journal
https://read.qxmd.com/read/37250177/the-impact-of-neisseria-gonorrhoeae-mono-and-coinfection-on-adverse-pregnancy-outcomes
#1
JOURNAL ARTICLE
Brandie DePaoli Taylor, Victor Adekanmbi, Yuanyi Zhang, Abbey Berenson
BACKGROUND: Sexually transmitted infections (STIs) have recently been linked to hypertensive disorders of pregnancy (HDP). However, the impact of Neisseria gonorrhoeae on risk of HDP is not well understood. This study determined the impact of gonorrhea and gonorrhea coinfection on HDP and other adverse pregnancy outcomes in a population with a high screening rate and presumed treatment. METHODS: This retrospective study included 29 821 singleton births between 2016 and 2021...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37250176/correction-to-effectiveness-of-covid-19-mrna-vaccines-in-preventing-covid-19-associated-outpatient-visits-and-hospitalizations-among-american-indian-and-alaska-native-persons-january-november-2021-a-test-negative-case-control-analysis-using-surveillance-data
#2
https://read.qxmd.com/read/37250175/antiviral-prescribing-among-patients-at-an-ambulatory-cancer-center-with-laboratory-confirmed-influenza
#3
JOURNAL ARTICLE
Woody Sorey, Elizabeth M Krantz, Jessica Morris, John Klaassen, Ania Sweet, Frank Tverdek, Zahra K Escobar, Denise J McCulloch, Steven A Pergam, Catherine Liu
Among 133 cancer outpatients diagnosed with influenza between 2016 and 2018, 110 (83%) were prescribed oseltamivir. Among 109 with a known symptom onset date, 53% presented for care and 31% were prescribed oseltamivir within 48 hours. Patient/provider education and rapid diagnostics are needed to improve early oseltamivir use among cancer patients with influenza.
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37250174/prevalence-of-sars-cov-2-viremia-in-presymptomatic-blood-donors-in-the-delta-and-omicron-variant-eras
#4
JOURNAL ARTICLE
Paula Saá, Rebecca V Fink, Hina Dawar, Clara Di Germanio, Leilani Montalvo, David J Wright, David E Krysztof, Steven H Kleinman, Theresa Nester, Debra A Kessler, Rebecca L Townsend, Bryan R Spencer, Hany Kamel, Jackie Vannoy, Michael P Busch, Susan L Stramer, Mars Stone, Philip J Norris
Presymptomatic plasma samples from 1596 donors reporting coronavirus disease 2019 infection or symptoms after blood donation were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA and anti-S and anti-N antibodies. Prior infection and vaccination both protected from developing SARS-CoV-2 RNAemia and from symptomatic infection. RNAemia rates did not differ in the Delta and Omicron variant eras.
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37234516/a-systematic-review-on-the-safety-of-mycobacterium-tuberculosis-specific-antigen-based-skin-tests-for-tuberculosis-infection-compared-with-tuberculin-skin-tests
#5
JOURNAL ARTICLE
Yohhei Hamada, Irina Kontsevaya, Elena Surkova, Ting Ting Wang, Liu Wan-Hsin, Aleksandr Matveev, Liliya Eugenevna Ziganshina, Claudia M Denkinger, Alexei Korobitsyn, Nazir Ismail, Ibrahim Abubakar, Molebogeng X Rangaka
BACKGROUND: A systematic review showed that the accuracy of Mycobacterium tuberculosis antigen-based skin tests (TBSTs) for tuberculosis is similar to that of interferon γ release assay, but the safety of TBSTs has not been systematically reviewed. METHODS: We searched for studies reporting injection site reactions (ISRs) and systemic adverse events associated with TBSTs. We searched Medline, Embase, e-library, the Chinese Biomedical Literature Database, and the China National Knowledge Infrastructure database for studies through 30 July 2021, and the database search was updated until 22 November 2022...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37234515/factors-associated-with-the-development-of-bacterial-pneumonia-related-to-seasonal-influenza-virus-infection-a-study-using-a-large-scale-health-insurance-claim-database
#6
JOURNAL ARTICLE
Masahiro Shirata, Isao Ito, Taisuke Jo, Tomohide Iwao, Issei Oi, Nobuyoshi Hamao, Kensuke Nishioka, Hayato Yamana, Takahide Nagase, Hideo Yasunaga, Toyohiro Hirai
BACKGROUND: Influenza-related bacterial pneumonia is a leading complication of influenza infection. However, the differences in the incidence rates and risk factors associated with concomitant viral/bacterial pneumonia (CP) and secondary bacterial pneumonia following influenza (SP) remain unclear. This study aimed to clarify the incidence rates of CP and SP following seasonal influenza and identify factors associated with their development. METHODS: This retrospective cohort study was conducted using the JMDC Claims Database, a health insurance claims database in Japan...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37234514/enterococci-in-diabetic-foot-infections-prevalence-clinical-characteristics-and-outcomes
#7
JOURNAL ARTICLE
Ofer Perzon, Avivit Cahn, Yechiel N Gellman, Michal Leibovitch, Shahar Peled, Ofer Elishoov, Amir Haze, Karen Olshtain-Pops, Hila Elinav
BACKGROUND: Diabetic foot infections (DFIs) are frequently polymicrobial, yet the relevance of each isolated pathogen, remains ill-defined. Specifically, the prevalence and pathogenicity of enterococcal DFIs and the impact of targeted antienterococcal treatment remain elusive. METHODS: We collected demographic, clinical, and outcome-related data on patients admitted with DFIs to the Hadassah Medical Center diabetic foot unit between 2014 and 2019. The primary outcome was a composite of in-hospital death or major amputation...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37234513/safety-and-effectiveness-of-miltefosine-in-post-kala-azar-dermal-leishmaniasis-an-observational-study
#8
JOURNAL ARTICLE
Shyam Sundar, Jitendra Singh, Anju Dinkar, Neha Agrawal
BACKGROUND: Post-kala-azar dermal leishmaniasis (PKDL) is a dermal complication of visceral leishmaniasis. Oral miltefosine (MF) is the first-line treatment for PKDL patients in South Asia. This study assessed the safety and effectiveness of MF therapy after 12 months of follow-up to explore more precise data. METHODS: In this observational study, 300 confirmed PKDL patients were enrolled. MF with the usual dose was administered to all patients for 12 weeks and followed up for 1 year...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37234512/factors-associated-with-coronavirus-disease-2019-vaccine-uptake-among-pregnant-women-and-nonpregnant-women-of-reproductive-age-in-jamaica
#9
JOURNAL ARTICLE
Jodian A Pinkney, Laura M Bogart, Kamali N Carroll, Lenroy Bryan, Givana Witter, Dina Ashour, Fatma M Shebl, Rocio M Hurtado, Ilona T Goldfarb, Emily P Hyle, Christina Psaros, Bisola O Ojikutu
BACKGROUND: Despite high rates of coronavirus disease 2019 (COVID-19)-related maternal mortality, Jamaica currently has little data on COVID-19 vaccine uptake among pregnant women. METHODS: We conducted a cross-sectional, web-based survey of 192 reproductive-aged women in Jamaica from February 1 to 8, 2022. Participants were recruited from a convenience sample of patients, providers, and staff at a teaching hospital. We assessed self-reported COVID-19 vaccination status and COVID-19-related medical mistrust (operationalized as vaccine confidence, government mistrust, and race-based mistrust)...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37234511/compassionate-use-of-bacteriophages-for-failed-persistent-infections-during-the-first-5-years-of-the-israeli-phage-therapy-center
#10
JOURNAL ARTICLE
Hadil Onallah, Ronen Hazan, Ran Nir-Paz
The use of bacteriophages (phages) is reemerging as a potential treatment option for antibiotic-resistant or nonresolving bacterial infections. Phages are bacteria-specific viruses that may serve as a personalized therapeutic option with minimal collateral damage to the patient or the microbiome. In 2018 we established the Israeli Phage Therapy Center (IPTC) as a shared initiative of the Hadassah Medical Center and the Hebrew University of Jerusalem, aiming to conduct all of the steps required for phage-based solutions, from phage isolation and characterization to treatments, for nonresolving bacterial infections...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37229175/correction-to-population-level-strategies-for-nirmatrelvir-ritonavir-prescribing-a-cost-effectiveness-analysis
#11
(no author information available yet)
[This corrects the article DOI: 10.1093/ofid/ofac637.].
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37229174/effectiveness-of-casirivimab-and-imdevimab-antibody-combination-in-immunocompromised-hospitalized-patients-with-coronavirus-disease-2019-a-post-hoc-analysis-in-a-phase-1-2-3-double-blind-trial
#12
JOURNAL ARTICLE
Selin Somersan-Karakaya, Eleftherios Mylonakis, Jenni Mou, Ernesto Oviedo-Orta, Meagan P O'Brien, Veronica Mas Casullo, Adnan Mahmood, Andrea T Hooper, Mohamed Hussein, Shazia Ali, Francisco M Marty, Eduardo Forleo-Neto, Rafia Bhore, Jennifer D Hamilton, Gary A Herman, Boaz Hirshberg, David M Weinreich
BACKGROUND: Individuals who are immunocompromised (IC) are at high risk for severe coronavirus disease 2019 (COVID-19). METHODS: Post hoc analyses of a double-blind trial conducted prior to Omicron (June 2020-April 2021), in hospitalized patients with COVID-19 assessed viral load, clinical outcomes, and safety of casirivimab plus imdevimab (CAS + IMD) versus placebo in IC versus overall study patients. RESULTS: Ninety-nine of 1940 (5.1%) patients were IC...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213429/gynoid-fat-distribution-and-adipocyte-trapping-may-explain-virological-failure-with-intramuscular-long-acting-cabotegravir-and-rilpivirine
#13
JOURNAL ARTICLE
Isabelle de Malliard, Anne-Laure Houist, Gilles Peytavin, Thomas L'Yavanc, Magali Bouvier, Pierre Cappy, Jean-Daniel Lelièvre, Elsa Feredj, William Vindrios, Sebastien Gallien, Giovanna Melica
Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index <30 kg/m2 .
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213428/effectiveness-of-booster-doses-of-monovalent-mrna-covid-19-vaccine-against-symptomatic-severe-acute-respiratory-syndrome-coronavirus-2-infection-in-children-adolescents-and-adults-during-omicron-subvariant-ba-2-ba-2-12-1-and-ba-4-ba-5-predominant-periods
#14
JOURNAL ARTICLE
Allison Avrich Ciesla, Ryan E Wiegand, Zachary R Smith, Amadea Britton, Katherine E Fleming-Dutra, Joseph Miller, Emma K Accorsi, Jennifer R Verani, Nong Shang, Gordana Derado, Tamara Pilishvili, Ruth Link-Gelles
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) BA.2/BA.2.12.1 and BA.4/BA.5 subvariants have mutations associated with increased capacity to evade immunity when compared with prior variants. We evaluated mRNA monovalent booster dose effectiveness among persons ≥5 years old during BA.2/BA.2.12.1 and BA.4/BA.5 predominance. METHODS: A test-negative, case-control analysis included data from 12 148 pharmacy SARS-CoV-2 testing sites nationwide for persons aged ≥5 years with ≥1 coronavirus disease-2019 (COVID-19)-like symptoms and a SARS-CoV-2 nucleic acid amplification test from April 2 to August 31, 2022...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213427/anaplasmosis-induced-hemophagocytic-lymphohistiocytosis-a-case-report-and-review-of-the-literature
#15
Jacob Scribner, Benita Wu, Andre Lamyaithong, Victor Arcega, Daphne-Dominique Villanueva
Cases of anaplasmosis have increased steadily and are appearing in states where it is less common. While symptoms are usually mild, in rare cases it can cause hemophagocytic lymphohistiocytosis. Here, we present a case of polymerase chain reaction-confirmed Anaplasma phagocytophilum with morulae on peripheral blood smear associated with biopsy-proven hemophagocytic lymphohistiocytosis.
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213426/investigation-of-blood-plasma-viral-nucleocapsid-antigen-as-a-marker-of-active-severe-acute-respiratory-syndrome-coronavirus-2-omicron-variant-infection
#16
JOURNAL ARTICLE
Gregory L Damhorst, Nils Schoof, Phuong-Vi Nguyen, Hans Verkerke, Eli Wilber, Kaleb McLendon, William O'Sick, Tyler Baugh, Suneethamma Cheedarla, Narayanaiah Cheedarla, Victoria Stittleburg, Eric C Fitts, Margaret A Neja, Ahmed Babiker, Anne Piantadosi, John D Roback, Jesse J Waggoner, Maud Mavigner, Wilbur A Lam
BACKGROUND: Nasopharyngeal qualitative reverse-transcription polymerase chain reaction (RT-PCR) is the gold standard for diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but it is not practical or sufficient in every clinical scenario due to its inability to distinguish active from resolved infection. Alternative or adjunct testing may be needed to guide isolation precautions and treatment in patients admitted to the hospital. METHODS: We performed a single-center, retrospective analysis of residual clinical specimens and medical record data to examine blood plasma nucleocapsid antigen as a candidate biomarker of active SARS-CoV-2...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213425/severe-acute-respiratory-syndrome-coronavirus-2-neutralizing-antibody-responses-after-community-infections-in-children-and-adults
#17
JOURNAL ARTICLE
Fatimah S Dawood, Alexia Couture, Xueyan Zhang, Melissa S Stockwell, Christina A Porucznik, Joseph B Stanford, Marissa Hetrich, Vic Veguilla, Natalie Thornburg, Christopher D Heaney, Jing Wang, Jazmin Duque, Zuha Jeddy, Maria Deloria Knoll, Ruth Karron
BACKGROUND: We compared postinfection severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (nAb) responses among children and adults while the D614G-like strain and Alpha, Iota, and Delta variants circulated. METHODS: During August 2020-October 2021, households with adults and children were enrolled and followed in Utah, New York City, and Maryland. Participants collected weekly respiratory swabs that were tested for SARS-CoV-2 and had sera collected during enrollment and follow-up...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213424/beyond-undetectable-modeling-the-clinical-benefit-of-improved-antiretroviral-adherence-in-persons-with-human-immunodeficiency-virus-with-virologic-suppression
#18
JOURNAL ARTICLE
Jose R Castillo-Mancilla, Mary Morrow, Peter W Hunt, Samuel R Schnittman, Andrew N Phillips, Jason V Baker, Jessica E Haberer, Maria Joao Janeiro, Filipa Aragao, Cal Cohen, Nicholas Musinguzi, Todd T Brown, Matthias Cavassini, Tracy R Glass, Sergio Serrano-Villar, Samantha Mawhinney, Mark Siedner
BACKGROUND: Incomplete antiretroviral therapy (ART) adherence has been linked to deleterious immunologic, inflammatory, and clinical consequences, even among virally suppressed (<50 copies/mL) persons with human immunodeficiency virus (PWH). The impact of improving adherence in the risk of severe non-AIDS events (SNAEs) and death in this population is unknown. METHODS: We estimated the reduction in the risk of SNAEs or death resulting from an increase in ART adherence by (1) applying existing data on the association between adherence with high residual inflammation/coagulopathy in virally suppressed PWH, and (2) using a Cox proportional hazards model derived from changes in plasma interleukin 6 (IL-6) and D-dimer from 3 randomized clinical trials...
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213423/limited-clinical-impact-of-ultralow-dose-computed-tomography-in-suspected-community-acquired-pneumonia
#19
JOURNAL ARTICLE
Tjitske S R van Engelen, Maadrika M N P Kanglie, Inge A H van den Berk, Josje Altenburg, Marcel G W Dijkgraaf, Patrick M M Bossuyt, Jaap Stoker, Jan M Prins
Patients clinically suspected of community-acquired pneumonia (CAP) were randomized between ultralow-dose chest computed tomography ([ULDCT] 261 patients) and chest radiograph ([CXR] 231 patients). We did not find evidence that performing ULDCT instead of CXR affects antibiotic treatment policy or patient outcomes. However, in a subgroup of afebrile patients, there were more patients diagnosed with CAP in the ULDCT group (ULDCT, 106 of 608 patients; CXR, 71 of 654 patients; P = .001).
May 2023: Open Forum Infectious Diseases
https://read.qxmd.com/read/37213422/immunogenicity-safety-and-breakthrough-severe-acute-respiratory-syndrome-coronavirus-2-infections-after-coronavirus-disease-2019-vaccination-in-organ-transplant-recipients-a-prospective-multicenter-canadian-study
#20
JOURNAL ARTICLE
Dima Kabbani, Demitra M Yotis, Victor H Ferreira, Sarah Shalhoub, Sara Belga, Varalika Tyagi, Matthew Ierullo, Vathany Kulasingam, Marie-Josée Hébert, Lori West, Jean-Sébastien Delisle, Normand Racine, Sacha A De Serres, Héloïse Cardinal, Mélanie Dieudé, Atul Humar, Deepali Kumar
BACKGROUND: Solid organ transplant (SOT) recipients are at risk for severe coronavirus disease 2019 (COVID-19), despite vaccination. Our study aimed to elucidate COVID-19 vaccine immunogenicity and evaluate adverse events such as hospitalization, rejection, and breakthrough infection in a SOT cohort. METHODS: We performed a prospective, observational study on 539 adult SOT recipients (age ≥18 years old) recruited from 7 Canadian transplant centers...
May 2023: Open Forum Infectious Diseases
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