Timothy E Albertson, Caitlin Hansen, Smiti Bihari, Juleen Gayed, Xia Xu, J Abraham Simón-Campos, Michael E Dever, Jose F Cardona, Essack Mitha, Jeffrey B Baker, Georgina Keep, Islamiat Oladipupo, Federico J Mensa, Ye Feng, Hua Ma, Kenneth Koury, Susan Mather, Claudia Ana Ianos, Annaliesa S Anderson, Özlem Türeci, Uǧur Şahin, William C Gruber, Alejandra Gurtman, Charu Sabharwal, Nicholas Kitchin
INTRODUCTION: Rare myocarditis and pericarditis cases have occurred in coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccine recipients. Troponin levels, a potential marker of myocardial injury, were assessed in healthy participants before and after BNT162b2 vaccination. METHODS: Vaccine-experienced 12- to 30-year-olds in phase 3 crossover C4591031 Substudy B (NCT04955626) who had two or three prior BNT162b2 30-μg doses were randomized to receive BNT162b2 30 μg followed by placebo, or placebo followed by BNT162b2 30 µg, 1 month apart...
March 15, 2024: Infectious Diseases and Therapy