journal
https://read.qxmd.com/read/38606162/physician-s-autonomy-in-the-face-of-ai-support-walking-the-ethical-tightrope
#1
JOURNAL ARTICLE
Florian Funer, Urban Wiesing
No abstract text is available yet for this article.
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606161/skin-barrier-inflammatory-pathway-is-a-driver-of-the-psoriasis-atopic-dermatitis-transition
#2
REVIEW
Sitan Dong, Dongmei Li, Dongmei Shi
As chronic inflammatory conditions driven by immune dysregulation are influenced by genetics and environment factors, psoriasis and atopic dermatitis (AD) have traditionally been considered to be distinct diseases characterized by different T cell responses. Psoriasis, associated with type 17 helper T (Th17)-mediated inflammation, presents as well-defined scaly plaques with minimal pruritus. AD, primarily linked to Th2-mediated inflammation, presents with poorly defined erythema, dry skin, and intense itching...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606160/drug-induced-hypersensitivity-syndrome-related-to-piperacillin-tazobactam-a-case-report-and-review-of-the-literature
#3
Ya Shen, Shun-Shun Cui, Xiao-Bao Teng, Ming-Feng Han
Allergic reactions to drugs caused by piperacillin-tazobactam are common in clinical practice. However, we also found a few cases of drug-induced hypersensitivity syndrome (DiHS)/Drug reaction with eosinophilia and systemic symptoms (DRESS) caused by piperacillin-tazobactam in our clinical work. We report a case of a 60-year-old female patient who was treated with piperacillin-tazobactam anti-infective therapy after the diagnosis of hematogenous lung abscess, developed fever, rash, and blood abnormalities after 26 days of application, and was later diagnosed as DIHS, which was improved after the administration of glucocorticoid and anti-allergic drugs...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606159/comprehensive-analysis-of-brain-injury-parameters-in-a-preclinical-porcine-model-of-acute-liver-failure
#4
JOURNAL ARTICLE
Philipp Felgendreff, Seyed M Hosseiniasl, Lisa Felgendreff, Bruce P Amiot, Anna Minshew, Boyukkhanim Ahmadzada, Zhi Qu, Silvana Wilken, Ines Arribas Gomez, Scott L Nyberg, Casey N Cook
INTRODUCTION: Acute liver failure (ALF) is defined as acute loss of liver function leading to hepatic encephalopathy associated with a high risk of patient death. Brain injury markers in serum and tissue can help detect and monitor ALF-associated brain injury. This study compares different brain injury parameters in plasma and tissue along with the progression of ALF. METHOD: ALF was induced by performing an 85% liver resection. Following the resection, animals were recovered and monitored for up to 48 h or until reaching the predefined endpoint of receiving standard medical therapy (SMT)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606158/editorial-reproducibility-and-rigour-in-rheumatology
#5
EDITORIAL
Augusto Silva, João Eurico Fonseca, Stephanie Finzel
No abstract text is available yet for this article.
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606157/innovative-research-methodologies-in-the-eu-regulatory-framework-an-analysis-of-ema-qualification-procedures-from-a-pediatric-perspective
#6
JOURNAL ARTICLE
Viviana Giannuzzi, Arianna Bertolani, Silvia Torretta, Giorgio Reggiardo, Eleonora Toich, Donato Bonifazi, Adriana Ceci
INTRODUCTION: The European Medicines Agency (EMA) offers scientific advice to support the qualification procedure of novel methodologies, such as preclinical and in vitro models, biomarkers, and pharmacometric methods, thereby endorsing their acceptability in medicine research and development (R&D). This aspect is particularly relevant to overcome the scarcity of data and the lack of validated endpoints and biomarkers in research fields characterized by small samples, such as pediatrics...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606156/myositis-associated-antibodies-predict-the-severity-of-lung-involvement-in-adult-patients-with-inflammatory-myositis-a-cohort-study-of-70-adult-patients-with-myositis-in-a-single-center
#7
JOURNAL ARTICLE
Josefin Marklund, Balsam Hanna, Tao Jin, Rille Pullerits
INTRODUCTION: Idiopathic inflammatory myopathies (IIMs) encompass a diverse group of diseases characterized by considerable variability in clinical manifestations, antibody profiles, and responsiveness to immunosuppressive therapies. This study aimed to investigate the association between organ involvement and distinct myositis autoantibodies in individuals with IIM in a single-center cohort. METHODS: Patients with ICD diagnoses M33.1, M33.2, M33.9, or M609 who (1) had been tested with Euroline blot assay for myositis autoantibodies and (2) met the classification criteria of definite/probable polymyositis (PM) or dermatomyositis (DM), anti-synthetase syndrome (ASS), or inclusion body myositis (IBM) were included...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606155/co-design-of-a-paediatric-oncology-medicines-database-procure-to-support-complex-care-provision-for-children-with-a-hard-to-treat-cancer
#8
JOURNAL ARTICLE
Carolyn G Mazariego, Skye McKay, Elijah Tyedmers, Lauren Kelada, Brittany C McGill, Rebecca Daly, Claire E Wakefield, David S Ziegler, Natalie Taylor
OBJECTIVES: Paediatric oncologists often encounter challenges when seeking compassionate access to off-label therapies for their patients. This study employed implementation science and co-design techniques to develop the ProCure medicines database, with the goal of streamlining the application process and addressing identified barriers in paediatric oncology. METHODS: This study utilised an exploratory qualitative research design. Seventeen healthcare providers, including oncologists, nurse consultants, and allied health professionals, participated in semi-structured interviews guided by the Consolidated Framework for Implementation Research (CFIR) and a visual process map aid...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606154/case-report-efficacy-of-icotinib-treatment-in-lung-adenocarcinoma-with-esophageal-squamous-cell-carcinoma-a-rare-case-of-double-primary-malignant-tumors
#9
Min Deng, Xiaoqing Li, Honghao Mu, Man Wei, Lan Sun
BACKGROUND: Lung adenocarcinoma with esophageal squamous cell carcinoma is rare and the prognosis is poor, therefore there is an urgent need to improve this situation. The objective of this study was to explore the effect of first-generation tyrosine kinase inhibitors (TKIs) in the patient of the double primary malignant tumors. CASE REPORT: We report a case of lung adenocarcinoma with esophageal squamous cell carcinoma treated by icotininb after five-year follow-up...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606153/potential-diagnostic-markers-shared-between-non-alcoholic-fatty-liver-disease-and-atherosclerosis-determined-by-machine-learning-and-bioinformatic-analysis
#10
JOURNAL ARTICLE
Lihong Wang, Wenhui He, Xilin Wang, Jianrong Wang, Xiaojuan Wei, Dongzhi Wu, Yundan Wu
BACKGROUND: Evidence indicates that chronic non-alcoholic fatty liver disease (NAFLD) can increase the risk of atherosclerosis (AS), but the underlying mechanism remains unclear. OBJECTIVE: This study is intended for confirming key genes shared between NAFLD and AS, and their clinical diagnostic value to establish a foundation for searching novel therapeutic targets. METHODS: We downloaded the Gene Expression Omnibus (GEO) datasets, GSE48452 and GSE89632 for NAFLD and GSE100927, GSE40231 and GSE28829 for AS...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606152/effects-of-general-and-spinal-anesthesia-on-postoperative-rehabilitation-in-older-adults-after-lower-limb-surgery-a-retrospective-cohort-study
#11
JOURNAL ARTICLE
Guifei Li, Qingjing Ma, Yizhen Li, Furong Tan, Xuan Li, Jie Chen
OBJECTIVE: To investigate the effects of perioperative general anesthesia (GA) and spinal anesthesia (SA) on postoperative rehabilitation in elderly patients with lower limb surgery. METHODS: This retrospective propensity score-matched cohort study included patients aged 65 years or older who underwent lower limb surgery between January 1, 2020, and May 31, 2023. The GA and SA were selected at the request of the orthopedic surgeon, patient, and their family members...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38606151/upadacitinib-sustained-release-tablets-for-the-treatment-of-chronic-refractory-gouty-arthritis-a-case-report-and-literature-review
#12
Lishi Yu, Weidong Huang, Honghua Lv, Lie Jin, Wenhui Lei
BACKGROUND: Gouty arthritis (GA) is a crystal-related joint disease caused by the deposition of monosodium urate (MSU) crystals, directly associated with hyperuricemia resulting from purine metabolism disorder and/or reduced uric acid excretion. Acute attacks of typical gouty arthritis are generally relieved through the clinical use of NSAIDs, colchicine, or glucocorticoids. However, managing patients with chronic refractory gout poses challenges due to complications such as multiple tophi, gouty nephropathy, diabetes, and gastrointestinal bleeding...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38601119/comparison-of-obgyn-postgraduate-curricula-and-assessment-methods-between-canada-and-the-netherlands-an-auto-ethnographic-study
#13
JOURNAL ARTICLE
Emma Paternotte, Marja Dijksterhuis, Angelique Goverde, Hanna Ezzat, Fedde Scheele
INTRODUCTION: Although the Dutch and the Canadian postgraduate Obstetrics and Gynecology (OBGYN) medical education systems are similar in their foundations [programmatic assessment, competency based, involving CanMED roles and EPAs (entrustable professional activities)] and comparable in healthcare outcome, their program structures and assessment methods considerably differ. MATERIALS AND METHODS: We compared both countries' postgraduate educational blueprints and used an auto-ethnographic method to gain insight in the effects of training program structure and assessment methods on how trainees work...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38601118/mesenchymal-stem-cell-based-therapies-for-treating-well-studied-neurological-disorders-a-systematic-review
#14
Gaurav Deepak Patel, Lichao Liu, Ailian Li, Yun-Hsuan Yang, Chia-Chi Shen, Beate Brand-Saberi, Xuesong Yang
BACKGROUND: Millions of people across the globe are affected by conditions like Amyotrophic Lateral Sclerosis (ALS), Parkinson's Disease (PD), Multiple Sclerosis (MS), Spinal Cord Injury (SCI), and Traumatic Brain Injury (TBI), although most occurrences are common in the elderly population. This systematic review aims to highlight the safety of the procedures, their tolerability, and efficacy of the available therapies conducted over the years using mesenchymal stem cells (MSCs) in treating the neurological conditions mentioned above...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38601117/differences-in-ocular-high-order-aberrations-before-and-after-small-incision-lenticule-extraction-for-correction-of-myopia-a-systematic-review-and-meta-analysis
#15
Yifan Du, Yu Di, Shan Yang, Fei Mo, Ge Cui, Di Chen, Ying Li
OBJECTIVE: To examine the causes and factors that lead to high order aberration (HOA) during the treatment of myopia using small incision lenticule extraction (SMILE), as well as the differences between SMILE and other corneal refractive surgeries through a systematic review and meta-analysis. METHODS: A systematic search was conducted from January 2015 to February 2023 in Pubmed, Embase, Web of Science, and Google Scholar databases to gather relevant studies on SMILE and HOA...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38601116/impact-of-preterm-birth-on-kidney-health-and-development
#16
REVIEW
Sara Akalay, Maissa Rayyan, Tom Fidlers, Lambertus van den Heuvel, Elena Levtchenko, Fanny Oliveira Arcolino
Preterm birth, defined as birth before the gestational age of 37 weeks, affects 11% of the newborns worldwide. While extensive research has focused on the immediate complications associated with prematurity, emerging evidence suggests a link between prematurity and the development of kidney disease later in life. It has been demonstrated that the normal course of kidney development is interrupted in infants born prematurely, causing an overall decrease in functional nephrons. Yet, the pathogenesis leading to the alterations in kidney development and the subsequent pathophysiological consequences causing kidney disease on the long-term are incompletely understood...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38601115/nocebo-effects-in-systemic-therapies-for-adult-plaque-psoriasis-a-systematic-review-and-meta-analysis
#17
Bryan Ma, Ye-Jean Park, Kirk Barber, P Régine Mydlarski
INTRODUCTION: The nocebo effect is defined as adverse outcomes secondary to negative patient expectations rather than the pharmacologic activity of an intervention. Nocebo effects can reduce treatment adherence and/or persistence. Therefore, nocebo effects in psoriasis need to be defined. METHODS: A Cochrane systematic review was updated with a search of MEDLINE, Embase, and the CENTRAL Register of Controlled Trials for phase II - IV RCTs comparing systemic therapy versus placebo for patients with moderate-to-severe plaque psoriasis...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38601114/influence-of-ovarian-torsion-on-reproductive-outcomes-and-mode-of-delivery
#18
JOURNAL ARTICLE
Tali Silberstein, Amir Freud, Yael Baumfeld, Eyal Sheiner, Adi Yehuda Weintraub, Salvatore Andrea Mastrolia, Giuseppe Trojano, Eli Harris Bernstein, Polina Schwarzman
PURPOSE: To investigate differences in reproductive outcomes among patients before and following ovarian torsion. STUDY DESIGN: In this retrospective cohort study, we investigated the reproductive outcomes of patients who underwent surgery for ovarian torsion between 1988 and 2015 in a tertiary medical center. Data on deliveries before and after ovarian torsion were compared. RESULTS: During the study period, 199 women underwent surgery due to ovarian torsion...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38601113/genotype-and-sex-specific-changes-in-vital-parameters-during-isoflurane-anesthesia-in-a-mouse-model-of-alzheimer-s-disease
#19
JOURNAL ARTICLE
Sebastian Bratke, Sebastian Schmid, Bernhard Ulm, Bettina Jungwirth, Manfred Blobner, Laura Borgstedt
BACKGROUND: The prevalence of neurodegenerative diseases is increasing as is life expectancy with Alzheimer's disease accounting for two-thirds of dementia cases globally. Whether general anesthesia and surgery worsen cognitive decline is still a matter of debate and most likely depending on the interplay of various influencing factors. In order to account for this complexity, Alzheimer's disease animal models have been developed. The Tg2576 model of Alzheimer's disease is a well-established mouse model exhibiting amyloidopathy and age-dependent sex-specific differences in Alzheimer's disease symptomology...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38596795/short-term-lifestyle-education-on-obesity-reduction-in-adolescents
#20
JOURNAL ARTICLE
Feng Ning, Xiaohui Sun, Bing Ge, Shunping Li, Binghui Hou, Yumei Wang, Dong Zhang
BACKGROUNDS: Obesity is increasing in adolescents in China. However, the awareness of obesity and prevention on related risk factors were not well known. We aim to assess the effectiveness of short-term health education intervention on obesity in Chinese adolescents. METHODS: In this study, 42 primary and secondary schools from Qingdao were randomly divided into the education and control groups. A total of 11,739 adolescents was included in the current study. The logistic regression was employed to assess odds ratio (OR) of education intervention on overweight and obesity prevalence adjusting for covariates...
2024: Frontiers in Medicine
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