncology
Shenglong Li, Peng Chen, Qiankun Yang
Background: Although denosumab has been approved as an antiresorptive agent for giant cell tumor of bone, its efficacy has not been proven. Objectives: To compare the efficacy and safety of denosumab and zoledronic acid treatment in patients with surgically unsalvageable giant cell tumor of bone. Methods: A total of 250 patients with surgically unsalvageable giant cell tumor of bone were included in this randomized clinical trial. Patients received either subcutaneous denosumab (DB group; 120 mg per 4 weeks plus an additional 120 mg on days 8 and 15; n  = 125) or intravenous zoledronic acid (ZA group; 4 mg per 4 weeks; n  = 125) for six cycles...
April 2019: Journal of Bone Oncology
Changye Zou, Tiao Lin, Bo Wang, Zhiqiang Zhao, Bin Li, Xianbiao Xie, Gang Huang, Junqiang Yin, Jingnan Shen
Background: Giant cell tumor of bone (GCTB) in distal radius is a benign but invasive bone tumor characterized by strong aggressive behavior and frequent recurrence. Methods: To identify recurrence related risk factors and decide suitable surgical strategy, the potential tumor- and treatment-specific factors, post-operative oncologic and functional outcomes were collected and analyzed from 58 patients with GCTB of the distal radius at our center. Results: With the numbers available, our analysis strongly indicated soft tissue extension (with vs...
February 2019: Journal of Bone Oncology
Asle Charles Hesla, Øyvind Sverre Bruland, Nina Jebsen, Emelie Styring, Sigvard Eriksson, Panagiotis Tsagozis
Object: Many patients with Ewing sarcoma (ES) of the mobile spine present with neurologic symptoms leading to emergency decompressive surgery. Only rarely is optimal treatment involving neo-adjuvant chemotherapy followed by en bloc excision possible. The purpose of this study was to study treatment, neurologic and oncologic outcome in patients with ES of the mobile spine. Methods: Twenty-four patients diagnosed between 1986 and 2012 were identified through the Scandinavian Sarcoma Group registry. Charts were reviewed in order to assess details in patient characteristics, neurologic status, treatment and outcome...
February 2019: Journal of Bone Oncology
Christopher Kim, Sumita Bhatta, Lori Cyprien, Rafael Fonseca, Rohini K Hernandez
Skeletal-related events (SREs) are common bone complications in multiple myeloma (MM). However, there are few real-world reports of their incidence. In this study, a database of oncology electronic health records was linked to administrative claims data. Patients identified were aged ≥18 years and newly diagnosed with MM, had ≥1 clinic visit within 1 month of diagnosis, and ≥1 year of follow-up after diagnosis. The study period was January 1, 2011 to December 31, 2016. 343 patients were included, 35% of whom had a baseline history of any SRE...
February 2019: Journal of Bone Oncology
Liang Zhang, Yichao Wang, Yutong Gu, Yingyong Hou, Zixian Chen
Objective: This study used a clinical dataset to investigate the proportion of the newly found bone lesions in malignant patients diagnosed by biopsy as being benign, malignant but unrelated to the primary malignancy, or bone metastases of the primary malignancy. The clinical factors that might affect the correlation between bone lesions and the primary malignancy were also analyzed. It is expected to obtain some information contributing to the clinical decision-making regarding the need for biopsy of these lesions from the research results...
February 2019: Journal of Bone Oncology
Jean-Jacques Body, Roger von Moos, Alex Rider, Pamela Hallworth, Debajyoti Bhowmik, Francesca Gatta, Guy Hechmati, Yi Qian
Background: Bone metastases (BMs) are common in patients with prostate cancer and can lead to skeletal-related events (SREs), which are associated with increased pain and reduced quality of life (QoL). Bone-targeted agents (BTAs), such as zoledronic acid and denosumab, reduce the incidence of SREs and delay progression of bone pain. Methods: We evaluated the management of BMs and pain in six European countries (Belgium, France, Germany, Italy, Spain and the UK) using the Adelphi Prostate Cancer Disease Specific Programme...
February 2019: Journal of Bone Oncology
Teng Dai, Ting Pan, Xing Zhang, Gang Chen, Pei Lu, Keqin Shi
Purpose: To obtain a better understanding of the structures around L5 vertebra and provide some anatomical evidence of the feasibility of total en-bloc spondylectomy (TES) on L5 in a posterior-only approach. Methods: 12 simulated TESs on L5 by a posterior-only approach were conducted on human cadavers. The distance between the traction point of L4 nerve root and the dural sac (Da), the anterior-posterior diameter of the vertebral body,(Va), the distance between the start point of L4 nerve root and the traction point of L5 nerve root (Dh) and the height of the vertebral body (Vh) were measured...
February 2019: Journal of Bone Oncology
Dumnoensun Pruksakorn, Jatupon Kongthavonskul, Pimpisa Teeyakasem, Areerak Phanphaisarn, Parunya Chaiyawat, Jeerawan Klangjorhor, Olarn Arpornchayanon
Purpose: To assess the failure rate and mode failure of high-grade osteosarcoma patients who received extracorporeal irradiation and re-implantation (ECIR) in extremities. Patients and Methods: For the cohort study, patients who had received ECIR at a single institution between January 1996 and December 2014 were retrospectively evaluated. Characteristics of failure and time to failure were recorded and analyzed. In addition, a systematically search of published literatures regarding the use of ECIR for osteosarcoma was conducted...
February 2019: Journal of Bone Oncology
Zhiqing Zhao, Taiqiang Yan, Wei Guo, Rongli Yang, Xiaodong Tang, Wei Wang
Background: Primary malignant or aggressive benign bone tumors rarely occur in distal tibia, and limb salvage remains the mainstay of surgical options. However, reconstruction methods for large bone defect after wide tumor resection in this location are debatable. The purpose of this systematical review is to critically evaluate each reconstruction method regarding the postoperative complications and functional outcome. Methods: A systematic review of the 33 studies including 337 cases with tumors affecting distal tibia was performed after searching the PubMed and EMBASE databases...
February 2019: Journal of Bone Oncology
Nilgun Kurucu, Gurses Şahin, Neriman Sarı, Serdar Ceylaner, İnci Ergurhan İlhan
Objective: Through its receptor (VDR), vitamin D3 plays an important role in a wide variety of cellular processes. Polymorphisms in VDR gene have been linked to risk of various cancers and their prognoses. We conducted a case-control study to analyze he relationship of VDR gene polymorphisms with the occurrence and prognosis of osteosarcoma. Methods: Fifty-eight osteosarcoma patients and 75 healthy controls were included in the study. Single nucleotide change polymorphisms (SNPs) in Cdx2, FokI, BsmI, ApaI and TaqI regions of VDR gene were examined with SNaPshot mini-sequencing technique...
February 2019: Journal of Bone Oncology
Kjetil Berner, Tom Børge Johannesen, Kirsten Sundby Hall, Øyvind S Bruland
Purpose: To describe epidemiological and clinical characteristics, as well as long-term treatment outcomes of spindle cell non-osteogenic bone sarcomas (SCS), comprising leiomyosarcoma, fibrosarcoma and undifferentiated pleomorphic sarcoma in bone. Method: We have analysed a nationwide cohort of 104 patients with histologically verified SCS diagnosed between 1975 and 2009, based on registry sources supplemented with clinical records from Norwegian hospitals involved in sarcoma management...
February 2019: Journal of Bone Oncology
Peyman Hadji, Oliver Stoetzer, Thomas Decker, Christian M Kurbacher, Frederik Marmé, Andreas Schneeweiss, Christoph Mundhenke, Andrea Distelrath, Peter A Fasching, Michael P Lux, Diana Lüftner, Wolfgang Janni, Mathias Muth, Julia Kreuzeder, Claudia Quiering, Eva-Marie Grischke, Hans Tesch
Background: Breast cancer and its treatments are associated with a detrimental effect on bone health. Here we report the results of an exploratory analysis assessing changes in levels of biomarkers of bone metabolism in patients enrolled in the phase IIIb 4EVER study. Methods: The 4EVER trial investigated everolimus in combination with exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer...
February 2019: Journal of Bone Oncology
Leilei Xu, Lujun Wang, Bingchuan Xue, Shoufeng Wang
Background: The role of Methylene tetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in the efficacy and toxicity of MTX-based therapy remains uncertain. Our purpose was to clarify whether these two polymorphisms are associated with the outcome of chemotherapy in a cohort of Chinese osteosarcoma (OS) patients treated by high-dose MTX. Methods: 109 OS patients who had sequentially received high-dose MTX therapy were included in this study. Plasma MTX level was measured routinely at 0, 24, 48 and 72 h after the administration of MTX...
November 2018: Journal of Bone Oncology
Gaëlle Couraud, Gaston André-Pierre, Tulier Titien, Eymard Florent, Hourdille Alexia, Chevalier Xavier-Jean, Hélene Boussion, Guignard Sandra
Objective: To study the effect on pain of per-cutaneous cementoplasty for painful extraspinal bone metastasis. Method: 43 patients with extraspinal bone metastasis were included between April 2006 and October 2014 in this retrospective monocenter study. The primary endpoint was pain level measured on a 0-10 numeric rating scale at week 1 after cementoplasty as compared with pre-cementoplasty. Secondary endpoints were long-term pain level and impact on quality of life and disability...
November 2018: Journal of Bone Oncology
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