Alan D Kaye, Dominique M Perilloux, Alison M Hawkins, Grace C Wester, Amanda R Ragaland, Sage V Hebert, Julian Kim, Michael Heisler, Rucha A Kelkar, Azem A Chami, Sahar Shekoohi, Adam M Kaye
Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines, specifically tumor necrosis factor (TNF) and interleukins (IL), are key mediators in the initiation and maintenance of chronic pain states. Sensory neurons expressing receptors for cytokines like TNF, IL-1, and IL-6 are implicated in peripheral sensitization, contributing to increased signaling of painful sensations. The potential of targeting TNF and IL for therapeutic intervention in chronic pain states is the focus of this review, with preclinical and clinical evidence supporting the use of TNF and IL modulators for pain management...
May 9, 2024: Pain and Therapy
Wessam Zakaria El-Amrawy, Ahmed Mohamed El-Attar
No abstract text is available yet for this article.
May 9, 2024: Pain and Therapy
Ángel González-de-la-Flor
Hip-related pain is a common issue in active adults affecting their quality of life, mobility, and overall function, and it can lead to persistent disability. However, diagnosing hip-related pain is challenging due to the many potential sources and causes, including intra-articular and extra-articular pathology, and referred pain from other areas (lumbar or groin related pain). To address this, there is a need for a clinical algorithm based on the best available evidence and expert consensus. This algorithm could guide healthcare professionals in assessing and managing patients with hip-related pain, during the diagnosis, test selection, intervention, monitoring, and promoting collaboration among various healthcare providers...
May 3, 2024: Pain and Therapy
Piero Barbanti, Gianni Allais, Sabina Cevoli, Simona Guerzoni, Massimiliano Valeriani, Fabrizio Vernieri
No abstract text is available yet for this article.
May 2, 2024: Pain and Therapy
Ilenia Casini, Valeria Ladisa, Livio Clemente, Marianna Delussi, Elvira Rostanzo, Sofia Peparini, Anna Maria Aloisi, Marina de Tommaso
INTRODUCTION: Fibromyalgia is a form of chronic pain that affects a large number of women. It can start at any age and last a lifetime, with no cure. The Mediterranean diet is said to have an anti-inflammatory effect. Therefore, this study was conducted to investigate possible beneficial effects of a personalized Mediterranean diet in patients with fibromyalgia. METHODS: Outpatients with fibromyalgia were recruited and invited to participate in the study, including clinical, nutritional, and dietary assessments...
April 29, 2024: Pain and Therapy
Jordi Folch Ibáñez, Maribel Vargas Domingo, Joan Coma Alemany, Roger Callao Sánchez, Jordi Guitart Vela
INTRODUCTION: Chronic pain (CP) and depression/anxiety often coexist, worsening each other's symptoms. Treating this comorbidity is challenging. Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are the first-line treatment options for this comorbidity, although sometimes they are not effective and/or well tolerated by patients, and there is little clinical evidence that selective serotonin reuptake inhibitors are useful for controlling CP. The antidepressant vortioxetine, with a multimodal mechanism that may help reduce pain, has proven clinical efficacy in patients with major depressive disorder (MDD)...
April 29, 2024: Pain and Therapy
Alberto Corriero, Mariateresa Giglio, Rossana Soloperto, Francesco Inchingolo, Giustino Varrassi, Filomena Puntillo
One of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preventative and disease-modifying therapies. In recent years, it has been acknowledged that gut microbiota (GM) can significantly contribute to the development of OA. Dysbiosis of GM can disrupt the "symphony" between the host and the GM, leading to a host immunological response that activates the "gut-joint" axis, ultimately worsening OA...
April 27, 2024: Pain and Therapy
Kelvin Le, Khang Duy Ricky Le, Johnny Nguyen, Jean Hua, Sarah Munday
This narrative review explores current insights into the potential use of medicinal cannabis-related products as an emerging therapy for opioid use disorder in the landscape of increasing knowledge about medicinal cannabis-based products, commercialisation and global legalisation. Preclinical studies have provided preliminary insight into the putative neurobiological mechanisms that underpin the potential for medicinal cannabis to be considered a therapeutic in opioid use disorder and addiction. With the progressive legalisation of cannabis in many jurisdictions worldwide, contemporary research has highlighted further evidence that medicinal cannabis may have efficacy in reducing cravings and withdrawal effects, and therefore may be considered as an adjunct or standalone to current medications for opioid use disorder...
April 27, 2024: Pain and Therapy
Stefan Neuwersch-Sommeregger, Markus Köstenberger, Andreas Sandner-Kiesling, Matthias Fürstner, Isabel Igerc, Brigitte Trummer, Jessica Wuntschek, Wolfgang Pipam, Haro Stettner, Rudolf Likar, Georg Feigl
INTRODUCTION: Ganglionic local opioid analgesia (GLOA) at the superior cervical ganglion (SCG) is performed for pain control and is known to be an effective procedure. In this study, we evaluated the spread of the injectate in the area of the SCG. Our expectation was that there would be a correlation between the area and volume of the injectate spread and post-procedural outcome measures. METHODS: This was a retrospective blinded review of magnetic resonance imaging (MRI) scans...
April 25, 2024: Pain and Therapy
Vidhu Sethi, Chetan Anand, Oscar Della Pasqua
The multifaceted nature of osteoarthritis (OA) pain presents a challenge in understanding and managing the condition. The diverse pain experiences, progression rates, individual responses to treatments, and complex disease mechanisms contribute to heterogeneity in the clinical studies outcomes. The lack of a standardized methodology for assessing and classifying OA pain challenges healthcare practitioners. This complicates the establishment of universally applicable protocols or standardized guidelines for treatment...
April 25, 2024: Pain and Therapy
Xia Xu, Ying-Xin Xie, Meng Zhang, Jian-Hui Du, Jin-Xian He, Li-Hong Hu
INTRODUCTION: Ultrasound-guided thoracic paravertebral block (UTPB) is widely used for postoperative analgesia in thoracic surgery. However, it has many disadvantages. Thoracoscopy-guided thoracic paravertebral block (TTPB) is a new technique for thoracic paravertebral block (TPB). In this study, we compared the use of TTPB and UTPB for pain management after thoracoscopic radical surgery for lung cancer. METHODS: In total, 80 patients were randomly divided 1:1 into the UTPB group and the TTPB group...
April 9, 2024: Pain and Therapy
Samuel Díaz Insa, Ángel Guerrero, Javier Viguera, Vicente Medrano Martínez, Carlos Calle de Miguel, Jesús Porta-Etessam, Antonio Ciudad, Silvia Diaz-Cerezo, Ana Roncero Martín, Mercedes Núñez
INTRODUCTION: The efficacy of galcanezumab has been demonstrated in randomized controlled trials, but evidence about its use under clinical practice conditions is still limited. This study aimed to describe the characteristics of the patients treated with galcanezumab in routine clinical practice in Spain as well as treatment patterns, persistence, and effectiveness. METHODS: A retrospective chart review study was carried out in six hospitals. Information of adults with migraine, who started treatment with galcanezumab between November 2019 and September 2021, was analyzed until end or loss of follow-up...
March 28, 2024: Pain and Therapy
Johannes Neumann, Helmar Bornemann-Cimenti, Gudrun Rumpold-Seitlinger, Kordula Lang-Illievich, Christoph Klivinyi
INTRODUCTION: Cluster headache is a severe and debilitating neurological condition characterized by intense, excruciating pain with a significant impact on patients' wellbeing. Although different treatment options are available, many patients continue to experience inadequate relief. Therefore, experimental strategies are increasingly studied. One of the more promising approaches is the use of ketamine. We present the currently available evidence and our own data. METHODS: In this mixed-methods paper, we first summarize the available evidence of ketamine for treatment of cluster headache based on a systematic review of literature in MEDLINE, EMBASE and the Cochrane library of systematic reviews...
June 2024: Pain and Therapy
Stefan Evers, Grazia Dell'Agnello, Diego Novick, H Saygin Gonderten, Tommaso Panni, Julio Pascual
INTRODUCTION: The ObserVational survey of the Epidemiology, tReatment and Care Of MigrainE (OVERCOME) European Union (EU) is part of an overarching population-based study program that also includes the United States and Japan. Here, we report data on the migraine/severe headache burden and the use of acute medication and healthcare resources in Spain and Germany. METHODS: OVERCOME (EU) was an online, non-interventional, cross-sectional survey conducted in adults in Spain and Germany between October 2020 and February 2021...
June 2024: Pain and Therapy
Shuang Chen, Ying Ding, Xiaoming Zhang, Xue Zhang, Jiajia Xiang, Yiling Deng, Xingran Tao, Wenke Cai, Zhigui Li, Jiayu Chen, Fanyi Kong, Na Li
INTRODUCTION: Patients undergoing video-assisted thoracoscopic lobectomy (VATL) often experience chronic postsurgical pain (CPSP). Postoperative pain can affect the recovery of postoperative lung function, prolong postoperative recovery time, and increase patient hospitalization expenses. Transcutaneous electrical acupoint stimulation (TEAS) is an alternative therapy based on acupuncture that has shown promise in postoperative recovery and pain management across various medical fields...
April 2024: Pain and Therapy
Michael J Dorsi, Patrick Buchanan, Chau Vu, Harjot S Bhandal, David W Lee, Samir Sheth, Phil M Shumsky, Nolan J Brown, Alexander Himstead, Ryan Mattie, Steven M Falowski, Ramana Naidu, Jason E Pope
INTRODUCTION: Interventional treatment options for the lumbar degenerative spine have undergone a significant amount of innovation over the last decade. As new technologies emerge, along with the surgical specialty expansion, there is no manuscript that utilizes a review of surgical treatments with evidence rankings from multiple specialties, namely, the interventional pain and spine communities. Through the Pacific Spine and Pain Society (PSPS), the purpose of this manuscript is to provide a balanced evidence review of available surgical treatments...
March 23, 2024: Pain and Therapy
Aitao Wang, Jingjing Bian, Na Li, Jiaxiang Ni, Lea Zila, Yuanzhang Tang
INTRODUCTION: Radiofrequency thermocoagulation (RFT) effectively alleviates idiopathic trigeminal neuralgia (ITN); however, postoperative facial numbness poses a significant challenge. This issue arises due to the close proximity of high-temperature thermocoagulation, which not only ablates pain-related nociceptive fibers but also affects tactile fibers. Intraoperative sensory stimulation voltage (SV), which reflects the distance between the RFT cannula and the target nerve, potentially possesses the ability to prevent tactile fiber injury...
March 15, 2024: Pain and Therapy
Huaichang Wen, Weihua Zhang, Yi Wang, Meijing Lu
INTRODUCTION: The pericapsular nerve group (PENG) block has been shown to be an effective approach to alleviating pain and reducing the need for opioids among older adults following hip surgery, with possible motor-sparing effects. No reports to date, however, have described appropriate ropivacaine volumes for use in the context of PENG block. The present prospective randomized controlled study was thus developed to assess the quadriceps muscle strength and analgesic efficacy associated with PENG block performed using three different volumes of 0...
March 13, 2024: Pain and Therapy
Dawn C Buse, Lynda J Krasenbaum, Michael J Seminerio, Elizabeth R Packnett, Karen Carr, Mario Ortega, Maurice T Driessen
INTRODUCTION: Fremanezumab, a humanized monoclonal antibody targeting calcitonin gene-related peptide, is indicated for preventive treatment of migraine in adults. Real-world evidence assessing the effect of fremanezumab on migraine-related medication use, health care resource utilization (HCRU), and costs in patient populations with comorbidities, acute medication overuse (AMO), and/or unsatisfactory prior migraine preventive response (UPMPR) is needed. METHODS: Data for this US, retrospective claims analysis were obtained from the Merative® MarketScan® Commercial and supplemental databases...
March 12, 2024: Pain and Therapy
Barbanti Piero, Allais Gianni, Cevoli Sabina, Guerzoni Simona, Valeriani Massimiliano, Vernieri Fabrizio
INTRODUCTION: Thirty years ago, the first migraine-specific drugs (triptans) appeared. Today two new categories (gepants and ditans) are marketed for acute migraine treatment. That said, is there still a role for conventional therapy? The aim of the present narrative review is to provide an expert overview examining the possible role of the combination paracetamol/caffeine in treatment of acute migraine pain. METHODS: To understand possible settings for more appropriate use of paracetamol/caffeine (1000 mg/130 mg) in treatment of acute migraine, a structured literature search was performed using the PubMed database by a panel of experts from major Italian headache centers; articles not referring to migraine pain were excluded from this review; review articles were prioritized...
March 6, 2024: Pain and Therapy
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