journal
https://read.qxmd.com/read/38778862/outpatient-parenteral-antimicrobial-therapy-in-a-safety-net-hospital-opportunities-for-improvement
#1
JOURNAL ARTICLE
Rory Bouzigard, Mark Arnold, Sithembiso S Msibi, Jacob K Player, Norman Mang, Brenton Hall, Joseph Su, Michael A Lane, Trish M Perl, Laila M Castellino
BACKGROUND: Outpatient parenteral antimicrobial therapy (OPAT) is a safe and cost-effective transitional care approach administered via different delivery models. No standards exist for appropriate OPAT program staffing. We examined outcomes of patients receiving OPAT via different care models to identify strategies to improve safety while reducing health care overuse. METHODS: Retrospective demographic, clinical, and outcome data of patients discharged with OPAT were reviewed in 2 periods (April-June 2021 and January-March 2022; ie, when staffing changed) and stratified by care model: self-administered OPAT, health care OPAT, and skilled nursing facility OPAT...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38778861/role-of-routine-suppressive-antibiotic-therapy-after-debridement-antibiotics-and-implant-retention-for-acute-periprosthetic-joint-infections
#2
JOURNAL ARTICLE
Don Bambino Geno Tai, Aaron J Tande, Benjamin Langworthy, Matthew P Abdel, Elie F Berbari, Bas Ten Have, Paul Jutte, Alex Soriano, Gina A Suh, Wierd Zijlstra, Marjan Wouthuyzen-Bakker
BACKGROUND: The first-line management strategy for acute periprosthetic joint infections (PJIs) is debridement, antibiotics, and implant retention (DAIR). Suppressive antibiotic therapy (SAT) after DAIR is proposed to improve outcomes, yet its efficacy remains under scrutiny. METHODS: We conducted a multicenter retrospective study in patients with acute PJI of the hip or knee who were treated with DAIR in centers from Europe and the United States. We analyzed the effect of SAT using a Cox model landmarked at 12 weeks...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38774792/the-role-of-frequent-screening-or-diagnostic-testing-of-serum-cryptococcal-antigen-in-liver-transplant-recipients-a-descriptive-epidemiology
#3
JOURNAL ARTICLE
Toshiki Miwa, Koh Okamoto, Kazuhiko Ikeuchi, Shinya Yamamoto, Shu Okugawa, Akihiko Ichida, Nobuhisa Akamatsu, Kiyoshi Hasegawa, Takeya Tsutsumi
BACKGROUND: Cryptococcosis is a notable infectious complication of liver transplantation. Currently, there is no recommendation for screening serum cryptococcal antigen (CrAg) levels in solid organ transplant recipients. We aimed to explore the role of serum CrAg in liver transplant recipients at an institution where posttransplant serum CrAg has been widely tested. METHODS: This retrospective study was conducted at a tertiary care center in Japan. All liver transplant recipients with serum CrAg measured either for screening or for diagnostic testing at least once after transplantation between April 2005 and March 2022 were included...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770214/should-blood-cultures-be-drawn-through-an-indwelling-catheter
#4
JOURNAL ARTICLE
Leonard A Mermel, Mark E Rupp
There is no practical way to definitively diagnose a catheter-related bloodstream infection in situ if blood cultures are only obtained percutaneously unless there is the rare occurrence of purulent drainage from a central venous catheter insertion site. That is why the Infectious Diseases Society of America guidelines for diagnosis and management of catheter-related bloodstream infections and Infectious Diseases Society of America guidelines for evaluation of fever in critically ill patients both recommend drawing blood cultures from a central venous catheter and percutaneously if the catheter is a suspected source of infection...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770213/integrating-infectious-disease-advanced-practice-providers-in-the-workforce-an-educational-step-forward
#5
EDITORIAL
Leah H Yoke, Michael Boeckh, Alison M Beieler
No abstract text is available yet for this article.
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770212/immunogenicity-of-current-and-next-generation-pneumococcal-conjugate-vaccines-in-children-current-challenges-and-upcoming-opportunities
#6
REVIEW
Kristen Feemster, Ulrike K Buchwald, Natalie Banniettis, Joseph G Joyce, Priscilla Velentgas, Timothy J Chapman, Inci Yildirim
Global use of pneumococcal conjugate vaccines (PCVs) with increasingly broader serotype coverage has helped to reduce the burden of pneumococcal disease in children and adults. In clinical studies comparing PCVs, higher-valency PCVs have met noninferiority criteria (based on immunoglobulin G geometric mean concentrations and response rates) for most shared serotypes. A numeric trend of declining immunogenicity against shared serotypes with higher-valency PCVs has also been observed; however, the clinical relevance is uncertain, warranting additional research to evaluate the effectiveness of new vaccines...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770211/impact-of-gram-negative-bacilli-resistance-rates-on-risk-of-death-in-septic-shock-and-pneumonia
#7
JOURNAL ARTICLE
Alison M Hixon, Scott Micek, Victoria J Fraser, Marin Kollef, M Cristina Vazquez Guillamet
BACKGROUND: Sepsis is a major cause of morbidity and mortality worldwide. When selecting empiric antibiotics for sepsis, clinicians are encouraged to use local resistance rates, but their impact on individual outcomes is unknown. Improved methods to predict outcomes are needed to optimize treatment selection and improve antibiotic stewardship. METHODS: We expanded on a previously developed theoretical model to estimate the excess risk of death in gram-negative bacilli (GNB) sepsis due to discordant antibiotics using 3 factors: the prevalence of GNB in sepsis, the rate of antibiotic resistance in GNB, and the mortality difference between discordant and concordant antibiotic treatments...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770210/global-seasonal-activities-of-respiratory-syncytial-virus-before-the-coronavirus-disease-2019-pandemic-a-systematic-review
#8
REVIEW
Songwei Shan, Weixin Zhang, Huizhi Gao, Pei-Yu Huang, Zhanwei Du, Yuan Bai, Yiu-Chung Lau, Dongxuan Chen, Eric H Y Lau, Joshua Nealon, Peng Wu
Varied seasonal patterns of respiratory syncytial virus (RSV) have been reported worldwide. We conducted a systematic review on articles identified in PubMed reporting RSV seasonality based on data collected before 1 January 2020. RSV seasonal patterns were examined by geographic location, calendar month, analytic method, and meteorological factors including temperature and absolute humidity. Correlation and regression analyses were conducted to explore the relationship between RSV seasonality and study methods and characteristics of study locations...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770209/hepatitis-c-cascade-of-care-in-a-multidisciplinary-substance-use-bridge-clinic-model-in-tennessee
#9
JOURNAL ARTICLE
Samantha Chirunomula, Anahit Muscarella, Kristen Whelchel, Fiona Gispen, David Marcovitz, Katie White, Cody Chastain
Many barriers prevent individuals with substance use disorders from receiving hepatitis C virus (HCV) treatment. This study describes 96 patients with active HCV treated in an opioid use disorder bridge clinic model. Of 33 patients who initiated treatment, 25 patients completed treatment, and 13 patients achieved sustained virologic response.
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770208/hepatitis-c-virus-clearance-and-diffusing-capacity-for-carbon-monoxide-in-women-with-and-without-human-immunodeficiency-virus
#10
JOURNAL ARTICLE
Andrew C Curnow, Laurence Huang, Margaret A Fischl, Michelle Floris-Moore, Alison Morris, Mehdi Nouraie, Divya B Reddy, Eric C Seaberg, Anandi N Sheth, Phyllis C Tien, Richard J Wang
Hepatitis C virus (HCV) infection is associated with extrahepatic effects, including reduced diffusing capacity of the lungs. It is unknown whether clearance of HCV infection is associated with improved diffusing capacity. In this sample of women with and without human immunodeficiency virus, there was no association between HCV clearance and diffusing capacity.
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38770207/do-all-emergency-room-patients-with-influenza-like-symptoms-need-blood-cultures-a-retrospective-cohort-study-of-2-annual-influenza-seasons
#11
JOURNAL ARTICLE
Simone Ehrhard, Lukas Herren, Meret E Ricklin, Franziska Suter-Riniker, Aristomenis K Exadaktylos, Wolf Hautz, Martin Müller, Philipp Jent
In this retrospective cohort study, we evaluated risk factors for bacteremia in emergency department patients presenting with influenza-like symptoms during influenza epidemic seasons. In patients without fever, chronic heart or chronic liver disease, blood culture collection might be omitted.
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756766/profiles-of-hbcrag-and-pgrna-in-pregnant-women-with-chronic-hbv-under-different-disease-phases-and-antiviral-prophylaxis
#12
JOURNAL ARTICLE
Chun-Rui Wang, Xiao-Qin Liu, Wei Shen, Guo-Chao Zhong, Hu Li, Qiao Tang, Yu-Xing Liu, Peng Hu
BACKGROUND: Pregnant women with chronic hepatitis B (CHB) exhibit unique clinical features in terms of postpartum immune system reconstitution and recovery from pregnancy-related changes. However, current studies focus primarily on the outcomes of maternal-infant transmission and postpartum hepatitis flares. We aimed to evaluate the profiles of hepatitis B core-related antigen (HBcrAg) and pregenomic RNA (pgRNA) in pregnant women with CHB. METHODS: This retrospective analysis included treatment-naïve pregnant women with CHB who were followed up regularly in an outpatient clinic from 2014 to 2021...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756765/isavuconazole-for-the-treatment-of-fungal-infections-a-real-life-experience-from-the-fungal-infection-network-of-switzerland-funginos
#13
JOURNAL ARTICLE
Jade Couchepin, Ilana Reinhold, Ilona Kronig, Monia Guidi, Thierry Buclin, Peter W Schreiber, Dionysios Neofytos, Frederic Lamoth
This analysis of 116 isavuconazole therapy courses shows that hepatic test disturbances (HTDs) were relatively frequent (29% of cases) but rarely led to treatment interruption (5%). Importantly, patients with baseline HTDs, including those attributed to a first-line triazole, did not exhibit a higher risk of subsequent HTD under isavuconazole therapy.
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756764/low-uptake-of-long-acting-injectables-in-the-first-2-5-years-following-approval-among-a-cohort-of-people-living-with-hiv
#14
JOURNAL ARTICLE
Priyanka Manghani, Anne Monroe, Amanda Castel, Princy Kumar, Jennifer Phunmongkol, Rachel Denyer, Lauren O'Connor
No abstract text is available yet for this article.
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756763/sequence-analysis-of-inducible-replication-competent-virus-reveals-no-evidence-of-hiv-1-evolution-during-suppressive-antiviral-therapy-indicating-a-lack-of-ongoing-viral-replication
#15
JOURNAL ARTICLE
Sook-Kyung Lee, Amy Sondgeroth, Yinyan Xu, Joanna Warren, Shuntai Zhou, Maria Gilleece, Blake M Hauser, Cynthia L Gay, JoAnn D Kuruc, Nancie M Archin, Joseph J Eron, David M Margolis, Nilu Goonetilleke, Ronald Swanstrom
BACKGROUND: Persistence of HIV-1 in reservoirs necessitates life-long antiretroviral therapy (ART). There are conflicting data using genetic analysis on whether persistence includes an actively replicating reservoir with strong evidence arguing against replication. METHODS: We investigated the possibility of ongoing viral evolution during suppressive therapy by comparing near full-length viral genomic sequences using phylogenetic analysis of viral RNA in plasma before therapy initiation early after infection and from virus induced to grow from the latent reservoir after a period of suppressive ART...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756762/impact-of-the-reverse-2-step-algorithm-for-clostridioides-difficile-testing-in-the-microbiology-laboratory-on-hospitalized-patients
#16
JOURNAL ARTICLE
Evann E Hilt, Byron P Vaughn, Alison L Galdys, Michael D Evans, Patricia Ferrieri
BACKGROUND: Multistep laboratory testing is recommended for the diagnosis of Clostridioides difficile infection (CDI). The aim of this study was to present the impact of multistep CDI diagnostic testing in an academic hospital system and evaluate the toxin B gene polymerase chain reaction (PCR) cycle threshold (Ct) values of PCR-positive tests. METHODS: In October 2022, our system began reflex testing all PCR-positive stool samples with the C. DIFF QUIK CHEK COMPLETE (Techlab), an enzyme immunoassay-based test with results for the glutamate dehydrogenase antigen (GDH) and C difficile toxin A/B...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756761/prognostic-accuracy-of-screening-tools-for-clinical-deterioration-in-adults-with-suspected-sepsis-in-northeastern-thailand-a-cohort-validation-study
#17
JOURNAL ARTICLE
Jenna Wixon-Genack, Shelton W Wright, Natalie L Cobb Ortega, Viriya Hantrakun, Kristina E Rudd, Prapit Teparrukkul, Direk Limmathurotsakul, T Eoin West
BACKGROUND: We sought to assess the performance of commonly used clinical scoring systems to predict imminent clinical deterioration in patients hospitalized with suspected infection in rural Thailand. METHODS: Patients with suspected infection were prospectively enrolled within 24 hours of admission to a referral hospital in northeastern Thailand between 2013 and 2017. In patients not requiring intensive medical interventions, multiple enrollment scores were calculated including the National Early Warning Score (NEWS), the Modified Early Warning Score, Between the Flags, and the quick Sequential Organ Failure Assessment score...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756760/antifungal-treatment-duration-in-hematology-patients-with-invasive-mold-infections-a-real-life-update
#18
JOURNAL ARTICLE
Vera Portillo, Silvio Ragozzino, Elisavet Stavropoulou, Celine El-Khoury, Pierre-Yves Bochud, Frederic Lamoth, Nina Khanna, Dionysios Neofytos
BACKGROUND: Limited data exist on when and how to stop antifungal treatment (AFT) in patients with invasive mold infections (IMIs) who are immunocompromised. METHODS: This retrospective multicenter study included adult patients with acute myelogenous leukemia and proven/probable IMI (1 January 2010-31 December 2022) in 3 university hospitals. The primary objective was to describe AFT duration and adaptation. Secondary objectives were to investigate the reasons for AFT adjustments and prolongation...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38756759/masqueraders-around-disaster-clinical-features-of-scrub-typhus-in-fukushima-japan
#19
JOURNAL ARTICLE
Masashi Narita, Naota Monma, Kazuki Chiba, Rie Suzuki, Shohei Fujita, Chisho Hoshino, Kiwamu Nakamura, Yoshiyuki Sekikawa, Hiroshi Ikeda, Minoru Inoue, Takuro Shimbo, Seigo Yamamoto, Shuji Ando, Nobuhiro Takada, Hiromi Fujita
BACKGROUND: Scrub typhus (ST) is endemic in Fukushima, with the largest number of cases reported in Japan from 2009 to 2010. Although ST is highly treatable, its atypical clinical presentation impedes diagnosis, causing delays in treatment. METHODS: We review the clinical features of ST in adults from 2008 to 2017 at Ohta Nishinouchi General Hospital in Fukushima, Japan. RESULTS: Fifty-five cases (serotype Karp 24, Irie/Kawasaki 21, Hirano/Kuroki 10) of ST were confirmed via serology based on elevated immunoglobulin (Ig)M and IgG and polymerase chain reaction positivity of eschar samples...
May 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38751899/infectious-mediastinitis-a-retrospective-cohort-study
#20
JOURNAL ARTICLE
Thomas Lemmet, Jean-Philippe Mazzucotelli, Olivier Collange, Léa Fath, Didier Mutter, Cécile Brigand, Pierre-Emmanuel Falcoz, François Danion, Nicolas Lefebvre, Morgane Bourne-Watrin, Victor Gerber, Baptiste Hoellinger, Thibaut Fabacher, Yves Hansmann, Yvon Ruch
BACKGROUND: This study aimed to characterize the demographics, microbiology, management and treatment outcomes of mediastinitis according to the origin of the infection. METHODS: This retrospective observational study enrolled patients who had mediastinitis diagnosed according to the criteria defined by the Centers for Disease Control and Prevention and were treated in Strasbourg University Hospital, France, between 1 January 2010 and 31 December 2020. RESULTS: We investigated 151 cases, including 63 cases of poststernotomy mediastinitis (PSM), 60 cases of mediastinitis due to esophageal perforation (MEP) and 17 cases of descending necrotizing mediastinitis (DNM)...
May 2024: Open Forum Infectious Diseases
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