journal
https://read.qxmd.com/read/38058459/risk-factors-for-hospitalization-and-effect-of-immunosuppression-on-clinical-outcomes-among-an-urban-cohort-of-patients-with-mpox
#1
JOURNAL ARTICLE
William M Garneau, Joyce L Jones, Gabriella M Dashler, Heba H Mostafa, Seth D Judson, Nathan Kwon, Matthew M Hamill, Elizabeth A Gilliams, David S Rudolph, Jeanne C Keruly, Amary Fall, Eili Y Klein, Bhakti Hansoti, Kelly A Gebo
BACKGROUND: During the 2022 mpox outbreak most patients were managed as outpatients, but some required hospitalization. Uncontrolled human immunodeficiency virus (HIV) has been identified as a risk factor for severe mpox. METHODS: Patients with mpox diagnosed or treated within the Johns Hopkins Health System between 1 June and 15 December 2022 were included. The primary outcome of interest was risk of hospitalization. Demographic features, comorbid conditions, treatment, and clinical outcomes were determined...
December 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38045558/clinical-outcomes-after-viremia-among-people-receiving-dolutegravir-vs-efavirenz-based-first-line-antiretroviral-therapy-in-south-africa
#2
JOURNAL ARTICLE
Kwabena Asare, Lara Lewis, Johan van der Molen, Yukteshwar Sookrajh, Thokozani Khubone, Pravikrishnen Moodley, Richard J Lessells, Kogieleum Naidoo, Phelelani Sosibo, Nigel Garrett, Jienchi Dorward
BACKGROUND: We aimed to compare clinical outcomes after viremia between dolutegravir vs efavirenz-based first-line antiretroviral therapy (ART) as evidence is lacking outside clinical trials in resource-limited settings. METHODS: We conducted a retrospective cohort analysis with routine data from 59 South African clinics. We included people with HIV aged ≥15 years receiving first-line tenofovir disoproxil fumarate, lamivudine, dolutegravir (TLD) or tenofovir disoproxil fumarate, emtricitabine, efavirenz (TEE) and with first viremia (≥50 copies/mL) between June and November 2020...
December 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033988/systematic-literature-review-of-risk-factors-for-poor-outcomes-among-adults-with-respiratory-syncytial-virus-infection-in-high-income-countries
#3
JOURNAL ARTICLE
Annete Njue, Weyinmi Nuabor, Matthew Lyall, Andrea Margulis, Josephine Mauskopf, Daniel Curcio, Samantha Kurosky, Bradford D Gessner, Elizabeth Begier
UNLABELLED: Identification of risk factors for severe respiratory syncytial virus (RSV) disease in adults could facilitate their appropriate vaccine recommendations. We conducted a systematic literature review (last 10 years in PubMed/Embase) to identify quantitative estimates of risk factors for severe RSV infection outcomes in high-income countries. Severe outcomes from RSV infection included hospitalization, excess mortality, lower respiratory tract infection, or a composite measure: severe RSV, which included these outcomes and others, such as mechanical ventilation and extended hospital stay...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033987/delays-in-hepatitis-b-immunization-series-completion-in-people-with-human-immunodeficiency-virus
#4
JOURNAL ARTICLE
Daanish Sheikh, Kristen A Staggers, Jennifer Carey, Wendy A Keitel, Robert L Atmar, Hana M El Sahly, Jennifer A Whitaker
BACKGROUND: Studies have demonstrated low hepatitis B virus (HBV) vaccine series completion among persons with human immunodeficiency virus (HIV). METHODS: We conducted a retrospective record review of persons entering HIV care at 2 clinics in Houston, Texas, between 2010 and 2018. Kaplan-Meier curves summarized time to receipt of HBV vaccines for those eligible for vaccination. We estimated the proportions of patients who had received 1, 2, or 3 HBV vaccine doses at 12 and 24 months after entry to care...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033986/human-immunodeficiency-virus-hiv-treatment-with-antiretroviral-therapy-mitigates-the-high-risk-of-mental-health-disorders-associated-with-hiv-infection-in-the-us-population
#5
JOURNAL ARTICLE
Djibril M Ba, Kathryn A Risher, Paddy Ssentongo, Yue Zhang, Qi Dai, Guodong Liu, Mamoudou Maiga, Xuehong Zhang, Brehima Diakite, Souleymane Dit Papa Coulibaly, Lifang Hou, Douglas L Leslie, Vernon M Chinchilli
BACKGROUND: Whether treatment of human immunodeficiency virus (HIV) with antiretroviral therapy (ART) is associated with lower risk of mental health disorders (MHDs) among people with HIV (PWH) remains unknown. We aim to determine the association between HIV and MHDs and whether ART alters the risk of MHDs among PWH in the US adult population. METHODS: We conducted a real-world study using the Merative MarketScan claims database (2016-2020), identifying individuals with HIV (diagnosed using International Classification of Diseases, Tenth Revision, Clinical Modification codes) and those without HIV...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033985/correction-to-clinician-testing-and-treatment-thresholds-for-management-of-urinary-tract-infection
#6
COMMENT
(no author information available yet)
[This corrects the article DOI: 10.1093/ofid/ofad455.].
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033984/association-of-insomnia-sleep-quality-and-sleep-duration-with-risk-of-physical-frailty-in-middle-aged-and-older-people-with-hiv
#7
JOURNAL ARTICLE
Qionggui Zhou, Yingying Ding, Xiaoxiao Chen, Shanling Wang, Haijiang Lin, Na He
BACKGROUND: Frailty is one of the major concerns among aging people with HIV (PWH). Evidence regarding the association between sleep disorders and physical frailty in PWH is limited. METHODS: PWH and HIV-negative individuals aged ≥40 years were included and frequency-matched in a 1:2 ratio by sex and age. Logistic regression models were used to estimate the odds ratios (ORs) and 95% CIs of the association between sleep disorders and physical frailty, and restricted cubic splines were used to describe the dose-response association...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033983/-blastomycosis-endocarditis-case-report-and-literature-review
#8
Franco Murillo Chavez, Evgenii Filippov, Francesca Licandro, Vishal Sethi, Brandon Eilertson
We report successful treatment of a case of disseminated blastomycosis originating in the right lung, with involvement of the right pleural space, multiple ribs and vertebral bodies, and the pericardium and mitral valve endocarditis. The 22-year-old patient presented with a 13-month history of right lower lobe pneumonia associated with fevers, night sweats, rib pain, and 27-kg weight loss. Pathology examination revealed Blastomyces from multiple biopsies of inflammatory masses in the right thorax. After a 4-week induction with liposomal amphotericin followed by oral itraconazole, the patient had complete resolution of the clinical and laboratory findings of blastomycosis...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033982/virologic-response-to-dolutegravir-plus-lamivudine-in-people-with-suppressed-human-immunodeficiency-virus-type-1-and-historical-m184v-i-a-systematic-literature-review-and-meta-analysis
#9
JOURNAL ARTICLE
Madhusudan Kabra, Tristan J Barber, Clotilde Allavena, Anne-Geneviève Marcelin, Simona Di Giambenedetto, Juan Pasquau, Nicola Gianotti, Josep M Llibre, David Rial-Crestelo, Rosa De Miguel-Buckley, Gary Blick, Matthew Turner, Cale Harrison, Tammy Wynne, Gustavo Verdier, Chris M Parry, Bryn Jones, Chinyere Okoli, Cynthia Donovan, Julie Priest, Emilio Letang
BACKGROUND: To investigate the impact of the M184V/I mutation on virologic response to dolutegravir plus lamivudine (DTG + 3TC) in suppressed-switch populations, a meta-analysis was performed using virologic outcomes from people with human immunodeficiency virus type 1 (PWH) with and without M184V/I before DTG + 3TC switch in real-world studies identified via systematic literature review. Sensitivity analyses were performed using data from PWH with M184V/I in interventional studies identified via targeted literature review...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38033981/correction-to-improving-the-efficiency-of-antimicrobial-stewardship-action-in-acute-care-facilities
#10
(no author information available yet)
[This corrects the article DOI: 10.1093/ofid/ofad412.].
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023565/stewardship-guided-t2candida-testing-shortens-time-to-antifungal-treatment-and-reduces-antifungal-usage-among-medical-intensive-care-unit-patients-with-septic-shock
#11
JOURNAL ARTICLE
Matthew O'Donnell, Ryan K Shields, Rachel V Marini, Lara M Groetzinger, Brian A Potoski, Bonnie A Falcione, Sunish Shah, Erin K McCreary, Lloyd Clarke, Emily Brant, Bryan J McVerry, Susan Liegey, A William Pasculle, Cornelius J Clancy, M Hong Nguyen
BACKGROUND: Diagnosis of invasive candidiasis (IC) is limited by insensitivity and slow turnaround of cultures. Our objectives were to define the performance of T2Candida, a nonculture test, under guidance of a diagnostic stewardship program, and evaluate impact on time to antifungal initiation and antifungal utilization. METHODS: This was a retrospective study of adult medical intensive care unit (MICU) patients with septic shock for whom T2Candida testing was performed from March 2017 to March 2020...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023564/antibody-response-after-the-third-sars-cov-2-vaccine-in-solid-organ-transplant-recipients-and-people-living-with-hiv-coverall-2
#12
JOURNAL ARTICLE
Alexandra Griessbach, Frédérique Chammartin, Irene A Abela, Patrizia Amico, Marcel P Stoeckle, Anna L Eichenberger, Barbara Hasse, Dominique L Braun, Macé M Schuurmans, Thomas F Müller, Michael Tamm, Annette Audigé, Nicolas J Mueller, Andri Rauch, Huldrych F Günthard, Michael T Koller, Alexandra Trkola, Selina Epp, Alain Amstutz, Christof M Schönenberger, Ala Taji Heravi, Matthaios Papadimitriou-Olivgeris, Alessio Casutt, Oriol Manuel, Katharina Kusejko, Heiner C Bucher, Matthias Briel, Benjamin Speich
BACKGROUND: After basic immunization with 2 mRNA SARS-CoV-2 vaccine doses, only a small proportion of patients who are severely immunocompromised generate a sufficient antibody response. Hence, we assessed the additional benefit of a third SARS-CoV-2 vaccine in patients with different levels of immunosuppression. METHODS: In this observational extension of the COVERALL trial (Corona Vaccine Trial Platform), we recruited patients from the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study (ie, lung and kidney transplant recipients)...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023563/ebv-encoded-microrna-bart17-3p-targets-ddx3x-and-promotes-ebv-infection-in-ebv-associated-t-natural-killer-cell-lymphoproliferative-diseases
#13
JOURNAL ARTICLE
Jin Jin, Ting Sun, Man Zhang, Jiali Cheng, Jia Gu, Liang Huang, Min Xiao, Jianfeng Zhou, Hui Luo
BACKGROUND: Epstein-Barr virus (EBV) persistently infects T/natural killer (NK) cells causing an array of refractory EBV-associated T/NK-cell lymphoproliferative disorders. EBV-encoded microRNAs are important regulators for EBV latent infection and tumorigenesis. However, the roles of most EBV microRNAs in EBV-infected T/NK cells remain poorly understood. METHODS: On the basis of a search of the doRiNA database and the BiBiServ2-RNAhybrid website, we predicted that EBV-miR-BART17-3p targeted DDX3X, and we verified the hypothesis by dual-luciferase reporter assay and cell function experiments...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023562/evolution-of-humoral-and-cellular-immunity-post-breakthrough-coronavirus-disease-2019-in-vaccinated-patients-with-hematologic-malignancy-receiving-tixagevimab-cilgavimab
#14
JOURNAL ARTICLE
Victoria G Hall, Thi H O Nguyen, Lilith F Allen, Louise C Rowntree, Lukasz Kedzierski, Brendon Y Chua, Chhay Lim, Natalie R Saunders, Emily Klimevski, Gayani S Tennakoon, John F Seymour, Vikas Wadhwa, Natalie Cain, Kim L Vo, Suellen Nicholson, Theo Karapanagiotidis, Deborah A Williamson, Karin A Thursky, Timothy Spelman, Michelle K Yong, Monica A Slavin, Katherine Kedzierska, Benjamin W Teh
BACKGROUND: In-depth immunogenicity studies of tixagevimab-cilgavimab (T-C) are lacking, including following breakthrough coronavirus disease 2019 (COVID-19) in vaccinated patients with hematologic malignancy (HM) receiving T-C as pre-exposure prophylaxis. METHODS: We performed a prospective, observational cohort study and detailed immunological analyses of 93 patients with HM who received T-C from May 2022, with and without breakthrough infection, during a follow-up period of 6 months and dominant Omicron BA...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023561/a-national-hiv-provider-survey-of-antiretroviral-therapy-preferences-for-management-of-treatment-naive-and-experienced-individuals-with-drug-resistance
#15
JOURNAL ARTICLE
Sonya Krishnan, Christopher K Lippincott, Stephanie Bjerrum, Marina B Martinez Rivera, Maunank Shah
BACKGROUND: HIV clinical practice guidelines outline broad treatment principles but offer less explicit recommendations by permutations of encountered viral resistance. We hypothesize that there is variability in antiretroviral (ARV) regimen decision making among providers when considering HIV drug resistance (HIVDR). METHODS: US HIV providers provided ARV regimen recommendations for case vignettes in a series of electronic surveys encompassing variations of HIVDR...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023560/prior-screening-for-latent-tuberculosis-among-patients-diagnosed-with-tuberculosis-disease-missed-opportunities
#16
JOURNAL ARTICLE
Heidi Fischer, Lei Qian, Zhuoxin Li, Saadiq Garba, Katia J Bruxvoort, Jacek Skarbinski, Jennifer H Ku, Bruno J Lewin, Parag S Mahale, Sally F Shaw, Brigitte C Spence, Sara Y Tartof
BACKGROUND: California has the largest number of tuberculosis (TB) disease cases in the United States. This study in a large California health system assessed missed opportunities for latent tuberculosis (LTBI) screening among patients with TB disease. METHODS: Kaiser Permanente Southern California patients who were ≥18 years old with membership for ≥24 months during the study period from 1 January 2008 to 31 December 2019 were included. Prior LTBI test (tuberculin skin test or interferon-γ release assay) or diagnosis code prior to TB disease diagnosis was assessed among patients with observed TB disease (confirmed by polymerase chain reaction and/or culture)...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023559/community-acquired-pneumonia-in-the-immunocompromised-host-epidemiology-and-outcomes
#17
JOURNAL ARTICLE
Julio A Ramirez, Thomas R Chandler, Stephen P Furmanek, Ruth Carrico, Ashley M Wilde, Daniya Sheikh, Raghava Ambadapoodi, Vidyulata Salunkhe, Mohammad Tahboub, Forest W Arnold, Jose Bordon, Rodrigo Cavallazzi
BACKGROUND: The epidemiology and outcomes of community-acquired pneumonia (CAP) in immunocompromised hosts (ICHs) are not well defined. The objective of this study was to define the epidemiology and outcomes of CAP in ICHs as compared with non-ICHs. METHODS: This ancillary study included a prospective cohort of hospitalized adult Louisville residents with CAP from 1 June 2014 to 31 May 2016. An ICH was defined per the criteria of the Centers for Disease Control and Prevention...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023558/association-of-the-streptococcus-bovis-streptococcus-equinus-complex-with-colorectal-neoplasia-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Konstantinos Ouranos, Angeliki Gardikioti, Dimitra Rafailia Bakaloudi, Evangelia K Mylona, Fadi Shehadeh, Eleftherios Mylonakis
BACKGROUND: Invasive infection with Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteria is associated with underlying colorectal neoplasia. However, the link between intestinal or fecal colonization with SBSEC isolates or antibody responses to SBSEC members and colorectal cancer is not thoroughly investigated in the literature. METHODS: We searched the PubMed, EMBASE, and Web of Science databases for case-control studies as well as retrospective or prospective cohort studies reporting an association between SBSEC bacteria and colorectal neoplasia...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023557/incidence-and-outcomes-of-bloodstream-infection-after-arterial-aneurysm-repair-findings-from-a-population-based-study
#19
JOURNAL ARTICLE
Hussam Tabaja, Larry M Baddour, Supavit Chesdachai, Randall R DeMartino, Brian D Lahr, Daniel C DeSimone
BACKGROUND: Limited research has focused on bloodstream infection (BSI) in patients with arterial grafts. This study aims to describe the incidence and outcomes of BSI after arterial aneurysm repair in a population-based cohort. METHODS: The expanded Rochester Epidemiology Project (e-REP) was used to analyze aneurysm repairs in adults (aged ≥18 years) residing in 8 counties in southern Minnesota from January 2010 to December 2020. Electronic records were reviewed for the first episode of BSI following aneurysm repair...
November 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/38023556/reduction-in-depressive-symptoms-in-people-who-inject-drugs-who-are-cured-of-hepatitis-c-virus-infection-the-hero-study
#20
JOURNAL ARTICLE
Irene Pericot-Valverde, Snehal S Lopes, Shadi Nahvi, James F Thrasher, Alison Karasz, Lynn E Taylor, Shruti H Mehta, Paula J Lum, Judith I Tsui, Kimberly Page, Judith Feinberg, Arthur Y Kim, Brianna L Norton, Julia H Arnsten, Sergio Fernandez-Artamendi, Moonseong Heo, Alain Litwin
BACKGROUND: Depressive symptoms are prevalent among people who inject drugs (PWID) and people with hepatitis C virus (HCV). We examined changes in depressive symptoms among HCV-infected PWID following direct-acting antiviral treatments to evaluate whether these changes differed by history of depressive symptoms, substance use, or HCV treatment outcome. METHODS: We conducted a secondary analysis of the HERO Study (NCT02824640), a pragmatic randomized clinical trial among PWID, to test the effectiveness of HCV care models...
November 2023: Open Forum Infectious Diseases
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