journal
https://read.qxmd.com/read/38645832/an-urgent-call-for-studies-that-address-the-cardiovascular-consequences-of-legalization-of-marijuana
#1
REVIEW
Shereif H Rezkalla, Robert A Kloner
In about a decade, half of the United States has legalized marijuana for recreational use. The drug has been associated with acute myocardial infarction, acute stroke, congestive heart failure, and various cardiac arrythmias. Data have shown that legalization of the drug led to an increase of its use as well as an increase in tetra hydro cannabinoid positive tests in patients admitted to emergency departments. In Colorado, one of the earlier states to implement legalization, there was an increase in traffic accidents, suicide rates, and even total mortality...
April 2024: Cardiology Research
https://read.qxmd.com/read/38645831/insights-into-differences-in-pulmonary-hemodynamics-in-hispanic-patients-with-pulmonary-arterial-hypertension
#2
JOURNAL ARTICLE
Kahtan Fadah, Kedzie Arrington, Seyed Khalafi, Michael Brockman, Hernando Garcia, Haider Alkhateeb, Debabrata Mukherjee, Nils P Nickel
BACKGROUND: Emerging data suggest that Hispanic patients with pulmonary arterial hypertension (PAH) exhibit improved survival rates compared to individuals of other ethnicities with similar baseline hemodynamics. However, the underlying reasons for this survival advantage remain unclear. This study focused on comparing pulmonary hemodynamics in Hispanic and non-Hispanic PAH patients and how these differences may contribute to varied clinical outcomes. METHODS: A retrospective analysis of right heart catheterization data was conducted on a treatment-naive PAH patient cohort from a single center...
April 2024: Cardiology Research
https://read.qxmd.com/read/38645830/acetazolamide-and-hydrochlorothiazide-in-patients-with-acute-decompensated-heart-failure-insights-from-recent-trials
#3
REVIEW
Chukwuemeka A Umeh, Tamanna Mohta, Gagan Kaur, Roland Truong, Puja Darji, Chong Vue, Vijaya Bhargavi Cherukuri, Benson Eghreriniovo, Rahul Gupta
Acetazolamide and thiazide diuretics have been combined with loop diuretics to overcome diuretic resistance in heart failure patients. However, recent studies have assessed the upfront combination of acetazolamide and hydrochlorothiazide with loop diuretics in hospitalized patients with acute decompensated heart failure without loop diuretic resistance. We reviewed two recent randomized controlled trials on the upfront use of acetazolamide and thiazide diuretics in acute decompensated heart failure, respectively...
April 2024: Cardiology Research
https://read.qxmd.com/read/38645829/increased-cyclic-guanosine-monophosphate-and-interleukin-1beta-is-activated-by-mitochondrial-dysfunction-and-associated-with-heart-failure-in-atrial-fibrillation-patients
#4
JOURNAL ARTICLE
Juledezi Hailati, Zhi Qiang Liu, Yun Fei Zhang, Lei Zhang, Hasidaer Midilibieke, Xiang Li Ma, Muhuyati Wulasihan
BACKGROUND: This study aimed to identify the association of cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase-stimulator interferon genes (cGAS-STING) pathway with heart failure (HF) in atrial fibrillation (AF) patients. METHODS: We prospectively enrolled 106 AF patients without evidence of HF. The serum levels of 2'3'-cyclic GMP-AMP (2'3'-cGAMP) and interleukin (IL)-1β were measured by enzyme-linked immunoassay (ELISA). To determine the underlying mechanism, we supplemented the complex I inhibitor rotenone and the specific cGAS inhibitor RU...
April 2024: Cardiology Research
https://read.qxmd.com/read/38645828/optimizing-patient-selection-for-physiological-pacing-in-bradyarrhythmia-factors-associated-with-high-ventricular-pacing-burden
#5
JOURNAL ARTICLE
James Mannion, Kathryn L Hong, Amy Hennessey, Anna Cleary, Anand Subramaniyan, Conor Sheahan, Kathleen E Bennett, Richard Sheahan
BACKGROUND: Right ventricular (RV) pacing is established as the most common ventricular pacing (VP) strategy for patients with symptomatic bradyarrhythmia. Some patients with high VP burden suffer deterioration of left ventricular (LV) function, termed pacing-induced cardiomyopathy (PICM). Patients who pace > 20% of the time from the RV apex are at increased risk of PICM, but independent predictors of increased RV pacing burden have not been elucidated in those who have a permanent pacemaker (PPM) inserted for bradyarrhythmia...
April 2024: Cardiology Research
https://read.qxmd.com/read/38645827/definition-of-polypharmacy-in-heart-failure-a-scoping-review-of-the-literature
#6
REVIEW
Keshav Patel, Jorge A Irizarry-Caro, Adil Khan, Travis Holder, Darrell Salako, Parag Goyal, Min Ji Kwak
Patients with heart failure (HF) have a high prevalence of polypharmacy, which can lead to drug interactions, cognitive impairment, and medication non-compliance. However, the definition of polypharmacy in these patients is still inconsistent. The aim of this scoping review was to find the most common definition of polypharmacy in HF patients. We conducted a scoping review searching Medline, Embase, CINAHL, and Cochrane using terms including polypharmacy, HF and deprescribing, which resulted in 7,949 articles...
April 2024: Cardiology Research
https://read.qxmd.com/read/38645826/prevalence-of-aortic-root-pathologies-in-platypnea-orthodeoxia-syndrome-secondary-to-intra-cardiac-shunts
#7
JOURNAL ARTICLE
Omer Farooq, Usman Ghani, Harvey Friedman, Muhammad Sikander Akbar, Hammad Saudye, Sundus Alam, Muhammad Junaid Khan, Sumeet Mutti
BACKGROUND: Atrial septal defects can allow right to left shunting of venous blood which presents clinically as platypnea-orthodeoxia syndrome. It is believed that concomitant presence of aortic root pathologies increases the likelihood of shunting. METHODS: The study included a review of 510 articles listed in PubMed of patients with platypnea-orthodeoxia syndrome. Case reports of patients with extra-cardiac etiologies of platypnea-orthodeoxia were excluded. RESULTS: We reviewed 191 case reports, and 98 cases (51...
April 2024: Cardiology Research
https://read.qxmd.com/read/38645825/the-resurgence-of-flecainide
#8
EDITORIAL
John Somberg
No abstract text is available yet for this article.
April 2024: Cardiology Research
https://read.qxmd.com/read/38645824/impact-of-covid-19-pandemic-on-sex-and-racial-disparities-in-chest-pain-presentation-and-management-through-the-emergency-department
#9
JOURNAL ARTICLE
Xuchen Hu, Elias Fanous, Nicholas J Jackson, Gabrielle I Daso, Icy Liang, Lynnell B McCullough, Richelle J Cooper, Tamara B Horwich, Karol E Watson, Janki B Shah, Negeen Shahandeh, Marcella A Calfon Press
BACKGROUND: Sex and racial disparities in the presentation and management of chest pain persist, however, the impact of coronavirus disease 2019 (COVID-19) on these disparities have not been studied. We sought to determine whether the COVID-19 pandemic contributed to pre-existing sex and racial disparities in the presentation, management, and outcomes of patients presenting to the emergency department (ED) with chest pain. METHODS: We conducted an observational cohort study with retrospective data collection of patients between January 1, 2016, and May 1, 2022...
April 2024: Cardiology Research
https://read.qxmd.com/read/38464711/evaluation-of-the-existence-of-post-covid-19-tachycardia-in-a-community-healthcare-system
#10
JOURNAL ARTICLE
Jifeng Wang, Dhaval Patel, Shane Robinson, Ania Rynarzewska, Oluseyi Abidoye
BACKGROUND: Post-coronavirus disease 2019 (COVID-19) syndrome derives from lingering symptoms after an acute COVID-19 infection. Palpitation was one of the most common symptoms of post-COVID-19 syndrome that correlated with objective data such as persisting sinus tachycardia; but to our best knowledge, there is a scarcity of research regarding the association of COVID-19 and sinus tachycardia in the post-acute setting. Therefore, the purpose was to identify if there is an association between COVID-19 infection and sinus tachycardia in the post-acute phase, namely post-COVID-19 tachycardia (PCT) other than inappropriate sinus tachycardia (IST) and postural orthostatic tachycardia syndrome (POTS)...
February 2024: Cardiology Research
https://read.qxmd.com/read/38464710/characteristics-and-outcomes-of-atrial-fibrillation-in-chronic-heart-failure-patients-a-comprehensive-analysis-of-the-colombian-heart-failure-registry
#11
JOURNAL ARTICLE
Alex Rivera-Toquica, Clara Saldarriaga, Jannes Buelvas-Herazo, Balkis Rolong, Fernando Manzur-Jatin, Jose Ignacio Mosquera-Jimenez, Oscar Alfredo Pacheco-Jimenez, Alvaro Hernan Rodriguez-Ceron, Patricia Rodriguez-Gomez, Fernando Rivera-Toquica, Guillermo Trout-Guardiola G, Marco Antonio De Leon-Espitia, Edgar Eduardo Castro-Osorio, Luis Eduardo Echeverria, Juan Esteban Gomez-Mesa
BACKGROUND: Heart failure (HF) and atrial fibrillation (AF) represent conditions that commonly coexist. The impact of AF in HF has yet to be well studied in Latin America. This study aimed to characterize the sociodemographic and clinical features, along with patients' outcomes with AF and HF from the Colombian Heart Failure Registry (RECOLFACA). METHODS: Patients with ambulatory HF and AF were included in RECOLFACA, mainly with persistent or permanent AF. A 6-month follow-up was performed...
February 2024: Cardiology Research
https://read.qxmd.com/read/38464709/partial-pressure-of-end-tidal-oxygen-and-blood-lactate-during-cardiopulmonary-exercise-testing-in-healthy-older-participants-and-patients-at-risk-of-cardiac-disease
#12
JOURNAL ARTICLE
Kazuyuki Kominami, Masatoshi Akino
BACKGROUND: The partial pressure of end-tidal oxygen (PETO2 ) and end-tidal oxygen concentration (ETO2 ) are among the indices that can be measured by exhaled gas analysis. Several observational studies have shown that skeletal muscle function is impaired in patients with cardiac disease; thus, the assessment of skeletal muscle function is important. Additionally, although it has recently been suggested that the difference in PETO2 from rest to the ventilatory anaerobic threshold (VAT) reflects oxygen availability in peripheral factors, primarily skeletal muscle, the evidence for this is not well established...
February 2024: Cardiology Research
https://read.qxmd.com/read/38464708/improving-respiratory-muscle-strength-and-overall-function-in-patients-with-cardiovascular-disease-through-rehabilitation-hospitals
#13
JOURNAL ARTICLE
Tomohiro Matsuo, Tomoyuki Morisawa, Takuro Ohtsubo, Katsuhiro Ueno, Shuichi Kozawa
BACKGROUND: The prevalence of respiratory sarcopenia and its effect on respiratory muscle strength (RMS) in patients with cardiovascular disease (CVD), who are transferred to a convalescent rehabilitation hospital after acute care and require continuous cardiac rehabilitation (CR), is currently unclear. This study aimed to assess changes in RMS, physical function, and activities of daily living (ADL) before and after CR performed in a rehabilitation hospital. METHODS: Of 50 consecutive patients transferred to a rehabilitation hospital for ongoing CR, 30 fulfilled the inclusion criteria...
February 2024: Cardiology Research
https://read.qxmd.com/read/38464707/pulse-of-progress-a-systematic-review-of-glucagon-like-peptide-1-receptor-agonists-in-cardiovascular-health
#14
REVIEW
Michael Sabina, M Mrhaf Alsamman
According to the World Health Organization (WHO), the prevalence of type 2 diabetes mellitus (T2DM) and obesity has increased globally over the past 50 years, affecting over 500 million adults worldwide in 2023. A novel class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as a beacon of hope in treating the pandemic of diabetes and obesity. This analysis' objective was to draw comparisons of how these medications reduce cardiovascular outcomes. The review revealed unique differences in GLP-1s, highlighting some of their strengths and weaknesses and which populations they can cater to preferentially...
February 2024: Cardiology Research
https://read.qxmd.com/read/38464706/hemodynamic-response-to-exercise-training-in-heart-failure-with-reduced-ejection-fraction-patients
#15
JOURNAL ARTICLE
Marine Kirsch, Marie-Christine Iliou, Damien Vitiello
BACKGROUND: Supervised exercise training decreases total and cardiac mortality and increases quality of life of heart failure with reduced ejection fraction (HFrEF) patients. However, response to training is variable from one patient to another and factors responsible for a positive response to training remain unclear. The aims of the study were to compare cardiac hemodynamic changes after an exercise training program in responders (R) versus non-responders (NR) HFrEF patients, and to compare different discriminators used to assess response to training...
February 2024: Cardiology Research
https://read.qxmd.com/read/38464705/preliminary-experience-with-remimazolam-for-procedural-sedation-and-as-an-adjunct-to-general-anesthesia-during-diagnostic-and-interventional-cardiac-procedures
#16
JOURNAL ARTICLE
Holly Gillis, Christopher McKee, Kristin Chenault, Marco Corridore, Joseph D Tobias
BACKGROUND: Remimazolam is a benzodiazepine which, like midazolam, has sedative, anxiolytic, and amnestic properties. Ester metabolism results in a half-life of 5 - 10 min, a limited context sensitive half-life, and rapid recovery when the infusion is discontinued. METHODS: Following the Institutional Review Board (IRB) approval, we performed a retrospective chart review of patients who received remimazolam in the cardiac catheterization, cardiac magnetic resonance imaging (MRI), and electrophysiology suites...
February 2024: Cardiology Research
https://read.qxmd.com/read/38187515/inhibition-of-the-stim1-orai1-signaling-pathway-by-glycine-betaine-mitigates-myocardial-hypertrophy-in-spontaneous-hypertension-rats
#17
JOURNAL ARTICLE
Bing Xiao, Yan Zhao, Ke Ke Wang, Xiu Chun Yang, Hai Juan Hu, Yue Li, Yun Fei Xu, Zhen Tian Zhang, Shuai Wang, Jing Chao Lu
BACKGROUND: Spontaneous hypertension is a leading risk factor for cardiovascular diseases morbidity and mortality. Glycine betaine (GB) is a natural vitamin that has the potential to lower blood pressure. This work attempted to investigate the role and mechanisms of GB in spontaneous hypertension. METHODS: Spontaneously hypertensive rats (SHRs) were administrated with 100, 200, or 400 mg/kg of GB by gavage or combined with by injection of lentivirus-mediated STIM1 overexpression vector...
December 2023: Cardiology Research
https://read.qxmd.com/read/38187514/pulseless-electrical-activity-and-perioperative-cardiac-arrest-due-to-undiagnosed-and-asymptomatic-hypothyroidism-during-outpatient-surgery-in-an-adolescent
#18
Josiane Kerbage, Olamide O Dairo, Lauren Ketchum, Craig Smith, Joseph D Tobias
Commonly identified risk factors for perioperative cardiac arrest in pediatric-aged patients include cardiac surgery, younger age, comorbid conditions including pulmonary hypertension and cyanotic congenital heart disease, and emergency surgery. Although medication-related etiologies formerly predominated, the elimination of halothane from anesthetic care has resulted in a shift in etiology to hemodynamic events related to blood loss or hyperkalemia associated with the rapid administration of blood products...
December 2023: Cardiology Research
https://read.qxmd.com/read/38187513/the-association-between-non-clinically-apparent-liver-fibrosis-and-pulmonary-arterial-hypertension-in-hispanic-patients
#19
JOURNAL ARTICLE
M Ammar Kalas, Yacoub Khatab, Gian Galura, Haider Alkhateeb, Debabrata Mukherjee, Hernando Garcia, Marc Zuckerman, Nils Patrick Nickel
BACKGROUND: Pulmonary arterial hypertension (PAH) is a deadly cardiopulmonary disease with multi-organ involvement including impaired liver function. Liver dysfunction in PAH is poorly understood but significantly associated with morbidity and mortality. Hispanics have a significantly higher prevalence of non-alcoholic fatty liver disease (NAFLD) and evidence of more advanced disease in comparison to other ethnic groups. The clinical impact of NAFLD in Hispanic PAH patients is unknown...
December 2023: Cardiology Research
https://read.qxmd.com/read/38187512/left-anterior-descending-artery-dissection-in-a-female-patient-with-history-of-chest-radiation-treatment-and-separate-ostia-of-the-left-coronary-arteries
#20
Christos Papageorgiou, Vaios Tzifos
Obstructive and flow limiting coronary artery dissections can be a catastrophic clinical scenario, requiring urgent treatment and tailored approach for each case. A 55-year-old female patient, with a history of breast cancer, chest radiation treatments and hypertension presented with episodes of angina and significant area of reversible ischemia on single-photon emission computerized tomography (SPECT). Coronary angiogram revealed separate ostia of the left coronary arteries and three-vessel disease (SYNTAX (Synergy between percutaneous coronary intervention (PCI) with Taxus and Cardiac Surgery) = 15); subsequent full revascularization was achieved successfully with two drug-eluting stents (DES) (mid left anterior descending artery (LAD), left circumflex coronary artery (LCx)) and one drug-coated balloon (posterior descending artery (PDA))...
December 2023: Cardiology Research
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