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Journals Frontiers in Bioengineering an...

Frontiers in Bioengineering and Biotechnology

https://read.qxmd.com/read/38515626/machine-learning-method-for-the-classification-of-the-state-of-living-organisms-oscillations
#21
JOURNAL ARTICLE
David Kweku, Maria I Villalba, Ronnie G Willaert, Osvaldo M Yantorno, Maria E Vela, Anna K Panorska, Sandor Kasas
The World Health Organization highlights the urgent need to address the global threat posed by antibiotic-resistant bacteria. Efficient and rapid detection of bacterial response to antibiotics and their virulence state is crucial for the effective treatment of bacterial infections. However, current methods for investigating bacterial antibiotic response and metabolic state are time-consuming and lack accuracy. To address these limitations, we propose a novel method for classifying bacterial virulence based on statistical analysis of nanomotion recordings...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515625/quantifying-walking-speeds-in-relation-to-ankle-biomechanics-on-a-real-time-interactive-gait-platform-a-musculoskeletal-modeling-approach-in-healthy-adults
#22
JOURNAL ARTICLE
M Peiffer, K Duquesne, M Delanghe, A Van Oevelen, S De Mits, E Audenaert, A Burssens
Background: Given the inherent variability in walking speeds encountered in day-to-day activities, understanding the corresponding alterations in ankle biomechanics would provide valuable clinical insights. Therefore, the objective of this study was to examine the influence of different walking speeds on biomechanical parameters, utilizing gait analysis and musculoskeletal modelling. Methods: Twenty healthy volunteers without any lower limb medical history were included in this study. Treadmill-assisted gait-analysis with walking speeds of 0...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515624/exploring-the-allelopathic-autotoxicity-mechanism-of-ginsenosides-accumulation-under-ginseng-decomposition-based-on-integrated-analysis-of-transcriptomics-and-metabolomics
#23
JOURNAL ARTICLE
Rui Wang, Tingting Zhou, Yikai Wang, Jinxu Dong, Yutao Bai, Xin Huang, Changbao Chen
Continuous cropping obstacles seriously constrained the sustainable development of the ginseng industry. The allelopathic autotoxicity of ginsenosides is the key "trigger" of continuous cropping obstacles in ginseng. During harvest, the ginseng plants could be broken and remain in the soil. The decomposition of ginseng residue in soil is one of the important release ways of ginsenosides. Therefore, the allelopathic mechanism of ginsenosides through the decomposed release pathway needs an in-depth study. To investigate this allelopathic regulation mechanism, the integrated analysis of transcriptomics and metabolomics was applied...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515623/application-of-pectin-hydrolyzing-bacteria-in-tobacco-to-improve-flue-cured-tobacco-quality
#24
JOURNAL ARTICLE
Shuning Weng, Meizhong Deng, Shanyi Chen, Renqiang Yang, Jingjing Li, Xianbo Zhao, Shunhua Ji, Lixiang Wu, Li Ni, Enren Zhang, Chaochao Wang, Lingfeng Qi, Kuanqi Liao, Yiqiang Chen, Wen Zhang
To study the relationship between the diversity of the surface microbial community and tobacco flavor, and to improve tobacco quality using microorganisms. The microbial community composition and diversity of 14 samples of flue-cured tobacco from tobacco-producing areas in Yunnan with varying grades were analyzed by high-throughput sequencing. PICRUSt was used for predicting microbial functions. A strain of Bacillus amyloliquefaciens W6-2 with the ability to degrade pectin was screened from the surface of flued-cured tobacco leaves from Yunnan reroasted tobacco leave...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515622/a-photoelectrochemical-aptasensor-based-on-double-z-scheme-%C3%AE-fe-2-o-3-mos-2-bi-2-s-3-ternary-heterojunction-for-sensitive-detection-of-circulating-tumor-cells
#25
JOURNAL ARTICLE
Kai Feng, Ya Di, Meng Han, Weitao Yan, Yulin Guo, Xiangqian Huai, Yimin Wang
A novel photoelectrochemical (PEC) aptasensor based on a dual Z-scheme α-Fe2 O3 /MoS2 /Bi2 S3 ternary heterojunction for the ultrasensitive detection of circulating tumor cells (CTCs) was developed. The α-Fe2 O3 /MoS2 /Bi2 S3 nanocomposite was prepared via a step-by-step route, and the photoproduced electron/hole transfer path was speculated by conducting trapping experiments of reactive species. α-Fe2 O3 /MoS2 /Bi2 S3 -modified electrodes exhibited greatly enhanced photocurrent under visible light due to the double Z-scheme charge transfer process, which met the requirement of the PEC sensor for detecting larger targets...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515621/therapeutic-role-of-neural-stem-cells-in-neurological-diseases
#26
REVIEW
Ling Yang, Si-Cheng Liu, Yi-Yi Liu, Fu-Qi Zhu, Mei-Juan Xiong, Dong-Xia Hu, Wen-Jun Zhang
The failure of endogenous repair is the main feature of neurological diseases that cannot recover the damaged tissue and the resulting dysfunction. Currently, the range of treatment options for neurological diseases is limited, and the approved drugs are used to treat neurological diseases, but the therapeutic effect is still not ideal. In recent years, different studies have revealed that neural stem cells (NSCs) have made exciting achievements in the treatment of neurological diseases. NSCs have the potential of self-renewal and differentiation, which shows great foreground as the replacement therapy of endogenous cells in neurological diseases, which broadens a new way of cell therapy...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515620/quantitative-evaluation-of-motion-compensation-in-post-stroke-rehabilitation-training-based-on-muscle-synergy
#27
JOURNAL ARTICLE
Yanhong Liu, Yaowei Li, Zan Zhang, Benyan Huo, Anqin Dong
Introduction: Stroke is the second leading cause of death globally and a primary factor contributing to disability. Unilateral limb motor impairment caused by stroke is the most common scenario. The bilateral movement pattern plays a crucial role in assisting stroke survivors on the affected side to relearn lost skills. However, motion compensation often lead to decreased coordination between the limbs on both sides. Furthermore, muscle fatigue resulting from imbalanced force exertion on both sides of the limbs can also impact the rehabilitation outcomes...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515619/chronic-lateral-ankle-instability-using-anterior-tibiofibular-ligament-distal-fascicle-transfer-augmentation-repair-an-anatomical-biomechanical-and-histological-study
#28
JOURNAL ARTICLE
Ruihan Wang, Yingqiu Yang, Guixuan You, Lei Huang, Xin Zhou, Songtao Jiang, Houyin Shi, Guoyou Wang, Lei Zhang
Background: The transfer of the anterior tibiofibular ligament distal fascicle (ATiFL-DF) for the augmentation repair of the anterior talofibular ligament (ATFL) shows potential as a surgical technique. However, evidences on the benefits and disadvantages of this method in relation to ankle joint function are lacking. Purpose: This study aimed to provide comprehensive experimental data to validate the feasibility of ATiFL-DF transfer augmentation repair of the ATFL. Methods: This study included 50 embalmed ankle specimens to measure various morphological features, such as length, width, thickness, and angle, for evaluating similarities between the ATiFL-DF and ATFL...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38515618/tension-band-high-strength-suture-combined-with-absorbable-cannulated-screws-for-treating-transverse-patellar-fractures-finite-element-analysis-and-clinical-study
#29
JOURNAL ARTICLE
Feifan Xiang, Yukun Xiao, Dige Li, Wenzhe Ma, Yue Chen, Yunkang Yang
Objective: Few reports exist on the treatment of transverse patellar fractures (TPFs) using absorbable cannulated screws and high-strength sutures, and most screws and sutures lack good biomechanics and clinical trials. Therefore, this study aimed to demonstrate the biomechanical stability and clinical efficacy of tension-band high-strength sutures combined with absorbable cannulated screws (TBSAS) in treating TPFs (AO/OTA 34 C1). Methods: Finite element models of five internal fixation schemes were established: tension-band wire with K-wire (TBW), TBW with cerclage wire (TBWC), TBW with headless pressure screws (TBWHS), TBW with full-thread screws (TBWFS), and TBSAS...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38511132/three-dimensional-model-of-normal-human-dermal-tissue-using-serial-tissue-sections
#30
JOURNAL ARTICLE
Peng Liu, Tao Zhang, Yihui Huang
Background: This study aims to construct a three-dimensional model of skin dermis utilizing continuous tissue sections, with the primary objective of obtaining anatomical structure data for normal human dermal tissues. Methods: Normal skin tissue specimens were acquired, paraffin-embedded, and subjected to HE staining. Panoramic images of skin sections were captured using a microscope. Tissue section images were aligned using the SIFT and StackReg image alignment methods, with analysis conducted using the OpenCV module...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38511131/editorial-advanced-oral-disease-therapy-approaches-biotechnology-and-bioactive-materials-volume-ii
#31
EDITORIAL
Xiaoxuan Zhang, Xianqi Li, Yuan Yin, Jianyun Zhang, Hai Zhang, Xing Wang
No abstract text is available yet for this article.
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38511130/implications-of-o-glycan-modifications-in-the-hinge-region-of-a-plant-produced-sars-cov-2-iga-antibody-on-functionality
#32
JOURNAL ARTICLE
Pia Uetz, Kathrin Göritzer, Emil Vergara, Stanislav Melnik, Clemens Grünwald-Gruber, Rudolf Figl, Ala-Eddine Deghmane, Elisabetta Groppelli, Rajko Reljic, Julian K-C Ma, Eva Stöger, Richard Strasser
Introduction: Prolyl-4-hydroxylases ( P4H ) catalyse the irreversible conversion of proline to hydroxyproline, constituting a common posttranslational modification of proteins found in humans, plants, and microbes. Hydroxyproline residues can be further modified in plants to yield glycoproteins containing characteristic O-glycans. It is currently unknown how these plant endogenous modifications impact protein functionality and they cause considerable concerns for the recombinant production of therapeutic proteins in plants...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38511129/doe-based-medium-optimization-for-improved-biosurfactant-production-with-aureobasidium-pullulans
#33
JOURNAL ARTICLE
Frederick Haala, Marie R E Dielentheis-Frenken, Friedrich M Brandt, Tobias Karmainski, Lars M Blank, Till Tiso
Polyol lipids (a.k.a. liamocins) produced by the polyextremotolerant, yeast-like fungus Aureobasidium pullulans are amphiphilic molecules with high potential to serve as biosurfactants. So far, cultivations of A. pullulans have been performed in media with complex components, which complicates further process optimization due to their undefined composition. In this study, we developed and optimized a minimal medium, focusing on biosurfactant production. Firstly, we replaced yeast extract and peptone in the best-performing polyol lipid production medium to date with a vitamin solution, a trace-element solution, and a nitrogen source...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38511128/robotic-assisted-anatomic-anterior-cruciate-ligament-reconstruction-a-comparative-analysis-of-modified-transtibial-and-anteromedial-portal-techniques-in-cadaveric-knees
#34
JOURNAL ARTICLE
Ling Zhang, Jinpeng Lin, Xuan Zhao, Mingwei Liu, Yao Hou, Yu Zhang, Jinzhong Zhao, Shaobai Wang
Introduction: This study employed surgical robot to perform anatomic single-bundle reconstruction using the modified transtibial (TT) technique and anteromedial (AM) portal technique. The purpose was to directly compare tunnel and graft characteristics of the two techniques. Methods: Eight cadaveric knees without ligament injury were used in the study. The modified TT and AM portal technique were both conducted under surgical robotic system. Postoperative data acquisition of the tunnel and graft characteristics included tibial tunnel position, tunnel angle, tunnel length and femoral tunnel-graft angle...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38497053/long-term-continuous-instrumented-insole-based-gait-analyses-in-daily-life-have-advantages-over-longitudinal-gait-analyses-in-the-lab-to-monitor-healing-of-tibial-fractures
#35
JOURNAL ARTICLE
Elke Warmerdam, Christian Wolff, Marcel Orth, Tim Pohlemann, Bergita Ganse
Introduction: Monitoring changes in gait during rehabilitation allows early detection of complications. Laboratory-based gait analyses proved valuable for longitudinal monitoring of lower leg fracture healing. However, continuous gait data recorded in the daily life may be superior due to a higher temporal resolution and differences in behavior. In this study, ground reaction force-based gait data of instrumented insoles from longitudinal intermittent laboratory assessments were compared to monitoring in daily life...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38497052/coupling-dairy-wastewaters-for-nutritional-balancing-and-water-recycling-sustainable-heterologous-2-phenylethanol-production-by-engineered-cyanobacteria
#36
JOURNAL ARTICLE
Giulia Usai, Alessandro Cordara, Elena Mazzocchi, Angela Re, Debora Fino, Candido Fabrizio Pirri, Barbara Menin
Microalgae biotechnology is hampered by the high production costs and the massive usage of water during large-volume cultivations. These drawbacks can be softened by the production of high-value compounds and by adopting metabolic engineering strategies to improve their performances and productivity. Today, the most sustainable approach is the exploitation of industrial wastewaters for microalgae cultivation, which couples valuable biomass production with water resource recovery. Among the food processing sectors, the dairy industry generates the largest volume of wastewaters through the manufacturing process...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38497051/cancer-diagnosis-and-treatment-platform-based-on-manganese-based-nanomaterials
#37
REVIEW
Jia Fei, Yanyan Liu, Ya Zeng, Mingqi Yang, Shanshan Chen, Xiaobing Duan, Ligong Lu, Muhe Chen
Cancer is a leading cause of death worldwide, and the development of new diagnostic and treatment methods is crucial. Manganese-based nanomaterials (MnNMs) have emerged as a focal point in the field of cancer diagnosis and treatment due to their multifunctional properties. These nanomaterials have been extensively explored as contrast agents for various imaging technologies such as magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and near-infrared fluorescence imaging (NIR-FL). The use of these nanomaterials has significantly enhanced the contrast for precise tumor detection and localization...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38486869/the-role-of-macrophage-polarization-in-tendon-healing-and-therapeutic-strategies-insights-from-animal-models
#38
REVIEW
Yicheng Wang, Xiao Lu, Jianxi Lu, Philippe Hernigou, Fangchun Jin
Tendon injuries, a common musculoskeletal issue, usually result in adhesions to the surrounding tissue, that will impact functional recovery. Macrophages, particularly through their M1 and M2 polarizations, play a pivotal role in the inflammatory and healing phases of tendon repair. In this review, we explore the role of macrophage polarization in tendon healing, focusing on insights from animal models. The review delves into the complex interplay of macrophages in tendon pathology, detailing how various macrophage phenotypes contribute to both healing and adhesion formation...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38486868/variability-of-intervertebral-joint-stiffness-between-specimens-and-spine-levels
#39
JOURNAL ARTICLE
Samuele L Gould, Giorgio Davico, Christian Liebsch, Hans-Joachim Wilke, Luca Cristofolini, Marco Viceconti
Introduction: Musculoskeletal multibody models of the spine can be used to investigate the biomechanical behaviour of the spine. In this context, a correct characterisation of the passive mechanical properties of the intervertebral joint is crucial. The intervertebral joint stiffness, in particular, is typically derived from the literature, and the differences between individuals and spine levels are often disregarded. Methods: This study tested if an optimisation method of personalising the intervertebral joint stiffnesses was able to capture expected stiffness variation between specimens and between spine levels and if the variation between spine levels could be accurately captured using a generic scaling ratio...
2024: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/38486867/inactivation-of-sars-cov-2-on-porous-and-nonporous-surfaces-by-compact-portable-plasma-reactor
#40
JOURNAL ARTICLE
Bhaswati Choudhury, John A Lednicky, Julia C Loeb, Sherlie Portugal, Subrata Roy
We report the inactivation of SARS CoV-2 and its surrogate-Human coronavirus OC43 (HCoV-OC43), on representative porous (KN95 mask material) and nonporous materials (aluminum and polycarbonate) using a Compact Portable Plasma Reactor (CPPR). The CPPR is a compact (48 cm3 ), lightweight, portable and scalable device that forms Dielectric Barrier Discharge which generates ozone using surrounding atmosphere as input gas, eliminating the need of source gas tanks. Iterative CPPR exposure time experiments were performed on inoculated material samples in 3 operating volumes...
2024: Frontiers in Bioengineering and Biotechnology
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