journal
https://read.qxmd.com/read/37731724/alpha-fetoprotein-elevated-postpubertal-testicular-teratoma-with-retroperitoneal-metastasis-on-18-f-fdg-pet-ct-case-report-and-literature-review
#1
Hao Jiao, Yongkang Qiu, Wenpeng Huang, Yongbai Zhang, Zhao Chen, Aixiang Wang, Lei Kang
Postpubertal testicular teratoma exhibits malignant biological behavior and has metastatic potential. We report a case of a 17-year-old patient diagnosed with postpubertal testicular teratoma with massive retroperitoneal metastasis. The pathological examination revealed a mature teratoma without any other components. However, the patient had a significantly increased level of AFP, and 18 F-FDG PET/CT showed the retroperitoneal metastasis had increased FDG uptake, with a SUVmax of 15.6, suggesting the coexistence of other germ cell tumor components, and the patient might have a poor prognosis...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731723/what-makes-joint-assessment-procedures-attractive-to-the-innovative-industry-successes-challenges-and-proposed-improvements
#2
REVIEW
Nevena Miletic, Sarah Adam, Jacqueline Acquah, Zainab Aziz, Angelika Joos, John M Mwangi
Regulatory harmonization and convergence have been identified as the key driver in promoting efficient evaluation of medicines, reducing workload, and supporting earlier access to medicines on the African continent. There has been great progress to date in enhancing regulatory harmonization and convergence on the African continent via the Regional Economic Communities (RECs) and with the establishment of the Africa Medicines Agency (AMA). In this article, the International Federation of Pharmaceutical Manufacturers and Associations (IFPMA) Africa Regulatory Network (ARN) presents its perspective based on the available literature review and results from a survey conducted with innovative biopharmaceutical companies to gather experiences using regional joint assessment procedures (JAPs) in Africa, such as the East African Community Medicines Regulatory Harmonization (EAC-MRH), the West African Medicines Regulatory Harmonization (WA-MRH), and the Southern African Development Community Medicines Regulatory Harmonization (SADC-MRH) initiative through the ZAZIBONA Collaborative Procedure for Medicines Registration (ZaZiBoNa), and provides best practices in this evolving landscape...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731722/causes-of-death-and-survival-analysis-for-patients-with-retinoblastoma-in-jordan
#3
JOURNAL ARTICLE
Tharwa Bilbeisi, Razaq Almasry, Mariam Obeidat, Mona Mohammad, Imad Jaradat, Hadeel Halalsheh, Ayat Alni'mat, Danah Kanj Ahmad, Nour Alsaket, Mustafa Mehyar, Ibrahim Al-Nawaiseh, Yacoub A Yousef
PURPOSE: To analyze causes and prognostic factors for death among Retinoblastoma (Rb) patients treated at a single specialized tertiary cancer center in Jordan. METHODS: We reviewed the mortality causes for all Rb patients who have been treated at the King Hussein Cancer Center between 2003 and 2019 and were followed for at least 3 years after diagnosis. The main outcome measures included demographics, laterality, tumor stage, treatment modalities, metastasis, survival, and causes of death...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731721/potential-molecular-targets-for-intervention-in-pelvic-organ-prolapse
#4
REVIEW
Xia Wu, Xiaochun Liu, Tingting Li
Pelvic organ prolapse (POP) is a concerning gynecological benign illness in middle-aged and senior women. Its etiology is complex, the incidence rate is high, symptoms are clinically subjective, and its influence tends to be polarized. At present, for those who need medical treatment, whether surgical or non-surgical, complications cannot be ignored, and treatment effect needs to be optimized. However, there is a lack of accurate molecular biological interventions for the prevention, diagnosis, progression delay, and treatment of POP...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731720/retraction-mesenchymal-stem-stromal-cells-as-a-vehicle-for-cytokine-delivery-an-emerging-approach-for-tumor-immunotherapy
#5
(no author information available yet)
[This retracts the article DOI: 10.3389/fmed.2021.721174.].
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731719/morphologic-variants-of-meibomian-glands-age-wise-distribution-and-differences-between-upper-and-lower-eyelids
#6
JOURNAL ARTICLE
Saumya Srivastav, Mohammed Hasnat Ali, Sayan Basu, Swati Singh
PURPOSE: To evaluate the distribution of various Meibomian gland morphologies across different age groups in healthy individuals. METHODS: The infrared meibographic morphologies of the Meibomian glands from the upper and lower eyelids of 236 healthy individuals (472 eyes; mean age 38.4 ± 17.5 years; 80 female participants: 156 male participants) were evaluated for their prevalence and differences across six decades of life, from 10 to 80 years. A linear mixed-effects modeling test was performed for statistical analysis...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731718/effect-of-individualized-positive-end-expiratory-pressure-based-on-electrical-impedance-tomography-guidance-on-pulmonary-ventilation-distribution-in-patients-who-receive-abdominal-thermal-perfusion-chemotherapy
#7
JOURNAL ARTICLE
Li Xiao, Kang Yu, Jiao-Jiao Yang, Wen-Tao Liu, Lei Liu, Hui-Hui Miao, Tian-Zuo Li
BACKGROUND: Electrical impedance tomography (EIT) has been shown to be useful in guiding individual positive end-expiratory pressure titration for patients with mechanical ventilation. However, the appropriate positive end-expiratory pressure (PEEP) level and whether the individualized PEEP needs to be adjusted during long-term surgery (>6 h) were unknown. Meanwhile, the effect of individualized PEEP on the distribution of pulmonary ventilation in patients who receive abdominal thermoperfusion chemotherapy is unknown...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731717/bone-wax-reduces-blood-loss-after-total-hip-arthroplasty-a-prospective-randomized-controlled-study
#8
JOURNAL ARTICLE
Hao Li, Chao Huang, Zi-Chuan Ding, Zun-Han Liu, En-Ze Zhao, Zong-Ke Zhou
BACKGROUND: Previous studies have demonstrated the efficacy of bone wax in reducing blood loss in various orthopedic surgeries. However, the effect of bone wax on total hip arthroplasty (THA) remains unclear. The objective of this study was to assess the efficacy of bone wax in THA. METHODS: We enrolled 104 patients in this randomized controlled trial. These patients were randomized (1:1) to either the bone wax or control group. The primary outcome was total blood loss after THA...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731716/restored-retinal-physiology-after-administration-of-niacin-with-citicoline-in-a-mouse-model-of-hypertensive-glaucoma
#9
JOURNAL ARTICLE
Alberto Melecchi, Rosario Amato, Massimo Dal Monte, Dario Rusciano, Paola Bagnoli, Maurizio Cammalleri
INTRODUCTION: Much interest has been addressed to antioxidant dietary supplements that are known to lower the risk of developing glaucoma or delay its progression. Among them, niacin and citicoline protect retinal ganglion cells (RGCs) from degeneration by targeting mitochondria, though at different levels. A well-established mouse model of RGC degeneration induced by experimental intraocular pressure (IOP) elevation was used to investigate whether a novel combination of niacin/citicoline has better efficacy over each single component in preserving RGC health in response to IOP increase...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731715/enhancing-nursing-education-to-bolster-nurse-governance-insights-from-nurse-managers
#10
JOURNAL ARTICLE
Sujin Choi
AIM: In South Korea, the level of nursing governance is moving toward shared governance. This study sought to explore nursing education contents in undergraduate nursing programs necessary to improve the governance of nurses from the perspectives of nurse managers. METHODS: The study employs thematic analysis following the guidelines outlined in the Consolidated Criteria for Reporting Qualitative Research utilizing a qualitative research design. Our investigation involves general or tertiary hospital nurse managers intending to gain valuable insights and perspectives...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731714/early-drainage-reduces-the-length-of-hospital-stay-in-patients-with-lung-abscess
#11
JOURNAL ARTICLE
Po-Chang Chiang, Chia-Ying Lin, Ya-Chun Hsu, Li-Ting Huang, Ta-Jung Chung, Yi-Sheng Liu, Chao-Chun Chang
BACKGROUND: Although percutaneous transthoracic catheter drainage (PCD) has been proven effective in lung abscesses, the optimal timing of PCD is still unclear. The study aimed to evaluate the safety and efficacy of early versus delayed drainage in patients with lung abscesses. METHODS: This retrospective study included 103 consecutive patients with liquefied lung abscesses more than 3 cm confirmed by a CT scan received CT-guided PCD over 16 years, from July 2005 to September 2021, in a single institution were reviewed...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731713/correlation-between-visual-field-index-and-quality-of-life-in-glaucoma-patients-a-new-tool-to-screen-quality-of-life-perception
#12
JOURNAL ARTICLE
Gemma Caterina Maria Rossi, Giovanni Milano, Annalisa De Silvestri, Lorenzo Savini, Chiara Bosi, Giulia Gambini, Paolo Rama
PURPOSE: To evaluate the correlation between the visual field index (VFI) and vision-related quality of life (QoL) considering several confounding variables that may have a positive or negative effect. METHODS: We conducted a cross-sectional, mono-centric study on glaucoma patients. Quality of life was examined with the NEI-VFQ 25 and the Glaucoma Symptom Scale (GSS). The visual field was examined with the Humphrey Field Analyzer. The variables considered were age, gender, comorbidities, years (at diagnosis and duration of the illness), treatment and related active principles, intraocular pressure, and visual acuity...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731712/a-nomogram-to-predict-in-hospital-mortality-of-gastrointestinal-bleeding-patients-in-the-intensive-care-unit
#13
JOURNAL ARTICLE
Xueyan Zhang, Jianfang Ni, Hongwei Zhang, Mengyuan Diao
BACKGROUND: Gastrointestinal bleeding (GIB) is a common condition in clinical practice, and predictive models for patients with GIB have been developed. However, assessments of in-hospital mortality due to GIB in the intensive care unit (ICU), especially in critically ill patients, are still lacking. This study was designed to screen out independent predictive factors affecting in-hospital mortality and thus establish a predictive model for clinical use. METHODS: This retrospective study included 1,442 patients with GIB who had been admitted to the ICU...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731711/editorial-role-of-membrane-bound-and-circulating-endoglin-in-disease
#14
EDITORIAL
Carmelo Bernabeu, Carla Olivieri, Elisa Rossi
No abstract text is available yet for this article.
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731710/patient-reported-outcomes-of-serum-eye-drops-manufactured-from-australian-blood-donations-and-packaged-using-meise-vials
#15
JOURNAL ARTICLE
Carley N Gemelli, Phillip Mondy, Athina Kakkos, Justine O'Donovan, Perfecto Diaz, Elizabeth Knight, Rena Hirani
INTRODUCTION: Serum eye drops (SED) are an effective treatment for dry eye syndrome. However, autologous serum collection can have challenges. Patient-tailored (allogeneic) SED (PT-SED) can be made from healthy blood donors. Australian Red Cross Lifeblood has manufactured both autologous SED (Auto-SED) and PT-SED and, in May 2021, introduced Meise vial packaging. This study aimed to explore SED patient-reported outcomes and vial packaging satisfaction. METHODS: A prospective cohort study was conducted with recruitment between 1 November 2021 and 30 June 2022...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37731709/virtual-reality-to-improve-low-back-pain-and-pelvic-pain-during-pregnancy-a-pilot-rct-for-a-multicenter-randomized-controlled-trial
#16
JOURNAL ARTICLE
Francisco-José García-López, José-Manuel Pastora-Bernal, Noelia Moreno-Morales, María-José Estebanez-Pérez, Antonio Liñán-González, Rocío Martín-Valero
A significant proportion of women experience low back and pelvic pain during and after pregnancy, which can negatively impact their daily lives. Various factors are attributed to these complaints, and many affected women do not receive adequate healthcare. However, there is evidence to support the use of different physiotherapeutic interventions to alleviate these conditions. Virtual reality is a promising complementary treatment to physiotherapy, particularly in improving pain perception and avoidance. The primary objective of this study is to evaluate the efficacy of a four-week program combining VR and physiotherapy compared to standard physiotherapy in pregnant women with low back and pelvic pain, in terms of improving pain avoidance, intensity, disability, and functional level...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37727768/development-and-validation-of-a-regression-model-with-nomogram-for-difficult-video-laryngoscopy-in-chinese-population-a-prospective-single-center-and-nested-case-control-study
#17
JOURNAL ARTICLE
Chenyu Jin, Bei Pei, Shuang Cao, Ningning Ji, Ming Xia, Hong Jiang
BACKGROUND: Airway management failure is associated with increased perioperative morbidity and mortality. Airway-related complications can be significantly reduced if difficult laryngoscopy is predicted with high accuracy. Currently, there are no large-sample studies on difficult airway assessments in Chinese populations. An airway assessment model based on the Chinese population is urgently needed to guide airway rescue strategy. METHODS: This prospective nested case-control study took place in a tertiary hospital in Shanghai, China...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37727767/-in-vitro-in-vivo-and-clinical-studies-comparing-the-efficacy-of-ceftazidime-avibactam-monotherapy-with-ceftazidime-avibactam-containing-combination-regimens-against-carbapenem-resistant-enterobacterales-and-multidrug-resistant-pseudomonas-aeruginosa-isolates
#18
Abdullah Tarık Aslan, Yukiko Ezure, Juan Pablo Horcajada, Patrick N A Harris, David L Paterson
INTRODUCTION: Carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity, mortality, and treatment costs. We aimed to evaluate in vitro , in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam (CZA) combination regimens with CZA alone against CRE and/or MDR-PA isolates or infections. METHODS: We systematically reviewed the relevant literature in CINAHL/MEDLINE, Pubmed, Cochrane, Web of Science, Embase, and Scopus until December 1, 2022...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37727766/an-exploratory-study-of-unexplained-concentration-of-18-f-psma-1007-in-the-bladder-for-prostate-cancer-pet-ct-imaging
#19
JOURNAL ARTICLE
Jun Dang, Yutang Yao, Yingchun Li, Xiaofei Tan, Zhenyan Ye, Yi Zhao, Shiwei Qing, Ying Kou, Xiao Jiang, Hao Lu, Shirong Chen, Meng Zhao, Zhuzhong Cheng
18 F-PSMA-1007 PET/CT imaging is increasingly used for the diagnosis, staging, and efficacy assessment of patients with prostate cancer. Compared with other PSMA tracers, 18 F-PSMA-1007 is mainly cleared by the liver and bile and has lower urinary clearance, thus allowing a better assessment of the lesions around the bladder. However, there were some patients who showed an obvious concentration of the 18 F-PSMA-1007 in the bladder, which may affect the observation of peripheral lesions, but the mechanism of this change is unknown...
2023: Frontiers in Medicine
https://read.qxmd.com/read/37727765/mtor-signaling-in-hair-follicle-and-hair-diseases-recent-progress
#20
REVIEW
Wei Tu, Yu-Wei Cao, Mang Sun, Qian Liu, Heng-Guang Zhao
Mammalian target of rapamycin (mTOR) signaling pathway is a major regulator of cell proliferation and metabolism, playing significant roles in proliferation, apoptosis, inflammation, and illness. More and more evidences showed that the mTOR signaling pathway affects hair follicle circulation and maintains the stability of hair follicle stem cells. mTOR signaling may be a critical cog in Vitamin D receptor (VDR) deficiency-mediated hair follicle damage and degeneration and related alopecia disorders. This review examines the function of mTOR signaling in hair follicles and hair diseases, and talks about the underlying molecular mechanisms that mTOR signaling regulates...
2023: Frontiers in Medicine
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