Chronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation

BACKGROUND: The incidence of chronic obstructive pulmonary disease (COPD) and osteoporosis are rising worldwide. Observational studies showed that COPD is associated with increased risk of osteoporosis. We performed the Mendelian randomization (MR) study to genetically investigate the causality of COPD on osteoporosis. METHODS: We explored the causal effect of COPD on osteoporosis by the MR analysis. A total of 108 genetic loci single nucleotide polymorphisms were related to COPD...

Smoking, a leading cause of chronic respiratory disorders, is elevated among sexual minority (i.e., lesbian, gay, and bisexual) individuals. Elevations in smoking among sexual minority individuals may contribute to increased rates of chronic respiratory disorders among older sexual minority individuals. Data from 161,741 individuals (3.6% sexual minorities) aged 45 and older from the 2020 Behavioral Risk Factor Surveillance System were used to examine disparities in chronic respiratory disorders among older sexual minority individuals...

BACKGROUND: The prevalence of iron deficiency in patients with COPD varies in previous studies. We aimed to assess its prevalence according to three well-known criteria for iron deficiency, its associations with clinical characteristics of COPD and mortality. METHODS: In a cohort study consisting of 84 COPD patients, of which 21 had chronic respiratory failure, and 59 non-COPD controls, ferritin, TSat and mortality across 6.5 years were assessed. Associations between clinical characteristics and iron deficiency were examined by logistic regression, while associations with mortality were assessed in mixed effects Cox regression analyses...

BACKGROUND: The blood eosinophil count (BEC) is an effective biomarker for predicting inhaled corticosteroid responsiveness in patients with chronic obstructive pulmonary disease (COPD). METHODS: A 12-month prospective observational study was conducted in patients with COPD. BEC was measured at enrolment, and after 6 and 12 months. Patients were classified into three groups according to their baseline BEC: <100, 100 - 299, and ≥300 cells/µL. We aimed to describe the patterns of blood eosinophil stability in patients with stable COPD and compare the exacerbation rates and other clinical outcomes at 6 and 12 months...

Chronic obstructive pulmonary disease (COPD) is a paramount contributor to global morbidity and mortality. Over the past decade, the concept of the "gut-lung axis" has emerged, offering a lens through which to examine the intricate interplay between the host, microbiome, and respiratory diseases, including COPD. An expanding body of evidence underscores that the composition of both the gastrointestinal and respiratory microbiome deviates in COPD patients compared to healthy individuals, leading to distinct host immune responses and clinical manifestations...

COPD is a significant cause of morbidity and mortality both in the US and worldwide. LGBTQ+ individuals (lesbian, gay, bisexual, transgender, or queer with the plus sign indicating inclusion of people who are questioning, intersex, asexual, or who hold other gender/sex/romantic identities not specifically identified) have a higher rate of tobacco smoking, predisposing them to an increased risk of developing COPD. Despite this risk, the burden of COPD in LGBTQ+ individuals is not known. Moreover, there is limited focus on efforts to identify and reduce disease risk in this population...

BACKGROUND: Daily physical activity is part of the self-management of COPD patients, didactic information sessions may be insufficient for provision of these skills. Prior activation can determine sensitivity to these sessions. We evaluated whether the activation in patients with chronic obstructive pulmonary disease (COPD), as measured by the Patient Activation Measure (PAM)-13 questionnaire, determined their responses to an educational group session on physical activity (PA), which were measured with actigraphy by the amount of steps/day...

No abstract text is available yet for this article.

BACKGROUND: A previous longitudinal study of chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) score changes suggested patients fall into three patterns: stable, improving, and worsening. This study assessed the evolution of CAT scores over time and its relationship to exacerbations. METHODS: In total, 84 participants used a telemedicine platform to complete CAT weekly for 52 weeks. Completion rates, annualized change in CAT score and learning effects were measured, as well as CAT changes of >4 units during look-back periods of 4 and 8 weeks...

OBJECTIVE: This study aimed to investigate dietary fiber (DF) intake with prevalence of chronic obstructive pulmonary disease (COPD) in the middle-aged and elderly population through analysis of the National Health and Nutrition Examination Survey (NHANES) data. METHODS: The study utilized data from three cycles of NHANES database (2007-2012). The exposure variable was DF intake, and the outcome variable was COPD prevalence. Weighted logistic regression was utilized to construct relationship models between the two variables...

BACKGROUND: Dyspnea is frequently a debilitating symptom in chronic obstructive pulmonary disease (COPD). Cannabinoid receptor agonists have potential to alter dyspnea in these patients. OBJECTIVE: To determine if dronabinol, a pure cannabinoid, improves dyspnea and exercise tolerance in COPD. METHODS: In this double-blind randomized, cross-over pilot study, COPD patients received up to 20mg oral dronabinol or placebo daily for six weeks with an intervening washout period...

No abstract text is available yet for this article.

No abstract text is available yet for this article.

BACKGROUND: Revefenacin, a once-daily, nebulized, long-acting muscarinic antagonist approved in the US for the maintenance of chronic obstructive pulmonary disease (COPD), significantly improves lung function and quality of life versus placebo in patients with moderate-to-very severe COPD. Comorbid anxiety and/or depression may alter patients' symptom perception and response to bronchodilators. The impact of revefenacin in patients with COPD with comorbid anxiety and/or depression has not been previously investigated...

BACKGROUND: Health inequities among individuals with chronic obstructive pulmonary disease (COPD) are often associated with differential access to healthcare and health outcomes. A greater understanding of the literature concerning such variation is necessary to determine where gaps or inequities exist along the continuum of COPD care. METHODS: A rapid review of the published and grey literature reporting variations in healthcare access and/or health outcomes for individuals with COPD was completed...

BACKGROUND: The Neutrophil to Lymphocyte ratio (NLR) is an inexpensive biomarker that potentially predicts Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD). We evaluated the association of baseline NLR and respiratory hospitalisation risk within one year among COPD patients in Uganda, Low- and Middle-Income Country. METHODS: 312 COPD patients were followed up for 1 year. Clinical characteristics and exacerbation rate were collected. Poisson regression with robust variance estimators were used to measure the association between NLR and hospital admissions due to COPD exacerbations...

BACKGROUND: We examined the effect of physical position on peak inspiratory flow (PIF) in patients with chronic obstructive pulmonary disease (COPD) using dry powder inhalers (DPIs) with low medium (R2) and/or high (R5) internal resistance. METHODS: This prospective study in stable, ambulatory patients with spirometry-confirmed COPD evaluated the effect of three physical positions on maximal PIF achieved. Participants had PIF of 30-90 L/min (R5) or 60-90 L/min (R2 DPIs) using the In-Check™ DIAL...

INTRODUCTION: We examined the association between tobacco product use and health-related quality of life (HRQOL) among individuals with COPD in Waves 1-5 of the Population Assessment of Tobacco and Health (PATH) Study. METHODS: Adults ≥40 years with an ever COPD diagnosis were included in cross-sectional (Wave 5) and longitudinal analyses (Waves 1 to 5). Tobacco use included 13 mutually exclusive categories of past 30-day (P30D) single use and polyuse with P30D exclusive cigarette use and ≥5 year cigarette cessation as reference groups...

Respiratory microbiome studies have fostered our understanding of the various phenotypes and endotypes of heterogeneous chronic obstructive pulmonary disease (COPD). This study aimed to identify microbiome-driven clusters that reflect the clinical features and dominant microbiota of COPD. This cross-sectional study included 32 patients with stable COPD between December 2019 and December 2020 from the outpatient clinic of China-Japan Friendship Hospital. Sputum samples were tested for 16S rRNA. Patients were classified according to the species level using an unsupervised clustering method to compare the inflammatory phenotypes of two clusters and analyze the correlation between the main bacteria and clinical indicators in each cluster...

STUDY OBJECTIVES: Observational studies link untreated obstructive sleep apnea (OSA) with adverse outcomes in chronic obstructive pulmonary disease (COPD). The first step in addressing OSA is a clinical assessment. However, given competing demands and a lack of high-quality evidence, it is unclear how often such assessments occur. We explored the documentation of OSA assessment among patients with COPD in primary care, and the patient and provider characteristics associated with these assessments...