Jose R Castillo-Mancilla, Mary Morrow, Peter W Hunt, Samuel R Schnittman, Andrew N Phillips, Jason V Baker, Jessica E Haberer, Maria Joao Janeiro, Filipa Aragao, Cal Cohen, Nicholas Musinguzi, Todd T Brown, Matthias Cavassini, Tracy R Glass, Sergio Serrano-Villar, Samantha Mawhinney, Mark Siedner
BACKGROUND: Incomplete antiretroviral therapy (ART) adherence has been linked to deleterious immunologic, inflammatory, and clinical consequences, even among virally suppressed (<50 copies/mL) persons with human immunodeficiency virus (PWH). The impact of improving adherence in the risk of severe non-AIDS events (SNAEs) and death in this population is unknown. METHODS: We estimated the reduction in the risk of SNAEs or death resulting from an increase in ART adherence by (1) applying existing data on the association between adherence with high residual inflammation/coagulopathy in virally suppressed PWH, and (2) using a Cox proportional hazards model derived from changes in plasma interleukin 6 (IL-6) and D-dimer from 3 randomized clinical trials...
May 2023: Open Forum Infectious Diseases