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Journal of Cancer Prevention

Sung Hyun Kim, Myoung-Ok Kim, Ki-Rim Kim
[This corrects the article on p. 170 in vol. 23, PMID: 30671399.].
March 2019: Journal of Cancer Prevention
Amir Sohrabi
No abstract text is available yet for this article.
March 2019: Journal of Cancer Prevention
Stephen E Langabeer
No abstract text is available yet for this article.
March 2019: Journal of Cancer Prevention
Suhn Hyung Kim, Joo Weon Lim, Hyeyoung Kim
Background: Helicobacter pylori increases production of reactive oxygen species (ROS), which activates inflammatory and carcinogenesis-related signaling pathways in gastric epithelial cells. Therefore, reducing ROS, by upregulating antioxidant enzyme, such as superoxide dismutase (SOD), may be a novel strategy to prevent H. pylori -associated gastric diseases. Astaxanthin is an antioxidant carotenoid that prevents oxidative stress-induced cell injury. The present study was aimed to determine whether H...
March 2019: Journal of Cancer Prevention
Ji Soo Park, Beodeul Kang, Yehyun Park, Soo Jung Park, Jae Hee Cheon, Minkyu Jung, Seung Hoon Beom, Sang Joon Shin, Hyuk Hur, Byung Soh Min, Seung Hyuk Baik, Kang Young Lee, Joong Bae Ahn, Nam Kyu Kim, Tae Il Kim
Background: The National Lung Screening Trial (NLST) and NELSON trial showed that low-dose chest computed tomography (LDCT) screening significantly reduced the mortality form lung cancer. Although cancer survivors are known to have high risk for second malignant neoplasm (SMN), the usefulness of LDCT screening for lung cancer in cancer survivors is not clear. Methods: Between August 2016 and August 2017, 633 long-term colorectal cancer (CRC) survivors visited the survivorship clinic in Cancer Prevention Center, Yonsei Cancer Center, Seoul, Republic of Korea...
March 2019: Journal of Cancer Prevention
Yun-Sook Jung, Eun-Young Park, Hae-Ok Sohn
Background: Oral mucositis during radiotherapy which is harmful to the patients with head and neck is suggested to be related to the oral hygiene and health. Therefore, we evaluated the oral health status in relation to the occurrence of mucositis among patients with head and neck cancer during radiotherapy. Methods: Tooth plaque index (PI), periodontal depth, and oral mucositis in 50 patients with head and neck cancer were examined by a dentist for 8 weeks after radiotherapy initiation...
March 2019: Journal of Cancer Prevention
Werissaw Haileselassie, Tefera Mulugeta, Wondemagegnhu Tigeneh, Mirgissa Kaba, Wajana Lako Labisso
Background: Less attention is given to cancer treatment and control in Ethiopia. Methods: To investigate the challenges and opportunities facing cancer treatment services in Ethiopia. A purposive sampling technique was applied to recruit the study subjects from Black Lion Specialized Hospital Oncology Department. A semi-structured interview guide was used to investigate challenges and opportunities in oncology service in Ethiopia. Data was transcribed and coded by two independent coders and analyzed thematically in reference to the objectives...
March 2019: Journal of Cancer Prevention
Se-Eun Lim, HyoJin Ahn, Eun Sook Lee, Sun-Young Kong, So-Youn Jung, Seeyoun Lee, Han-Sung Kang, Eun-Gyeong Lee, Jai Hong Han, Boyoung Park
Background: This study was conducted to explore the effect of known risk factors, focusing on risk factors including age at menarche, age at menopause, number of children, family history of breast cancer, and age at first birth according to breast density, in consideration of interaction among East-Asian women. Methods: Case-control study with 2,123 cases and 2,121 controls with mammographic density was conducted. Using the mammographic film, breast density was measured using Breast Imaging-Reporting and Data System...
March 2019: Journal of Cancer Prevention
Soo In Choi, Nayoung Kim, Sun Min Lee, Ryoung Hee Nam, So Ra Kang, Chin-Hee Song, Young-Tae Park, Huitae Min, Yeon-Ran Kim, Yeong-Jae Seok
Background: High-fat diet is known to be implicated in the pathogenesis of various metabolic disorders related to an inflammatory response. The aim of this study was to investigate the influence of high-fat diet for intestinal acetic acid and butyric acid concentrations which are related to inflammation-associated colon cancer risk. Methods: Both male and female rats of 6, 31, 74 and 104-week of age were fed chow diet or high-fat diet for 8 weeks. Body weight and food intake were measured weekly during the feeding period...
March 2019: Journal of Cancer Prevention
Eun Ok Choi, Hye-Jin Hwang, Yung Hyun Choi
Background: The roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used in traditional medicine for treatment of various diseases. In this study, we investigated the effects of ethanol extracts of S. baicalensis roots (EESB) on the growth ofn human leukemia U937 cells. Methods: The effect of EESB on cell viability was measured by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide assay. Apoptosis was determined using 4,6-diamidino-2-phenyllindile staining and flow cytometry...
March 2019: Journal of Cancer Prevention
Yehyun Park, Soo Jung Park, Jae Hee Cheon, Won Ho Kim, Tae Il Kim
Background: The influence of family history (FH) on cancer recurrence and survival among patients with established colorectal cancer (CRC) remains uncertain. This study aimed to evaluate the association of FH with cancer recurrence, survival, and the incidence of colorectal adenomas in patients with CRC. Methods: Consecutive patients with stage III CRC diagnosed between 2004 and 2009 and followed-up in Severance Hospital were retrospectively enrolled and followed until December 2014...
March 2019: Journal of Cancer Prevention
Jung Ran Choi, Sang-Baek Koh, Seong Yong Park, Hye Ryun Kim, Hyojin Lee, Dae Ryong Kang
[This corrects the article on p. 234 in vol. 22, PMID: 29302581.].
December 2018: Journal of Cancer Prevention
Ha-Neul Choi, Jung-Eun Yim
Background: Type 2 diabetes mellitus (T2DM) and cancer are serious health problems worldwide, and their prevalences have been on the rise in recent years. It has been reported that adropin plays an important role in the development of T2DM, oxidative stress, inflammation, and obesity. However, there is limited information available on T2DM from human studies, especially for the Korean population. In this study, we aimed to investigate the correlation between adropin levels and obesity of Korean T2DM patients...
December 2018: Journal of Cancer Prevention
Young-Jae Hwang, Nayoung Kim, Chang Yong Yun, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Il Tae Son, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee, Seon Mee Park, Dong Ho Lee
Background: As the number of big-cohort studies increases, validation becomes increasingly more important. We aimed to validate administrative database categorized as colorectal cancer (CRC) by the International Classification of Disease (ICD) 10th code. Methods: Big-cohort was collected from Clinical Data Warehouse using ICD 10th codes from May 1, 2003 to November 30, 2016 at Seoul National University Bundang Hospital. The patients in the study group had been diagnosed with cancer and were recorded in the ICD 10th code of CRC by the National Health Insurance Service...
December 2018: Journal of Cancer Prevention
Raziye Özdemir, Sevda Ural, Merve Karaçalı
Background: Family physicians (FPs) play an important role in cancer control. The aim of this study was to understand the functions of FPs in cancer control and to explore FPs' perceptions of their own roles and the difficulties they face in cancer control in Karabuk province, Turkey. Methods: The study consisted of two methodological parts. The qualitative part included a descriptive study in which data were collected from 87.5% (n=56) out of all FPs in Karabuk using a questionnaire...
December 2018: Journal of Cancer Prevention
Sung Hyun Kim, Myoung-Ok Kim, Ki-Rim Kim
Background: Human hepatocellular carcinoma (HCC) is a common liver tumor and the main cause of cancer-related death. Tyrosine kinase inhibitors, such as imatinib and GNF5 which were developed to treat chronic myelogenous leukemia, regulate the progression of various cancers. The aim of this study was to confirm the anti-tumor activity of tyrosine kinase inhibitors through regulation of S-phase kinase-associated protein 2 (Skp2), an important oncogenic factor in various cancer cells, in human hepatocarcinoma SK-HEP1 cells...
December 2018: Journal of Cancer Prevention
Ho-Jae Lee
TGF-β signaling plays a tumor suppressive role in normal and premalignant cells but promotes tumor progression during the late stages of tumor development. The TGF-β signaling pathway is tightly regulated at various levels, including transcriptional and post-translational mechanisms. Ubiquitination of signaling components, such as receptors and Smad proteins is one of the key regulatory mechanisms of TGF-β signaling. Tripartite motif (TRIM) family of proteins is a highly conserved group of E3 ubiquitin ligase proteins that have been implicated in a variety of cellular functions, including cell growth, differentiation, immune response, and carcinogenesis...
December 2018: Journal of Cancer Prevention
Ho Hee Jang
Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining normal cellular functions. Protein degradation pathways in eukaryotes are largely divided into proteasome-mediated degradation and lysosome-mediated degradation. Proteasome is a multisubunit complex that selectively degrades 80% to 90% of cellular proteins. Proteasome-mediated degradation can be divided into 26S proteasome (20S proteasome + 19S regulatory particle) and free 20S proteasome degradation...
December 2018: Journal of Cancer Prevention
Thaís da Rocha Boeira, Janaina Coser, Jonas Michel Wolf, Bruna Klahr Manggini Cardinal, Ivana Grivicich, Daniel Simon, Vagner Ricardo Lunge
Cervical cancer (CC) is caused by persistent human papillomavirus (HPV) infection and affects women worldwide. The progression of an HPV persistent infection to CC is influenced by genetic factors. Three single nucleotide polymorphisms (SNPs) in TP53 , NQO1 and RPS19 genes (rs1042522, rs1800566, rs2305809, respectively) were previously associated with CC in European and North American populations. The present case-control study aimed to investigate the association of the SNPs rs1042522, rs1800566, and rs2305809 with CC in an admixed population in southern Brazil...
September 2018: Journal of Cancer Prevention
Min Kyeong Lee, Ji Hyeon Park, Seol Hwa Gi, Young Sun Hwang
Background: Cancer invasion is a critical factor for survival and prognosis of patients with cancer. Identifying and targeting factors that influence cancer invasion are an important strategy to overcome cancer. In this study, we investigated the role of fascin known to be associated with cancer invasion. Methods: Fascin depletion was performed with lentiviral short hairpin RNA against fascin mRNA and stable cell line (Fascindep ) was established. Matrigel-Transwell invasion and three-dimensional (3D) culture system were used to observe fascin depletion effects...
September 2018: Journal of Cancer Prevention
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