journal
MENU ▼
Read by QxMD icon Read
search

Central-European Journal of Immunology

journal
https://read.qxmd.com/read/30588179/rosai-dorfman-disease-as-a-rare-cause-of-cervical-lymphadenopathy-case-report-and-literature-review
#1
REVIEW
Aleksandra Miękus, Joanna Stefanowicz, Grażyna Kobierska-Gulida, Elżbieta Adamkiewicz-Drożyńska
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy, is a rare, benign clinical entity of unknown cause. RDD is characterised by the overproduction and accumulation of histiocytes, primarily in the lymph nodes, although it may affect every organ and system. It predominantly affects children and young adults. Typically, patients are in good general condition, with massive cervical lymphadenopathy and fever. In about 40% of cases extranodal localisation of RDD is diagnosed...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588178/specific-humoral-immunity-in-osteichthyes
#2
REVIEW
Michał P Stosik, Beata Tokarz-Deptuła, Wiesław Deptuła
The fish immune system is extremely complex and has considerable adaptive potential. In Osteichthyes, the system is formed by lymphopoietic organs which are important for the differentiation and maturation of the immune system cells. These organs include the anterior kidney (phronephros), the thymus, the spleen, the posterior kidney (mesonephros), and mucosa-associated lymphoid tissues (MALT). Apart from the lymphocytic organs and the MALT system, the immune system components include defensive cells and their products...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588177/the-immunological-implication-of-the-new-vitamin-d-metabolism
#3
REVIEW
Giulia Bivona, Luisa Agnello, Marcello Ciaccio
Vitamin D is a neuro-hormone regulating calcium-phosphate homeostasis, cell proliferation, and immunomodulation. Exogenous and endogenous vitamin D is inactive, and two hydroxylations are required to produce the active hormone. The first hydroxylation is unique to the liver, while the second step occurs in kidney, brain, lung, prostate, placenta, and immune cells. Kidney-derived calcitriol regulates calcium homeostasis. Active hormone produced by brain and immune cells mediates immune system response; lung calcitriol is involved in fighting respiratory tract infections; finally, prostate and placenta vitamin D regulates cells growth and proliferation within such tissues...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588176/micrornas-in-pancreatic-cancer-diagnosis-and-therapy
#4
REVIEW
Robert Słotwiński, Gustaw Lech, Sylwia Małgorzata Słotwińska
Pancreatic cancer remains a disease with very poor prognosis (only 5-6% of patients are still alive after five years). Attempts to improve the results of treatment of pancreatic cancer focus on a better understanding of the pathogenesis, and non-invasive diagnostic methods (genetic testing from peripheral blood), which would create the possibility of early diagnosis and early surgical treatment before the onset of metastasis. New hopes for the improvement of early diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC) are associated with genetic testing of microRNA expression changes...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588175/diversity-of-dendritic-cells-generated-from-umbilical-cord-or-adult-peripheral-blood-precursors
#5
Magdalena Szaryńska, Krzysztof Preis, Piotr Zabul, Zbigniew Kmieć
Following the discovery of methods to generate large numbers of specific dendritic cells (DCs) ex vivo, the possibility of exploiting these cells in immunotherapeutic strategies will become a reality. It seems to be rationally to analyse the influence of the precursor source for further features and applications. For the needs of the given project DCs were derived from precursors derived from adult peripheral blood (APB) and umbilical cord blood (UCB). During some expansions of UCB CD34+ cells were separated giving non-adherent DCs (NA-DCs) or adherent DCs (A-DCs), whereas DCs derived from UCB precursors without separation gave rise to All-DCs...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588174/serum-adiponectin-as-a-predictor-of-laboratory-response-to-anti-tnf-%C3%AE-therapy-in-rheumatoid-arthritis
#6
Dorota Sikorska, Rafał Rutkowski, Joanna Łuczak, Włodzimierz Samborski, Janusz Witowski
Introduction: While adiponectin is typically viewed as an anti-inflammatory mediator, such an activity of adiponectin in rheumatoid arthritis (RA) is not so obvious. In the present study we examined whether serum levels of adiponectin reflect the clinical phenotype of RA patients and/or correlate with severity of the disease and the response to anti-TNF- α therapy. Material and methods: Twenty-one female RA patients qualified to receive anti-TNF- α treatment were prospectively assessed before and after 12 weeks of therapy...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588173/correlation-of-interleukin-6-and-transforming-growth-factor-%C3%AE-1-with-peripheral-blood-regulatory-t-cells-in-rheumatoid-arthritis-patients-a-potential-biomarker
#7
Majid Khoshmirsafa, Farhad Seif, Nader Bagheri, Pezhman Beshkar, Mohammad Mousavi, Hedayatollah Shirzad
Introduction: Proinflammatory cytokines and regulatory T cells (Tregs) are considered as important factors involved in autoimmunity development especially in rheumatoid arthritis (RA). Aim of the study: To investigate the frequency of peripheral blood Tregs and related cytokines in RA patients and to determine the possible correlation between Treg percentage and interleukin 6 (IL-6) and transforming growth factor β 1 (TGF- β 1) as indicators in assessment of Treg function and mechanisms preceding autoimmunity in RA...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588172/serum-carbonic-anhydrase-i-and-ii-autoantibodies-in-patients-with-chronic-lymphocytic-leukaemia
#8
Ahmet Mentese, Nergiz Erkut, Selim Demir, Serap Ozer Yaman, Aysegul Sumer, Mehmet Erdem, Ahmet Alver, Mehmet Giray Sönmez
Cancer is the second most important cause of mortality, and millions of people either have or have had the disease. Leukaemia is one of the most common forms of cancer. Autoantibodies that have developed against the organism's self-antigens are detected in the sera of subjects with cancer. In recent years carbonic anhydrase (CA) autoantibodies have been determined in some autoimmune diseases and carcinomas, but the mechanisms underlying this immune response have not yet been fully explained. The purpose of this study was to determine CA I and II autoantibodies in subjects with chronic lymphocytic leukaemia (CLL) and to provide a novel perspective regarding the autoimmune basis of the disease...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588171/no-effect-of-anti-tnf-%C3%AE-treatment-on-serum-il-17-in-patients-with-rheumatoid-arthritis
#9
Dorota Sikorska, Rafał Rutkowski, Joanna Łuczak, Włodzimierz Samborski, Janusz Witowski
Introduction: Interleukin 17 (IL-17) and CC-chemokine ligand 20 (CCL20) are increasingly implicated in the pathogenesis of rheumatoid arthritis (RA). A correlation has been reported to exist between serum levels of IL-17 and CCL20 and the disease activity. However, such an effect has not been universally demonstrated. The aim of the present study was to investigate if serum levels of IL-17 and/or CCL20 reflect the disease activity and response to anti-TNF- α therapy in patients with RA...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588170/utility-of-leucocyte-antigens-in-distinguishing-between-bacterial-and-viral-infection-in-children
#10
Anna Stelmaszczyk-Emmel, Anna Sosnowska, Justyna Kurkowiak, Magdalena Sagała, Lidia Zawadzka-Głos, Beata PyrŻak, Urszula Demkow
Introduction: Accurate diagnosis of bacterial and viral infection is very difficult. Unfortunately, there is still no quick and discriminative diagnostic test that would help clinicians in establishing the diagnosis and taking a decision on treatment. The aim of the study was to compare the expression of antigens on phagocytes, which are involved in the first defence line during bacterial and viral infections in children, as a potential tool to distinguish the etiology of the infection...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588169/thyroid-function-in-children-with-growth-hormone-deficiency-during-long-term-growth-hormone-replacement-therapy
#11
Ewelina Witkowska-Sędek, Ada Borowiec, Anna Majcher, Maria Sobol, Małgorzata Rumińska, Beata Pyrżak
Aim of the study: The aim of this study was to investigate the effects of growth hormone (GH) therapy on thyroid function in a group of euthyroid children with isolated idiopathic growth hormone deficiency (GHD). Material and methods: The study was retrospective and included 117 children treated with GH for 1-4 years. Anthropometric measurements and serum concentrations of insulin-like growth factor-1 (IGF-1), thyroid-stimulating hormone (TSH), and free thyroxine (fT4) were analysed at baseline and during GH therapy...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588168/lymphocyte-subgroups-and-recurrent-infections-in-children-with-down-syndrome-a-prospective-case-control-study
#12
Maha Mitwalli, Yahya Wahba, Ali Shaltout, Mona Gouida
Down syndrome (DS) is the commonest genetic disorder and more liable for recurrent infections. We aimed to determine the differences in lymphocyte subgroups between DS children and the healthy population and to study the pattern and likelihood for recurrent infections and hospital admission due to infection. Our study was carried out in the Genetic Unit of Mansoura University Children's Hospital, Egypt. The study enrolled 150 DS (DS group) and 100 controls (CG group). They were assessed for recurrent infections (including tonsillitis, otitis media [OM], pneumonia, upper respiratory tract infections [URTI], sinusitis, and gastroenteritis [GE]) and hospital admission due to infections...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30588167/influence-of-trans-resveratrol-on-macrophage-and-lymphocyte-activity-in-rainbow-trout-oncorhynchus-mykiss-in-vitro-study
#13
Elżbieta Terech-Majewska, Andrzej Krzysztof Siwicki, Sylwia Hermańska, Edyta Kaczorek-Łukowska, Joanna Pajdak-Czaus, Patrycja Schulz
The objective of this study was to investigate the effect of trans-resveratrol, a potent antioxidant with anti-inflammatory and chemopreventive properties, naturally occurring in many fruits and plants on lymphocytes proliferation and also on macrophages metabolic and phagocytic activity. The aim of this study was to demonstrate the immunomodulatory effects of the compound on fish immunocompetent cells and determine the type of this interaction (immunosuppression or immunostimulation). Proliferative activity of lymphocytes was studied by MTT assay, and the respiratory burst was evaluated using the respiratory burst activity (RBA) test...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30135638/changes-in-the-immune-system-the-key-to-diagnostics-and-therapy-of-patients-with-non-alcoholic-fatty-liver-disease
#14
REVIEW
Marcin Kosmalski, Łukasz Mokros, Piotr Kuna, Andrzej Witusik, Tadeusz Pietras
Non-alcoholic fatty liver disease (NAFLD) is one of the most common pathologies of that organ. The development of the disease involves a variety of mechanisms, including insulin resistance, oxidative stress, endoplasmic reticulum stress, endotoxins from the intestinal flora and genetic predispositions. Additionally, clinical data suggest that the presence of NAFLD is associated with excessive activation of the immune system. For practical purposes, attention should be paid to the moment when the subjects predisposed to NAFLD develop inflammatory infiltration and signs of fibrosis in the liver (non-alcoholic steatohepatitis - NASH)...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30135637/can-components-of-the-plasminogen-activation-system-predict-the-outcome-of-kidney-transplants
#15
REVIEW
Jerzy Jankun, Omar A Khan, Hesham I Mostafa, Puneet Sindhwani, Ewa Skrzypczak-Jankun
Proteolytic and antiproteolytic enzymes play a critical role in the physiology and pathology of different stages of human life. One of the important members of the proteolytic family is the plasminogen activation system (PAS), which includes several elements crucial for this review: the 50 kDa glycoprotein plasminogen activator inhibitor 1 (PAI-1) that inhibits tissue-type (tPA) and urokinase-type plasminogen activator (uPA). These two convert plasminogen into its active form named plasmin that can lyse a broad spectrum of proteins...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30135636/the-role-of-pharmacogenetics-of-cytochrome-p450s-in-phenytoin-induced-dress-syndrome
#16
REVIEW
Ümit Yaşar
Anil et al. (2017) report a patient who presented with drug rash with eosinophilia and systemic symptom (DRESS) syndrome. It may be induced by various drugs. In the mentioned report DRESS syndrome has been attributed to phenytoin use. CYP2C9 is a genetically polymorphic enzyme, and decreased metabolism of many drugs has been reported in the subjects carrying variants of rs1799853 and rs1057910, which were designated as CYP2C9*2 and *3. rs3758581, the variant investigated by Anil et al., is a genetic variant of CYP2C19 (not that of CYP2C9, as stated and discussed in the report)...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30135635/antigenic-and-immunogenic-properties-of-chondrocytes-implications-for-chondrocyte-therapeutic-transplantation-and-pathogenesis-of-inflammatory-and-degenerative-joint-diseases
#17
REVIEW
Anna Osiecka-Iwan, Anna Hyc, Dorota M Radomska-Lesniewska, Adrian Rymarczyk, Piotr Skopinski
In physiological conditions chondrocytes are protected from contact with immunocompetent cells by the extracellular matrix, and transplanted fragments of allogeneic cartilage are not rejected. Cartilage produced by allogeneic chondrocytes, however, evokes the immune response of the recipient and is gradually destroyed. Immunisation by allogeneic chondrocytes is induced by the contact of their surface molecules with cells of the immune system. Chondrocytes constitutively express class I and, in some species, class II major histocompatibility complex (MHC) molecules...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30135634/igg4-related-disease-why-is-it-so-important
#18
REVIEW
Marta Legatowicz-Koprowska
IgG4-related disease (IgG4-RD) is a recently defined systemic inflammatory and fibrous condition of unknown etiology and multiple clinical presentations. Characteristic features include elevated serum IgG4 levels in approximately 70% of patients; diffuse lymphoplasmocytic infiltrates rich in IgG4(+) cells; a "storiform" fibrosis pattern; and obliterative phlebitis affecting various organs. The disease responds well to corticosteroid treatment, with a second-line therapy involving B-cell-directed immunosuppressive biologic agents...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30135633/immunological-memory-cells
#19
REVIEW
Weronika Ratajczak, Paulina Niedźwiedzka-Rystwej, Beata Tokarz-Deptuła, Wiesław Deptuła
This article reviews immunological memory cells, currently represented by T and B lymphocytes and natural killer (NK) cells, which determine a rapid and effective response against a second encounter with the same antigen. Among T lymphocytes, functions of memory cells are provided by their subsets: central memory, effector memory, tissue-resident memory, regulatory memory and stem memory T cells. Memory T and B lymphocytes have an essential role in the immunity against microbial pathogens but are also involved in autoimmunity and maternal-fetal tolerance...
2018: Central-European Journal of Immunology
https://read.qxmd.com/read/30135632/changes-in-chosen-immune-system-indicators-and-the-level-of-hsp-70-after-single-whole-body-cryostimulation-in-healthy-men
#20
Barbara Szpotowicz-Czech, Magdalena Wiecek, Jadwiga Szymura, Marcin Maciejczyk, Zbigniew Szygula
Aim of the study: The aim of our research was to examine the influence of single whole-body cryostimulation (WBC) on chosen immune system indicators including the heat shock protein HSP-70. Material and methods: The study was carried out among ten young and healthy men (mean age 22.4 ±1.65, with a body mass index of 22.91 ±2.39 kg/m2 ). The participants were subjected to single whole-body cryostimulation (at -130°C temperatures) in a special cryogenic chamber for 3 minutes...
2018: Central-European Journal of Immunology
journal
journal
49731
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"