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Developmental Period Medicine

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https://read.qxmd.com/read/30636240/-the-role-of-emollients-in-atopic-dermatitis-in-children
#1
Ewa Kamińska
Atopic dermatitis is a chronic inflammatory disease characterized by recurrent flares, intense itching, erythema, dry skin resulting from skin barrier defects, and staphylococcal infections. Multiple factors may affect the skin`s normal barrier function, including filaggrin gene mutations, immune dysregulation, altered skin microbiome, altered lipids in stratum corneum, or deficiency of antimicrobial peptides AMPs. The disease mainly affects children, causing a considerable impact on the quality of their life; its first manifestations occur with up to 90% of cases before the age of 5...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636239/prophphylactic-bilateral-salpingngectomy-why-is-it-worthwhile
#2
Łukasz Kurek, Krzysztof Jabłoński, Natalia Góralska, Joanna Żuchlińska, Łukasz Stelmaszczyk, Paweł Różanowski
Malignant tumors of the ovary are characterized by late detection which is the chief factor responsible for their poor prognosis. Almost 70% of ovarian cancers are diagnosed at clinical stage III or IV. At present, effective methods for early detection of ovarian cancer are lacking. One accepted approach to reduce the risk of ovarian cancer is bilateral salpingo-oophorectomy. However, it is increasingly widely believed that even a more limited surgery of bilateral salpingectomy may be also used prophylactically as an effective means to reduce cancer risk...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636238/-progressive-familial-intrahepatic-cholestasis-type-3
#3
Patryk Lipiński, Irena Jankowska
Progressive familial intrahepatic cholestasis is caused by mutations in the ABCB4 gene and belongs to the family of familial intrahepatic cholestais disorders inherited in an autosomal recessive pattern. To date, about 200 patients with various hepatobiliary disorders associated with ABCB4 gene mutations have been described in the literature. The aim of this manuscript was to describe the pathogenesis, clinical presentation, diagnostic process and treatment of progressive familial intrahepatic cholestais type 3, based on the literature review...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636237/-new-recommendations-on-the-diagnosis-and-treatment-of-eosinophilic-esophagitis-in-children-and-adults
#4
Barbara Iwańczak, Franciszek Iwańczak
Besides gastro-esophageal reflux, eosinophilic esophagitis (EoE), is the most frequently diagnosed chronic inflammatory disease both in children and adults. Clinical symptoms depend on the age of the patient and the time of the disease. In infants and younger children feeding disturbances, physical development retardation, vomiting and abdominal pain are most frequent. Difficulty in solid food swallowing, food impaction in the esophagus and chest pain are the most frequent symptoms in older children and adults...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636236/-vemurafenib-in-refractory-langerhans-histiocytosis
#5
Anna Raciborska, Zofia Małas, Andrzej Tysarowski
Langerhans Cell Histiocytosis (LCH) is a rare disease involving the occurrence of disturbances in the mitogene-activated kinases pathway (MAPK). At present, it is known that the appearance of such disorders is usually connected with a more aggressive form of the disease, more frequently resistant to conventional chemotherapy, as well as characterised by a higher probability of relapse and progression. Since recently, it has been possible to apply BRAF inhibitors in the treatment of LCH patients, however, there are no clear guidelines regarding the criteria for implementing this type of therapy...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636235/-high-ureteral-insertion-as-the-cause-of-extreme-hydronephrosis-in-a-5-year-old-child-with-horseshoe-kidney
#6
Grażyna Krzemień, Agnieszka Turczyn, Małgorzata Pańczyk-Tomaszewska, Przemysław Bombiński, Agnieszka Szmigielska
The incidence of horseshoe kidney is 1 per 400-800 live births. From 44-52% of the patients with horseshoe kidney have other coexisting abnormalities of the urinary tract, such as hydronephrosis, vesicoureteral reflux and a duplex collecting system. Our patient, a 5-year old boy, was admitted to a pediatric nephrology department because of abdominal pain and vomiting. He had ultrasonography of the abdomen performed for the first time at the age of 9-months and horseshoe kidney was shown. In a control ultrasonography, a mild dilatation of the pyelocalyceal system in the left kidney was described...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636234/-ganglioneuroblastoma-in-a-child-with-chronic-abdominal-pain-a-case-report
#7
Tatiana Jamer, Tomasz Pytrus, Urszula Zaleska-Dorobisz, Barbara Iwańczak
Chronic abdominal pain is a very common complaint in the population of children and adolescents. In most cases, the usual cause are functional gastrointestinal disorders. However, in a few percent of children, the reason for persistent chronic stomach pain are organic diseases occurring in the gastrointestinal tract, as well as parenteral diseases, including uro-genital tract abnormalities, inflammation of the lower respiratory tract and cancer processes. Among organic causes, in addition to those commonly encountered, such as: intolerances and food allergies, gastroesophageal reflux disease, chronic gastritis or duodenitis, or urinary tract infections, the diagnosis should also include very rare causes, for example, neoplastic diseases, among them tumors of the abdominal cavity...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636233/malignant-gastrointestinal-neuroectodermal-tumor-clear-cell-sarcoma-like-tumor-of-the-gastrointestinal-tract-of-the-small-intestine-in-a-12-year-old-boy
#8
Przemysław Wolak, Andrzej Wincewicz, Piotr Czauderna, Michał Spałek, Anna Kruczak, Sławka Urbaniak-Wąsik, Janusz Ryś, Elżbieta Michalak, Martyna Woltanowska, Stanisław Sulkowski
The aim of this paper is a clinical and anatomopathological demonstration of a malignant lesion, a gastrointestinal neuroectodermal tumor (GNET), as an exceedingly rare cause of ileus in the pediatric population. Specifically, we present the case of a 12-year-old boy who showed dramatic weight loss, hypochromic anemia, fever, dehydration, exaggerated granulation of the terminal ileum, and mechanical ileus due to the obstruction by an intramural tumor of the small intestine. A 50cm-long part of the small intestine with pathological stricture was surgically removed, sampled and routinely fixed and stained with hematoxylin and eosin...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636232/metabolic-syndrome-in-overweight-or-obese-children-and-adolescents-based-on-own-material-abstract-key-words
#9
Katarzyna Szabelska-Zakrzewska, Alina Durko, Anna Socha-Banasiak, Małgorzata Majewska, Michał Kolejwa, Joanna Kazanek-Zasada, Elżbieta Czkwianianc
OBJECTIVE: Aim: To assess the prevalence of metabolic syndrome (MS) components in overweight or obese children and adolescents, as well as analyze the risk factors of its occurrence. PATIENTS AND METHODS: Material and methods: The study was conducted in a group of 70 children and adolescents aged 5-18 hospitalized in the Department of Gastroenterology, Allergology and Pediatrics, Polish Mother's Memorial Hospital - Research Institute in Lodz (Poland) based on the results of medical histories, physical examination, biochemical investigation, and calculation of the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636231/-early-risk-factors-for-the-development-of-inflammatory-bowel-disease-in-the-pediatric-population-of-the-kuyavian-pomeranian-voivodeship
#10
Aleksandra Dolińska, Zuzanna Wasielewska, Aneta Krogulska
OBJECTIVE: Introduction: In recent years there has been an increase in the incidence of new cases of inflammatory bowel disease in children, which is why research is underway to determine the likely predisposing factors for the disease. Aim of the study: To assess the prevalence of early risk factors in children with inflammatory bowel disease. PATIENTS AND METHODS: Methods: The study included 60 children with inflammatory bowel disease, aged 2-19 years. Diagnosis was based on the current criteria [ESPGHAN]...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636230/-chronic-cough-in-children
#11
Katarzyna Ptak, Ewa Cichocka-Jarosz, Przemko Kwinta
Coughing is one of the most common patient complaints at physicians' office. The majority of children experience 5 to 8 episodes of cough lasting about a week throughout the year. Episodes of cough which last longer than 4 weeks, defined as a chronic cough, result in serious parental concern, impaired quality of life, increased number of medical consultations and the adverse effects of inappropriately used medications. Overall, a chronic cough is not only a serious health problem, but also a social one. The article presented below summarizes our current knowledge on the pathophysiology of chronic cough, the latest diagnostics and most recent measurement and monitoring methods as well as recommendations for therapeutic proceedings...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636229/bronchiolitis-in-children-do-we-choose-wisely
#12
Beata Kusak, Emilia Grzesik, Kaja Konarska-Gabryś, Zofia Pacek, Barnaba Piwowarczyk, Grzegorz Lis
OBJECTIVE: Aim: The aim of our study was to evaluate the adherence to the 2014 American Academy of Pediatrics guidelines for bronchiolitis. PATIENTS AND METHODS: Material and methods: The study measured the utility of diagnostic and therapeutic procedures in children with the first episode of bronchiolitis in their lives hospitalized at the University Children's Hospital in Krakow, Poland, between September 2014 and March 2015. The results were compared with the achievable benchmarks of care (ABCs) for hospitalized children with bronchiolitis...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636228/-parents-avoiding-child-vaccination-in-the-neonatal-period-an-analysis-of-attitudes
#13
Maria Wilińska, Małgorzata Warakomska
OBJECTIVE: Parents' avoidance of vaccination is a growing phenomenon and leads to the deterioration of the epidemiological situation regarding diseases included in active prevention programs. The aim of the study was to analyze the attitudes of parents who avoid vaccination in newborns. PATIENTS AND METHODS: Material and methods: The study included parents who refused to perform vaccination in theirnewborn. A survey analyzing the attitudes of parents avoiding vaccination in newborns was performed in a tertiary referral hospital in the years 2015-2017...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636227/compliance-with-the-rsv-immunoprophylaxis-dosing-schedule-in-the-polish-registry-for-palivizumab-2008-2014
#14
Róża Borecka, Ryszard Lauterbach
OBJECTIVE: Background: Respiratory syncytial virus infection causes respiratory diseases in about 90% of the children under 2 years of age. Currently the only way to prevent infection is through immunoprophylaxis based on palivizumab. Aim: The aim of the study was to assess compliance with the recommended prophylaxis regimen in children qualified for the Polish National Programme for Respiratory Syncytial Virus Immunoprophylaxis over six consecutive virus seasons (2008-2014). PATIENTS AND METHODS: Material and methods: A retrospective analysis of data obtained from a multicentre, non-interventional observational study was performed...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636226/the-effect-of-the-release-of-exogenous-nitric-oxide-on-the-responses-of-the-pregnant-human-myometrium-to-oxytocin
#15
Beata Modzelewska, Tomasz Kleszczewski, Anna Kostrzewska
OBJECTIVE: Introduction: Currently there is insufficient evidence to support the routine administration of nitric oxide donors in the treatment of threatened preterm labor. An understanding of the role that nitric oxide plays in the management of threatened preterm labor may lead to more effective treatment and prevention. The aim of our study was to examine the involvement of exogenous nitric oxide release in regulating responses of the human pregnant myometrium to oxytocin. PATIENTS AND METHODS: Material and methods: Biopsies of human myometrial tissue during pregnancy were obtained from 8 pregnant women, aged 21-35 years...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30636225/chromogranin-a-its-known-and-possible-roles-in-obstetrics-and-gynecology
#16
Michał Niezgoda, Irena Kasacka
Chromogranin A (CgA) is a prohormone initially extracted from the adrenal medulla, however, increased quantities of CgA are secreted by a wide array of human tissues in the course of a variety of disorders. This protein exhibits a number of interesting endocrine and non-endocrine functions. Here we briefly review the possible involvements of CgA in the areas covered by obstetrics and gynecology. Our account indicates the need to verify its association with the intrapartum fetal stress, and the involvement of CgA in the pathomechanisms of obstetric disorders related to placental dysfunction, as well as in the pathogenesis of endometrioid endometrial cancer as a hormonally regulated malignancy...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30281525/cortisol-deficiency-as-a-rare-cause-of-neonatal-cholestasis
#17
Patryk Lipiński, Karolina Kot, Irena Jankowska, Mieczysław Szalecki
Cortisol deficiency constitutes a rare cause of neonatal cholestasis. The aim of this manuscript was to present the pathogenesis of cortisol deficiency in neonatal cholestasis. The authors also present the characteristics of selected disorders resulting in cortisol deficiency.
2018: Developmental Period Medicine
https://read.qxmd.com/read/30281524/the-role-of-perinatal-cardiology-in-saving-the-life-and-its-quality-of-fetuses-newborns-and-children-on-the-basis-of-own-experience-and-review-of-the-literature
#18
Maria Respondek-Liberska
The role of prenatal cardiology and the organization of perinatal cardiological centers in early diagnostics and early therapeutic procedures in fetuses and newborns with cardiac malformations and circulatory disturbances was discussed on the basis of the literature and own experience. The possibilities of an early perinatal diagnosis and early therapeutic approaches to cardiac defects were presented. It was stressed that there is a necessity to broaden the educational aims in these areas and in the near future to prepare multidisciplinary teams working together in specialist centers...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30281523/pathophysiology-and-symptoms-of-renal-colic-in-children-a-case-report
#19
Magda Rakowska, Katarzyna Królikowska, Katarzyna Jobs, Małgorzata Placzyńska, Bolesław Kalicki
Urolithiasis is a disease characterized by the presence of stones in the kidney or urinary tract. It is often detected accidentally during an ultrasound or an abdominal x-ray performed for other reasons. However, the first symptom of kidney stone disease can be severe pain called renal colic. Pain caused by a colic attack is characterized by sudden onset. In half of the cases it is associated with nausea or vomiting and can lead to hypotension and fainting. The exact location and radiation of the pain depends on the location of the stone in the urinary tract...
2018: Developmental Period Medicine
https://read.qxmd.com/read/30281522/early-complications-of-extracorporeal-shockwave-lithotripsy-in-the-records-of-the-department-of-paediatrics-nephrology-and-allergology-of-the-military-institute-of-medicine-preliminary-results
#20
Katarzyna Dobrowiecka, Jędrzej Przekora, Katarzyna Jobs, Katarzyna Kowalczyk, Katarzyna Plewka, Aleksandra Paturej, Bolesław Kalicki
The aim of the study was to analyse the frequency and type of early complications of extracorporeal shock wave lithotripsy (ESWL) and to assess the safety of the procedure among paediatric patients. The study is a retrospective analysis of all ESWL procedures carried out due to urolithiasis in 2009-2015 in the Department of Paediatrics, Nephrology and Allergology of the Military Institute of Medicine. Medical records of 170 children were analysed: 94 girls (55.3%) and 76 boys (44.7%) aged 1 to 18 years. Out of the 272 procedures performed, 247 were included in the study...
2018: Developmental Period Medicine
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