journal
https://read.qxmd.com/read/38316493/efficacy-and-safety-of-novel-left-ventricular-pacing-leads-1-year-analysis-of-the-navigator-trial
#41
JOURNAL ARTICLE
Juan Gabriel Martinez, Joao De Sousa, Antoine Dompnier, Mario Martins-Oliveira, Carsten W Israel, Elvis Teijeira, José Manuel Rubin, Frederic Sebag, Maria Martino, Yann Michel, Pedro Marques
OBJECTIVES: Assess safety and performance of novel quadripolar preshaped left ventricular (LV) leads: NAVIGO 4LV 2D ('S shaped') and NAVIGO 4LV ARC ('U shaped'). METHODS: Patients indicated for cardiac resynchronisation therapy were enrolled in a multicentre, prospective, controlled study (NAVIGATOR, NCT03279484). Patients were implanted with either a NAVIGO 4LV 2D or ARC lead, and assessed at 10 weeks, 6, 12 and 24 months post-implant. Co-primary safety and performance endpoints were assessed at 10 weeks...
February 5, 2024: Open Heart
https://read.qxmd.com/read/38302139/patients-on-vitamin-k-treatment-is-switching-to-direct-acting-oral-anticoagulation-cost-effective-a-target-trial-on-a-prospective-cohort
#42
JOURNAL ARTICLE
Helena Aebersold, Fabienne Foster-Witassek, Stefanie Aeschbacher, Juerg H Beer, Eva Blozik, Manuel Blum, Leo Bonati, Giulio Conte, Michael Coslovsky, Maria Luisa De Perna, Marcello Di Valentino, Stefan Felder, Carola A Huber, Giorgio Moschovitis, Andreas Mueller, Rebecca E Paladini, Tobias Reichlin, Nicolas Rodondi, Annina Stauber, Christian Sticherling, Thomas D Szucs, David Conen, Michael Kuhne, Stefan Osswald, Matthias Schwenkglenks, Miquel Serra-Burriel
AIMS: Direct-acting oral anticoagulants (DOACs) have, to a substantial degree, replaced vitamin K antagonists (VKA) as treatments for stroke prevention in atrial fibrillation (AF) patients. However, evidence on the real-world causal effects of switching patients from VKA to DOAC is lacking. We aimed to assess the empirical incremental cost-effectiveness of switching patients to DOAC compared with maintaining VKA treatment. METHODS: The target trial approach was applied to the prospective observational Swiss-AF cohort, which enrolled 2415 AF patients from 2014 to 2017...
January 31, 2024: Open Heart
https://read.qxmd.com/read/38302138/initiation-patterns-of-anticoagulants-for-atrial-fibrillation-among-older-uk-adults-with-and-without-chronic-kidney-disease-2010-2020
#43
JOURNAL ARTICLE
Julia Liaw, Deborah Liaw, Chintan Dave
BACKGROUND: There is a paucity of data on the initiation patterns of anticoagulants among older atrial fibrillation patients with and without chronic kidney disease (CKD). SETTING AND METHODS: We used the UK Clinical Practice Research Datalink (2010-2020) to conduct a retrospective cohort study to evaluate anticoagulant initiation patterns for older adults (≥65 years) with CKD (N=18 421) and without CKD (N=41 901), categorised by severity of CKD: stages 3a, 3b and 4, and initiation dose by respective direct oral anticoagulant (DOAC)...
January 31, 2024: Open Heart
https://read.qxmd.com/read/38290731/implementing-a-comprehensive-stemi-protocol-to-improve-care-metrics-and-outcomes-in-patients-with-in-hospital-stemi-an-observational-cohort-study
#44
JOURNAL ARTICLE
Christopher N Kanaan, Nicholas Kassis, Raunak M Nair, Anirudh Kumar, Chetan P Huded, Kathleen Kravitz, Grant W Reed, Amar Krishnaswamy, A Michael Lincoff, Jaikirshan Khatri, Rishi Puri, Khaled Ziada, Ravi Nair, Samir Kapadia, Umesh Khot
BACKGROUND: Patients who experience in-hospital ST-segment elevation myocardial infarction (iSTEMI) represent a uniquely high-risk cohort owing to delays in diagnosis, prolonged time to reperfusion and increased mortality. Quality initiatives aimed at improving the care of this vulnerable, yet understudied population are needed. METHODS: This study included consecutive patients with iSTEMI treated with percutaneous coronary intervention (PCI) between 1 January 2011 and 15 July 2019 at a single, tertiary referral centre...
January 30, 2024: Open Heart
https://read.qxmd.com/read/38290732/thromboembolic-and-bleeding-events-after-valvular-intervention-in-patients-with-atrial-fibrillation
#45
JOURNAL ARTICLE
Ebba-Louise Skogseid, Gorav Batra, Johan Westerbergh, Claes Held, Christina Christersson
AIM: To assess outcomes after cardiac surgery with biological valve replacement, valve repair or transcatheter aortic valve implantation (TAVI) in patients with atrial fibrillation (AF) in accordance with oral anticoagulant (OAC) treatment. METHODS: All patients in Sweden undergoing valvular intervention with AF were included. Associations between OAC exposure and cardiovascular (CV) events (composite of CV death, ischaemic stroke or systemic embolism) and major bleeding were investigated using Cox regression analysis...
January 29, 2024: Open Heart
https://read.qxmd.com/read/38286570/outpatient-care-of-adults-with-congenital-heart-disease-in-the-uk-a-qualitative-appraisal-of-the-clinician-perspective
#46
JOURNAL ARTICLE
Isobel Chaudhry, Anisa Ghassani, Jo Wray, Bill Chaudhry, Louise Coats
OBJECTIVE: This study aimed to explore clinicians' perspectives of ambulatory care in adult congenital heart disease (ACHD). METHODS: Semistructured interviews were carried out remotely (Zoom) with a range of physicians providing ambulatory care to patients with ACHD across the UK. The chronic care model, thrive and candidacy frameworks were used to design prompt guides and subsequently develop themes. A framework approach was used to code and analyse transcripts, which were managed in NVivo...
January 29, 2024: Open Heart
https://read.qxmd.com/read/38286569/effect-of-ischaemic-postconditioning-on-markers-of-myocardial-injury-in-st-elevation-myocardial-infarction-a-meta-analysis
#47
JOURNAL ARTICLE
Idan Bergman, Shaul Gelikas, Yehuda Wexler, Omri Braver, Dennis Boyle, Udi Nussinovitch
OBJECTIVES: This study aimed to perform a meta-analysis of the short-term impact of ischaemic postconditioning (IPoC) on myocardial injury in ST elevation myocardial infarction (STEMI) using surrogate cardiac biomarkers. METHODS: Eligible studies were identified using several article databases. Randomised controlled trials published between 1 January 2000 and 1 December 2021 comparing IPoC to standard of therapy in STEMI patients were included in the search. Outcomes included surrogates of myocardial injury, specifically peak troponin, creatine-kinase (CK) and CK myoglobin binding (CK-MB) enzyme levels...
January 29, 2024: Open Heart
https://read.qxmd.com/read/38242561/multiprofessional-heart-failure-self-development-framework
#48
JOURNAL ARTICLE
Paul Forsyth, Susan Young, Kirsty Hughes, Ruby James, Cheryl Oxley, Ruth Kelly, Rebecca Jones, Sarah Briggs, Lynn Mackay-Thomas, Yvonne Millerick, Maggie Simpson, Clare J Taylor, Simon Beggs, Susan Piper, Simon Duckett
OBJECTIVE: Heart failure remains a key public health priority across the globe. The median age of people with heart failure admitted to hospital in the UK is 81 years old. Many such patients transcend the standard interventions that are well characterised and evidenced in guidelines, into holistic aspects surrounding frailty, rehabilitation and social care. Previous published competency frameworks in heart failure have focused on the value of doctors, nurses and pharmacists. We aimed to provide an expert consensus on the minimum heart failure-specific competencies necessary for multiple different healthcare professionals, including physiotherapists, occupational therapists, dietitians and cardiac physiologists...
January 19, 2024: Open Heart
https://read.qxmd.com/read/38242557/cost-effectiveness-of-stepwise-provisional-versus-systematic-dual-stenting-strategies-in-patients-with-distal-bifurcation-left-main-stem-lesions-economic-analysis-of-the-ebc-main-trial
#49
JOURNAL ARTICLE
Alicia Le Bras, David Hildick-Smith, Arnaud Nze Ossima, Olivier Supplisson, Mohaned Egred, Philippe Brunel, Adrian P Banning, Marie-Claude Morice, Isabelle Durand-Zaleski
BACKGROUND: In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic dual stenting. AIMS: To estimate the 1-year cost-effectiveness of stepwise provisional versus systematic dual stenting strategies...
January 19, 2024: Open Heart
https://read.qxmd.com/read/38242560/prognostic-value-of-right-ventricular-dyssynchrony-in-adults-with-repaired-tetralogy-of-fallot
#50
JOURNAL ARTICLE
Andrea Papa, Clement Nussbaumer, Eleni Goulouti, Fabienne Schwitz, Kerstin Wustmann, Daniel Tobler, Matthias Greutmann, Markus Schwerzmann
OBJECTIVE: Residual sequelae after surgical repair of tetralogy of Fallot (rTOF) affect clinical outcome. We investigated the prognostic impact of right ventricular (RV) dyssynchrony in adults with rTOF years after the surgical repair. METHODS: Patients from the Swiss Adult Congenital HEart disease Registry were included. NT-proBNP levels, echocardiography, exercise testing and MRI data were collected. An offline strain analysis to quantify RV-ventricular and interventricular dyssynchrony was performed...
January 18, 2024: Open Heart
https://read.qxmd.com/read/38242559/association-of-hfa-peff-score-with-clinical-outcomes-after-catheter-ablation-for-atrial-fibrillation
#51
JOURNAL ARTICLE
Taiji Okada, Takeshi Kitai, Atsushi Kobori, Madoka Sano, Ryosuke Murai, Toshiaki Toyota, Yasuhiro Sasaki, Tomohiko Taniguchi, Kitae Kim, Natsuhiko Ehara, Makoto Kinoshita, Yutaka Furukawa
BACKGROUND: The Heart Failure Association Pretest assessment, echocardiography and natriuretic peptide, functional testing and final aetiology (HFA-PEFF) score has been developed for diagnosing heart failure with preserved ejection fraction (HFpEF), which is frequently associated with atrial fibrillation (AF). We aimed to investigate whether preprocedural HFA-PEFF score could be used to predict clinical outcomes in patients with AF who underwent catheter ablation (CA). METHODS: Overall, 1679 patients with AF who underwent primary CA (71±10 years, 1218 males (72...
January 18, 2024: Open Heart
https://read.qxmd.com/read/38242558/reflections-on-my-journey-as-editor-in-chief-of-open-heart
#52
EDITORIAL
Pascal Meier
No abstract text is available yet for this article.
January 18, 2024: Open Heart
https://read.qxmd.com/read/38238027/use-of-sacubitril-valsartan-early-after-cabg
#53
RANDOMIZED CONTROLLED TRIAL
Madina Nurzhanova, Aisulu Musagaliyeva, Raushan Zhakypova, Daniya Senkibayeva, Amina Rakisheva
BACKGROUND: Heart failure (HF) remains a major public health problem with a high mortality and morbidity worldwide. Currently, there is no optimal revascularisation strategy for patients with ischaemic cardiomyopathy despite suggestions that coronary artery bypass graft (CABG) may be superior to medical therapy in improving survival. However, CABG may be associated with substantial risk in HF subjects. We therefore aimed to evaluate the safety and efficacy of the early initiation of sacubitril/valsartan in haemodynamically stabilised patients with HF with reduced ejection fraction (HFrEF) after early CABG...
January 18, 2024: Open Heart
https://read.qxmd.com/read/38238026/economic-evaluation-of-first-line-cryoballoon-ablation-versus-antiarrhythmic-drug-therapy-for-the-treatment-of-paroxysmal-atrial-fibrillation-from-an-english-national-health-service-perspective
#54
JOURNAL ARTICLE
John Paisey, Joe Moss, Jason Andrade, Malte Kuniss, Oussama Wazni, Gian Battista Chierchia, Stuart Mealing, Eleni Ismyrloglou, Alicia Sale, Maxim Souter, Rachelle Kaplon, Tom Bromilow, Emily Lane, Damian Lewis, Derick Todd
INTRODUCTION: Three recent randomised controlled trials have demonstrated that pulmonary vein isolation as an initial rhythm control strategy with cryoablation reduces atrial arrhythmia recurrence in patients with symptomatic paroxysmal atrial fibrillation (PAF) compared with antiarrhythmic drug (AAD) therapy. The aim of this study was to evaluate the cost-effectiveness of first-line cryoablation compared with first-line AADs for treating symptomatic PAF in an English National Health Service (NHS) setting...
January 18, 2024: Open Heart
https://read.qxmd.com/read/38233044/correction-multimorbidity-of-cardiovascular-disease-subtypes-in-a-prospective-cohort-of-1-2-million-uk-women
#55
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 17, 2024: Open Heart
https://read.qxmd.com/read/38233043/accelerating-progress-in-cardiology-embracing-open-science
#56
EDITORIAL
Pascal Meier
No abstract text is available yet for this article.
January 17, 2024: Open Heart
https://read.qxmd.com/read/38233042/colchicine-in-acute-myocardial-infarction-cardiovascular-events-at-1-year-follow-up
#57
RANDOMIZED CONTROLLED TRIAL
Claire Bouleti, Simon Viscogliosi, Didier Bresson, Simon Leboube, Thomas Bochaton, Naoual El-Jonhy, Camille Amaz, Fabrice Prunier, Gabriel Bidaux, Francois Roubille, Denis Angoulvant, Nathan Mewton
OBJECTIVE: In the COVERT-MI randomised placebo-controlled trial, oral administration of high-dose colchicine at the time of reperfusion and for 5 days in acute ST-elevated myocardial infarction did not reduce infarct size but was associated with a significant increase in left ventricular thrombus (LVT) in comparison to placebo. We aimed to assess the 1-year clinical outcomes of the study population. METHODS: This study is a follow-up analysis of the COVERT-MI study on prespecified secondary clinical endpoints at 1 year...
January 17, 2024: Open Heart
https://read.qxmd.com/read/38233041/cardiology-researchers-practices-and-perceived-barriers-to-open-science-an-international-survey
#58
JOURNAL ARTICLE
Kelly D Cobey, Mohsen Alayche, Sara Saba, Nana Yaa Barnes, Sanam Ebrahimzadeh, Emilio Alarcón, Benjamin Hibbert, David Moher
OBJECTIVE: Open science is a movement and set of practices to conduct research more transparently. Implementing open science will significantly improve public access and supports equity. It also has the potential to foster innovation and reduce duplication through data and materials sharing. Here, we survey an international group of researchers publishing in cardiovascular journals regarding their perceptions and practices related to open science. METHODS: We identified the top 100 'Cardiology and Cardiovascular Medicine' subject category journals from the SCImago journal ranking platform...
January 17, 2024: Open Heart
https://read.qxmd.com/read/38216172/fluoroquinolones-do-not-provide-added-risk-of-out-of-hospital-cardiac-arrest-a-nationwide-study
#59
JOURNAL ARTICLE
Viktoría Ellenardóttir, Ruben Coronel, Fredrik Folke, Andrim Halili, Anojhaan Arulmurugananthavadivel, Saaima Parveen, Mikkel Porsborg Andersen, Morten Schou, Christian Torp-Pedersen, Gunnar Gislason, Talip E Eroglu
AIM: Conflicting results have been reported regarding the association between fluoroquinolones (FQs) and the risk of out-of-hospital cardiac arrest (OHCA). In particular, it has not become clear whether OHCA in FQ users is related to the inherent comorbidities or whether there is a direct pro-arrhythmic effect of FQs. Therefore, we studied the relation between FQs and OHCA in the general population. METHODS: Through Danish nationwide registries, we conducted a nested case-control study with OHCA cases of presumed cardiac causes and age/sex/OHCA date-matched non-OHCA controls from the general population...
January 12, 2024: Open Heart
https://read.qxmd.com/read/38216173/nitroglycerin-use-and-adverse-clinical-outcomes-in-elderly-patients-with-acute-coronary-syndrome
#60
JOURNAL ARTICLE
Soichi Komaki, Yunosuke Matsuura, Hiroki Tanaka, Kohei Moribayashi, Yoshimasa Yamamura, Kazumasa Kurogi, Takeshi Ideguchi, Nobuyasu Yamamoto, Michikazu Nakai, Toshihiro Tsuruda, Koichi Kaikita
OBJECTIVE: The primary care for acute coronary syndrome (ACS) includes the administration of nitroglycerin (GTN). This study aimed to investigate the association between the use of GTN before percutaneous coronary intervention (PCI) for ACS and clinical outcomes. METHODS: Nine-hundred and forty-seven patients who underwent PCI for ACS were examined and classified into two groups: those who were treated with GTN before PCI (GTN group) and those who were not (non-GTN group)...
January 11, 2024: Open Heart
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