Critical Reviews in Analytical Chemistry

Monitoring food safety is crucial and significantly impacts the ecosystem and human health. To adequately address food safety problems, a collaborative effort needed from government, industry, and consumers. Modern sensing technologies with outstanding performance are needed to meet the growing demands for quick and accurate food safety monitoring. Recently, emerging sensors for regulating food safety have been extensively explored. Along with the development in sensing technology, the metal-organic frameworks (MOF)-based sensors gained more attention due to their excellent sensing, catalytic, and adsorption properties...

Environmental measures have drawn more attention recently as a means of identifying cost-effective, safe, and green approaches in analytical methods. As a result, white and green analytical chemistry was developed. Greenness, whiteness, and chemical risks are all measured under the general expression "environmental measurements." For the first time, the greenness, whiteness, and chemical risk-measuring programs are presented along with their histories, concepts, advantages, and disadvantages. The six scales that were published between 2020 and 2023, including the Analytical Greenness Calculator (AGREE), the Analytical Greenness Metric for Sample Preparation (AGREEprep), the Complementary Green Analytical Procedure Index (ComplexGAPI), Red-Green-Blue (RGB12), blue applicability grade index (BAGI), and the Chloroform-oriented Toxicity Estimation (ChlorTox) scales are discussed...

Gas chromatography (GC) is crucial for measuring atmospheric halogenated greenhouse gases (hGHGs), usually coupled with electron capture detector (ECD, with higher sensitivity) or mass spectrometry (MS, with higher selectivity). This review compares GC-ECD and GC-MS for analyzing atmospheric hGHGs in terms of analytical methodology, performance, and instrumentation. For hGHGs such as SF6 , chlorofluorocarbons, and N2 O, ECD can be employed in the single column, forecut-backflush (FCBF), and preconcentration methods...

Per- and polyfluoroalkyl substances (PFASs) have emerged as a prominent environmental pollutant in recent years, primarily due to their tendency to accumulate and magnify in both the environment and living organisms. The entry of PFASs into the environment can have detrimental effects on human health. Hence, it is crucial to actively monitor and detect the presence of PFASs. The current standard detection method of PFAS is the combination of chromatography and mass spectrometry. However, this requires expensive instruments, extra sample pretreatment steps, complicated operation and long analysis time...

Hemoglobin plays a vital role in a series of biological activities. Abnormal levels of hemoglobin in blood are associated with many clinical diseases. Therefore, development of simple and accurate methods for sensing hemoglobin is of considerable significance. The blowout advancement in nanotechnology has urged the use of different types of fluorescent nanomaterials for hemoglobin assay. The past decades have witnessed the rapid progress of fluorescent nanosensors for hemoglobin assay. In the review, the sensing principles of fluorescent nanomaterials for sensing hemoglobin were briefly discussed...

TORCH infection is a significant risk factor for severe fetal damage, especially congenital malformations. Screening pregnant women for TORCH pathogens could reduce the incidence of adverse pregnancy outcomes and prevent birth defects. Hence, timely identification and inhibition of TORCH infections are effective ways to successfully prevent them in pregnant women. Recently, the superiority of biosensors in TORCH pathogen sensing has been emphasized due to their intrinsic benefits, such as rapid response time, portability, cost-effectiveness, much friendlier preparation and determination steps...

High-performance liquid chromatography (HPLC) is one of the most useful techniques for the separation and determination of new drugs with a complex nature. The selection of an HPLC detector depends on the chemical nature of molecules, potential impurities, matrix of the sample, sensitivity, availability, and/or cost of the detector. HPLC methods with UV/Vis detectors are the most used and simple analytical procedures in pharmaceutical applications, but it is limited to compounds that possess a chromophore. Hence, this review provides an overview on the development of analytical methods for compounds with weak chromophores...

Sample clean-up and pre-concentration are critical components of pharmaceutical analysis. The dispersive liquid-liquid microextraction (DLLME) technique is widely recognized as the most effective approach for enhancing overall detection sensitivity. While various DLLME modes have been advanced in pharmaceutical analysis, there need to be more discussions on pre-concentration techniques specifically developed for this field. This review presents a comprehensive overview of the different DLLME modes used in pharmaceutical analysis from 2017 to May 2023...

The selective and sensitive diagnosis of diseases is a significant matter in the early stages of the cure of illnesses. To elaborate, although several types of probes have been broadly applied in clinics, magnetic nanomaterials-aptamers, as new-generation probes, are becoming more and more attractive. The presence of magnetic nanomaterials brings about quantification, purification, and quantitative analysis of biomedical, especially in complex samples. Elaborately, the superparamagnetic properties and numerous functionalized groups of magnetic nanomaterials are considered two main matters for providing separation ability and immobilization substrate, respectively...

Molecularly imprinted polymer (MIP)-based electrochemical sensors have been extensively researched due to their higher sensitivity, quick response, and operational ease. To develop more advanced sensing devices with enhanced properties, MIPs have been integrated with two-dimensional (2D) layered materials such as transition metal dichalcogenides (TMDs) and MXenes. These 2D materials have unique electronic properties and an extended surface area, making them promising sensing materials that can improve the performance of MIPs...

Lipid peroxidation occurs when substances, such as reactive oxygen species, attack lipids. Polyunsaturated fatty acids are the main targets. Several products are formed, including primary products such as lipid hydroperoxides and secondary products such as malondialdehyde (MDA), the most used lipid peroxidation biomarker. As MDA levels are elevated in several diseases, MDA is an essential indicator for assessing pathological states. The thiobarbituric acid reactive substances assay is the most widely used method for MDA determination...

Shilajit, a natural material known for thousands of years, is primarily famous because it was the main constituent used for the mummification of bodies by dynastic Egyptians. However, for millennia, it has also been an important drug and supplement in traditional and modern medicine. A full search of Shilajit in the literature, reveals that its chemical composition is not known with certainty. That's due to the fact that surprisingly, no comprehensive chemical analysis has ever been performed to find all the chemicals and species present in it...

Mycotoxins are toxic compounds that are formed as secondary metabolites by some fungal species that contaminate crops during pre- and postharvest stages. Exposure to mycotoxins can lead to adverse health effects in humans, such as carcinogenicity, mutagenicity, and teratogenicity. Hence, there is a need to develop analytical methods for their determination in vegetable oils that possess high sensitivity and selectivity. In the current review (116 references), the recent developments, current challenges, and perspectives in sample preparation techniques and chromatographic determination are summarized...

The advent of biosensors has tremendously increased our potential of identifying and solving important problems in various domains, ranging from food safety and environmental analysis, to healthcare and medicine. However, one of the most prominent drawbacks of these technologies, especially in the biomedical field, is to employ conventional samples, such as blood, urine, tissue extracts and other body fluids for analysis, which suffer from the drawbacks of invasiveness, discomfort, and high costs encountered in transportation and storage, thereby hindering these products to be applied for point-of-care testing that has garnered substantial attention in recent years...

The quality of Chinese herbal medicine (CHM) directly impacts clinical efficacy and safety. Fingerprint technology is an internationally recognized method for evaluating the quality of CHM. However, the existing quality evaluation models based on fingerprint technology have blocked the ability to assess the internal quality of CHM and cannot comprehensively reflect the correlation between pharmacodynamic information and active constituents. Through mathematical methods, a connection between the "Spectrum" (fingerprint) and the "Effect" (pharmacodynamic data) was established to conduct a spectrum-effect relationship (SER) of CHM to unravel the active component information associated with the pharmacodynamic activity...

Rapidly detecting potentially toxic ions such as cyanide is paramount to maintaining a sustainable and environmentally friendly ecosystem for living organisms. In recent years, molecular sensors have been developed to detect cyanide ions, which provide a naked-eye or fluorometric response, making them an ideal choice for cyanide sensing. Nanosensors, on the other hand, have become increasingly popular over the last two decades due water solubility, quick reaction times, environmental friendliness, and straightforward synthesis...

This work describes current trends in the development of headspace microextraction methods. The main trends in the selection of detection techniques used in combination with microextraction and preferences in the selection of headspace liquid-phase microextraction (HS-LPME) or headspace solid-phase microextraction (HS-SPME) methods, depending on the analytes and their quantity, are also briefly presented. In the main part of the work, on the basis of current journal literature, headspace microextraction analytical methods used for the determination of various inorganic and organic analytes are classified and compared over the last five years...

Saliva is one of the most critical human body fluids that can reflect the state of the human body. The detection of saliva is of great significance for disease diagnosis and health monitoring. Microfluidics, characterized by microscale size and high integration, is an ideal platform for the development of rapid and low-cost disease diagnostic techniques and devices. Microfluidic-based saliva testing methods have aroused considerable interest due to the increasing need for noninvasive testing and frequent or long-term testing...

The drug rapamycin is a potent inhibitor of the mTOR complex, acting directly in the signaling cascade of this protein complex; interrupting cell proliferation, in addition to being an extremely efficient immunosuppressant. Currently this drug is being used in several types of cancer. Rapamycin has been a target of great interest within nanomedicine involving nanostructured systems for drug delivery aiming to increase the bioactivity and bioavailability of this drug. In addition, there is a constant search for analytical methods to identify and quantify this drug...

Peptides and proteins having D-amino acids in their sequences are now believed to be widespread among different living organisms. Their significance is attributed to the diverse functions of these molecules, such as having a certain pathological implication or enhancing biological activity. Indeed, some peptide molecules with D-amino acids in their structure have already found their way to clinical use such as the antibacterial gramicidin and the antidiabetic nateglinide. Ion mobility mass spectrometry (IM-MS) added an additional dimension of separation as it depends on ions mobility in the space, which is dependent on their shapes, and the shape depends on the orientation of atoms...