journal
https://read.qxmd.com/read/38596788/advancements-in-acne-detection-application-of-the-centernet-network-in-smart-dermatology
#61
JOURNAL ARTICLE
Daojun Zhang, Huanyu Li, Jiajia Shi, Yue Shen, Ling Zhu, Nianze Chen, Zikun Wei, Junwei Lv, Yu Chen, Fei Hao
INTRODUCTION: Acne detection is critical in dermatology, focusing on quality control of acne imagery, precise segmentation, and grading. Traditional research has been limited, typically concentrating on singular aspects of acne detection. METHODS: We propose a multi-task acne detection method, employing a CenterNet-based training paradigm to develop an advanced detection system. This system collects acne images via smartphones and features multi-task capabilities for detecting image quality and identifying various acne types...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38596787/critical-bloodstream-infection-caused-by-chromobacterium-violaceum-a-case-report-in-a-15-year-old-male-with-sepsis-induced-cardiogenic-shock-and-purpura-fulminans
#62
Xueqing Wang, Yunliang Tu, Yingqun Chen, Huilin Yang, Minghua Luo, Yanyan Li, Lei Huang, Hua Luo
Chromobacterium violaceum ( C. violaceum ) is a gram-negative bacillus that is widespread in tropical and subtropical areas. Although C. violaceum rarely infects humans, it can cause critical illness with a mortality rate above 50%. Here, we report the successful treatment of a 15-year-old male who presented with bloodstream infection of C. violaceum along with sepsis, specific skin lesions, and liver abscesses. Cardiogenic shock induced by sepsis was reversed by venoarterial extracorporeal membrane oxygenation (VA ECMO)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38596786/case-report-a-novel-col3a1-variant-in-a-colombian-patient-with-isolated-cerebrovascular-involvement-in-vascular-ehlers-danlos-syndrome
#63
Valeria Valencia-Cifuentes, Stiven Ernesto Sinisterra-Díaz, Valentina Quintana-Peña, Edgar Folleco, José A Nastasi-Catanese, Harry Pachajoa, Juan P Fernández-Cubillos
INTRODUCTION: To date, approximately 600 unique pathogenic variants have been reported in COL3A1 associated with vascular Ehlers-Danlos syndrome (vEDS). The objective of this study was to describe a patient with a novel variant in COL3A1 associated with vEDS. CASE REPORT: We describe the clinical history and thorough phenotyping of a patient with brain aneurysms and identified a novel pathogenic variant in COL3A1 . This male patient reported transient focal neurologic symptoms...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38596785/erratum-expression-of-concern-on-comparative-genomics-and-characterization-of-sars-cov-2-p-1-gamma-variant-of-concern-from-amazonas-brazil
#64
(no author information available yet)
[This corrects the article DOI: 10.3389/fmed.2022.806611.].
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590321/evaluating-an-obstetrics-and-gynecology-teaching-program-for-medical-students-incorporating-simulation-based-education-underpinned-by-cognitive-load-theory
#65
JOURNAL ARTICLE
William Atiomo, Farah Ennab, Adrian Stanley, Mutairu Ezimokhai
Although there have been previous publications on curriculum innovations in teaching O&G to medical students, especially utilizing simulation-based education, there have been none, as far as we know, incorporating and evaluating the outcomes using cognitive load theory. The aim of this article was to describe the introduction, implementation, and evaluation of an innovative teaching program in O&G, incorporating simulation-based education, underpinned by cognitive load theory. Cognitive load is defined as the amount of information a working memory can hold at any one time and incorporates three types of cognitive load-intrinsic, extraneous, and germane...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590320/diagnostic-yield-of-fap-guided-positron-emission-tomography-in-thyroid-cancer-a-systematic-review
#66
Alessio Rizzo, Domenico Albano, Francesco Dondi, Martina Cioffi, Barbara Muoio, Salvatore Annunziata, Manuela Racca, Francesco Bertagna, Arnoldo Piccardo, Giorgio Treglia
BACKGROUND: Several recent studies have proposed the possible application of positron emission tomography/computed tomography (PET/CT) administering radiolabelled fibroblast-activation protein (FAP) inhibitors for various forms of thyroid cancer (TC), including differentiated TC (DTC), and medullary TC (MTC). METHODS: The authors conducted an extensive literature search of original studies examining the effectiveness of FAP-guided PET/CT in patients with TC. The papers included were original publications exploring the use of FAP-targeted molecular imaging in restaging metastatic DTC and MTC patients...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590319/editorial-multimorbidity-in-primary-care
#67
EDITORIAL
Stefan Essig, Sanghamitra Pati
No abstract text is available yet for this article.
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590318/exploring-the-association-between-serum-phosphate-levels-and-mortality-in-patients-hospitalized-with-infectious-diseases-a-nationwide-study
#68
JOURNAL ARTICLE
Amit Frenkel, Adi Shiloh, Victoria Vinokur, Matthew Boyko, Yair Binyamin, Jacob Dreiher
OBJECTIVE: The purpose of this study was to examine associations of serum phosphate levels with mortality, target organ damage and length of hospital stay in adults with infectious diseases hospitalized outside of the intensive care unit. METHODS: This nationwide retrospective cohort study comprised patients admitted with infections, to medical and surgical departments in eight tertiary hospitals during 2001-2020. The main exposure variable was the first serum phosphate levels at admission (up to 1 week)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590317/exploring-primary-care-physicians-challenges-in-using-home-blood-pressure-monitoring-to-manage-hypertension-in-singapore-a-qualitative-study
#69
JOURNAL ARTICLE
Aminath Shiwaza Moosa, Prawira Oka, Chirk Jenn Ng
OBJECTIVE: Hypertension guidelines recommend using home blood pressure (HBP) to diagnose, treat and monitor hypertension. This study aimed to explore the challenges primary care physicians (PCPs) face in using HBP to manage patients with hypertension. METHOD: A qualitative study was conducted in 2022 at five primary care clinics in Singapore. An experienced qualitative researcher conducted individual in-depth interviews with 17 PCPs using a semi-structured interview guide...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590316/association-between-early-spontaneous-abortion-and-homocysteine-metabolism
#70
JOURNAL ARTICLE
Fangliang Lei, Lili Zhang, Li Wang, Wentao Wu, Fei Wang
OBJECTIVE: The purpose of this study is to explore the effects of homocysteine (HCY) metabolism and related factors on early spontaneous abortion. METHODS: We conducted a hospital-based case-control study and included a total of 500 cases and 1,000 controls in Shaanxi China. Pregnant women waiting for delivery in the hospital were interviewed to report their characteristics and other relevant information during pregnancy. The unconditional Logisitic regression model was applied to assess the association between early spontaneous abortion and HCY metabolism and related factors...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590315/mechanisms-of-ferroptosis-in-nonalcoholic-fatty-liver-disease-and-therapeutic-effects-of-traditional-chinese-medicine-a-review
#71
REVIEW
Nan Wang, Hanyun Que, Qiulin Luo, Wenxin Zheng, Hong Li, Qin Wang, Jian Gu
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive accumulation of fat in hepatocytes (nonalcoholic fatty liver (NAFL)), and lobular inflammation and hepatocyte damage (which characterize nonalcoholic steatohepatitis (NASH) are found in most patients). A subset of patients will gradually develop liver fibrosis, cirrhosis, and eventually hepatocellular carcinoma, which is a deadly disease that threatens human life worldwide. Ferroptosis, a novel nonapoptotic form of programmed cell death (PCD) characterized by iron-dependent accumulation of reactive oxygen radicals and lipid peroxides, is closely related to NAFLD...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590314/interplay-of-cytokines-in-the-pathophysiology-of-atopic-dermatitis-insights-from-murin-models-and-human
#72
REVIEW
Yuto Yamamura, Chisa Nakashima, Atsushi Otsuka
The pathogenesis of atopic dermatitis (AD) is understood to be crucially influenced by three main factors: dysregulation of the immune response, barrier dysfunction, and pruritus. In the lesional skin of AD, various innate immune cells, including Th2 cells, type 2 innate lymphoid cells (ILC2s), and basophils, produce Th2 cytokines [interleukin (IL)-4, IL-5, IL-13, IL-31]. Alarmins such as TSLP, IL-25, and IL-33 are also produced by epidermal keratinocytes, amplifying type 2 inflammation. In the chronic phase, not only Th2 cells but also Th22 and Th17 cells increase in number, leading to suppression of filaggrin expression by IL-4, IL-13, and IL-22, which further deteriorates the epidermal barrier function...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590313/the-role-of-pi3k-akt-signaling-pathway-in-attenuating-liver-fibrosis-a-comprehensive-review
#73
REVIEW
Emad Shamsan, Maged Almezgagi, Mohammed Gamah, Naveed Khan, Abdulkareem Qasem, Liu Chuanchuan, Fan Haining
Excessive accumulation of extracellular matrix (ECM) components within the liver leads to a pathological condition known as liver fibrosis. Alcohol abuse, non-alcoholic fatty liver disease (NAFLD), autoimmune issues, and viral hepatitis cause chronic liver injury. Exploring potential therapeutic targets and understanding the molecular mechanisms involved in liver fibrosis are essential for the development of effective interventions. The goal of this comprehensive review is to explain how the PI3K/AKT signaling pathway contributes to the reduction of liver fibrosis...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38590312/comparison-of-combined-intravenous-and-inhalation-anesthesia-and-total-intravenous-anesthesia-in-laparoscopic-surgery-and-the-identification-of-predictive-factors-influencing-the-delayed-recovery-of-neurocognitive-function
#74
JOURNAL ARTICLE
Teng Song, Li-Jun Wu, Li Li
BACKGROUND: Compare the anesthesia effects of combined intravenous and inhalation anesthesia (CIVIA) and total intravenous anesthesia (TIVA) in laparoscopic surgery. Furthermore, our objective is to examine the elements that contribute to the delay in postoperative recovery of neurocognitive function and anticipate the manifestation of delayed recovery by analyzing serum cytokines. METHODS: The CIVIA group and the TIVA group both consisted of 130 patients who were scheduled to have elective major abdominal surgery through laparoscopy...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38585154/accuracy-of-an-artificial-intelligence-as-a-medical-device-as-part-of-a-uk-based-skin-cancer-teledermatology-service
#75
JOURNAL ARTICLE
Helen Marsden, Polychronis Kemos, Marcello Venzi, Mariana Noy, Shameera Maheswaran, Nicholas Francis, Christopher Hyde, Daniel Mullarkey, Dilraj Kalsi, Lucy Thomas
INTRODUCTION: An artificial intelligence as a medical device (AIaMD), built on convolutional neural networks, has demonstrated high sensitivity for melanoma. To be of clinical value, it needs to safely reduce referral rates. The primary objective of this study was to demonstrate that the AIaMD had a higher rate of correctly classifying lesions that did not need to be referred for biopsy or urgent face-to-face dermatologist review, compared to teledermatology standard of care (SoC), while achieving the same sensitivity to detect malignancy...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38585153/impact-of-patient-centered-communication-on-patient-satisfaction-scores-in-patients-with-chronic-life-limiting-illnesses-an-experience-from-kenya
#76
JOURNAL ARTICLE
Betty Sirera, Violet Naanyu, Peter Kussin, David Lagat
BACKGROUND: Patient satisfaction remains a key area of interest worldwide; utilizing a patient-centered communication approach, particularly with patients with chronic life-limiting illnesses may be one way to achieve this. However, there is a dearth of empirical information on the effect of patient-centered communication strategies in patients with chronic life-limiting illnesses in Kenya on patient satisfaction. OBJECTIVES: The objective of this study was to assess the impact of patient-centered communication on patient satisfaction...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38585152/case-report-dengue-fever-associated-acute-macular-neuroretinopathy
#77
How-Chen Wang, Chia-Ching Lin, Chia-Hsin Chang, Jih-Jin Tsai
Dengue fever (DF), which is caused by the dengue virus (DENV) and transmitted through Aedes mosquitoes, is well recognized for its systemic manifestations, with its ocular involvement gaining recent attention. We present a case of a 41-year-old Taiwanese female who developed acute macular neuroretinopathy (AMN) following a DF diagnosis related to DENV-1, emphasizing the need for awareness of this complication. The patient, with a history of completely resolved optic neuritis (ON) and comorbidities, experienced blurred vision on day 10 after the onset of DF...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38585151/mepolizumab-and-benralizumab-in-patients-with-severe-asthma-and-a-history-of-eosinophilic-granulomatosis-with-polyangiitis
#78
JOURNAL ARTICLE
Charlene Desaintjean, Kaïs Ahmad, Julie Traclet, Mathieu Gerfaud-Valentin, Cecile-Audrey Durel, Jean-Charles Glerant, Arnaud Hot, François Lestelle, Sabine Mainbourg, Mouhamad Nasser, Pascal Seve, Ségolène Turquier, Gilles Devouassoux, Vincent Cottin
INTRODUCTION: Asthma associated with eosinophilic granulomatosis with polyangiitis (EGPA) is often severe and corticosteroid-dependent, leading to significant morbidity. Mepolizumab and benralizumab are humanized monoclonal antibodies targeting interleukin 5 (IL-5) and its receptor, respectively. They have been shown to be effective in steroid-sparing in patients with severe eosinophilic asthma. OBJECTIVE: Our aim was to evaluate the efficacy and safety of mepolizumab and benralizumab prescribed for severe asthma in patients with EGPA under "real-world" conditions...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38585150/evaluating-the-efficacy-of-a-standardized-4%C3%A2-ml-kg-fluid-bolus-technique-in-critically-ill-patients-with-elevated-p-va-co-2-secondary-analysis-of-two-prospective-studies
#79
JOURNAL ARTICLE
Rachid Attou, Thierry Du, Dimitrios Velissaris, Sebastien Redant, Mircea T Talpoș, Charalampos Pierrakos
BACKGROUND: Limiting the fluid bolus (FB) volume may attenuate side effects, including hemodilution and increased filling pressures, but it may also reduce hemodynamic responsiveness. The minimum volume to create hemodynamic effects is considered to be 4 mL/kg. In critically ill patients, the hemodynamic effects of FB with this volume have not been adequately investigated and compared to higher quantities. We hypothesized that a standardized FB approach using 4 mL/kg has comparable hemodynamic and metabolic effects to the common practice of physician-determined FB in critically ill patients...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38585149/serum-phosphate-levels-and-the-development-of-sepsis-associated-acute-kidney-injury-evidence-from-two-independent-databases
#80
JOURNAL ARTICLE
Yipeng Fang, Yuan Zhang, Xin Zhang
OBJECTIVE: We aimed to investigate the association between serum phosphate levels and the risk for developing sepsis associated acute kidney injury (SAKI). METHODS: Septic patients from the Medical Information Mart for Intensive Care IV (MIMIC IV) and the eICU Collaborative Research Database (eICU-CRD) were enrolled. Restricted cubic spline (RCS) was used to visualize the relationship between phosphate levels and the risk of SAKI. Patients were divided into four categories based on their serum phosphate levels...
2024: Frontiers in Medicine
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