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Neurology® Neuroimmunology & Neuroinflammation

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https://read.qxmd.com/read/30697587/anti-nmdar-encephalitis-with-concomitant-varicella-zoster-virus-detection-and-nonteratomatous-malignancy
#1
Preeti A Prakash, Jingxiao Jin, Kanwal Matharu, Tanu Garg, Wendy C Tsai, Purvesh Patel, Jill E Weatherhead, Joseph S Kass
No abstract text is available yet for this article.
March 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30697586/episodic-ataxia-in-caspr2-autoimmunity
#2
A Sebastian López Chiriboga, Sean Pittock
No abstract text is available yet for this article.
March 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30697585/inflammatory-myopathy-with-myasthenia-gravis-thymoma-association-and-polymyositis-pathology
#3
Naohiro Uchio, Kenichiro Taira, Chiseko Ikenaga, Masato Kadoya, Atsushi Unuma, Kenji Yoshida, Setsu Nakatani-Enomoto, Yuki Hatanaka, Yasuhisa Sakurai, Yasushi Shiio, Kenichi Kaida, Akatsuki Kubota, Tatsushi Toda, Jun Shimizu
Objective: To provide evidence that idiopathic inflammatory myopathy (IM) with myasthenia gravis (MG) frequently shows thymoma association and polymyositis (PM) pathology and shares clinicopathologic characteristics with IM induced by immune checkpoint inhibitors (ICIs). Methods: We analyzed the clinicopathologic features of 10 patients with idiopathic IM and MG identified in 970 consecutive patients with biopsy-proven IM. Results: Seven patients (70%) had thymoma...
March 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30697584/prnfl-as-a-marker-of-disability-worsening-in-the-medium-long-term-in-patients-with-ms
#4
Christian Cordano, Bardia Nourbakhsh, Michael Devereux, Vincent Damotte, Daniel Bennett, Stephen L Hauser, Bruce A C Cree, Jeffrey M Gelfand, Ari J Green
No abstract text is available yet for this article.
March 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30697583/hiv-is-associated-with-endothelial-activation-despite-art-in-a-sub-saharan-african-setting
#5
Joseph Kamtchum-Tatuene, Henry Mwandumba, Zaid Al-Bayati, Janet Flatley, Michael Griffiths, Tom Solomon, Laura Benjamin
Objective: To study the relationship between endothelial dysfunction, HIV infection, and stroke in Malawians. Methods: Using a cross-sectional design, we measured plasma levels of intercellular adhesion molecule-1 (ICAM-1), plasminogen activator inhibitor-1 (PAI-1), vascular endothelial growth factor (VEGF), and soluble thrombomodulin (sTM) in stroke patients and controls, stratified by HIV status. These biomarkers were measured using ELISA. After dichotomization, each biomarker was used as the dependent variable in a multivariable logistic regression model...
March 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30697582/mouse-model-of-anti-nmda-receptor-post-herpes-simplex-encephalitis
#6
Jenny Linnoila, Benjamin Pulli, Thaís Armangué, Jesús Planagumà, Radha Narsimhan, Stefan Schob, Matthias W G Zeller, Josep Dalmau, John Chen
Objective: To develop an endogenous rodent model of postinfectious anti-NMDA receptor (NMDAR) encephalitis. Methods: Six mice were inoculated intranasally with herpes simplex virus (HSV) 1 and subsequently treated with acyclovir for 2 weeks. Serum was collected at 3, 6, and 8 weeks postinoculation and tested for NMDAR antibodies through a cell-based assay. Eight weeks postinoculation, mice were killed and their brains were sectioned and immunostained with antibodies to postsynaptic density (PSD)-95 and NMDARs...
March 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30697581/real-world-validation-of-the-2017-mcdonald-criteria-for-pediatric-ms
#7
Yu Yi M Wong, C Louk de Mol, Roos M van der Vuurst de Vries, E Daniëlle van Pelt, Immy A Ketelslegers, Coriene E Catsman-Berrevoets, Rinze F Neuteboom, Rogier Q Hintzen
Objective: To compare the diagnostic accuracy of the McDonald 2017 vs the McDonald 2010 criteria to predict a second attack of MS (clinically definite MS [CDMS]) at the first attack of acquired demyelinating syndromes (ADS). Methods: One hundred sixty-four children (aged <18 years) with an incident attack of ADS were included in a prospective multicenter study between June 2006 and December 2016. Brain (and spinal if available) MRI was performed ≤3 months after symptom onset...
March 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30637300/a-young-man-in-double-trouble-hallucinations-and-cranial-nerve-palsies-from-the-national-multiple-sclerosis-society-case-conference-proceedings
#8
Michael J Bradshaw, Robert P Lisak, Ethan Meltzer, Esther Melamed, Ashlea Lucas, Leorah Freeman, Teresa C Frohman, Kathleen Costello, Laura Balcer, Steven Galetta, Tanuja Chitnis, Scott S Zamvil, Elliot M Frohman
No abstract text is available yet for this article.
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30637299/n2-year-in-review-and-message-from-the-editor-to-our-reviewers
#9
EDITORIAL
Josep Dalmau, Dennis L Kolson, Friedemann Paul, Scott S Zamvil
No abstract text is available yet for this article.
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30588485/erratum-autoimmune-septin-5-cerebellar-ataxia
#10
(no author information available yet)
[This corrects the article on p. e474 in vol. 5, PMID: 29998156.].
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30588484/balint-syndrome-in-anti-nmda-receptor-encephalitis
#11
Aude Metzger, Laure Pisella, Alain Vighetto, Bastien Joubert, Jérôme Honnorat, Caroline Tilikete, Virginie Desestret
No abstract text is available yet for this article.
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30588483/paraneoplastic-recurrent-tumefactive-demyelination-in-a-62-year-old-man-with-metastatic-seminoma
#12
Simon Thebault, Ilana Hanes, John Woulfe, Pierre R Bourque
No abstract text is available yet for this article.
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30588482/anti-hmgcr-myopathy-may-resemble-limb-girdle-muscular-dystrophy
#13
Payam Mohassel, Océane Landon-Cardinal, A Reghan Foley, Sandra Donkervoort, Katherine S Pak, Colleen Wahl, Robert T Shebert, Amy Harper, Pierre Fequiere, Matthew Meriggioli, Camilo Toro, Daniel Drachman, Yves Allenbach, Olivier Benveniste, Anthony Béhin, Bruno Eymard, Pascal Lafôret, Tanya Stojkovic, Andrew L Mammen, Carsten G Bönnemann
Objective: To determine the prevalence and clinical features of anti-HMGCR myopathy among patients with presumed limb-girdle muscular dystrophy (LGMD) in whom genetic testing has failed to elucidate causative mutations. Methods: Patients with presumed LGMD and unrevealing genetic testing were selected based on a few clinico-pathologic features and tested for anti-HMGCR autoantibodies (n = 11). These clinico-pathologic features are peak creatine kinase (CK) greater than 1,000 IU/L and at least 3 of the following features: (1) limb-girdle pattern of weakness, (2) selective involvement of posterior thigh on clinical examination or muscle imaging, (3) dystrophic changes on muscle biopsy, and (4) no family history of muscular dystrophy...
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30569001/drugs-bugs-and-ms-the-interplay-between-disease-modifying-therapy-and-gut-microbiota
#14
EDITORIAL
Ashutosh K Mangalam
No abstract text is available yet for this article.
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30569000/on-razor-s-edge-managing-analgosedation-during-severe-anti-nmda-receptor-encephalitis
#15
Sarah Jesse, Jan Wagner, Regina Gastl, Petra Steinacker, Markus Otto, Jan Kassubek, Jan Lewerenz
No abstract text is available yet for this article.
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30568999/circulating-inflammatory-biomarkers-are-related-to-cerebrovascular-disease-in-older-adults
#16
Yian Gu, Jose Gutierrez, Irene B Meier, Vanessa A Guzman, Jennifer J Manly, Nicole Schupf, Adam M Brickman, Richard Mayeux
Objective: This investigation aimed at examining whether circulating inflammatory biomarkers C-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to cerebrovascular disease (CVD) assessed by MRI. Methods: The study included nondemented elderly participants of a community-based, multiethnic cohort, who received baseline MRI scans and had CRP (n = 508), ACT (435), and IL6 (N = 357) measured by ELISA. Silent brain infarcts and white matter hyperintensities (WMH) were derived from all available MRI scans at baseline, approximately 4...
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30568998/clinical-utility-of-a-molecular-signature-in-inflammatory-demyelinating-disease
#17
Andrew R Pachner, Krista DiSano, Darlene B Royce, Francesca Gilli
Objective: We sought to develop molecular biomarkers of intrathecal inflammation to assist neurologists in identifying patients most likely to benefit from a range of immune therapies. Methods: We used Luminex technology and index determination to search for an inflammatory activity molecular signature (IAMS) in patients with inflammatory demyelinating disease (IDD), other neuroinflammatory diagnoses, and noninflammatory controls. We then followed the clinical characteristics of these patients to find how the presence of the signature might assist in diagnosis and prognosis...
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30568997/neuroparacoccidioidomycosis
#18
Euripedes Gomes Carvalho Neto, Aline Coletto, Paula Ghidini Biazus, Iuri Pereira Dos Santos, Carlos R M Rieder, Marlise de Castro Ribeiro
No abstract text is available yet for this article.
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30568996/erratum-plasmapheresis-for-acute-attacks-in-neuromyelitis-optica-spectrum-disorders
#19
(no author information available yet)
[This corrects the article on p. e510 in vol. 5, PMID: 30345335.].
January 2019: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/30568995/disease-modifying-therapies-alter-gut-microbial-composition-in-ms
#20
Ilana Katz Sand, Yunjiao Zhu, Achilles Ntranos, Jose C Clemente, Egle Cekanaviciute, Rachel Brandstadter, Elizabeth Crabtree-Hartman, Sneha Singh, Yadira Bencosme, Justine Debelius, Rob Knight, Bruce A C Cree, Sergio E Baranzini, Patrizia Casaccia
Objective: To determine the effects of the disease-modifying therapies, glatiramer acetate (GA) and dimethyl fumarate (DMF), on the gut microbiota in patients with MS. Methods: Participants with relapsing MS who were either treatment-naive or treated with GA or DMF were recruited. Peripheral blood mononuclear cells were immunophenotyped. Bacterial DNA was extracted from stool, and amplicons targeting the V4 region of the bacterial/archaeal 16S rRNA gene were sequenced (Illumina MiSeq)...
January 2019: Neurology® Neuroimmunology & Neuroinflammation
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