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BMJ Open Respiratory Research

Nayra Cardenes, Paola Aranda-Valderrama, Jonathan P Carney, Jacobo Sellares Torres, Diana Alvarez, Ergin Kocydirim, Julie A Wolfram Smith, Antony E Ting, Luigi Lagazzi, Zheming Yu, Scott Mason, Ernesto Santos, Brian J Lopresti, Mauricio Rojas
Introduction: Bone marrow-derived multipotent adult progenitor cells (MAPCs) are adult allogeneic adherent stem cells currently investigated clinically for use in acute respiratory distress syndrome (ARDS). To date, there is no agreement on which is the best method for stem cells delivery in ARDS. Here, we compared the efficacy of two different methods of administration and biodistribution of MAPC for the treatment of ARDS in a sheep model. Methods: MAPC were labelled with [18 F] fluoro-29-deoxy-D-glucose and delivered by endobronchial (EB) or intravenous route 1 hour after lipopolysaccharide infusion in sheep mechanically ventilated...
2019: BMJ Open Respiratory Research
Claire Matthews, Carol Freeman, Linda D Sharples, Julia Fox-Rushby, Angela Tod, Nicholas A Maskell, John G Edwards, Aman S Coonar, Pasupathy Sivasothy, Victoria Hughes, Najib M Rahman, David A Waller, Robert Campbell Rintoul
Introduction: One of the most debilitating symptoms of malignant pleural mesothelioma (MPM) is dyspnoea caused by pleural effusion. MPM can be complicated by the presence of tumour on the visceral pleura preventing the lung from re-expanding, known as trapped lung (TL). There is currently no consensus on the best way to manage TL. One approach is insertion of an indwelling pleural catheter (IPC) under local anaesthesia. Another is video-assisted thoracoscopic partial pleurectomy/decortication (VAT-PD)...
2019: BMJ Open Respiratory Research
Arora Ros Ingadottir, Anne Marie Beck, Christine Baldwin, Christine Elizabeth Weekes, Olof Gudny Geirsdottir, Alfons Ramel, Thorarinn Gislason, Ingibjorg Gunnarsdottir
Introduction: Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD...
2019: BMJ Open Respiratory Research
Adam T Hill, Anita L Sullivan, James D Chalmers, Anthony De Soyza, J Stuart Elborn, R Andres Floto, Lizzie Grillo, Kevin Gruffydd-Jones, Alex Harvey, Charles S Haworth, Edwin Hiscocks, John R Hurst, Christopher Johnson, W Peter Kelleher, Pallavi Bedi, Karen Payne, Hesham Saleh, NIcholas J Screaton, Maeve Smith, Michael Tunney, Deborah Whitters, Robert Wilson, Michael R Loebinger
The full British Thoracic Society Guideline for Bronchiectasis in Adults is published in Thorax . The following is a summary of the recommendations and good practice points. The sections referred to in the summary refer to the full guideline. The appendices are available in the full guideline.
2018: BMJ Open Respiratory Research
Peter Hertz, Katrine Jensen, Saleh N Abudaff, Michael Strøm, Yousif Subhi, Hani Lababidi, Lars Konge
Introduction: Chest tube insertion can be associated with serious complications. A structured training programme is needed to minimise complications and enhance patient safety. Novices should pass a reliable test with solid evidence of validity before performing the procedure supervised on patients. The aim of this study was to establish a credible pass/fail standard. Methods: We used an established assessment tool the Chest Tube Insertion Competency Test (TUBE-iCOMPT)...
2018: BMJ Open Respiratory Research
Shaney L Barratt, Michelle Morales, Toby Spiers, Khaled Al Jboor, Heather Lamb, Sarah Mulholland, Adrienne Edwards, Rachel Gunary, Patricia Meek, Nikki Jordan, Charles Sharp, Clare Kendall, Huzaifa I Adamali
Introduction: Patients with progressive idiopathic fibrotic interstitial lung disease (ILD), such as those with idiopathic pulmonary fibrosis (IPF), can have an aggressive disease course, with a median survival of only 3-5 years from diagnosis. The palliative care needs of these patients are often unmet. There are calls for new models of care, whereby the patient's usual respiratory clinician remains central to the integration of palliative care principles and practices into their patient's management, but the optimal model of service delivery has yet to be determined...
2018: BMJ Open Respiratory Research
Sarah Koch, Sean Michael Sinden, Michael Stephen Koehle
Introduction: The eucapnic voluntary hyperpnoea (EVH) challenge is used to screen for exercise-induced bronchoconstriction. Several criteria have been proposed to determine the decrease in lung function (fall index, FI) following EVH. We compared three published FI calculation methods to determine if they affect the diagnostic classification. Methods: The three FIs were calculated for 126 EVH tests. Spirometry was performed in duplicate at baseline and repeated 3, 5, 10, 15 and 20 min following 6 min of EVH...
2018: BMJ Open Respiratory Research
Jennifer L Lenahan, Giovanni Volpicelli, Alessandro Lamorte, Fyezah Jehan, Quique Bassat, Amy Sarah Ginsburg
Introduction: Pneumonia is the leading infectious cause of death among children under 5 years of age worldwide. However, pneumonia is challenging to diagnose. Lung ultrasound (LUS) is a promising diagnostic technology. Further evidence is needed to better understand the role of LUS as a tool for the diagnosis of childhood pneumonia in low-resource settings. Methods and analysis: This study aims to pilot LUS in Mozambique and Pakistan and to generate evidence regarding the use of LUS as a diagnostic tool for childhood pneumonia...
2018: BMJ Open Respiratory Research
Mitsutomo Kohno, Ryo Hashimoto, Kana Oiwa, Hideki Yashiro, Seishi Nakatsuka, Masafumi Kawamura, Masayuki Iwazaki
Introduction: Percutaneous cryoablation has been adopted for small, malignant peripheral pulmonary lesions and has yielded favourable results as a less invasive local treatment. A transbronchial approach may reduce the risks of complications, such as pneumothorax and pleural haemorrhage. A fundamental animal experiment on transbronchial cryoablation was performed to examine its immediate safety and effectiveness. Methods: Experimental cryoablation was performed on swine lungs using a rigid cryoprobe, 2...
2018: BMJ Open Respiratory Research
Wim A Wuyts, Caroline Dahlqvist, Hans Slabbynck, Marc Schlesser, Natacha Gusbin, Christophe Compere, Sofie Maddens, Klaus-Uwe Kirchgaessler, Karen Bartley, Benjamin Bondue
Introduction: PROOF (a Prospective Observational Registry to Describe the Disease Course and Outcomes of Idiopathic Pulmonary Fibrosis) is an ongoing, observational registry initiated in 2013 with the aim of collecting real-world data from patients with idiopathic pulmonary fibrosis (IPF). Here, we present comprehensive baseline data, which were collected from patients on registry inclusion. Methods: Patients with IPF were enrolled across eight centres in Belgium and Luxembourg...
2018: BMJ Open Respiratory Research
Charlotte Claire Savage, Piers Henry Anderson Dixey, Catherine Pennington, James W Dodd
Introduction: Widespread white matter damage and cognitive impairment have been demonstrated in chronic obstructive pulmonary disease (COPD). However, it remains unclear if brain atrophy is a global phenomenon or if specific subregions are differentially affected. The aims of this study are, first, to test a simple, validated visual analogue grading technique. Second, we hypothesised that frontal regions of the brains of patients with COPD will show greater signs of atrophy compared with control subjects...
2018: BMJ Open Respiratory Research
Anne Caroline Krefis, Jana Fischereit, Peter Hoffmann, Hans Pinnschmidt, Christina Sorbe, Matthias Augustin, Jobst Augustin
Introduction: Associations between air pollutants, meteorological conditions and respiratory diseases have been extensively shown. The aim of this study was to investigate associations between daily meteorological data, data on air pollution and emergency department (ED) visits depending on the day of the week, season and year (study period from 2013 to 2015). Methods: Highly correlated environmental data entered a categorical principal components analysis (CATPCA)...
2018: BMJ Open Respiratory Research
Masatoshi Yamazoe, Hiromi Tomioka
Introduction: In 2016, an international working group proposed a revised definition and new diagnostic criteria for the acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). Based on these criteria, AE-IPF was diagnosed regardless of the presence or absence of a known trigger and categorised as triggered (T-AE) or idiopathic (I-AE) AE-IPF. However, the clinical characteristics of the newly defined AE-IPF and clinical differences between T-AE and I-AE are unresolved. Methods: We retrospectively analysed 64 patients with AE-IPF (I-AE (42), T-AE (22)) admitted to our hospital over a 10- year period...
2018: BMJ Open Respiratory Research
Laila Parvaresh, Shopna K Bag, Jin-Gun Cho, Neil Heron, Hassan Assareh, Sophie Norton, Stephen Corbett, Ben J Marais
Treatment of latent tuberculosis infection (LTBI) is an important component of strategies to achieve global tuberculosis (TB) elimination, but implementation is rarely monitored. This is a retrospective review of TB contact tracing outcomes at one of the busiest TB clinics in Australia, measured against the Centre for Disease Control and Prevention performance indicators. In total, 45 of 53 (85%) pulmonary TB cases had 171 close contacts, of whom 139 (81%) were evaluated with a tuberculin skin test (TST); 58 of 139 (42%) were positive at baseline...
2018: BMJ Open Respiratory Research
Alexander Pate, Michael Barrowman, David Webb, Jeanne M Pimenta, Kourtney J Davis, Rachael Williams, Tjeerd Van Staa, Matthew Sperrin
Introduction: Traditional phase IIIb randomised trials may not reflect routine clinical practice. The Salford Lung Study in chronic obstructive pulmonary disease (SLS COPD) allowed broad inclusion criteria and followed patients in routine practice. We assessed whether SLS COPD approximated the England COPD population and evidence for a Hawthorne effect. Methods: This observational cohort study compared patients with COPD in the usual care arm of SLS COPD (2012-2014) with matched non-trial patients with COPD in England from the Clinical Practice Research Datalink database...
2018: BMJ Open Respiratory Research
Nicholas David Lane, Karen Brewin, Tom Murray Hartley, William Keith Gray, Mark Burgess, John Steer, Stephen C Bourke
Introduction: In exacerbation of chronic obstructive pulmonary disease (ECOPD) requiring hospitalisation greater access to respiratory specialists improves outcome, but is not consistently delivered. The UK National Confidential Enquiry into Patient Outcome and Death 2015 enquiry showed over 25% of patients receiving acute non-invasive ventilation (NIV) for ECOPD died in hospital. On 16 June 2015 the Northumbria Specialist Emergency Care Hospital (NSECH) opened, introducing 24/7 specialty consultant on-call, direct admission from the emergency department to specialty wards and 7-day consultant review...
2018: BMJ Open Respiratory Research
Michela Tinelli, John White, Andrea Manfrin
Introduction: A key priority in asthma management is achieving control. The Asthma Control Test (ACT) is a validated tool showing a numerical indicator which has the potential to provide a target to drive management. A novel pharmacist-led intervention recently evaluated and introduced in the Italian setting with a cluster randomised controlled trial (C-RCT) showed effectiveness and cost-effectiveness. This paper evaluates whether the intervention is successful in securing the minimally important difference (MID) in the ACT score and provides better health outcomes and economic savings...
2018: BMJ Open Respiratory Research
Koichi Nishimura, Saya Nakamura, Masaaki Kusunose, Kazuhito Nakayasu, Ryo Sanda, Yoshinori Hasegawa, Toru Oga
Introduction: The aim of this study was to investigate which patient-reported outcome measure was the best during the recovery phase from severe exacerbation of chronic obstructive pulmonary disease (COPD). Methods: The Exacerbations of Chronic Pulmonary Disease Tool (EXACT), the COPD Assessment Test (CAT), the St George's Respiratory Questionnaire (SGRQ), the Dyspnoea-12 (D-12) and the Hyland Scale (global scale) were recorded every week for the first month and at 2 and 3 months in 33 hospitalised subjects with acute exacerbation of COPD (AECOPD)...
2018: BMJ Open Respiratory Research
Synne Jenum, Selvam Sumithra, Jesuraj Nelson, Ritz Christian, Hesseling Anneke C, Cardenas Vicky, Lau Esther, Doherty T Mark, Grewal Harleen M S, Vaz Mario
Introduction: Accurate tuberculosis (TB) incidence and optimal surveillance strategies are pertinent to TB vaccine trial design. Infants are a targeted population for new TB vaccines, but data from India, with the highest global burden of TB cases, is limited. Methods: In a population-based prospective trial conducted between November 2006 and July 2008, BCG-vaccinated neonates in South India were enrolled and cluster-randomised to active or passive surveillance...
2018: BMJ Open Respiratory Research
Andrew Walden, Nicholas Smallwood, Martin Dachsel, Ashley Miller, Jennifer Stephens, Michael Griksaitis
No abstract text is available yet for this article.
2018: BMJ Open Respiratory Research
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