journal
https://read.qxmd.com/read/38534702/-helicobacter-pylori-in-inflammatory-bowel-diseases-active-protagonist-or-innocent-bystander
#21
REVIEW
Elisabetta Bretto, Simone Frara, Angelo Armandi, Gian Paolo Caviglia, Giorgio Maria Saracco, Elisabetta Bugianesi, Demis Pitoni, Davide Giuseppe Ribaldone
Helicobacter pylori ( H. pylori ) infection is a prominent entity within human infectious diseases which cause chronic gastritis, peptic ulcers, gastric malignancies, and extragastric disorders. Its persistent colonization can lead to a systemic inflammatory cascade, potentially instigating autoimmune responses and contributing to the pathogenesis of autoimmune diseases. While the specific etiopathogenesis of inflammatory bowel diseases (IBDs) is still unknown, it is widely recognized that immunological, genetic, and environmental factors are implicated...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38534701/identification-and-clinical-characteristics-of-community-acquired-acinetobacter-baumannii-in-patients-hospitalized-for-moderate-or-severe-covid-19-in-peru
#22
JOURNAL ARTICLE
Wilmer Silva-Caso, Giancarlo Pérez-Lazo, Miguel Angel Aguilar-Luis, Adriana Morales-Moreno, José Ballena-López, Fernando Soto-Febres, Johanna Martins-Luna, Luis J Del Valle, Sungmin Kym, Deysi Aguilar-Luis, Dayana Denegri-Hinostroza, Juana Del Valle-Mendoza
Acinetobacter baumannii has been described as a cause of serious community-acquired infections in tropical countries. Currently, its implications when simultaneously identified with other pathogens are not yet adequately understood. A descriptive study was conducted on hospitalized patients with a diagnosis of moderate/severe SARS-CoV-2-induced pneumonia confirmed via real-time RT-PCR. Patients aged > 18 years who were admitted to a specialized COVID-19 treatment center in Peru were selected for enrollment...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534700/the-clinical-efficacy-of-adding-ceftazidime-avibactam-to-standard-therapy-in-treating-infections-caused-by-carbapenem-resistant-klebsiella-pneumonia-with-blaoxa-48-like-genes
#23
JOURNAL ARTICLE
Al Maamon R Abu Jaber, Bilgen Basgut, Ali Abdullah Hawan, Ali Amer Al Shehri, Sultan Ahmad AlKahtani, Nehad J Ahmed, Abdikarim Abdi
Ceftazidime/avibactam (CAZ-AVI) is FDA-approved for managing infections caused by resistant gram-negative bacilli, particularly infections via carbapenem-resistant Enterobacterales pathogens. The clinical data are still limited, particularly those in Saudi Arabia. The present study is a retrospective cohort study that was carried out at the Armed Forces Hospital in the southern region of Saudi Arabia to compare the clinical and microbiological outcomes for CAZ-AVI-treated patients as monotherapy and as an add-on to standard therapy for carbapenem-resistant Klebsiella pneumonia (CRKP) OXA-48 infections to those treated with standard drugs...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534699/generation-and-characterization-of-stable-small-colony-variants-of-usa300-staphylococcus-aureus-in-raw-264-7-murine-macrophages
#24
JOURNAL ARTICLE
Dalida Bivona, Carmelo Bonomo, Lorenzo Colombini, Paolo G Bonacci, Grete F Privitera, Giuseppe Caruso, Filippo Caraci, Francesco Santoro, Nicolò Musso, Dafne Bongiorno, Francesco Iannelli, Stefania Stefani
Intracellular survival and immune evasion are typical features of staphylococcal infections. USA300 is a major clone of methicillin-resistant S. aureus (MRSA), a community- and hospital-acquired pathogen capable of disseminating throughout the body and evading the immune system. Carnosine is an endogenous dipeptide characterized by antioxidant and anti-inflammatory properties acting on the peripheral (macrophages) and tissue-resident (microglia) immune system. In this work, RAW 264.7 murine macrophages were infected with the USA300 ATCC BAA-1556 S...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534698/biofilm-development-by-mycobacterium-avium-complex-clinical-isolates-effect-of-clarithromycin-in-ultrastructure
#25
JOURNAL ARTICLE
Arij Akir, Abrar Senhaji-Kacha, Maria Carmen Muñoz-Egea, Jaime Esteban, John Jairo Aguilera-Correa
BACKGROUND: The Mycobacterium avium complex includes the commonest non-tuberculous mycobacteria associated with human infections. These infections have been associated with the production of biofilms in many cases, but there are only a few studies about biofilms produced by the species included in this group. METHODS: Three collection strains ( M. avium ATCC25291, M. intracellulare ATCC13950, and M. chimaera DSM756), three clinically significant strains (647, 657, and 655), and three clinically non-significant ones (717, 505, and 575) of each species were included...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38534697/post-covid-19-pandemic-rebound-of-macrolide-resistant-mycoplasma-pneumoniae-infection-a-descriptive-study
#26
JOURNAL ARTICLE
Fan-Fan Xing, Kelvin Hei-Yeung Chiu, Chao-Wen Deng, Hai-Yan Ye, Lin-Lin Sun, Yong-Xian Su, Hui-Jun Cai, Simon Kam-Fai Lo, Lei Rong, Jian-Liang Chen, Vincent Chi-Chung Cheng, David Christopher Lung, Siddharth Sridhar, Jasper Fuk-Woo Chan, Ivan Fan-Ngai Hung, Kwok-Yung Yuen
The rebound characteristics of respiratory infections after lifting pandemic control measures were uncertain. From January to November 2023, patients presenting at a teaching hospital were tested for common respiratory viruses and Mycoplasma pneumoniae using a combination of antigen, nucleic acid amplification, and targeted next-generation sequencing (tNGS) tests. The number and rate of positive tests per month, clinical and microbiological characteristics were analyzed. A rapid rebound of SARS-CoV-2 was followed by a slower rebound of M...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534696/current-therapeutic-approaches-for-multidrug-resistant-and-extensively-drug-resistant-acinetobacter-baumannii-infections
#27
REVIEW
Petros Rafailidis, Periklis Panagopoulos, Christos Koutserimpas, George Samonis
The treatment of Acinetobacter baumannii infections remains a challenge for physicians worldwide in the 21st century. The bacterium possesses a multitude of mechanisms to escape the human immune system. The consequences of A. baumannii infections on morbidity and mortality, as well on financial resources, remain dire. Furthermore, A. baumannii superinfections have also occurred during the COVID-19 pandemic. While prevention is important, the antibiotic armamentarium remains the most essential factor for the treatment of these infections...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534695/role-of-%C3%AE-lactamase-inhibitors-as-potentiators-in-antimicrobial-chemotherapy-targeting-gram-negative-bacteria
#28
REVIEW
Song Zhang, Xinyu Liao, Tian Ding, Juhee Ahn
Since the discovery of penicillin, β-lactam antibiotics have commonly been used to treat bacterial infections. Unfortunately, at the same time, pathogens can develop resistance to β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapenems by producing β-lactamases. Therefore, a combination of β-lactam antibiotics with β-lactamase inhibitors has been a promising approach to controlling β-lactam-resistant bacteria. The discovery of novel β-lactamase inhibitors (BLIs) is essential for effectively treating antibiotic-resistant bacterial infections...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534694/detection-of-extended-spectrum-beta-lactamase-esbl-producing-enterobacteriaceae-from-diseased-broiler-chickens-in-lusaka-district-zambia
#29
JOURNAL ARTICLE
Chikwanda Chileshe, Misheck Shawa, Nelson Phiri, Joseph Ndebe, Cynthia Sipho Khumalo, Chie Nakajima, Masahiro Kajihara, Hideaki Higashi, Hirofumi Sawa, Yasuhiko Suzuki, Walter Muleya, Bernard Mudenda Hang'ombe
Poultry products in Zambia form an integral part of the human diet in many households, as they are cheap and easy to produce. The burden of poultry diseases has, however, remained a major challenge. Growing consumer demand for poultry products in Zambia has resulted in non-prudent antimicrobial use on farms, intending to prevent and treat poultry diseases for growth optimisation and maximising profits. This cross-sectional study aimed to identify the different types of bacteria causing diseases in chickens in Lusaka and to detect the extended-spectrum lactamase (ESBL)-encoding genes...
March 15, 2024: Antibiotics
https://read.qxmd.com/read/38534693/intrapulmonary-and-systemic-pharmacokinetics-of-colistin-following-nebulization-of-low-dose-colistimethate-sodium-in-patients-with-ventilator-associated-pneumonia-caused-by-carbapenem-resistant-acinetobacter-baumannii
#30
JOURNAL ARTICLE
Dong-Hwan Lee, Shin-Young Kim, Yong-Kyun Kim, So-Young Jung, Ji-Hoon Jang, Hang-Jea Jang, Jae-Ha Lee
Colistimethate sodium (CMS) nebulization is associated with reduced systemic toxicity compared to intravenous injection, with potentially enhanced clinical efficacy. This study aimed to assess the pharmacokinetic (PK) properties of colistin during low-dose CMS nebulization in patients with ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii . A nonlinear mixed-effects modeling approach was applied to develop population PK models for colistin in both epithelial lining fluid (ELF) and plasma...
March 14, 2024: Antibiotics
https://read.qxmd.com/read/38534692/pan-genome-plasticity-and-virulence-factors-a-natural-treasure-trove-for-acinetobacter-baumannii
#31
REVIEW
Theodoros Karampatakis, Katerina Tsergouli, Payam Behzadi
Acinetobacter baumannii is a Gram-negative pathogen responsible for a variety of community- and hospital-acquired infections. It is recognized as a life-threatening pathogen among hospitalized individuals and, in particular, immunocompromised patients in many countries. A. baumannii, as a member of the ESKAPE group, encompasses high genomic plasticity and simultaneously is predisposed to receive and exchange the mobile genetic elements (MGEs) through horizontal genetic transfer (HGT). Indeed, A. baumannii is a treasure trove that contains a high number of virulence factors...
March 14, 2024: Antibiotics
https://read.qxmd.com/read/38534691/microbiological-quality-and-safety-of-fresh-rabbit-meat-with-special-reference-to-methicillin-resistant-s-aureus-mrsa-and-esbl-producing-e-coli
#32
JOURNAL ARTICLE
Jessica da Silva Guedes, David Velilla-Rodriguez, Elena González-Fandos
The purpose of this investigation was to evaluate the microbial quality and safety of rabbit meat. A total of 49 rabbit meat samples were taken at the retail level. The mesophiles, staphylococci, Enterobacterales , and Pseudomonas spp. counts were 4.94 ± 1.08, 2.59 ± 0.70, 2.82 ± 0.67, and 3.23 ± 0.76 log CFU/g, respectively. Campylobacter spp. were not detected in any sample. Listeria monocytogenes was isolated from one sample (2.04%) at levels below 1.00 log CFU/g. Multi-resistant S aureus was found in seven samples (14...
March 13, 2024: Antibiotics
https://read.qxmd.com/read/38534690/chestnut-honey-is-effective-against-mixed-biofilms-at-different-stages-of-maturity
#33
JOURNAL ARTICLE
Regina Koloh, Viktória L Balázs, Lilla Nagy-Radványi, Béla Kocsis, Erika Beáta Kerekes, Marianna Kocsis, Ágnes Farkas
The irresponsible overuse of antibiotics has increased the occurrence of resistant bacterial strains, which represents one of the biggest patient safety risks today. Due to antibiotic resistance and biofilm formation in bacteria, it is becoming increasingly difficult to suppress the bacterial strains responsible for various chronic infections. Honey was proven to inhibit bacterial growth and biofilm development, offering an alternative solution in the treatment of resistant infections and chronic wounds. Our studies included chestnut honey, valued for its high antibacterial activity, and the bacteria Pseudomonas aeruginosa , methicillin-resistant Staphylococcus aureus , and S...
March 13, 2024: Antibiotics
https://read.qxmd.com/read/38534689/daptomycin-use-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-a-neonatal-intensive-care-unit
#34
JOURNAL ARTICLE
Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic, has been used in neonates with persistent coagulase-negative staphylococci (CoNS) bacteremia with promising results, but studies reporting on the efficacy and safety of the agent are scarce...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38534688/evaluation-of-hospital-antimicrobial-stewardship-programs-implementation-process-impact-and-outcomes-review-of-systematic-reviews
#35
REVIEW
Hamad Abdel Hadi, Faiha Eltayeb, Sara Al Balushi, Joanne Daghfal, Faraz Ahmed, Ceu Mateus
Antimicrobial Stewardship Programs (ASP) were introduced in healthcare as a public health priority to promote appropriate prescribing of antimicrobials, to reduce adverse events related to antimicrobials, as well as to control the escalating challenges of antimicrobial resistance. To deliver aimed outcome objectives, ASPs involve multiple connected implementation process measures. A systematic review was conducted to evaluate both concepts of ASPs. Guided by PRISMA frames, published systematic reviews (SR) focusing on ASPs restricted to secondary and tertiary healthcare were evaluated over the past 10 years involving all age groups...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38534687/navigating-the-chemical-space-of-enr-inhibitors-a-comprehensive-analysis
#36
JOURNAL ARTICLE
Vid Kuralt, Rok Frlan
Antimicrobial resistance is a global health threat that requires innovative strategies against drug-resistant bacteria. Our study focuses on enoyl-acyl carrier protein reductases (ENRs), in particular FabI, FabK, FabV, and InhA, as potential antimicrobial agents. Despite their promising potential, the lack of clinical approvals for inhibitors such as triclosan and isoniazid underscores the challenges in achieving preclinical success. In our study, we curated and analyzed a dataset of 1412 small molecules recognized as ENR inhibitors, investigating different structural variants...
March 11, 2024: Antibiotics
https://read.qxmd.com/read/38534686/antimicrobial-properties-of-colostrum-and-milk
#37
REVIEW
Furkan Eker, Emir Akdaşçi, Hatice Duman, Yalçın Mert Yalçıntaş, Ahmet Alperen Canbolat, Arda Erkan Kalkan, Sercan Karav, Dunja Šamec
The growing number of antibiotic resistance genes is putting a strain on the ecosystem and harming human health. In addition, consumers have developed a cautious attitude towards chemical preservatives. Colostrum and milk are excellent sources of antibacterial components that help to strengthen the immunity of the offspring and accelerate the maturation of the immune system. It is possible to study these important defenses of milk and colostrum, such as lactoferrin, lysozyme, immunoglobulins, oligosaccharides, etc...
March 11, 2024: Antibiotics
https://read.qxmd.com/read/38534685/an-overview-of-antibiotic-therapy-for-early-and-late-onset-neonatal-sepsis-current-strategies-and-future-prospects
#38
REVIEW
Giovanni Boscarino, Rossana Romano, Carlotta Iotti, Francesca Tegoni, Serafina Perrone, Susanna Esposito
Neonatal sepsis is a clinical syndrome mainly associated with a bacterial infection leading to severe clinical manifestations that could be associated with fatal sequalae. According to the time of onset, neonatal sepsis is categorized as early- (EOS) or late-onset sepsis (LOS). Despite blood culture being the gold standard for diagnosis, it has several limitations, and early diagnosis is not immediate. Consequently, most infants who start empirical antimicrobial therapy do not have an underlying infection. Despite stewardship programs partially reduced this negative trend, in neonatology, antibiotic overuse still persists, and it is associated with several relevant problems, the first of which is the increase in antimicrobial resistance (AMR)...
March 10, 2024: Antibiotics
https://read.qxmd.com/read/38534684/national-level-cross-sectional-study-on-antibiotic-use-in-children-during-the-pre-and-early-covid-19-eras
#39
JOURNAL ARTICLE
Ji Young Park, Hyun Mi Kang
This study aimed to investigate national data for a quantitative evaluation of antibiotic usage in Korean children during the pre- and early COVID-19 period. This was a cross-sectional study from 2016 to 2021 of children <18 years, grouped by age (0, 1, 2-4, 5-11, and 12-17 years) and city/province. Systemic antibiotic prescriptions, days of administration, and population by age and region were collected. Days of therapy (DOT)/1000 pediatric inhabitant per day (PID) was used for antibiotic quantitative monitoring...
March 9, 2024: Antibiotics
https://read.qxmd.com/read/38534683/the-synthetic-peptide-lyetx-i-mn%C3%A2-k-derived-from-lycosa-erythrognatha-spider-toxin-is-active-against-methicillin-resistant-staphylococcus-aureus-mrsa-in-vitro-and-in-vivo
#40
JOURNAL ARTICLE
Ana Paula Gonçalves Coelho Vieira, Amanda Neves de Souza, William Gustavo Lima, Julio Cesar Moreira Brito, Daniela Carolina Simião, Lucas Vinícius Ribeiro Gonçalves, Lídia Pereira Barbosa Cordeiro, Denise de Oliveira Scoaris, Simone Odília Antunes Fernandes, Jarbas Magalhães Resende, Burkhard Bechinger, Rodrigo Moreira Verly, Maria Elena de Lima
The urgent global health challenge posed by methicillin-resistant Staphylococcus aureus (MRSA) infections demands effective solutions. Antimicrobial peptides (AMPs) represent promising tools of research of new antibacterial agents and LyeTx I mn∆K, a short synthetic peptide based on the Lycosa erythrognatha spider venom, is a good representative. This study focused on analyzing the antimicrobial activities of LyeTx I mn∆K, including minimum inhibitory and bactericidal concentrations, synergy and resensitization assays, lysis activity, the effect on biofilm, and the bacterial death curve in MRSA...
March 8, 2024: Antibiotics
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