journal
Journals Translational Perioperative an...

Translational Perioperative and Pain Medicine

https://read.qxmd.com/read/37538443/trailblazing-through-the-opioid-epidemic-will-science-prevail
#1
JOURNAL ARTICLE
Panop Limratana, Koichi Yuki
No abstract text is available yet for this article.
2023: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/37538442/predictability-of-pediatric-sepsis-outcome-using-sepsis-3-definition-in-a-single-tertiary-pediatric-institution
#2
JOURNAL ARTICLE
Andrew Rosenzweig, Koichi Yuki
Sepsis is a syndrome of dysregulated response to infection and is associated with high morbidity and mortality. Sepsis was initially defined as a host's systemic inflammatory response syndrome (SIRS) to infection. In 2016, the importance of dysregulated response was incorporated into the definition of sepsis; adult sepsis was redefined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, with organ function being evaluated by the Sequential Organ Failure Assessment (SOFA) score (Sepsis-3 definition)...
2023: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/37168240/intraoperative-intercostal-nerve-cryoneurolysis-for-post-thoracotomy-pain-control-a-case-discussion
#3
JOURNAL ARTICLE
Xiaowei Lu, Ning Miao, Sandra Orfgen, Andrew Mannes
No abstract text is available yet for this article.
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/37009203/why-we-shouldn-t-ask-pacu-patients-are-you-having-pain
#4
JOURNAL ARTICLE
Barry L Friedberg, Andrew Mannes
No abstract text is available yet for this article.
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/36935906/a-brief-overview-of-the-neuropharmacology-of-opioid-addiction
#5
JOURNAL ARTICLE
John R Grothusen, Julie A Blendy, Gordon A Barr
The world is in the midst of an opioid crisis. Nearly 92,000 persons in the U.S. alone died from illicit drugs and prescription opioids in 2020 [1]. This number does not include the countless other individuals who die as a result of the violent crime that accompanies the illicit drug trade. To address this crisis, we need to appreciate aspects of drug addiction. The goal of this brief review is to highlight some major facets of addiction neurobiology, focused on opioids, to provide a basic understanding of the research and terminology encountered in more detailed in-depth articles and discussions on addiction...
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/36545239/intrathecal-administration-of-the-fat-mass-and-obesity-associated-protein-inhibitor-mitigates-neuropathic-pain-in-female-rats
#6
JOURNAL ARTICLE
Xiang Li, Yuan-Xiang Tao
Several intracellular signals are involved in the sexual dimorphism of chronic pain. Our previous studies demonstrated that the fat-mass and obesity-associated protein (FTO), a demethylase of RNA N 6-methyladenosine, in the injured dorsal root ganglion (DRG) contributed to the development and maintenance of nerve injury-induced nociceptive hypersensitivity in male rats and male mice. However, whether these effects of DRG FTO are in a sex-dependent manner is still unknown. The present study sought to investigate the effect of intrathecal administration of a specific FTO inhibitor, meclofenamic acid (MA), on chronic constriction injury (CCI)-induced nociceptive hypersensitivity in female rats...
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/36381996/perspective-covid-19-and-its-neurologic-sequelae
#7
JOURNAL ARTICLE
Aaron Rothstein, Christopher Favilla, Kelly Sloane, Jens Witsch
COVID-19 led to a catastrophic, international, public health crisis after its first detection in 2019 [1]. Though it is primarily a respiratory virus, it impacts the central and peripheral nervous systems leading to further COVID-19-associated disability [2]. This Perspective reviews our current understanding of the neurological sequelae of COVID-19 and the gaps in our understanding of their treatment and epidemiology.
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/35959414/therapeutic-potential-of-salvinorin-a-and-its-analogues-in-various-neurological-disorders
#8
JOURNAL ARTICLE
Joseph Cichon, Renyu Liu, Hoang V Le
No abstract text is available yet for this article.
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/35903541/neurocysticercosis-a-rare-cause-of-headache-needing-craniotomy
#9
JOURNAL ARTICLE
Xiaowei Lu, Ning Miao, Andrew Mannes
No abstract text is available yet for this article.
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/35875368/the-role-of-pulmonary-function-test-in-perioperative-management-of-patients-with-cystic-fibrosis
#10
JOURNAL ARTICLE
Mariel Manzor, Gabor Asztalos, Koichi Yuki
Cystic fibrosis (CF) is one of chronic illness affecting many different organs. Although the outcome of CF patients undergoing procedures was not favorable more than half a century ago, it showed a continuous improvement based on the previous reports. However, recent outcome report of CF patients' procedural outcomes is limited. We analyzed CF patients who underwent procedures from 2010 to 2020 in our institution. The mortality of 1,903 procedures performed in 430 CF patients was 0.74%, seen in high-risk procedures such as lung transplantation...
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/35572183/dezocine-is-a-biased-ligand-without-significant-beta-arrestin-activation-of-the-mu-opioid-receptor
#11
JOURNAL ARTICLE
John Grothusen, Wenzhen Lin, Jin Xi, Giulia Zanni, Gordon A Barr, Renyu Liu
Dezocine is an opioid that was used in clinical practice for acute pain management in the US (1986 to 2011) and is currently in use in China. It is not listed as a controlled substance in the US due to no reported cases of addiction. Dezocine is a partial agonist at the mu opioid receptor (MOR); however, it is unclear whether dezocine can activate both the G protein pathway and the beta-arrestin pathway. In this study we hypothesized that dezocine does not activate the beta-arrestin pathway, which could be the potential molecular mechanism by which dezocine is not addictive or at least less addictive than other classic opioids...
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/35296038/how-should-we-care-for-patients-with-congenital-heart-diseases-undergoing-surgical-procedures-in-ambulatory-settings
#12
JOURNAL ARTICLE
Rebecca Hamilton, Kirsten C Odegard, Koichi Yuki
Congenital heart diseases (CHDs) are the most common of all congenital birth anomalies. As the survival of patients with CHDs continues to improve, this patient population is presenting for non-cardiac procedures more frequently than in the past. With ambulatory based procedures becoming increasingly common, it is critical to consider how we should best triage these patients for procedures in ambulatory settings. This paper reviews the current literature on the subject and considers strategies to guide future management...
2022: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/34993270/translational-role-of-rodent-models-to-study-ventilator-induced-lung-injury
#13
JOURNAL ARTICLE
Koichi Yuki, Sophia Koutsogiannaki
Mechanical ventilation is an important part of medical care in intensive care units and operating rooms to support respiration. While it is a critical component of medical care, it is well known that mechanical ventilation itself can be injurious to the lungs. Despite a large number of clinical and preclinical studies that have been done so far, there still exists a gap of knowledge regarding how to ventilate patients mechanically without increasing lung injury. Here, we will review what we have learned so far from preclinical and clinical studies and consider how to use preclinical models of ventilation-induced lung injury that better recapitulate the clinical scenarios...
December 2021: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/33521166/the-microbial-flora-in-an-experimental-polymicrobial-abdominal-sepsis-model-probed-by-16s-rrna-sequencing
#14
JOURNAL ARTICLE
Miho Shibamura-Fujiogi, Sophia Koutsogiannaki, Lifei Hou, Koichi Yuki
Background: Cecal ligation and puncture (CLP) surgery is a widely used preclinical model to induce and study sepsis because it is considered to recapitulate the course of human sepsis the most. This model is highly dependent on the polymicrobial gut flora and represents polymicrobial abdominal sepsis. While the majority of studies using CLP model have focused on the delineation of host immune responses, a limited number of reports have described the composition of microbial strains in this model, although microbial composition can significantly affect the outcome of sepsis in general...
2021: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/33869664/intraoperative-laryngeal-mask-airway-related-hiccup-an-overview
#15
JOURNAL ARTICLE
Johann Mathew, Shiqian Shen, Henry Liu
Hiccup is an involuntary contraction of the diaphragm and intercostal muscles resulting in sudden inspiration and closure of the glottis. The presence of hiccup in the perioperative period can be a challenging problem. Sudden movements of the patient from hiccups can interfere preoperative diagnostic procedures, intraoperative hiccup may delay the beginning of surgery, interfere with the surgical process, and affect intraoperative monitoring, and postoperative hiccup may affect would healing and hemodynamic stability...
2020: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/33204767/kappa-opioid-receptor-on-pulmonary-macrophages-and-immune-function
#16
JOURNAL ARTICLE
Si Zeng, Yinbo Zhong, Jie Xiao, Jiafu Ji, Jin Xi, Xinchuan Wei, Renyu Liu
Background: Respiratory failure significantly increases mortality in critically ill patients. While opioids are often used during the perioperative period and in critically ill situations, little is known about how opioids are involved in pulmonary immune function and the inflammatory response. There is currently no clear information on the role of the kappa opioid receptor (KOR) in pulmonary inflammation. Here we evaluate whether KORs are involved in the modulation of lung macrophages by the use of selective KOR agonists in lipopolysaccharide (LPS) activated alveolar macrophages...
2020: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/32542183/-in-vitro-model-of-stretch-induced-lung-injury-to-study-different-lung-ventilation-regimens-and-the-role-of-sedatives
#17
JOURNAL ARTICLE
Yusuke Mitsui, Sophia Koutsogiannaki, Miho Fujiogi, Koichi Yuki
Background: Currently lung injury is managed conservatively through supportive care including mechanical ventilation. However, mechanical ventilation can also cause additional lung injury due to over-stretch along with atelectasis and cytokine release. Here we developed an in vitro mechanical ventilation model using cyclic stretch of lung epithelial cells to mimic high and low tidal volume (TV) ventilation strategy, so that we could use this platform for pathophysiology analysis and screening for therapeutic drugs...
2020: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/32377555/anesthetic-management-for-heart-transplantation-in-adults-with-congenital-heart-disease
#18
JOURNAL ARTICLE
Koichi Yuki
As the outcome of patients with congenital heart disease (CHD) has improved, the number of adults with congenital heart disease (ACHD) outnumbered pediatric population with CHD. Heart failure is responsible for 40% of mortality among ACHD, and the number of heart transplantation for ACHD is gradually increasing. However, the early mortality rate of heart transplantation is significantly higher in ACHD than in non-ACHD. Understanding the unique characteristics of heart transplantation in ACHD is critical. In contrast to their early outcome their long-term survival is better in ACHD than in non-CHD patients, and they are likely to present to anesthesia care after heart transplantation for various reasons...
2020: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/32099850/long-noncoding-rna-h19-in-the-injured-dorsal-root-ganglion-contributes-to-peripheral-nerve-injury-induced-pain-hypersensitivity
#19
JOURNAL ARTICLE
Jing Wen, Yong Yang, Shaogen Wu, Guihua Wei, Shushan Jia, Stephen Hannaford, Yuan-Xiang Tao
Peripheral nerve injury-induced changes in gene transcription and translation in the dorsal root ganglion (DRG) play a critical role in the development and maintenance of neuropathic pain. Long noncoding RNAs (lncRNAs) regulate gene expression. Here, we report that peripheral nerve injury caused by ligation of the fourth spinal nerve (SNL) led to a time-dependent increase in the expression in H19, an lncRNA, in the injured DRG. Microinjection of a specific H19 siRNA, but not negative control scrambled siRNA, into the injured DRG 4 days before SNL alleviated mechanical allodynia and thermal hyperalgesia on days 3 and 5 post-SNL...
2020: Translational Perioperative and Pain Medicine
https://read.qxmd.com/read/32039284/should-we-routinely-reverse-neuromuscular-blockade-with-sugammadex-in-patients-with-a-history-of-heart-transplantation
#20
JOURNAL ARTICLE
Koichi Yuki, Rebecca Scholl
Cases of cardiac arrest after administration of neostigmine as a neuromuscular reversal agent have been reported in the literature. Sugammadex is a new neuromuscular reversal agent that acts via a different mechanism than acetylcholinesterase inhibitors. Here we reviewed the currently available literature on the use of sugammadex and potential considerations of using sugammadex in patients with a history of heart transplantation. Based on our currently available information, sugammadex administration in heart transplant patients should warrant similar caution and preparation for cardiovascular collapse as acetylcholinesterase inhibitors...
2020: Translational Perioperative and Pain Medicine
journal
journal
49508
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.