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Journals Chronic Obstructive Pulmonary ...

Chronic Obstructive Pulmonary Diseases : Journal of the COPD Foundation

https://read.qxmd.com/read/38310543/effects-of-dronabinol-on-dyspnea-and-quality-of-life-in-patients-with-copd
#1
JOURNAL ARTICLE
Abdul H Zaid, Suman B Thapamagar, James D Anholm, Laura Weaver-Carnahan, Lien Duong, Lennard Specht
BACKGROUND: Dyspnea is frequently a debilitating symptom in chronic obstructive pulmonary disease (COPD). Cannabinoid receptor agonists have potential to alter dyspnea in these patients. OBJECTIVE: To determine if dronabinol, a pure cannabinoid, improves dyspnea and exercise tolerance in COPD. METHODS: In this double-blind randomized, cross-over pilot study, COPD patients received up to 20mg oral dronabinol or placebo daily for six weeks with an intervening washout period...
February 2, 2024: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38241514/post-hoc-analysis-of-lung-function-improvement-and-patient-reported-outcomes-with-revefenacin-in-adults-with-moderate-to-very-severe-copd-and-comorbid-anxiety-or-depression
#2
JOURNAL ARTICLE
Abebaw M Yohannes, Anand S Iyer, Candice Clay, Lauren Cochran, Xianyi Chen, David A Lombardi, Surya P Bhatt
BACKGROUND: Revefenacin, a once-daily, nebulized, long-acting muscarinic antagonist approved in the US for the maintenance of chronic obstructive pulmonary disease (COPD), significantly improves lung function and quality of life versus placebo in patients with moderate-to-very severe COPD. Comorbid anxiety and/or depression may alter patients' symptom perception and response to bronchodilators. The impact of revefenacin in patients with COPD with comorbid anxiety and/or depression has not been previously investigated...
January 19, 2024: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38241509/variations-in-copd-health-care-access-and-outcomes-a-rapid-review
#3
JOURNAL ARTICLE
Julie A Shatto, Michael K Stickland, Leslie J J Soril
BACKGROUND: Health inequities among individuals with chronic obstructive pulmonary disease (COPD) are often associated with differential access to healthcare and health outcomes. A greater understanding of the literature concerning such variation is necessary to determine where gaps or inequities exist along the continuum of COPD care. METHODS: A rapid review of the published and grey literature reporting variations in healthcare access and/or health outcomes for individuals with COPD was completed...
January 19, 2024: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38237091/the-neutrophil-lymphocyte-ratio-as-a-predictor-of-acute-exacerbations-among-patients-with-copd-in-uganda
#4
JOURNAL ARTICLE
Patricia Alupo, Winceslaus Katagira, David Mukunya, Paul Okimat, Vickram Tejwani, Alex Kayongo, Joanitah Nalunjogi, Nicole M Robertson, Rupert Jones, John R Hurst, Bruce Kirenga, Trishul Siddharthan
BACKGROUND: The Neutrophil to Lymphocyte ratio (NLR) is an inexpensive biomarker that potentially predicts Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD). We evaluated the association of baseline NLR and respiratory hospitalisation risk within one year among COPD patients in Uganda, Low- and Middle-Income Country. METHODS: 312 COPD patients were followed up for 1 year. Clinical characteristics and exacerbation rate were collected. Poisson regression with robust variance estimators were used to measure the association between NLR and hospital admissions due to COPD exacerbations...
January 18, 2024: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38236166/effect-on-physical-position-of-peak-inspiratory-flow-in-stable-copd-an-observational-study
#5
JOURNAL ARTICLE
Roy A Pleasants, Ashley G Henderson, Valentina Bayer, Asif Shaikh, M Bradley Drummond
BACKGROUND: We examined the effect of physical position on peak inspiratory flow (PIF) in patients with chronic obstructive pulmonary disease (COPD) using dry powder inhalers (DPIs) with low medium (R2) and/or high (R5) internal resistance. METHODS: This prospective study in stable, ambulatory patients with spirometry-confirmed COPD evaluated the effect of three physical positions on maximal PIF achieved. Participants had PIF of 30-90 L/min (R5) or 60-90 L/min (R2 DPIs) using the In-Check™ DIAL...
January 17, 2024: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38113525/relationship-between-tobacco-product-use-and-health-related-quality-of-life-among-individuals-with-copd-in-waves-1-5-2013-2019-of-the-population-assessment-of-tobacco-and-health-study
#6
JOURNAL ARTICLE
Laura M Paulin, Michael J Halenar, Kathryn C Edwards, Kristin Lauten, Kristie Taylor, Mary Brunette, Susanne Tanski, Todd MacKenzie, Cassandra A Stanton, Dorothy Hatsukami, Andrew Hyland, Martin C Mahoney, Ray Niaura, Dennis Trinidad, Carlos Blanco, Wilson Compton, Lisa D Gardner, Heather L Kimmel, K Michael Cummings, Dana Lauterstein, Ester J Roh, Daniela Marshall, James D Sargent
INTRODUCTION: We examined the association between tobacco product use and health-related quality of life (HRQOL) among individuals with COPD in Waves 1-5 of the Population Assessment of Tobacco and Health (PATH) Study. METHODS: Adults ≥40 years with an ever COPD diagnosis were included in cross-sectional (Wave 5) and longitudinal analyses (Waves 1 to 5). Tobacco use included 13 mutually exclusive categories of past 30-day (P30D) single use and polyuse with P30D exclusive cigarette use and ≥5 year cigarette cessation as reference groups...
December 19, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38113524/respiratory-microbiome-profiles-associated-with-distinct-inflammatory-phenotype-and-clinical-indexes-in-chronic-obstructive-pulmonary-disease
#7
JOURNAL ARTICLE
Tao Yu, Yunru Chen, Xiaoxia Ren, Ting Yang
Respiratory microbiome studies have fostered our understanding of the various phenotypes and endotypes of heterogeneous chronic obstructive pulmonary disease (COPD). This study aimed to identify microbiome-driven clusters that reflect the clinical features and dominant microbiota of COPD. This cross-sectional study included 32 patients with stable COPD between December 2019 and December 2020 from the outpatient clinic of China-Japan Friendship Hospital. Sputum samples were tested for 16S rRNA. Patients were classified according to the species level using an unsupervised clustering method to compare the inflammatory phenotypes of two clusters and analyze the correlation between the main bacteria and clinical indicators in each cluster...
December 19, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38095613/assessment-of-obstructive-sleep-apnea-among-patients-with-chronic-obstructive-pulmonary-disease-in-primary-care
#8
JOURNAL ARTICLE
Lucas M Donovan, Thomas L Keller, Nancy H Stewart, Jennifer Wright, Laura J Spece, Kevin I Duan, Aristotle Leonhard, Brian N Palen, Martha E Billings, David H Au, Laura C Feemster
STUDY OBJECTIVES: Observational studies link untreated obstructive sleep apnea (OSA) with adverse outcomes in chronic obstructive pulmonary disease (COPD). The first step in addressing OSA is a clinical assessment. However, given competing demands and a lack of high-quality evidence, it is unclear how often such assessments occur. We explored the documentation of OSA assessment among patients with COPD in primary care, and the patient and provider characteristics associated with these assessments...
December 13, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38081161/any-decrease-in-lung-function-is-associated-with-worse-clinical-outcomes-post-hoc-analysis-of-the-impact-interventional-trial
#9
JOURNAL ARTICLE
MeiLan K Han, Gerard J Criner, David M G Halpin, Edward M Kerwin, Lee Tombs, David A Lipson, Fernando J Martinez, Robert A Wise, Dave Singh
No abstract text is available yet for this article.
December 11, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/38277667/editorial-2014-2024-celebrating-10-years-of-nonprofit-open-access-publishing-focused-on-copd-bronchiectasis-and-nontuberculous-mycobacteria-research
#10
JOURNAL ARTICLE
Mark T Dransfield
No abstract text is available yet for this article.
January 25, 2024: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37963303/associations-between-coronary-artery-calcium-score-and-exacerbation-risk-in-block-copd
#11
JOURNAL ARTICLE
R Chad Wade, Sharon X Ling, Erika S Helgeson, Helen Voelker, Wassim W Labaki, Daniel Meza, Oisin O'Corragain, Jennifer Y So, Gerard J Criner, MeiLan K Han, Ravi Kalhan, Robert M Reed, Mark T Dransfield, J Michael Wells
INTRODUCTION: In 2019, BLOCK-COPD (Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease) evaluated the effect of metoprolol on exacerbation risk and mortality in a COPD population without indications for beta-blocker use. We hypothesized that an imaging metric of coronary artery disease (CAD), the coronary artery calcium (CAC) score, would predict exacerbation risk and identify a differential response to metoprolol treatment. METHODS: The study population includes participants in BLOCK-COPD from multiple study sites...
November 13, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37931598/a-plant-centered-diet-is-inversely-associated-with-radiographic-emphysema-findings-from-the-cardia-lung-study
#12
JOURNAL ARTICLE
Mariah K Jackson, Yuni Choi, Elliot Eisenberg, Corrine Hanson, Ann Wang, Jing Gennie Wang, George R Washko, Samuel Ash, Raul San Jose Estepar, Gabrielle Liu, James M Shikany, Lyn M Steffen, Robert Wharton, Ravi Kalhan, David R Jacobs, Sonali Bose
Chronic obstructive pulmonary disease (COPD) is a significant public health concern and intercepting the development of emphysema is vital for COPD prevention. Smokers are a high-risk population for emphysema with limited prevention strategies. We aimed to determine if adherence to a nutritionally rich plant-centered diet among young ever-smokers is associated with reduced risk of future radiographic emphysema. We studied participants from the Coronary Artery Risk Development in Young Adults (CARDIA) Lung Prospective Cohort Study who were 18-30 years old at enrollment and followed for 30 years...
November 6, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37931596/food-insecurity-is-associated-with-copd-morbidity-and-perceived-stress
#13
JOURNAL ARTICLE
Daniel C Belz, Han Woo, Mariah K Jackson, Nirupama Putcha, Ashraf Fawzy, Wendy Lorizio, Meredith C McCormack, Michelle N Eakin, Corrine K Hanson, Nadia N Hansel
BACKGROUND: Low socioeconomic status (SES) has been associated with worse clinical outcomes in chronic obstructive pulmonary disease (COPD). Food insecurity is more common among individuals with low SES and has been associated with poor outcomes in other chronic illnesses, but its impact on COPD has not been studied. METHODS: Former smokers with spirometry-confirmed COPD were recruited from low-income areas of Baltimore, Maryland and followed for 9 months as part of a cohort study of diet and indoor air pollution...
November 6, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37931593/inhaler-formulary-change-in-copd-and-the-association-with-exacerbations-health-care-utilization-and-costs
#14
JOURNAL ARTICLE
Kevin I Duan, Lucas M Donovan, Laura J Spece, Edwin S Wong, Laura C Feemster, Alexander D Bryant, Robert Plumley, Kristina Crothers, David H Au
RATIONALE: Prescription formularies specify which medications are available to patients. Formularies change frequently, potentially forcing patients to switch medications for non-clinical indications ("non-medical switching"). Non-medical switching is known to impact disease control and adherence. The consequences of non-medical switching have not been rigorously studied in COPD. METHODS: We conducted a cohort study of Veterans with COPD on inhaler therapy in January 2016 when formoterol was removed from the Department of Veterans Affairs (VA) national formulary...
November 6, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37931592/lung-structure-and-risk-of-sleep-apnea-in-spiromics
#15
JOURNAL ARTICLE
Abigail L Koch, Tracie L Shing, Andrew Namen, David Couper, Benjamin Smith, R Graham Barr, Surya Bhatt, Nirupama Putcha, Aaron Baugh, Amit K Saha, Michelle Ziedler, Alejandro Comellas, Christopher B Cooper, Igor Barjaktarevic, Russell P Bowler, Meilan K Han, Victor Kim, Robert Paine, Richard E Kanner, Jerry A Krishnan, Fernando J Martinez, Prescott G Woodruff, Nadia N Hansel, Eric A Hoffman, Stephen P Peters, Victor E Ortega
RATIONALE: SPIROMICS is a prospective cohort study that enrolled 2,981 participants with the goal of identifying new COPD subgroups and intermediate markers of disease progression. Individuals with COPD and sleep apnea (OSA) experience impaired quality of life and more frequent exacerbations. COPD severity also associates with CT-scan based emphysema and alterations in airway dimensions. OBJECTIVES: To determine whether the combination of lung function and structure influences the risk of OSA among current and former smokers...
November 6, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37931590/the-long-term-impact-of-frailty-after-an-intensive-care-unit-admission-due-to-chronic-obstructive-pulmonary-disease
#16
JOURNAL ARTICLE
Matthew T Donnan, Shailesh Bihari, Ashwin Subramaniam, Eli J Dabscheck, Brooke Riley, David V Pilcher
RATIONALE: Frailty is an increasingly recognized aspect of chronic obstructive pulmonary disease (COPD). The impact of frailty on long-term survival after admission to an Intensive Care Unit (ICU) due to an exacerbation of COPD has not been described. OBJECTIVE: To quantify the impact of frailty on time to death up to four years after admission to ICU in Australia and New Zealand with an exacerbation of COPD. METHODS: We performed a multicenter retrospective cohort study of adult patients admitted to 179 ICUs with a primary diagnosis of an exacerbation of COPD using the Australian and New Zealand Intensive Care Society Adult Patient Database from 1st January 2018 through 31st December 2020 in New Zealand, and 31st March 2022 in Australia...
November 6, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37879732/the-6th-world-bronchiectasis-and-nontuberculous-mycobacteria-conference-abstract-presentations
#17
JOURNAL ARTICLE
Timothy R Aksamit, Elizabeth J Emery, Ashwin Basavaraj, Mark L Metersky, Anne E O'Donnell, Doreen J Addrizzo-Harris
No abstract text is available yet for this article.
October 26, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37828634/copd-and-smoking-status-it-does-matter-characteristics-and-prognosis-of-copd-according-to-smoking-status
#18
JOURNAL ARTICLE
Anne O Nielsen, Peter Lange, Ole Hilberg, Ingeborg Farver-Vestergaard, Rikke Ibsen, Anders L√łkke
BACKGROUND: Chronic Obstructive Pulmonary Disease is a chronic, often progressive disease, which in most patients is caused by tobacco smoking. Our study focuses on differences in COPD-related outcomes between never-smokers, former smokers and current smokers. METHODS: A nationwide, population-based cohort study utilizing Danish health registries. Clinical and socioeconomical variables including smoking status, comorbidities, and dyspnoea were obtained. Poisson and Cox Regression were used to calculate the impact of these clinical parameters on risk of moderate and severe exacerbations and mortality during 12 months of follow-up...
October 10, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37813826/feasibility-trial-of-a-comprehensive-highly-patient-centered-copd-self-management-support-program
#19
JOURNAL ARTICLE
Alex D Federman, Rachel O'Conor, Jeannys Nnemnbeng, Jyoti Ankam, Danielle McDermott, Peter K Lindenauer, Michael S Wolf, Juan P Wisnivesky
PURPOSE: To test the feasibility of a novel self-management support intervention for people with chronic obstructive pulmonary disease (COPD). METHODS: We conducted a feasibility randomized controlled trial involving patients ≥40 years with severe or very severe COPD in New York, NY (n=59). Community health workers screened patients and addressed barriers to COPD self-management. Patients were also offered home-based pulmonary rehabilitation (HBPR) and an antibiotic and steroid rescue pack...
October 9, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
https://read.qxmd.com/read/37813825/pulmonary-rehabilitation-for-chronic-obstructive-pulmonary-disease-patients-with-underlying-alpha-1-antitrypsin-deficiency-a-systematic-review-and-practical-recommendations
#20
JOURNAL ARTICLE
Fawaz A Alwadani, Kyrie Wheeler, Harriet Pittaway, Alice M Turner
BACKGROUND: Alpha-1 antitrypsin deficiency (AATD) is an often-overlooked genetic condition that makes individuals susceptible to early-onset of Chronic Obstructive Pulmonary Disease (COPD). The established benefits of exercise-based Pulmonary Rehabilitation (PR) for usual COPD patients are unclear for those with underlying AATD, especially given potential differing muscle adaptations to exercise. This review seeks to compare PR outcomes between AATD and usual COPD patients, and to consolidate current knowledge on exercise intervention outcomes for the AATD population...
October 9, 2023: Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation
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