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Christian Tardif, Gabriel Nadeau, Simon Labrecque, Daniel Côté, Flavie Lavoie-Cardinal, Paul De Koninck
Microscopy methods used to measure Förster resonance energy transfer (FRET) between fluorescently labeled proteins can provide information on protein interactions in cells. However, these methods are diffraction-limited, thus do not enable the resolution of the nanodomains in which such interactions occur in cells. To overcome this limitation, we assess FRET with an imaging system combining fluorescence lifetime imaging microscopy with stimulated emission depletion, termed fluorescence lifetime imaging nanoscopy (FLIN)...
January 2019: Neurophotonics
(no author information available yet)
Neurophotonics thanks the individuals who served as reviewers in 2018.
January 2019: Neurophotonics
Stephanie Sutoko, Yee Ling Chan, Akiko Obata, Hiroki Sato, Atsushi Maki, Takashi Numata, Tsukasa Funane, Hirokazu Atsumori, Masashi Kiguchi, Tong Boon Tang, Yingwei Li, Blaise deB Frederick, Yunjie Tong
Functional near-infrared spectroscopy (fNIRS) is a noninvasive functional imaging technique measuring hemodynamic changes including oxygenated ( <mml:math xmlns:mml=""> <mml:mrow> <mml:msub> <mml:mrow> <mml:mi>O</mml:mi> </mml:mrow> <mml:mrow> <mml:mn>2</mml:mn> </mml:mrow> </mml:msub> <mml:mi>Hb</mml:mi> </mml:mrow> </mml:math> ) and deoxygenated (HHb) hemoglobin. Low frequency (LF; 0...
January 2019: Neurophotonics
Joël Lefebvre, Patrick Delafontaine-Martel, Philippe Pouliot, Hélène Girouard, Maxime Descoteaux, Frédéric Lesage
An automated dual-resolution serial optical coherence tomography (2R-SOCT) scanner is developed. The serial histology system combines a low-resolution ( <mml:math xmlns:mml=""> <mml:mrow> <mml:mn>25</mml:mn> <mml:mtext>  </mml:mtext> <mml:mi>μ</mml:mi> <mml:mi>m</mml:mi> <mml:mo>/</mml:mo> <mml:mi>voxel</mml:mi> </mml:mrow> </mml:math> ) <mml:math xmlns:mml="http://www.w3...
October 2018: Neurophotonics
Peyman Zirak, Clara Gregori-Pla, Igor Blanco, Ana Fortuna, Gianluca Cotta, Pau Bramon, Isabel Serra, Anna Mola, Jordi Solà-Soler, Beatriz F Giraldo-Giraldo, Turgut Durduran, Mercedes Mayos
Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event...
October 2018: Neurophotonics
L Nathan Perkins, Anna Devor, Timothy J Gardner, David A Boas
Previously introduced bundles of hundreds or thousands of microfibers have the potential to extend optical access to deep brain regions, sampling fluorescence activity throughout a three-dimensional volume. Each fiber has a small diameter ( <mml:math xmlns:mml=""> <mml:mrow> <mml:mn>8</mml:mn> <mml:mtext>  </mml:mtext> <mml:mi>μ</mml:mi> <mml:mi>m</mml:mi> </mml:mrow> </mml:math> ) and follows a path of least resistance, splaying during insertion...
October 2018: Neurophotonics
Carlos A Gómez, Buyin Fu, Sava Sakadžić, Mohammad A Yaseen
Disruptions and alterations to cerebral energy metabolism play a vital role in the onset and progression of many neurodegenerative disorders and cerebral pathologies. In order to precisely understand the complex alterations underlying Alzheimer's disease (AD) progression, in vivo imaging at the microscopic level is required in preclinical animal models. Utilizing two-photon fluorescence lifetime imaging microscopy and the phasor analysis method, we have observed AD-related variations of endogenous fluorescence of reduced nicotinamide adenine dinucleotide (NADH) in vivo ...
October 2018: Neurophotonics
David Rosenbaum, Leonore Blum, Paul Schweizer, Andreas J Fallgatter, Martin J Herrmann, Ann-Christine Ehlis, Florian G Metzger
The use of functional near-infrared spectroscopy (fNIRS) in block designs provides measures of cortical activity in ecologically valid environments. However, in some cases, the use of block designs may be problematic when data are not corrected for performance in a time-restricted block. We sought to investigate the effects of task complexity and processing speed on hemodynamic responses in an fNIRS block design. To differentiate the effects of task complexity and processing speed, 20 subjects completed the trail making test (TMT) in two versions (TMT-A versus TMT-B) and three different speed levels (slow versus moderate versus fast)...
October 2018: Neurophotonics
Amalie la Cour, Gorm Greisen, Simon Hyttel-Sorensen
We summarize the available in vivo validation of cerebral near-infrared spectroscopy (NIRS) oximetry to inform future in vivo validation strategies. In particular, to establish a way forward in the assessment of NIRS instrumentation for future randomized trials, a systematic literature search is performed. The records are screened and abstracts are assessed to select studies fulfilling our inclusion criteria. Twenty-two pediatric and 28 adult studies are analyzed after exclusion of three articles in each group...
October 2018: Neurophotonics
Lian He, Wesley B Baker, Daniel Milej, Venkaiah C Kavuri, Rickson C Mesquita, David R Busch, Kenneth Abramson, Jane Y Jiang, Mamadou Diop, Keith St Lawrence, Olivia Amendolia, Francis Quattrone, Ramani Balu, W Andrew Kofke, Arjun G Yodh
We investigate a scheme for noninvasive continuous monitoring of absolute cerebral blood flow (CBF) in adult human patients based on a combination of time-resolved dynamic contrast-enhanced near-infrared spectroscopy (DCE-NIRS) and diffuse correlation spectroscopy (DCS) with semi-infinite head model of photon propogation. Continuous CBF is obtained via calibration of the DCS blood flow index (BFI) with absolute CBF obtained by intermittent intravenous injections of the optical contrast agent indocyanine green...
October 2018: Neurophotonics
Stephanie Sutoko, Yukifumi Monden, Tsukasa Funane, Tatsuya Tokuda, Takusige Katura, Hiroki Sato, Masako Nagashima, Masashi Kiguchi, Atsushi Maki, Takanori Yamagata, Ippeita Dand
[This corrects the article DOI: 10.1117/1.NPh.5.4.045001.].
October 2018: Neurophotonics
Juliette Selb, Kuan-Cheng Wu, Jason Sutin, Pei-Yi Ivy Lin, Parisa Farzam, Sophia Bechek, Apeksha Shenoy, Aman B Patel, David A Boas, Maria Angela Franceschini, Eric S Rosenthal
Monitoring of cerebral blood flow (CBF) and autoregulation are essential components of neurocritical care, but continuous noninvasive methods for CBF monitoring are lacking. Diffuse correlation spectroscopy (DCS) is a noninvasive diffuse optical modality that measures a CBF index ( <mml:math xmlns:mml=""> <mml:mrow> <mml:msub> <mml:mrow> <mml:mi>CBF</mml:mi> </mml:mrow> <mml:mrow> <mml:mi>i</mml:mi> </mml:mrow> </mml:msub> </mml:mrow> </mml:math> ) in the cortex microvasculature by monitoring the rapid fluctuations of near-infrared light diffusing through moving red blood cells...
October 2018: Neurophotonics
Mark R Hutchinson, Paul R Stoddart, Anita Mahadevan-Jansen
Neurophotonics is an exploding field that spans the intersection of light and neurons for fundamental discovery and clinical translation. Optical technologies have significantly impacted brain research by probing into the mysteries of the brain, modulating brain activity, and improving patient care. Based on a discussion held at the International Conference on Biophotonics 2017, a group of leading researchers brainstormed to identify areas of unmet need in neuroscience and medicine, where biophotonics research could have the highest affect...
October 2018: Neurophotonics
Yingyue Xu, Nan Xia, Michelle Lim, Xiaodong Tan, Minh Ha Tran, Erin Boulger, Fei Peng, Hunter Young, Christoph Rau, Alexander Rack, Claus-Peter Richter
An emerging method in the field of neural stimulation is the use of photons to activate neurons. The possible advantage of optical stimulation over electrical is attributable to its spatially selective activation of small neuron populations, which is promising in generating superior spatial resolution in neural interfaces. Two principal methods are explored for cochlear prostheses: direct stimulation of nerves with infrared light and optogenetics. This paper discusses basic requirements for developing a light delivery system (LDS) for the cochlea and provides examples for building such devices...
October 2018: Neurophotonics
Borja Blanco, Monika Molnar, César Caballero-Gaudes
Near-infrared spectroscopy (NIRS) offers the potential to characterize resting-state functional connectivity (RSFC) in populations that are not easily assessed otherwise, such as young infants. In addition to the advantages of NIRS, one should also consider that the RS-NIRS signal requires specific data preprocessing and analysis. In particular, the RS-NIRS signal shows a colored frequency spectrum, which can be observed as temporal autocorrelation, thereby introducing spurious correlations. To address this issue, prewhitening of the RS-NIRS signal has been recently proposed as a necessary step to remove the signal temporal autocorrelation and therefore reduce false-discovery rates...
October 2018: Neurophotonics
Stephanie Sutoko, Yukifumi Monden, Tsukasa Funane, Tatsuya Tokuda, Takusige Katura, Hiroki Sato, Masako Nagashima, Masashi Kiguchi, Atsushi Maki, Takanori Yamagata, Ippeita Dan
Functional near-infrared spectroscopy (fNIRS) signals are prone to problems caused by motion artifacts and physiological noises. These noises unfortunately reduce the fNIRS sensitivity in detecting the evoked brain activation while increasing the risk of statistical error. In fNIRS measurements, the repetitive resting-stimulus cycle (so-called block-design analysis) is commonly adapted to increase the sample number. However, these blocks are often affected by noises. Therefore, we developed an adaptive algorithm to identify, reject, and select the noise-free and/or least noisy blocks in accordance with the preset acceptance rate...
October 2018: Neurophotonics
Lucas R Trambaiolli, Claudinei E Biazoli, André M Cravo, Tiago H Falk, João R Sato
Background: Affective neurofeedback constitutes a suitable approach to control abnormal neural activities associated with psychiatric disorders and might consequently relief symptom severity. However, different aspects of neurofeedback remain unclear, such as its neural basis, the performance variation, the feedback effect, among others. Aim: First, we aimed to propose a functional near-infrared spectroscopy (fNIRS)-based affective neurofeedback based on the self-regulation of frontal and occipital networks...
July 2018: Neurophotonics
Adam Vittrup Andersen, Sofie Amalie Simonsen, Henrik Winther Schytz, Helle Klingenberg Iversen
Background: Cerebral autoregulation (CA) is the brain's ability to always maintain an adequate and relatively constant blood supply, which is often impaired in cerebrovascular diseases. Near-infrared spectroscopy (NIRS) examines oxygenated hemoglobin (OxyHb) in the cerebral cortex. Low- and very low-frequency oscillations ( <mml:math xmlns:mml=""> <mml:mrow> <mml:mi>LFOs</mml:mi> <mml:mo>≈</mml:mo> <mml:mn>0...
July 2018: Neurophotonics
Sabrina Brigadoi, Domenico Salvagnin, Matteo Fischetti, Robert J Cooper
The position of each source and detector "optode" on the scalp, and their relative separations, determines the sensitivity of each functional near-infrared spectroscopy (fNIRS) channel to the underlying cortex. As a result, selecting appropriate scalp locations for the available sources and detectors is critical to every fNIRS experiment. At present, it is standard practice for the user to undertake this task manually; to select what they believe are the best locations on the scalp to place their optodes so as to sample a given cortical region-of-interest (ROI)...
July 2018: Neurophotonics
Takahiro Ikeda, Masahiro Hirai, Takeshi Sakurada, Yukifumi Monden, Tatsuya Tokuda, Masako Nagashima, Hideo Shimoizumi, Ippeita Dan, Takanori Yamagata
Autism spectrum disorder (ASD) is characterized by impairment in social communication and the presence of restricted and repetitive behaviors and interests. Executive function impairment is reportedly partially responsible for these symptoms. Executive function includes planning, flexibility, and inhibitory control. Although planning and flexibility in ASD have been consistently reported as atypical, the atypicality of inhibitory control remains controversial. As most previous studies have used nonsocial stimuli to investigate inhibitory control in ASD, the effects of socially relevant information on the inhibitory control system in individuals with ASD remain unclear...
July 2018: Neurophotonics
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