journal
https://read.qxmd.com/read/38882931/cabotegravir-rilpivirine-long-acting-overview-of-injection-guidance-injection-site-reactions-and-best-practices-for-intramuscular-injection-administration
#21
JOURNAL ARTICLE
Paula Teichner, Nadine Chamay, Emilie Elliot, Miguel Pascual-Bernáldez, Deanna Merrill, Cindy Garris, Ronald D'Amico, Cecy Felizarta, Emma Torres, Rodica Van Solingen-Ristea, Bryan Baugh, Parul Patel, Vani Vannappagari, Samia Dakhia, Joseph W Polli, Louise Garside, Richard Grove, Shanker Thiagarajah, Eileen Birmingham, Jean van Wyk
BACKGROUND: Cabotegravir (CAB) + rilpivirine (RPV) dosed monthly or every 2 months is a complete long-acting (LA) regimen for the maintenance of human immunodeficiency virus type 1 virologic suppression. Across the phase 3/3b trials, the most frequently reported adverse events were injection site reactions (ISRs). METHODS: We present pooled ISR characteristics and outcomes for participants receiving CAB + RPV LA through week 96 of the FLAIR and ATLAS-2M studies, and survey results from healthcare providers (HCPs) giving injections (eg, injectors) in the ATLAS, FLAIR, and ATLAS-2M studies to determine optimal injection techniques...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38872851/landscape-of-invasive-fusariosis-in-pediatric-cancer-patients-results-of-a-multicenter-observational-study-from-latin-america
#22
JOURNAL ARTICLE
Fabianne Carlesse, Adriana Maria Paixão de Sousa da Silva, Jaques Sztajnbok, Nadia Litivinov, Karina Peron, Marcelo Otsuka, Mariana Volpe Arnoni, Marcelo Schirmer, Patricia de Oliveira Costa, Ana Lucia Munhoz Cavalcanti de Albuquerque, Hugo Morales, Eduardo Lopez-Medina, Carlos A Portilla, Romina Valenzuela, Fabrizio Motta, Fabio Araújo Motta, João Nobrega de Almeida Junior, Maria Elena Santolaya, Arnaldo Lopes Colombo
Invasive fusariosis (IF) is a life-threatening opportunistic infection that affects vulnerable hosts. We conducted a multicenter and multinational retrospective study to characterize the natural history and clinical management of IF in pediatric cancer patients. We selected patients <18 years old who were sequentially hospitalized in 10 Latin American medical centers with a diagnosis of IF between 2002 and 2021. Data were collected using an electronic case report form complemented by a dictionary of terms...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38872850/serological-responses-to-streptococcus-pyogenes-vaccine-candidate-antigens-suggests-that-streptococcus-dysgalactiae-is-the-predominant-cause-of-lower-limb-cellulitis
#23
JOURNAL ARTICLE
Michael Taggart, Kristyn Langworthy, Siong Hui, Conchita Boyder, Alma Fulurija, Michael Morici, Edward Raby, Laurens Manning
BACKGROUND: A future Streptococcus pyogenes (Strep A) vaccine will ideally prevent a significant burden of lower limb cellulitis; however, natural immune responses to proposed vaccine antigens following an episode of cellulitis remain uncharacterized. METHODS: We enrolled 63 patients with cellulitis and 26 with invasive beta hemolytic streptococci infection, using a multiplexed assay to measure immunoglobulin G against Strep A vaccine candidate antigens, including: streptolysin O (SLO), deoxyribonuclease B (DNB), group A carbohydrate (GAC), C5a peptidase (ScpA), cell envelope proteinase (SpyCEP), and adhesion and division protein (SpyAD)...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38872849/second-time-s-the-charm-assessing-the-sensitivity-and-yield-of-inpatient-diagnostic-algorithms-for-pulmonary-tuberculosis-in-a-low-prevalence-setting
#24
JOURNAL ARTICLE
Caitlin M Dugdale, Kimon C Zachary, Dustin S McEvoy, John A Branda, Amy Courtney, Rebecca Craig, Alexandra Doms, Lindsay Germaine, Chloe V Green, Eren Gulbas, David C Hooper, Rocio M Hurtado, Emily P Hyle, Michelle S Jerry, Jacob E Lazarus, Molly Paras, Sarah E Turbett, Erica S Shenoy
BACKGROUND: For persons with suspected pulmonary tuberculosis, the guidelines of the Centers for Disease Control and Prevention recommend collecting 3 respiratory specimens 8 to 24 hours apart for acid-fast bacilli (AFB) smear and culture, in addition to 1 nucleic acid amplification test (NAAT). However, data supporting this approach are limited. Our objective was to estimate the performance of 1, 2, or 3 AFB smears with or without NAATs to detect pulmonary tuberculosis in a low-prevalence setting...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38872848/ocular-mpox-in-a-breastfeeding-healthcare-provider
#25
JOURNAL ARTICLE
Sara Lovett, Jayne Griffith, Nick Lehnertz, Teresa Fox, Greg Siwek, Aaron M T Barnes, Aaron D Kofman, Kaitlin Hufstetler, Alexander L Greninger, Michael B Townsend, William C Carson, Ruth Lynfield, Shama Cash-Goldwasser
A healthcare provider unknowingly treated a patient with mpox and subsequently developed ocular mpox without rash. She breastfed during illness; her infant was not infected. This report addresses 3 challenges in mpox management and control: diagnosis in the absence of rash, exposures in healthcare settings, and management of lactating patients.
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38872847/deep-sternal-wound-infection-caused-by-rhizopus-species-after-coronary-artery-bypass-graft
#26
JOURNAL ARTICLE
Cody A Cunningham, Thomas E Grys, Francis X Downey, Christopher F Saling, Robert Orenstein, Janis E Blair
Deep sternal wound infection is a rare complication of cardiac surgery that is typically caused by skin resident flora, such as species of Staphylococcus and Streptococcus . Infections caused by fungi are less common and are generally caused by Candida species. Regardless of etiology, these infections are associated with significant morbidity and mortality. We present a case of postoperative mediastinitis that occurred following a 5-vessel coronary artery bypass graft and was caused by a filamentous fungus of the Rhizopus genus...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38872846/tailoring-interventions-for-control-of-endemic-carbapenem-resistant-acinetobacter-baumannii-an-interrupted-time-series-analysis
#27
JOURNAL ARTICLE
Vered Schechner, Adi Cohen, Yehuda Carmeli
BACKGROUND: We examined temporal trends in carbapenem-resistant Acinetobacter baumannii (CRAB) infections in a hospital with hyperendemic CRAB and assessed the efficacy of varied infection control strategies in different ward types. METHODS: We retrospectively analyzed all CRAB clinical samples from 2006 to 2019 and categorized infections as hospital-onset (HO) or community-onset. We used interrupted time series analysis to assess the impact of interventions on the incidence of all HO-CRAB infections and bloodstream infections (BSIs) at the hospital and ward group levels...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868314/fungal-foe-and-mechanical-hearts-a-retrospective-case-series-on-candida-auris-bloodstream-infection-with-left-ventricular-assist-devices
#28
JOURNAL ARTICLE
Ajay Kerai, Saumil Doshi, Ashley Laleker, Anjali Majumdar
No guidelines currently exist for the management of Candida auris bloodstream infection in patients with left ventricular assist devices (LVADs). We aim to share our management experience through this retrospective case series outlining 15 episodes of C auris candidemia identified in 7 patients over 18 months. The initial source of candidemia was central venous catheter in 5 patients, driveline exit site infection in 1 patient, and possible pump infection in 1 patient. All patients were initially treated with micafungin...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868313/recurrence-of-diabetic-foot-complications-a-domino-effect-leading-to-lethal-consequences-insights-from-a-national-longitudinal-study
#29
JOURNAL ARTICLE
Chun-Chien Hsu, Hsi-Yu Lai, Hung-Yu Lin, Sung-Ching Pan, Nai-Chen Cheng, Liang-Kung Chen, Fei-Yuan Hsiao, Shu-Wen Lin
BACKGROUND: Foot complications are common in people with diabetes mellitus (DM), leading to increased health care utilization, heightened mortality risk, and notable recurrence rates even after treatment. This retrospective cohort study aimed to investigate the impact of repeated occurrence of DM-related foot complications on the risk of all-cause mortality and to identify the potential risk factors associated with repeated events. METHODS: People with DM admitted with foot complications (ulcer, skin and soft tissue infection, or osteomyelitis) from 2012 to 2014 were identified from Taiwan's National Health Insurance Research Database, with a 3-year follow-up for repeated events...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868312/invasive-pneumococcal-disease-epidemiology-and-serotype-replacement-after-the-introduction-of-the-13-valent-pneumococcal-conjugate-vaccine-in-ontario-canada-2007-2022
#30
JOURNAL ARTICLE
Ramandip Grewal, Kelty Hillier, Shelley L Deeks, Allison H Yeung, Sarah E Wilson, Shinthuja Wijayasri, Tara M Harris, Sarah A Buchan
BACKGROUND: New vaccine products were recently authorized for protection against invasive pneumococcal disease (IPD) in Canada. Our aim was to determine age- and serotype-specific trends in IPD incidence and severity in Canada's largest province, Ontario. METHODS: We included all confirmed IPD cases reported in Ontario and defined the pre-pneumococcal 13-valent conjugate vaccine (PCV13) era (01/2007 to 12/2010), post-PCV13 era (01/2011 to 12/2019), and coronavirus disease 2019 (COVID-19) pandemic era (01/2020 to 12/2022)...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868311/acute-coxiella-burnetii-infection-a-10-year-clinical-experience-at-a-tertiary-care-center-in-the-united-states
#31
JOURNAL ARTICLE
Said El Zein, Doug W Challener, Nischal Ranganath, Ryan B Khodadadi, Elitza S Theel, Omar M Abu Saleh
BACKGROUND: Identifying and treating patients with acute Q fever who are at an increased risk of progressing to persistent disease is crucial for preventing future complications. In this study, we share our decade-long clinical experience with acute Q fever, highlighting the challenges that clinicians encounter from making an initial diagnosis and performing risk stratification to determining the appropriate prophylaxis regimen and duration. METHODS: We retrieved records of adult Mayo Clinic patients (≥18 years) with positive Coxiella burnetii serology results between 1 January 2012 and 31 March 2022...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868310/liver-steatosis-is-prevalent-in-lean-people-with-hiv-and-associated-with-exposure-to-antiretroviral-treatment-a-cross-sectional-study
#32
JOURNAL ARTICLE
Louise E van Eekeren, Nadira Vadaq, Wilhelm A J W Vos, Marc J T Blaauw, Albert L Groenendijk, Jan van Lunzen, Janneke E Stalenhoef, Marvin A H Berrevoets, Annelies Verbon, Gert Weijers, Mihai G Netea, André J A M van der Ven, Quirijn de Mast, Leo A B Joosten, Eric T T L Tjwa
BACKGROUND: Steatotic liver disease is suggested to have a higher prevalence and severity in people with HIV (PHIV), including in those with a normal body mass index (BMI). In this study, we used data from the 2000HIV cohort to (1) assess the prevalence of liver steatosis and fibrosis in lean versus overweight/obese PHIV and (2) assess associations in these subgroups between steatosis and fibrosis with traditional risk factors and HIV-specific characteristics. METHODS: The 2000HIV study cohort comprises 1895 virally suppressed PHIV that were included between 2019 and 2021 in 4 HIV treatment centers in the Netherlands...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868309/in-home-tb-testing-using-genexpert-edge-is-acceptable-feasible-and-improves-the-proportion-of-symptomatic-household-contacts-tested-for-tb-a-proof-of-concept-study
#33
JOURNAL ARTICLE
Andrew Medina-Marino, Dana Bezuidenhout, Charl Bezuidenhout, Shelley N Facente, Bernard Fourie, Sanghyuk S Shin, Adam Penn-Nicholson, Grant Theron
BACKGROUND: Household contact investigations are effective for finding tuberculosis (TB) cases but are hindered by low referral uptake for clinic-based evaluation and testing. We assessed the acceptability and feasibility of in-home testing of household contacts (HHC) using the GeneXpert Edge platform. METHODS: We conducted a 2-arm, randomized study in Eastern Cape, South Africa. HHCs were verbally assessed using the World Health Organization-recommended 4-symptom screen...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868308/review-of-the-in-vitro-microbiological-activity-of-mecillinam-against-common-uropathogens-in-uncomplicated-urinary-tract-infection-focus-on-resistant-pathogens
#34
REVIEW
Thomas P Lodise, Keith S Kaye, Anne Santerre Henriksen, Gunnar Kahlmeter
Antimicrobial resistance in uropathogens commonly causing urinary tract infections (UTIs) is a growing problem internationally. Pivmecillinam, the oral prodrug of mecillinam, has been used for over 40 years, primarily in Northern Europe and Canada. It is recommended in several countries as a first-line agent for the treatment of uncomplicated UTIs (uUTIs) and is now approved in the United States. We performed a structured literature search to review the available evidence on susceptibility of common uUTI-causing uropathogens to mecillinam...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868307/severe-mpox-among-people-with-advanced-human-immunodeficiency-virus-receiving-prolonged-tecovirimat-in-new-york-city
#35
JOURNAL ARTICLE
Elizabeth A Garcia, Mary M K Foote, Tristan D McPherson, Maura K Lash, Amma N Bosompem, Alyssa Bouscaren, Justin Chan, Madeline A DiLorenzo, Dennis Feihel, Randal C Fowler, Vani Gandhi, Elizabeth R Jenny-Avital, Erik J Kopping, Dana Mazo, Jacob McLean, Ofole Mgbako, Mark N Sayegh, Raphael N Shaw, Michelle Su, Jeanne Sullivan Meissner, Jade C Wang, Wendy Wen, John C Winters, Cosmina B Zeana, Jason Zucker, Marcia Wong
Severe mpox has been observed in people with advanced human immunodeficiency virus (HIV). We describe clinical outcomes of 13 patients with advanced HIV (CD4 <200 cells/μL), severe mpox, and multiorgan involvement. Despite extended tecovirimat courses and additional agents, including vaccinia immune globulin, cidofovir, and brincidofovir, this group experienced prolonged hospitalizations and high mortality.
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868306/syndromic-gastrointestinal-panel-diagnostic-tests-have-changed-our-understanding-of-the-epidemiology-of-yersiniosis-foodborne-diseases-active-surveillance-network-2010-2021
#36
JOURNAL ARTICLE
Logan C Ray, Daniel C Payne, Joshua Rounds, Rosalie T Trevejo, Elisha Wilson, Kari Burzlaff, Katie N Garman, Sarah Lathrop, Tamara Rissman, Katie Wymore, Sophia Wozny, Siri Wilson, Louise K Francois Watkins, Beau B Bruce, Daniel L Weller
BACKGROUND: In the US, yersinosis was understood to predominantly occur in winter and among Black or African American infants and Asian children. Increased use of culture-independent diagnostic tests (CIDTs) has led to marked increases in yersinosis diagnoses. METHODS: We describe differences in the epidemiology of yersiniosis diagnosed by CIDT versus culture in 10 US sites, and identify determinants of health associated with diagnostic method. RESULTS: Annual reported incidence increased from 0...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868305/varicella-zoster-virus-induced-neurologic-disease-after-covid-19-vaccination-a-multicenter-observational-cohort-study
#37
JOURNAL ARTICLE
Meital Elbaz, Tomer Hoffman, Dafna Yahav, Sarah Dovrat, Nesrin Ghanem-Zoubi, Alaa Atamna, Daniel Grupel, Sharon Reisfeld, Mirit Hershman-Sarafov, Pnina Ciobotaro, Ronza Najjar-Debbiny, Tal Brosh-Nissimov, Bibiana Chazan, Orit Yossepowitch, Yonit Wiener-Well, Ora Halutz, Shelley Reich, Ronen Ben-Ami, Yael Paran
BACKGROUND: Early reports described an increased risk of herpes zoster following receipt of mRNA-based COVID-19 vaccines. The objective was to assess whether COVID-19 vaccine is associated with varicella-zoster virus-induced neurologic disease (VZV-ND). METHODS: This multicenter retrospective case-control study with a test-negative design was conducted at 12 hospitals in Israel. We included all patients admitted with VZV-ND between January 2020 and December 2021 and matched controls with a negative polymerase chain reaction result for VZV in cerebrospinal fluid...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868304/variation-in-north-american-infectious-disease-specialists-practice-regarding-oral-and-suppressive-antibiotics-for-adult-osteoarticular-infections-results-of-an-emerging-infections-network-ein-survey
#38
JOURNAL ARTICLE
Nicolás Cortés-Penfield, Susan E Beekmann, Philip M Polgreen, Keenan Ryan, Jonas Marschall, Poorani Sekar
BACKGROUND: Osteoarticular infections (OAIs) are commonly treated with prolonged intravenous (IV) antimicrobials. The Oral versus Intravenous Antibiotics for Bone and Joint Infection (OVIVA) trial demonstrated that oral (PO) antibiotics are noninferior to IV antibiotics in the treatment of OAIs. We surveyed infectious disease (ID) physicians about their use of PO antibiotics in the treatment of OAIs. METHODS: An Emerging Infection Network survey with 9 questions regarding antibiotic prescribing for the treatment of OAIs was sent to 1475 North American ID physicians...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868303/characteristics-and-outcome-of-vascular-graft-infections-a-risk-factor-and-survival-analysis
#39
JOURNAL ARTICLE
Leonie Stockschläder, Donara Margaryan, Safwan Omran, Martin Schomaker, Andreas Greiner, Andrej Trampuz
BACKGROUND: Vascular graft infection (VGI) is a serious complication after implantation of arterial vascular grafts. Optimal surgical and pathogen-specific antimicrobial treatment regimens for VGI are largely unknown. We evaluated patients with arterial VGI according to onset, location, microbiological and imaging characteristics, and surgical and antimicrobial treatment and performed an outcome evaluation. METHODS: Consecutive patients with VGI treated in 2 hospitals from 2010 through 2020 were retrospectively analyzed...
June 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38868302/diagnostic-value-of-microbial-cell-free-dna-sequencing-for-suspected-invasive-fungal-infections-a-retrospective-multicenter-cohort-study
#40
JOURNAL ARTICLE
Sammy Huygens, Alexander Schauwvlieghe, Nick Wlazlo, Ine Moors, Jerina Boelens, Marijke Reynders, Ga-Lai Chong, Corné H W Klaassen, Bart J A Rijnders
BACKGROUND: An early diagnosis and treatment of invasive fungal disease (IFD) is associated with improved outcome, but the moderate sensitivity of noninvasive diagnostic tests makes this challenging. Invasive diagnostic procedures such as bronchoalveolar lavage (BAL) have a higher yield but are not without risk. The detection and sequencing of microbial cell-free DNA (mcfDNA) may facilitate a noninvasive diagnosis. MATERIALS: In a prospective observational study, we collected plasma in the 120 hours preceding or following a BAL in patients with hematological malignancies suspected for a pulmonary IFD...
June 2024: Open Forum Infectious Diseases
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