Johanna Oechtering, Kerstin Stein, Sabine A Schaedelin, Aleksandra M Maceski, Annette Orleth, Stephanie Meier, Eline Willemse, Ferhan Qureshi, Ingmar Heijnen, Axel Regeniter, Tobias Derfuss, Pascal Benkert, Marcus D'Souza, Marguerite Limberg, Bettina Fischer-Barnicol, Lutz Achtnichts, Stefanie Mueller, Anke Salmen, Patrice H Lalive, Claire Bridel, Caroline Pot, Renaud A Du Pasquier, Claudio Gobbi, Heinz Wiendl, Cristina Granziera, Ludwig Kappos, Marten Trendelenburg, David Leppert, Jan D Luenemann, Jens Kuhle
BACKGROUND AND OBJECTIVES: Histopathologic studies have identified immunoglobulin (Ig) deposition and complement activation as contributors of CNS tissue damage in multiple sclerosis (MS). Intrathecal IgM synthesis is associated with higher MS disease activity and severity, and IgM is the strongest complement-activating immunoglobulin. In this study, we investigated whether complement components (CCs) and complement activation products (CAPs) are increased in persons with MS, especially in those with an intrathecal IgM synthesis, and whether they are associated with disease severity and progression...
March 2024: Neurology® Neuroimmunology & Neuroinflammation