journal
https://read.qxmd.com/read/38388190/blood-pressure-status-trajectories-and-cardiovascular-disease-the-colaus-psycolaus-prospective-study
#1
JOURNAL ARTICLE
Yaniv Chocron, Markos Rousakis, Peter Vollenweider, Julien Vaucher, Pedro-Manuel Marques-Vidal
BACKGROUND: High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Adequate treatment of high BP should reduce the risk of CVD, but this association has seldom been assessed in a general population setting. METHODS: Population-based prospective study conducted in Lausanne, Switzerland, with a follow-up between 2003 and 2021. Participants were categorised as normal BP, untreated high BP, treated and uncontrolled BP and treated and controlled BP...
February 22, 2024: Open Heart
https://read.qxmd.com/read/38388189/skeletal-muscle-mitochondrial-capacity-in-patients-with-statin-associated-muscle-symptoms-sams
#2
JOURNAL ARTICLE
Laura A Mangone, Beth A Taylor, Robert Schmelzer, Sung Gi Noh, Michael C White, Oh Sung Kwon, Paul D Thompson
OBJECTIVE: The objective of this article is to evaluate near-infrared spectroscopy (NIRS), a non-invasive technique to assess tissue oxygenation and mitochondrial function, as a diagnostic tool for statin-associated muscle symptoms (SAMS). METHODS: We verified SAMS in 39 statin-treated patients (23 women) using a double-blind, placebo-controlled, cross-over protocol. Subjects with suspected SAMS were randomised to simvastatin 20 mg/day or placebo for 8 weeks, followed by a 4-week no treatment period and then assigned to the alternative treatment, either simvastatin or placebo...
February 22, 2024: Open Heart
https://read.qxmd.com/read/38388188/personalised-preinterventional-risk-stratification-of-mortality-length-of-stay-and-hospitalisation-costs-in-transcatheter-aortic-valve-implantation-using-a-machine-learning-algorithm-a-pilot-trial
#3
JOURNAL ARTICLE
Maria Zisiopoulou, Alexander Berkowitsch, Leonard Redlich, Thomas Walther, Stephan Fichtlscherer, David M Leistner
INTRODUCTION: Risk stratification based on Euroscore II (ESII) is used in some centres to assist decisions to perform transcatheter aortic valve implant (TAVI) procedures. ESII is a generic, non-TAVI-specific metric, and its performance fades for mortality at follow-up longer than 30 days. We investigated if a TAVI-specific predictive model could achieve improved predictive preinterventional accuracy of 1-year mortality compared with ESII. PATIENTS AND METHODS: In this prospective pilot study, 284 participants with severe symptomatic aortic valve stenosis who underwent TAVI were enrolled...
February 22, 2024: Open Heart
https://read.qxmd.com/read/38367984/effect-of-psychosocial-aspects-on-medication-adherence-in-patients-with-heart-failure-amid-socioeconomic-challenges
#4
JOURNAL ARTICLE
Hiba Deek, Angela Massouh
OBJECTIVE: To evaluate stress, depression and quality of life among community-dwelling patients with heart failure (HF) and evaluate their effect on perceived medication adherence in a socioeconomically challenged setting. DESIGN: A cross-sectional design with self-administered questionnaire with data collected between October 2021 and September 2022. METHODS: Patients with confirmed diagnosis of HF were sought for data collection in the community and cardiology clinics through an electronic platform...
February 17, 2024: Open Heart
https://read.qxmd.com/read/38331473/living-with-myocardial-ischaemia-and-no-obstructive-coronary-arteries-a-qualitative-study
#5
JOURNAL ARTICLE
Helen Humphreys, Danielle Paddock, Sarah Brown, Colin Berry, Aynsley Cowie, Susan Dawkes, Simon Nichols
OBJECTIVE: To explore the lived experience of people with myocardial ischaemia with no obstructive arteries. DESIGN: Qualitative study using semistructured interviews. SETTING: Telephone interviews with 17 participants living in the UK. PARTICIPANTS: 17 people (2 males, 15 females; aged 31-69 years) with a presumed or confirmed diagnosis of myocardial ischaemia with no obstructive arteries, recruited via social media and online patient-led support forums...
February 8, 2024: Open Heart
https://read.qxmd.com/read/38331472/correction-contemporary-use-and-outcome-of-cabrol-shunt-in-type-a-aortic-dissection-surgery-insight-from-china-5a-study
#6
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
February 8, 2024: Open Heart
https://read.qxmd.com/read/38325907/prognostic-value-of-right-ventricular-free-wall-longitudinal-strain-in-patients-with-pulmonary-hypertension-systematic-review-and-meta-analyses
#7
JOURNAL ARTICLE
Yosuke Nabeshima, Tetsuji Kitano, Koichi Node, Masaaki Takeuchi
BACKGROUND: Right ventricular (RV) dysfunction is associated with adverse outcomes in patients with pulmonary hypertension (PH). This systematic review and meta-analysis evaluated the prognostic value of RV free-wall longitudinal strain (RVfwLS), compared with other RV parameters in PH. METHODS: We searched for articles presenting the HR of two-dimensional RVfwLS in PH. HRs were standardised using the within-study SD. The ratio of HRs of a 1 SD change in RVfwLS versus systolic pulmonary arterial pressure (SPAP), systolic tricuspid annular velocities (s'-TV), RV fractional area change (FAC) or tricuspid annular plane systolic excursion (TAPSE) was calculated for each study, after which we conducted a random model meta-analysis...
February 7, 2024: Open Heart
https://read.qxmd.com/read/38316493/efficacy-and-safety-of-novel-left-ventricular-pacing-leads-1-year-analysis-of-the-navigator-trial
#8
JOURNAL ARTICLE
Juan Gabriel Martinez, Joao De Sousa, Antoine Dompnier, Mario Martins-Oliveira, Carsten W Israel, Elvis Teijeira, José Manuel Rubin, Frederic Sebag, Maria Martino, Yann Michel, Pedro Marques
OBJECTIVES: Assess safety and performance of novel quadripolar preshaped left ventricular (LV) leads: NAVIGO 4LV 2D ('S shaped') and NAVIGO 4LV ARC ('U shaped'). METHODS: Patients indicated for cardiac resynchronisation therapy were enrolled in a multicentre, prospective, controlled study (NAVIGATOR, NCT03279484). Patients were implanted with either a NAVIGO 4LV 2D or ARC lead, and assessed at 10 weeks, 6, 12 and 24 months post-implant. Co-primary safety and performance endpoints were assessed at 10 weeks...
February 5, 2024: Open Heart
https://read.qxmd.com/read/38302139/patients-on-vitamin-k-treatment-is-switching-to-direct-acting-oral-anticoagulation-cost-effective-a-target-trial-on-a-prospective-cohort
#9
JOURNAL ARTICLE
Helena Aebersold, Fabienne Foster-Witassek, Stefanie Aeschbacher, Juerg H Beer, Eva Blozik, Manuel Blum, Leo Bonati, Giulio Conte, Michael Coslovsky, Maria Luisa De Perna, Marcello Di Valentino, Stefan Felder, Carola A Huber, Giorgio Moschovitis, Andreas Mueller, Rebecca E Paladini, Tobias Reichlin, Nicolas Rodondi, Annina Stauber, Christian Sticherling, Thomas D Szucs, David Conen, Michael Kuhne, Stefan Osswald, Matthias Schwenkglenks, Miquel Serra-Burriel
AIMS: Direct-acting oral anticoagulants (DOACs) have, to a substantial degree, replaced vitamin K antagonists (VKA) as treatments for stroke prevention in atrial fibrillation (AF) patients. However, evidence on the real-world causal effects of switching patients from VKA to DOAC is lacking. We aimed to assess the empirical incremental cost-effectiveness of switching patients to DOAC compared with maintaining VKA treatment. METHODS: The target trial approach was applied to the prospective observational Swiss-AF cohort, which enrolled 2415 AF patients from 2014 to 2017...
January 31, 2024: Open Heart
https://read.qxmd.com/read/38302138/initiation-patterns-of-anticoagulants-for-atrial-fibrillation-among-older-uk-adults-with-and-without-chronic-kidney-disease-2010-2020
#10
JOURNAL ARTICLE
Julia Liaw, Deborah Liaw, Chintan Dave
BACKGROUND: There is a paucity of data on the initiation patterns of anticoagulants among older atrial fibrillation patients with and without chronic kidney disease (CKD). SETTING AND METHODS: We used the UK Clinical Practice Research Datalink (2010-2020) to conduct a retrospective cohort study to evaluate anticoagulant initiation patterns for older adults (≥65 years) with CKD (N=18 421) and without CKD (N=41 901), categorised by severity of CKD: stages 3a, 3b and 4, and initiation dose by respective direct oral anticoagulant (DOAC)...
January 31, 2024: Open Heart
https://read.qxmd.com/read/38290731/implementing-a-comprehensive-stemi-protocol-to-improve-care-metrics-and-outcomes-in-patients-with-in-hospital-stemi-an-observational-cohort-study
#11
JOURNAL ARTICLE
Christopher N Kanaan, Nicholas Kassis, Raunak M Nair, Anirudh Kumar, Chetan P Huded, Kathleen Kravitz, Grant W Reed, Amar Krishnaswamy, A Michael Lincoff, Jaikirshan Khatri, Rishi Puri, Khaled Ziada, Ravi Nair, Samir Kapadia, Umesh Khot
BACKGROUND: Patients who experience in-hospital ST-segment elevation myocardial infarction (iSTEMI) represent a uniquely high-risk cohort owing to delays in diagnosis, prolonged time to reperfusion and increased mortality. Quality initiatives aimed at improving the care of this vulnerable, yet understudied population are needed. METHODS: This study included consecutive patients with iSTEMI treated with percutaneous coronary intervention (PCI) between 1 January 2011 and 15 July 2019 at a single, tertiary referral centre...
January 30, 2024: Open Heart
https://read.qxmd.com/read/38290732/thromboembolic-and-bleeding-events-after-valvular-intervention-in-patients-with-atrial-fibrillation
#12
JOURNAL ARTICLE
Ebba-Louise Skogseid, Gorav Batra, Johan Westerbergh, Claes Held, Christina Christersson
AIM: To assess outcomes after cardiac surgery with biological valve replacement, valve repair or transcatheter aortic valve implantation (TAVI) in patients with atrial fibrillation (AF) in accordance with oral anticoagulant (OAC) treatment. METHODS: All patients in Sweden undergoing valvular intervention with AF were included. Associations between OAC exposure and cardiovascular (CV) events (composite of CV death, ischaemic stroke or systemic embolism) and major bleeding were investigated using Cox regression analysis...
January 29, 2024: Open Heart
https://read.qxmd.com/read/38286570/outpatient-care-of-adults-with-congenital-heart-disease-in-the-uk-a-qualitative-appraisal-of-the-clinician-perspective
#13
JOURNAL ARTICLE
Isobel Chaudhry, Anisa Ghassani, Jo Wray, Bill Chaudhry, Louise Coats
OBJECTIVE: This study aimed to explore clinicians' perspectives of ambulatory care in adult congenital heart disease (ACHD). METHODS: Semistructured interviews were carried out remotely (Zoom) with a range of physicians providing ambulatory care to patients with ACHD across the UK. The chronic care model, thrive and candidacy frameworks were used to design prompt guides and subsequently develop themes. A framework approach was used to code and analyse transcripts, which were managed in NVivo...
January 29, 2024: Open Heart
https://read.qxmd.com/read/38286569/effect-of-ischaemic-postconditioning-on-markers-of-myocardial-injury-in-st-elevation-myocardial-infarction-a-meta-analysis
#14
JOURNAL ARTICLE
Idan Bergman, Shaul Gelikas, Yehuda Wexler, Omri Braver, Dennis Boyle, Udi Nussinovitch
OBJECTIVES: This study aimed to perform a meta-analysis of the short-term impact of ischaemic postconditioning (IPoC) on myocardial injury in ST elevation myocardial infarction (STEMI) using surrogate cardiac biomarkers. METHODS: Eligible studies were identified using several article databases. Randomised controlled trials published between 1 January 2000 and 1 December 2021 comparing IPoC to standard of therapy in STEMI patients were included in the search. Outcomes included surrogates of myocardial injury, specifically peak troponin, creatine-kinase (CK) and CK myoglobin binding (CK-MB) enzyme levels...
January 29, 2024: Open Heart
https://read.qxmd.com/read/38242561/multiprofessional-heart-failure-self-development-framework
#15
JOURNAL ARTICLE
Paul Forsyth, Susan Young, Kirsty Hughes, Ruby James, Cheryl Oxley, Ruth Kelly, Rebecca Jones, Sarah Briggs, Lynn Mackay-Thomas, Yvonne Millerick, Maggie Simpson, Clare J Taylor, Simon Beggs, Susan Piper, Simon Duckett
OBJECTIVE: Heart failure remains a key public health priority across the globe. The median age of people with heart failure admitted to hospital in the UK is 81 years old. Many such patients transcend the standard interventions that are well characterised and evidenced in guidelines, into holistic aspects surrounding frailty, rehabilitation and social care. Previous published competency frameworks in heart failure have focused on the value of doctors, nurses and pharmacists. We aimed to provide an expert consensus on the minimum heart failure-specific competencies necessary for multiple different healthcare professionals, including physiotherapists, occupational therapists, dietitians and cardiac physiologists...
January 19, 2024: Open Heart
https://read.qxmd.com/read/38242557/cost-effectiveness-of-stepwise-provisional-versus-systematic-dual-stenting-strategies-in-patients-with-distal-bifurcation-left-main-stem-lesions-economic-analysis-of-the-ebc-main-trial
#16
JOURNAL ARTICLE
Alicia Le Bras, David Hildick-Smith, Arnaud Nze Ossima, Olivier Supplisson, Mohaned Egred, Philippe Brunel, Adrian P Banning, Marie-Claude Morice, Isabelle Durand-Zaleski
BACKGROUND: In patients with distal bifurcation left main stem lesions requiring intervention, the European Bifurcation Club Left Main Coronary Stent Study trial found a non-significant difference in major adverse cardiac events (MACEs, composite of all-cause death, non-fatal myocardial infarction and target lesion revascularisation) favouring the stepwise provisional strategy, compared with the systematic dual stenting. AIMS: To estimate the 1-year cost-effectiveness of stepwise provisional versus systematic dual stenting strategies...
January 19, 2024: Open Heart
https://read.qxmd.com/read/38242560/prognostic-value-of-right-ventricular-dyssynchrony-in-adults-with-repaired-tetralogy-of-fallot
#17
JOURNAL ARTICLE
Andrea Papa, Clement Nussbaumer, Eleni Goulouti, Fabienne Schwitz, Kerstin Wustmann, Daniel Tobler, Matthias Greutmann, Markus Schwerzmann
OBJECTIVE: Residual sequelae after surgical repair of tetralogy of Fallot (rTOF) affect clinical outcome. We investigated the prognostic impact of right ventricular (RV) dyssynchrony in adults with rTOF years after the surgical repair. METHODS: Patients from the Swiss Adult Congenital HEart disease Registry were included. NT-proBNP levels, echocardiography, exercise testing and MRI data were collected. An offline strain analysis to quantify RV-ventricular and interventricular dyssynchrony was performed...
January 18, 2024: Open Heart
https://read.qxmd.com/read/38242559/association-of-hfa-peff-score-with-clinical-outcomes-after-catheter-ablation-for-atrial-fibrillation
#18
JOURNAL ARTICLE
Taiji Okada, Takeshi Kitai, Atsushi Kobori, Madoka Sano, Ryosuke Murai, Toshiaki Toyota, Yasuhiro Sasaki, Tomohiko Taniguchi, Kitae Kim, Natsuhiko Ehara, Makoto Kinoshita, Yutaka Furukawa
BACKGROUND: The Heart Failure Association Pretest assessment, echocardiography and natriuretic peptide, functional testing and final aetiology (HFA-PEFF) score has been developed for diagnosing heart failure with preserved ejection fraction (HFpEF), which is frequently associated with atrial fibrillation (AF). We aimed to investigate whether preprocedural HFA-PEFF score could be used to predict clinical outcomes in patients with AF who underwent catheter ablation (CA). METHODS: Overall, 1679 patients with AF who underwent primary CA (71±10 years, 1218 males (72...
January 18, 2024: Open Heart
https://read.qxmd.com/read/38242558/reflections-on-my-journey-as-editor-in-chief-of-open-heart
#19
EDITORIAL
Pascal Meier
No abstract text is available yet for this article.
January 18, 2024: Open Heart
https://read.qxmd.com/read/38238027/use-of-sacubitril-valsartan-early-after-cabg
#20
RANDOMIZED CONTROLLED TRIAL
Madina Nurzhanova, Aisulu Musagaliyeva, Raushan Zhakypova, Daniya Senkibayeva, Amina Rakisheva
BACKGROUND: Heart failure (HF) remains a major public health problem with a high mortality and morbidity worldwide. Currently, there is no optimal revascularisation strategy for patients with ischaemic cardiomyopathy despite suggestions that coronary artery bypass graft (CABG) may be superior to medical therapy in improving survival. However, CABG may be associated with substantial risk in HF subjects. We therefore aimed to evaluate the safety and efficacy of the early initiation of sacubitril/valsartan in haemodynamically stabilised patients with HF with reduced ejection fraction (HFrEF) after early CABG...
January 18, 2024: Open Heart
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