Andi Orlowski, Jack Ettinger, Alex Bottle, Sally Snow, Rachel Ashton, Jennifer K Quint
Chronic obstructive pulmonary disease (COPD) is a multisystem disease, and many patients have multiple conditions. We explored multimorbidity patterns that might inform intervention planning to reduce health-care costs while preserving quality of life for patients. Literature searches up to February 2022 revealed 4419 clinical observational and comparative studies of risk factors for multimorbidity in people with COPD, pulmonary emphysema, or chronic bronchitis at baseline. Of these, 29 met the inclusion criteria for this review...
April 22, 2024: BMJ Open Respiratory Research
Weiwei Meng, Ruoyan Xiong, Zhiqi Zhao, Huihui Zeng, Yan Chen
BACKGROUND: Inhaler concordance and the peak inspiratory flow rate (PIFR) are important determinants of treatment effects in patients with chronic airway diseases. Adequate PIFR is required for driving aerosol medication into the lower respiratory tract. However, the relationship between them has not been discussed previously. This study aimed to describe the characteristics of inhaler concordance and PIFR in Chinese patients with chronic airway diseases and discuss the associated variables and the relationship between them...
April 19, 2024: BMJ Open Respiratory Research
Rodrigo Abensur Athanazio, Laura Bernal Villada, Sergey N Avdeev, Hao-Chien Wang, Alejandra Ramírez-Venegas, Martín Sivori, Jorge Dreyse, Manuel Pacheco, Sin Kit Man, Lorena Noriega-Aguirre, Hisham Farouk
INTRODUCTION: The <u>EXA</u>cerbations of <u>C</u>hronic obstructive lung disease (COPD) and their <u>O</u>utcome<u>S</u> (EXACOS) International Study aimed to quantify the rate of severe exacerbations and examine healthcare resource utilisation (HCRU) and clinical outcomes in patients with COPD from low-income and middle-income countries. METHODS: EXACOS International was an observational, cross-sectional study with retrospective data collection from medical records for a period of up to 5 years...
April 18, 2024: BMJ Open Respiratory Research
Wang Chun Kwok, Chung Ki Tsui, Sze Him Isaac Leung, Chun Ka Emmanuel Wong, Terence Chi Chun Tam, James Chung-Man Ho
BACKGROUND: Although bronchiectasis is reported to be associated with cardiovascular disease, evidence for an association with cardiovascular events (CVEs) is lacking. METHODS: A territory-wide retrospective cohort study was conducted in Hong Kong involving all patients who had bronchiectasis diagnosed in public hospitals and clinics between 1 January 1993 and 31 December 2017 were included. Patients were allocated to be exacerbator or non-exacerbator group based on hospitalzied bronchiecsis history and CVEs over the next 5 years determined...
April 18, 2024: BMJ Open Respiratory Research
David M G Halpin, Donald A Mahler
BACKGROUND: Errors using inhaled delivery systems for COPD are common and it is assumed that these lead to worse clinical outcomes. Previous systematic reviews have included patients with both asthma and COPD and much of the evidence related to asthma. More studies in COPD have now been published. Through systematic review, the relationship between errors using inhalers and clinical outcomes in COPD, including the importance of specific errors, was assessed.MethodsElectronic databases were searched on 27 October 2023 to identify cohort, case-control or randomised controlled studies, which included patients with COPD, an objective assessment of inhaler errors and data on at least one outcome of interest (forced expiratory volume in 1 s, (FEV1 ), dyspnoea, health status and exacerbations)...
April 16, 2024: BMJ Open Respiratory Research
Vikram Mohan, Chandrasekar Rathinam, Derick Yates, Aatit Paungmali, Christopher Boos
OBJECTIVE: This study aimed to systematically review the psychometric properties of outcome measures that assess dysfunctional breathing (DB) in adults. METHODS: Studies on developing and evaluating measurement properties to assess DB were included. The study investigated the empirical research published between 1990 and February 2022, with an updated search in May 2023 in the Cochrane Library database of systematic reviews and the Cochrane Central Register of Controlled Trials, the Ovid Medline (full), the Ovid Excerta Medica Database, the Ovid allied and complementary medicines database, the Ebscohost Cumulative Index to Nursing and Allied Health Literature and the Physiotherapy Evidence Database...
April 16, 2024: BMJ Open Respiratory Research
Netsanet Belete, Sebsibe Tadesse, Mulugeta Hailu
BACKGROUND: Respiratory diseases disproportionately affect people living in resource-limited settings. However, obtaining information that explains respiratory-related deaths has been difficult, mainly due to a lack of medical certification of death and the fact that most deaths occur outside of health institutions. This study aimed to determine the proportion of respiratory-related deaths and identify associated factors in Alicho-Weriro district, southern Ethiopia, using the verbal autopsy method...
April 15, 2024: BMJ Open Respiratory Research
Jiachen Li, Yingting Zuo, Lin Feng, Yutong Samuel Cai, Jian Su, Zhaohui Tong, Lirong Liang
BACKGROUND: Recent studies have suggested elevated blood eosinophils are independent predictors of response to corticosteroid therapy in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Smoking status has been shown to affect corticosteroid response. Whether the association between high blood eosinophils and corticosteroid treatment failure is modified by smoking has not been fully investigated so far. OBJECTIVES: This study aimed to assess whether the association between high blood eosinophils and corticosteroid treatment failure is modified by smoking...
April 12, 2024: BMJ Open Respiratory Research
Mark Youssef, Marina Boutros Salama, Nadia Rehman, Christina Hanna, Mary Rose Waniss, Lawrence Mbuagbaw
INTRODUCTION: People living with HIV (PLHIV) have a higher risk of developing pulmonary hypertension (PH) with subsequent poorer prognosis. This review aimed to determine the (1) survival outcomes and (2) proportion of emergency department (ED) visits and hospitalisations of PLHIV and PH. METHODS: We conducted a systematic review and meta-analysis of observational studies reporting survival outcomes for PLHIV and PH. Electronic databases (Medline, EMBASE, PubMed, Web of Science, Global Index Medicus and Cochrane Library), trial registries and conference proceedings were searched until 22 July 2023...
April 11, 2024: BMJ Open Respiratory Research
Huan Zhang, Tan Xiaojiao, Junjun Chen, Zheng Zhang, Chenxi Wang, Haiqing Shi, Yao Li, Jianbo Li, Yan Kang, Xiaodong Jin, Xuelian Liao
BACKGROUND: In China, both nirmatrelvir-ritonavir (Paxlovid) and azvudine have been granted approval to treat adult SARS-CoV-2-infected patients with moderate symptoms. Information about the clinical effect of the two available agents among inpatients with severe or critical COVID-19 is scarce. PURPOSE: To compare the clinical outcomes of Paxlovid and azvudine among adult inpatients with severe or critical COVID-19. METHOD: We conducted a retrospective cohort study in two large medical centres after the epidemic control measures were lifted in China...
April 10, 2024: BMJ Open Respiratory Research
Daisuke Yamada, Fumitsugu Kojima, Yujiro Otsuka, Kouhei Kawakami, Naoki Koishi, Ken Oba, Toru Bando, Masaki Matsusako, Yasuyuki Kurihara
BACKGROUND: Diagnosing mediastinal tumours, including incidental lesions, using low-dose CT (LDCT) performed for lung cancer screening, is challenging. It often requires additional invasive and costly tests for proper characterisation and surgical planning. This indicates the need for a more efficient and patient-centred approach, suggesting a gap in the existing diagnostic methods and the potential for artificial intelligence technologies to address this gap. This study aimed to create a multimodal hybrid transformer model using the Vision Transformer that leverages LDCT features and clinical data to improve surgical decision-making for patients with incidentally detected mediastinal tumours...
April 8, 2024: BMJ Open Respiratory Research
Liliana Fernandez-Trujillo, Saveria Sangiovanni, Ana Isabel Castrillon, Lina Hincapie-Zapata, Lina Maria Góez-Mogollón, Marcela Brun Vergara, Sergio I Prada
PURPOSE: This study examines the financial impact of the COVID-19 pandemic on the Colombian Health System, focusing on the adequacy of reimbursement rates for inpatient stays. The study, based on a cost of illness analysis, aims to evaluate the effectiveness of the reimbursement scheme and identify potential economic losses within the health system. PATIENTS AND METHODS: The study protocol outlines the inclusion criteria for patients >18 years with confirmed COVID-19 infection and moderate to critical disease...
April 5, 2024: BMJ Open Respiratory Research
Xingru Zhao, Haonan Kang, Yunxia An, Zhiwei Xu, Meihui Wei, Quncheng Zhang, Linqi Diao, Zhiping Guo, Xiaoju Zhang
BACKGROUND: Despite substantial progress in reducing the global burden of chronic obstructive pulmonary disease (COPD), traditional methods to promote understanding and management of COPD are insufficient. We developed an innovative model based on the internet of things (IoT) for screening and management of COPD in primary healthcare (PHC). METHODS: Electronic questionnaire and IoT-based spirometer were used to screen residents. We defined individuals with a questionnaire score of 16 or higher as high-risk population, COPD was diagnosed according to 2021 Global Initiative for COPD (Global Initiative for Chronic Obstructive Lung Disease) criteria...
April 5, 2024: BMJ Open Respiratory Research
Myriam Drysdale, Evgeniy R Galimov, Marcus James Yarwood, Vishal Patel, Bethany Levick, Daniel C Gibbons, Jonathan D Watkins, Sophie Young, Benjamin F Pierce, Emily J Lloyd, William Kerr, Helen J Birch, Tahereh Kamalati, Stephen J Brett
BACKGROUND: We assessed the effectiveness of sotrovimab vs no early COVID-19 treatment in highest-risk COVID-19 patients during Omicron predominance. METHODS: Retrospective cohort study using the Discover dataset in North West London. Included patients were non-hospitalised, aged ≥12 years and met ≥1 National Health Service highest-risk criterion for sotrovimab treatment. We used Cox proportional hazards models to compare HRs of 28-day COVID-19-related hospitalisation/death between highest-risk sotrovimab-treated and untreated patients...
April 4, 2024: BMJ Open Respiratory Research
Xingyu Rao, Zicheng Lei, Huifang Zhu, Kaiyuan Luo, Chaohua Hu
BACKGROUND: Asthma is a chronic disease affecting the lower respiratory tract, which can lead to death in severe cases. The cause of asthma is not fully known, so exploring its potential mechanism is necessary for the targeted therapy of asthma. METHOD: Asthma mouse model was established with ovalbumin (OVA). H&E staining, immunohistochemistry and ELISA were used to detect the inflammatory response in asthma. Transcriptome sequencing was performed to screen differentially expressed genes (DEGs)...
April 2, 2024: BMJ Open Respiratory Research
Claus F Vogelmeier, Kirsty Rhodes, Edeltraut Garbe, Melanie Abram, Marija Halbach, Hana Müllerová, Nils Kossack, Patrick Timpel, Nikolaus Kolb, Clementine Nordon
BACKGROUND: Exacerbations of chronic obstructive pulmonary disease (COPD) represent a period of vulnerability. This study explored the association between time periods following an exacerbation and the risk of severe cardiovascular (CV) events or death in Germany. METHODS: A longitudinal cohort study was conducted using routinely collected healthcare data. Individuals with COPD were identified between 2014 and 2018. Exposure was moderate or severe exacerbation of COPD...
March 30, 2024: BMJ Open Respiratory Research
Chun-Ta Huang, Sheng-Yuan Ruan, Yi-Ju Tsai, Jung-Yien Chien, Chong-Jen Yu
BACKGROUND: Impact of lung fluid content changing during exercise has not been investigated in chronic obstructive pulmonary disease (COPD). Using a novel point-of-care measurement system (remote dielectric sensing (ReDS) system), we aimed to investigate changes in lung fluid content before and after 6-minute walk test (6MWT); especially, differences between patients with and without comorbid heart failure (HF) were evaluated. METHODS: From June 2021 to July 2022, patients with COPD referred for 6MWT were prospectively enrolled...
March 30, 2024: BMJ Open Respiratory Research
Ruddy Richard, Dennis Jensen, Julianne Touron, Costes Frederic, Aurélien Mulliez, Bruno Pereira, Laura Filaire, Darcy Marciniuk, François Maltais, Wan Tan, Jean Bourbeau, Hélène Perrault
BACKGROUND: Cardiovascular comorbidities are increasingly being recognised in early stages of chronic obstructive pulmonary disease (COPD) yet complete cardiorespiratory functional assessments of individuals with mild COPD or presenting with COPD risk factors are lacking. This paper reports on the effectiveness of the cardiocirculatory-limb muscles oxygen delivery and utilisation axis in smokers exhibiting no, or mild to moderate degrees of airflow obstruction using standardised cardiopulmonary exercise testing (CPET)...
March 28, 2024: BMJ Open Respiratory Research
Össur Ingi Emilsson, Thor Aspelund, Christer Janson, Bryndis Benediktsdottir, Sigurdur Juliusson, Greg Maislin, Allan I Pack, Brendan T Keenan, Thorarinn Gislason
AIM: To assess respiratory symptoms and nocturnal gastro-oesophageal reflux (nGER) among untreated obstructive sleep apnoea (OSA) patients, compared with the general population. Also, if nGER associates differently with respiratory symptoms among OSA patients. METHODS: 2 study cohorts were included: 822 newly diagnosed subjects with moderate-severe OSA and 738 Icelandic general population study participants. All participants answered the same questionnaires. Those reporting nGER symptoms at least once per week were defined as 'with nGER'; those without nGER symptoms and without nGER medication were defined as 'no nGER'; and other participants were defined as having 'possible nGER'...
March 25, 2024: BMJ Open Respiratory Research
Harrison D Stubbs, John Cannon, Emily Knightbridge, Charlotte Durrington, Chloe Roddis, Wendy Gin-Sing, Fiona Massey, Daniel S Knight, Ruta Virsinskaite, James L Lordan, Eleanor Sear, Joy Apple-Pinguel, Eleanor Morris, Martin K Johnson, Stephen J Wort
BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker of cardiac ventricular wall stress that is incorporated into pulmonary hypertension (PH) risk stratification models. Sendaway sampling may enable patients to perform NT-proBNP tests remotely. This UK-wide study aimed to assess the agreement of sendaway NT-proBNP with standard venous NT-proBNP and to assess the effect of delayed processing. METHODS: Reference venous NT-proBNP was collected from PH patients...
March 22, 2024: BMJ Open Respiratory Research
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