Lingli Qin, Ping Song, Xian Li, Longhui Yang, Feng Xu, Xueying Zhu, Lizhen Cai, Guangdi Hu, Weijia Sun, Yunling Zhang, Lu Zhang
INTRODUCTION: Tension-type headache (TTH) is common but challenging to manage due to limited effectiveness of conventional treatments. This study examines six complementary and alternative medicine (CAM) interventions through network meta-analysis to identify effective TTH management strategies. METHODS: We searched PubMed, Embase, Web of Science, Cochrane Library, OVID, CNKI, Wanfang, VIP, and CBM databases for randomized controlled trials on CAM for TTH treatment...
May 15, 2024: Pain and Therapy
Victor M Silva-Ortiz, Alaa Abd-Elsayed, Jesus Medina-Razcon, Christopher L Robinson
BACKGROUND: Lumbar foraminal stenosis is a common cause of chronic lower back pain and radiculopathy often treated by epidural steroid injections. In the absence of imaging findings with a positive physical exam demonstrating symptoms, percutaneous neuroplasty (PNP) may be an alternative to transforaminal epidural steroid injections that have otherwise failed. CASE PRESENTATION: We present two cases (55-year-old man and 65-year-old woman) with chronic low back pain and radiculopathy with otherwise normal imaging demonstrating no lumbar foraminal stenosis refractory to transforaminal epidural steroid injections...
May 15, 2024: Pain and Therapy
Meng-Fan Yang, Dong-Xue Ren, Xue Pan, Chang-Xin Li, Sui-Yi Xu
Cortical spreading depression (CSD) is a slow wave of cortical depolarization closely associated with migraines with an aura. Previously, it was thought that CSD depolarization was mainly driven by neurons, with characteristic changes in neuronal swelling and increased extracellular potassium (K+ ) and glutamate. However, the role of astrocytes, a member of the neurovascular unit, in migraine with CSD has recently received increasing attention. In the early stages of CSD, astrocytes provide neurons with energy support and clear K+ and glutamate from synaptic gaps...
May 14, 2024: Pain and Therapy
Ashim Gupta, David Han, Stephen M Norwood
INTRODUCTION: Chronic neck pain (cNP) is one of the leading causes of disability worldwide, often being refractory to conventional forms of treatment. Various forms of electrical stimulation have been proposed to decrease pain and improve function. Patient-reported outcome measures (PROMs) for treatment of cNP have rarely been published. METHODS: An independent retrospective statistical analysis of PROMs data for users of H-Wave® device stimulation (HWDS), prospectively collected by the device manufacturer over a 4-year period, was conducted...
May 11, 2024: Pain and Therapy
Yuan Li, Shuwu Zhao, Keith Candiotti, Chen Su
INTRODUCTION: To determine risk factors associated with postoperative cerebrospinal fluid leaks (CSFLs) after intrathecal drug delivery system (IDDS) and external pump implantation. METHODS: The clinical data of 248 patients with advanced cancer who underwent IDDS implantation from January 2021 to December 2022 at the Department of Pain Medicine at the Hunan Cancer Hospital were retrospectively reviewed. Information regarding age, gender, height, weight, body mass index (BMI), tumour type, albumin levels, haemoglobin levels, history of diabetes and pre- and postoperative anti-tumour therapy was collected and analysed...
May 9, 2024: Pain and Therapy
Alan D Kaye, Dominique M Perilloux, Alison M Hawkins, Grace C Wester, Amanda R Ragaland, Sage V Hebert, Julian Kim, Michael Heisler, Rucha A Kelkar, Azem A Chami, Sahar Shekoohi, Adam M Kaye
Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines, specifically tumor necrosis factor (TNF) and interleukins (IL), are key mediators in the initiation and maintenance of chronic pain states. Sensory neurons expressing receptors for cytokines like TNF, IL-1, and IL-6 are implicated in peripheral sensitization, contributing to increased signaling of painful sensations. The potential of targeting TNF and IL for therapeutic intervention in chronic pain states is the focus of this review, with preclinical and clinical evidence supporting the use of TNF and IL modulators for pain management...
May 9, 2024: Pain and Therapy
Wessam Zakaria El-Amrawy, Ahmed Mohamed El-Attar
No abstract text is available yet for this article.
May 9, 2024: Pain and Therapy
Johannes Neumann, Helmar Bornemann-Cimenti, Gudrun Rumpold-Seitlinger, Kordula Lang-Illievich, Christoph Klivinyi
INTRODUCTION: Cluster headache is a severe and debilitating neurological condition characterized by intense, excruciating pain with a significant impact on patients' wellbeing. Although different treatment options are available, many patients continue to experience inadequate relief. Therefore, experimental strategies are increasingly studied. One of the more promising approaches is the use of ketamine. We present the currently available evidence and our own data. METHODS: In this mixed-methods paper, we first summarize the available evidence of ketamine for treatment of cluster headache based on a systematic review of literature in MEDLINE, EMBASE and the Cochrane library of systematic reviews...
May 9, 2024: Pain and Therapy
Ángel González-de-la-Flor
Hip-related pain is a common issue in active adults affecting their quality of life, mobility, and overall function, and it can lead to persistent disability. However, diagnosing hip-related pain is challenging due to the many potential sources and causes, including intra-articular and extra-articular pathology, and referred pain from other areas (lumbar or groin related pain). To address this, there is a need for a clinical algorithm based on the best available evidence and expert consensus. This algorithm could guide healthcare professionals in assessing and managing patients with hip-related pain, during the diagnosis, test selection, intervention, monitoring, and promoting collaboration among various healthcare providers...
May 3, 2024: Pain and Therapy
Piero Barbanti, Gianni Allais, Sabina Cevoli, Simona Guerzoni, Massimiliano Valeriani, Fabrizio Vernieri
No abstract text is available yet for this article.
May 2, 2024: Pain and Therapy
Ilenia Casini, Valeria Ladisa, Livio Clemente, Marianna Delussi, Elvira Rostanzo, Sofia Peparini, Anna Maria Aloisi, Marina de Tommaso
INTRODUCTION: Fibromyalgia is a form of chronic pain that affects a large number of women. It can start at any age and last a lifetime, with no cure. The Mediterranean diet is said to have an anti-inflammatory effect. Therefore, this study was conducted to investigate possible beneficial effects of a personalized Mediterranean diet in patients with fibromyalgia. METHODS: Outpatients with fibromyalgia were recruited and invited to participate in the study, including clinical, nutritional, and dietary assessments...
April 29, 2024: Pain and Therapy
Jordi Folch Ibáñez, Maribel Vargas Domingo, Joan Coma Alemany, Roger Callao Sánchez, Jordi Guitart Vela
INTRODUCTION: Chronic pain (CP) and depression/anxiety often coexist, worsening each other's symptoms. Treating this comorbidity is challenging. Tricyclic antidepressants and serotonin noradrenaline reuptake inhibitors are the first-line treatment options for this comorbidity, although sometimes they are not effective and/or well tolerated by patients, and there is little clinical evidence that selective serotonin reuptake inhibitors are useful for controlling CP. The antidepressant vortioxetine, with a multimodal mechanism that may help reduce pain, has proven clinical efficacy in patients with major depressive disorder (MDD)...
April 29, 2024: Pain and Therapy
Alberto Corriero, Mariateresa Giglio, Rossana Soloperto, Francesco Inchingolo, Giustino Varrassi, Filomena Puntillo
One of the most common musculoskeletal disorders, osteoarthritis (OA), causes worldwide disability, morbidity, and poor quality of life by degenerating articular cartilage, modifying subchondral bone, and inflaming synovial membranes. OA pathogenesis pathways must be understood to generate new preventative and disease-modifying therapies. In recent years, it has been acknowledged that gut microbiota (GM) can significantly contribute to the development of OA. Dysbiosis of GM can disrupt the "symphony" between the host and the GM, leading to a host immunological response that activates the "gut-joint" axis, ultimately worsening OA...
April 27, 2024: Pain and Therapy
Kelvin Le, Khang Duy Ricky Le, Johnny Nguyen, Jean Hua, Sarah Munday
This narrative review explores current insights into the potential use of medicinal cannabis-related products as an emerging therapy for opioid use disorder in the landscape of increasing knowledge about medicinal cannabis-based products, commercialisation and global legalisation. Preclinical studies have provided preliminary insight into the putative neurobiological mechanisms that underpin the potential for medicinal cannabis to be considered a therapeutic in opioid use disorder and addiction. With the progressive legalisation of cannabis in many jurisdictions worldwide, contemporary research has highlighted further evidence that medicinal cannabis may have efficacy in reducing cravings and withdrawal effects, and therefore may be considered as an adjunct or standalone to current medications for opioid use disorder...
April 27, 2024: Pain and Therapy
Stefan Neuwersch-Sommeregger, Markus Köstenberger, Andreas Sandner-Kiesling, Matthias Fürstner, Isabel Igerc, Brigitte Trummer, Jessica Wuntschek, Wolfgang Pipam, Haro Stettner, Rudolf Likar, Georg Feigl
INTRODUCTION: Ganglionic local opioid analgesia (GLOA) at the superior cervical ganglion (SCG) is performed for pain control and is known to be an effective procedure. In this study, we evaluated the spread of the injectate in the area of the SCG. Our expectation was that there would be a correlation between the area and volume of the injectate spread and post-procedural outcome measures. METHODS: This was a retrospective blinded review of magnetic resonance imaging (MRI) scans...
April 25, 2024: Pain and Therapy
Vidhu Sethi, Chetan Anand, Oscar Della Pasqua
The multifaceted nature of osteoarthritis (OA) pain presents a challenge in understanding and managing the condition. The diverse pain experiences, progression rates, individual responses to treatments, and complex disease mechanisms contribute to heterogeneity in the clinical studies outcomes. The lack of a standardized methodology for assessing and classifying OA pain challenges healthcare practitioners. This complicates the establishment of universally applicable protocols or standardized guidelines for treatment...
April 25, 2024: Pain and Therapy
Stefan Evers, Grazia Dell'Agnello, Diego Novick, H Saygin Gonderten, Tommaso Panni, Julio Pascual
INTRODUCTION: The ObserVational survey of the Epidemiology, tReatment and Care Of MigrainE (OVERCOME) European Union (EU) is part of an overarching population-based study program that also includes the United States and Japan. Here, we report data on the migraine/severe headache burden and the use of acute medication and healthcare resources in Spain and Germany. METHODS: OVERCOME (EU) was an online, non-interventional, cross-sectional survey conducted in adults in Spain and Germany between October 2020 and February 2021...
April 16, 2024: Pain and Therapy
Xia Xu, Ying-Xin Xie, Meng Zhang, Jian-Hui Du, Jin-Xian He, Li-Hong Hu
INTRODUCTION: Ultrasound-guided thoracic paravertebral block (UTPB) is widely used for postoperative analgesia in thoracic surgery. However, it has many disadvantages. Thoracoscopy-guided thoracic paravertebral block (TTPB) is a new technique for thoracic paravertebral block (TPB). In this study, we compared the use of TTPB and UTPB for pain management after thoracoscopic radical surgery for lung cancer. METHODS: In total, 80 patients were randomly divided 1:1 into the UTPB group and the TTPB group...
April 9, 2024: Pain and Therapy
Samuel Díaz Insa, Ángel Guerrero, Javier Viguera, Vicente Medrano Martínez, Carlos Calle de Miguel, Jesús Porta-Etessam, Antonio Ciudad, Silvia Diaz-Cerezo, Ana Roncero Martín, Mercedes Núñez
INTRODUCTION: The efficacy of galcanezumab has been demonstrated in randomized controlled trials, but evidence about its use under clinical practice conditions is still limited. This study aimed to describe the characteristics of the patients treated with galcanezumab in routine clinical practice in Spain as well as treatment patterns, persistence, and effectiveness. METHODS: A retrospective chart review study was carried out in six hospitals. Information of adults with migraine, who started treatment with galcanezumab between November 2019 and September 2021, was analyzed until end or loss of follow-up...
March 28, 2024: Pain and Therapy
Michael J Dorsi, Patrick Buchanan, Chau Vu, Harjot S Bhandal, David W Lee, Samir Sheth, Phil M Shumsky, Nolan J Brown, Alexander Himstead, Ryan Mattie, Steven M Falowski, Ramana Naidu, Jason E Pope
INTRODUCTION: Interventional treatment options for the lumbar degenerative spine have undergone a significant amount of innovation over the last decade. As new technologies emerge, along with the surgical specialty expansion, there is no manuscript that utilizes a review of surgical treatments with evidence rankings from multiple specialties, namely, the interventional pain and spine communities. Through the Pacific Spine and Pain Society (PSPS), the purpose of this manuscript is to provide a balanced evidence review of available surgical treatments...
March 23, 2024: Pain and Therapy
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