journal
https://read.qxmd.com/read/38567111/efficacy-of-bacillus-calmette-gu%C3%A3-rin-in-cancer-prevention-and-its-putative-mechanisms
#1
REVIEW
Sakshi Gupta, Saurabh Yadav, Pawan Kumar
Bacillus Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis . Although it was developed as a prophylactic vaccine against tuberculosis (TB), researchers have also evaluated it for preventing cancer development or progression. These studies were inspired by the available data regarding the protective effects of microbial infection against cancers and an inverse relationship between TB and cancer mortality. Initial studies demonstrated the efficacy of BCG in preventing leukemia, melanoma and a few other cancers...
March 30, 2024: Journal of Cancer Prevention
https://read.qxmd.com/read/38567110/resveratrol-promotes-self-digestion-to-put-cancer-to-sleep
#2
JOURNAL ARTICLE
Alessandra Ferraresi, Suyanee Thongchot, Ciro Isidoro
Resveratrol, a natural polyphenol present in a variety of food stuff, has been shown to exert preventive and curative anticancer activity in several in vitro and in vivo models. Such chemopreventive/anticancer activity has been linked to biochemical and epigenetic modifications of multiple pathways involved in carcinogenesis and metastasization. In this commentary, we focus on the recent work done in our laboratory showing that resveratrol has potential to prevent and cure cancer by promoting epigenetic-mediated autophagy-dependent tumor dormancy, an effect associated with re-education of the cancer-associated fibroblasts and reduced production of inflammatory cytokines in the tumor microenvironment...
March 30, 2024: Journal of Cancer Prevention
https://read.qxmd.com/read/38567109/sex-difference-in-the-effect-of-bifidobacterium-longum-on-repeated-water-avoidance-stress-induced-gut-dysbiosis-in-wistar-rats
#3
JOURNAL ARTICLE
Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Eun Hye Kim, SungChan Ha, Kisung Kang, Wonseok Lee, Cheol Min Shin, Dong Ho Lee
Dysbiosis in gut microbiota is known to contribute to development of irritable bowel syndrome. We tried to investigate the effect of Bifidobacterium longum on repeated water avoidance stress (WAS) in a Wistar rat model. The three groups (no-stress, WAS, and WAS with B. longum ) of rats were allocated to sham or WAS for 1 hour daily for 10 days, and B. longum was administered through gavage for 10 days. Fecal pellet numbers were counted at the end of each 1-hour session of WAS. After 10 days of repeated WAS, the rats were eutanized, and the feces were collected...
March 30, 2024: Journal of Cancer Prevention
https://read.qxmd.com/read/38205367/cadmium-induced-carcinogenesis-in-respiratory-organs-and-the-prostate-insights-from-three-perspectives-on-toxicogenomic-approach
#4
REVIEW
Jun Lee, Dong Yeop Shin, Yujin Jang, Jun Pyo Han, Eun-Min Cho, Young Rok Seo
Cadmium (Cd) exposure primarily occurs through inhalation, either by smoking or occupational exposure to contaminated air. Upon inhalation, Cd ultimately reaches the prostate through the bloodstream. In this review, we investigate the carcinogenic potential of Cd in both respiratory organs and the prostate. Specifically, this review examines cellular metabolism, comprehensive toxicity, and carcinogenic mechanisms by exploring gene ontology, biological networks, and adverse outcome pathways. In the respiratory organs, Cd induces lung cancer by altering the expression of IL1B and FGF2 , causing DNA damage, reducing cell junction integrity, and promoting apoptosis...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205366/erratum-the-protective-effect-of-roseburia-faecis-against-repeated-water-avoidance-stress-induced-irritable-bowel-syndrome-in-a-wister-rat-model
#5
Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Eun Hye Kim, SungChan Ha, Kisung Kang, Wonseok Lee, HyeLim Choi, Yeon-Ran Kim, Yeong-Jae Seok, Cheol Min Shin, Dong Ho Lee
[This corrects the article on p. 93 in vol. 28, PMID: 37830115.].
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205365/nrf2-a-target-for-precision-oncology-in-cancer-prognosis-and-treatment
#6
REVIEW
Hoang Kieu Chi Ngo, Hoang Le, Young-Joon Surh
Activating nuclear factor-erythroid 2-related factor (Nrf2), a master regulator of redox homeostasis, has been shown to suppress initiation of carcinogenesis in normal cells. However, this transcription factor has recently been reported to promote proliferation of some transformed or cancerous cells. In tumor cells, Nrf2 is prone to mutations that result in stabilization and concurrent accumulation of its protein product. A hyperactivated mutant form of Nrf2 could support the cancer cells for enhanced proliferation, invasiveness, and resistance to chemotherapeutic agents and radiotherapy, which are associated with a poor clinical outcome...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205364/effects-of-black-raspberry-supplementation-on-methylation-pathways-in-vav-cre-asxl1-fl-fl-tet2-fl-fl-double-knockout-mice-with-early-stage-myelodysplastic-syndrome
#7
JOURNAL ARTICLE
Athena Dong, Yi-Wen Huang, Ben Niu, Ruiling Liu, Weijie Wu, Haiyan Gao, Jianhua Yu, Li-Shu Wang
Myelodysplastic syndromes (MDS) are a subset of myeloid malignancies defined by clonality of immature hematopoietic stem cells that leads to faulty blood cell development. These syndromes can lead to an increased risk of infection and may transform into acute myeloid leukemia, making it critical to determine effective treatments for the condition. While hypomethylating agents such as azacitidine and decitabine, as well as stem cell transplants, have been delineated as favored treatments for MDS, not all patients are physiologically receptive to these treatments...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205363/diagnostic-validity-of-a-serological-test-with-the-current-infection-marker-in-thai-adults-before-and-after-helicobacter-pylori-eradication-therapy
#8
JOURNAL ARTICLE
Setthachai Piwchan, Kittipoom Tossapornpong, Suppana Chuensakul, Ekawee Sripariwuth
Helicobacter pylori infection poses significant health risks, such as gastric adenocarcinoma, necessitating accurate diagnosis and effective treatment in primary care. This study evaluated the diagnostic efficacy of the serological current infection marker (CIM) test in identifying current H. pylori infection. The CIM test samples from 159 participants undergoing gastroscopy were collected, and H. pylori -positive outpatients received triple therapy based on histology or rapid urease test results. Following treatment, 45 patients underwent a 13 C-urea breath test and the CIM test for eradication assessment...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205362/cyclic-gmp-amp-synthase-in-cancer-prevention
#9
REVIEW
Weidong Chen, Ga-Eun Lee, Dohyun Jeung, Jiin Byun, Wu Juan, Yong-Yeon Cho
Cyclic GMP-AMP (cGAMP), synthesized by cGAMP synthase (cGAS), serves as a secondary messenger that modulates various cellular processes, including cell proliferation, cell death, immune response, and inflammation. cGAS is activated upon detecting cytoplasmic DNA, which may originate from damaged genomic and mitochondrial DNA or from viral and bacterial infections. The presence of DNA in the cytoplasm can trigger a substantial inflammatory reaction and cytokine production via the cGAS-STING signaling pathway...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205361/induction-of-hepatocellular-carcinoma-cell-cycle-arrest-and-apoptosis-by-dendropanax-morbifera-leveille-leaf-extract-via-the-pi3k-akt-mtor-pathway
#10
JOURNAL ARTICLE
Gi Dae Kim
Liver cancer is prevalent worldwide and associated with a high mortality rate. Therefore, developing novel drugs derived from natural products to reduce the side effects of chemotherapy is urgently needed. In this study, the inhibitory effect of Dendropanax morbifera Leveille extract (DME) on growth of hepatocellular carcinoma (HCC) cells and its underlying mechanisms were investigated. DME suppressed the growth, migration, and invasion of SK-Hep1 human HCC cells. It also reduced the expression of the G0/G1 phase regulator proteins cyclin-dependent kinase (CDK) 4, cyclin D, CDK2, and cyclin E, thereby inducing G0/G1 arrest...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205360/antiproliferative-activity-of-gibbosic-acid-h-through-induction-of-g-0-g-1-cell-cycle-arrest-and-apoptosis-in-human-lung-cancer-cells
#11
JOURNAL ARTICLE
Jaeho Han, Donghwa Kim, Hyen Joo Park, Hee-Juhn Park, Sang Kook Lee
Lung cancer is one of the most common causative cancers worldwide. Particularly, non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. NSCLC is a serious form of lung cancer that requires prompt diagnosis, and the 5-year survival rate for patients with this disease is only 24%. Gibbosic acid H (GaH), a natural lanostanoid obtained from the Ganoderma species (Ganodermataceae), has antiproliferative activities against colon and lung cancer cells. The aim of the present study was to evaluate the antiproliferative activity of GaH in NSCLC cells and to elucidate the underlying molecular mechanisms...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205359/prognostic-significance-of-tumor-mutation-burden-among-patients-with-non-small-cell-lung-cancer-who-received-platinum-based-adjuvant-chemotherapy-an-exploratory-study
#12
JOURNAL ARTICLE
Wei-Xi Shen, Guang-Hua Li, Yu-Jia Li, Peng-Fei Zhang, Jia-Xing Yu, Di Shang, Qiu-Shi Wang
This study aimed to investigate the prognostic significance of tumor mutation burden (TMB) among patients with non-small cell lung cancer (NSCLC) who received platinum-based adjuvant chemotherapy. Tumor tissue specimens after surgical resection were collected for DNA extraction. Somatic mutation detection and TMB analysis were conducted using next-generation sequencing (NGS). Recurrence status of the patients was assessed in the hospital during the adjuvant chemotherapy period, and long-term survival data of patients were obtained by telephone follow-up...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/38205358/potent-suppression-of-prostate-cancer-cell-growth-and-eradication-of-cancer-stem-cells-by-cd44-targeted-nanoliposome-quercetin-nanoparticles
#13
JOURNAL ARTICLE
Kader Turkekul, Suat Erdogan
The bioavailability of quercetin, a natural compound, is hindered by low solubility, limited absorption, and restricted systemic availability. Therefore, encapsulating it in biocompatible nanoparticles presents a promising solution. This study aimed to target prostate cancer stem cells (CSCs) overexpressing CD44+ receptors as well as cancer cells, employing quercetin-loaded hyaluronic acid-modified nanoliposomes (LP-Quer-HA). Synthesized via a green ethanol injection method, these nanoliposomes had an average diameter of 134 nm and an impressive loading efficiency of 96...
December 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/37830117/effectiveness-and-safety-of-apatinib-plus-programmed-cell-death-protein-1-blockades-for-patients-with-treatment-refractory-metastatic-colorectal-cancer-a-retrospective-exploratory-study
#14
JOURNAL ARTICLE
Shenglong Li, Hao Zheng, Qinghong Ge, Shuli Xia, Ke Zhang, Chunjing Wang, Fujing Wang
This study aimed to investigate the efficacy and safety of apatinib plus programmed cell death protein 1 (PD-1) blockades for patients with metastatic colorectal cancer (CRC) who were refractory to the standard regimens. In this retrospective study, patients with metastatic CRC who received apatinib plus PD-1 blockades in clinical practice were included. The initial dosage of apatinib was 250 mg or 500 mg, and PD-1 blockades were comprised of camrelizumab, sintilimab and pembrolizumab. Efficacy and safety data were collected through the hospital's electronic medical record system...
September 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/37830116/organic-acids-derived-from-saliva-amalgamated-betel-quid-filtrate-are-predicted-as-a-ten-eleven-translocation-2-inhibitor
#15
JOURNAL ARTICLE
Devyani Bhatkar, Nistha Ananda, Kiran Bharat Lokhande, Kratika Khunteta, Priyadarshini Jain, Ameya Hebale, Sachin C Sarode, Nilesh Kumar Sharma
There is a lack of evidence regarding the use of betel quid (BQ) and its potential contribution to oral cancer. Limited attention has been directed towards investigating the involvement of BQ-derived organic acids in the modulation of metabolic-epigenomic pathways associated with oral cancer initiation and progression. We employed novel protocol for preparing saliva-amalgamated BQ filtrate (SABFI) that mimics the oral cavity environment. SABFI and saliva control were further purified by an in-house developed vertical tube gel electrophoresis tool...
September 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/37830115/the-protective-effect-of-roseburia-faecis-against-repeated-water-avoidance-stress-induced-irritable-bowel-syndrome-in-a-wister-rat-model
#16
JOURNAL ARTICLE
Soo In Choi, Nayoung Kim, Ryoung Hee Nam, Jae Young Jang, Eun Hye Kim, SungChan Ha, Kisung Kang, Wonseok Lee, HyeLim Choi, Yeon-Ran Kim, Yeong-Jae Seok, Cheol Min Shin, Dong Ho Lee
Roseburia faecis, a butyrate-producing, gram-positive anaerobic bacterium, was evaluated for its usefulness against repeated water avoidance stress (WAS)-induced irritable bowel syndrome (IBS) in a rat model, and the underlying mechanism was explored. We divided the subjects into three groups: one without stress exposure, another subjected to daily 1-hour WAS for 10 days, and a third exposed to the same WAS regimen while also receiving two different R. faecis strains (BBH024 or R22-12-24) via oral gavage for the same 10-day duration...
September 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/37830114/novel-insight-into-the-cellular-and-molecular-signalling-pathways-on-cancer-preventing-effects-of-hibiscus-sabdariffa-a-review
#17
REVIEW
Raihana Yasmin, Sangeeta Gogoi, Jumi Bora, Arijit Chakraborty, Susmita Dey, Ghazal Ghaziri, Surajit Bhattacharjee, Laishram Hemchandra Singh
A category of diseases known as cancer includes abnormal cell development and the ability to infiltrate or spread to other regions of the body, making them a major cause of mortality worldwide. Chemotherapy, radiation, the use of cytotoxic medicines, and surgery are the mainstays of cancer treatment today. Plants or products produced from them hold promise as a source of anti-cancer medications that have fewer adverse effects. Due to the presence of numerous phytochemicals that have been isolated from various parts of the Hibiscus sabdariffa (HS) plant, including anthocyanin, flavonoids, saponins, tannins, polyphenols, organic acids, caffeic acids, citric acids, protocatechuic acid, and others, extracts of this plant have been reported to have anti-cancer effects...
September 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/37434799/immunohistochemistry-versus-pcr-technology-for-molecular-subtyping-of-breast-cancer-multicentered-expereinces-from-addis-ababa-ethiopia
#18
JOURNAL ARTICLE
Dessiet Oma, Maria Teklemariam, Daniel Seifu, Zelalem Desalegn, Endale Anberbir, Tamrat Abebe, Solomon Mequannent, Solomon Tebeje, Wajana Lako Labisso
The application of immunohistochemistry (IHC) for molecular characterization of breast cancer (BC) is of paramount importance; however, it is not universally standardized, subject to observer variability and quantifying is a challenge. An alternative molecular technology, such as endpoint reverse transcription (RT)-PCR gene expression analysis, may improve observer variability and diagnostic accuracy. This study was intended to compare IHC with the RT-PCR based technique and assess the potential of RT-PCR for molecular subtyping of BC...
June 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/37434798/erratum-cedrol-a-sesquiterpene-isolated-from-juniperus-chinensis-inhibits-human-colorectal-tumor-growth-associated-through-downregulation-of-minichromosome-maintenance-proteins
#19
Soojung Jin, Jung-Ha Park, Hee Jung Yun, You Na Oh, Seunghye Oh, Yung Hyun Choi, Byung Woo Kim, Hyun Ju Kwon
[This corrects the article on p. 221 in vol. 27, PMID: 36713942.].
June 30, 2023: Journal of Cancer Prevention
https://read.qxmd.com/read/37434797/economic-burden-of-cancer-for-the-first-five-years-after-cancer-diagnosis-in-patients-with-human-immunodeficiency-virus-in-korea
#20
JOURNAL ARTICLE
Yoonyoung Jang, Taehwa Kim, Brian H S Kim, Jung Ho Kim, Hye Seong, Youn Jeong Kim, Boyoung Park
This study aimed to estimate the medical cost of cancer in the first five years of diagnosis and in the final six months before death in people who developed cancer after human immunodeficiency virus (HIV) infection in Korea. The study utilized the Korea National Health Insurance Service-National Health Information Database (NHIS-NHID). Among 16,671 patients diagnosed with HIV infection from 2004 to 2020 in Korea, we identified 757 patients newly diagnosed with cancer after HIV diagnosis. The medical costs for 60 months after diagnosis and the last six months before death were calculated from 2006 to 2020...
June 30, 2023: Journal of Cancer Prevention
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