Lavinia Curini, Brunilda Alushi, Mary Roxana Christopher, Simone Baldi, Leandro Di Gloria, Pierluigi Stefano, Anna Laganà, Luisa Iannone, Herko Grubitzsch, Ulf Landmesser, Matteo Ramazzotti, Elena Niccolai, Alexander Lauten, Amedeo Amedei
INTRODUCTION: Calcific aortic valve disease (CAVD) is the most common heart valve disorder, defined by a remodeling multistep process: namely, valve fibrosis with its area narrowing, impaired blood flow, and final calcification phase. Nowadays, the only treatment is the surgical valve replacement. As for other cardiovascular diseases, growing evidence suggest an active role of the immune system in the calcification process that could be modulated by the microbiota. To address this point, we aimed to investigate and characterize, for the first time, the presence of a valve microbiota and associated immune response in human CAVD...
February 6, 2023: Microbial Cell