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Journals Frontiers in Cell and Developm...

Frontiers in Cell and Developmental Biology

https://read.qxmd.com/read/38516131/parallel-evolution-of-gravity-sensing
#21
JOURNAL ARTICLE
Daria Y Romanova, Leonid L Moroz
Omnipresent gravity affects all living organisms; it was a vital factor in the past and the current bottleneck for future space exploration. However, little is known about the evolution of gravity sensing and the comparative biology of gravity reception. Here, by tracing the parallel evolution of gravity sensing, we encounter situations when assemblies of homologous modules result in the emergence of non-homologous structures with similar systemic properties. This is a perfect example to study homoplasy at all levels of biological organization...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38516130/morphology-of-the-immune-cells-in-the-wall-of-the-human-uterine-tube-and-their-possible-impact-on-reproduction-uterine-tube-as-a-possible-immune-privileged-organ
#22
REVIEW
Kristína Visnyaiová, Ivan Varga, Claudia Feitscherová, Lada Pavlíková, Jozef Záhumenský, Renáta Mikušová
The uterine tube, as well as other parts of the upper female reproductive system, is immunologically unique in its requirements for tolerance to allogenic sperm and semi-allogenic embryos, yet responds to an array of sexually transmitted pathogens. To understand this dichotomy, there is a need to understand the functional morphology of immune cells in the wall of the uterine tube. Thus, we reviewed scientific literature regarding immune cells and the human uterine tube by using the scientific databases. The human uterine tube has a diverse population of immunocompetent cells representing both the innate and adaptive immune systems...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38516129/editorial-reviews-and-advances-in-the-molecular-mechanisms-of-breast-cancer
#23
EDITORIAL
A Redfern, V Agarwal, S Alahari
No abstract text is available yet for this article.
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38516128/nest3d-printed-bone-mimicking-scaffolds-assessment-of-the-effect-of-geometrical-design-on-stiffness-and-angiogenic-potential
#24
JOURNAL ARTICLE
Stephanie E Doyle, Micaela Pannella, Carmine Onofrillo, Chiara Bellotti, Claudia Di Bella, Cathal D O'Connell, Elena Pirogova, Enrico Lucarelli, Serena Duchi
Tissue-engineered implants for bone regeneration require consideration regarding their mineralization and vascularization capacity. Different geometries, such as biomimetic designs and lattices, can influence the mechanical properties and the vascularization capacity of bone-mimicking implants. Negative Embodied Sacrificial Template 3D (NEST3D) printing is a versatile technique across a wide range of materials that enables the production of bone-mimicking scaffolds. In this study, different scaffold motifs (logpile, Voronoi, and trabecular bone) were fabricated via NEST3D printing in polycaprolactone to determine the effect of geometrical design on stiffness (10...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38516127/editorial-new-advancement-in-tumor-microenvironment-remodeling-and-cancer-therapy
#25
EDITORIAL
Yi Yao, Ying Shen, James C Yao, Xiangsheng Zuo
No abstract text is available yet for this article.
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38510179/increased-hif-2%C3%AE-activity-in-the-nucleus-pulposus-causes-intervertebral-disc-degeneration-in-the-aging-mouse-spine
#26
JOURNAL ARTICLE
Shira N Johnston, Maria Tsingas, Rahatul Ain, Ruteja A Barve, Makarand V Risbud
Hypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown. We expressed HIF-2α with proline to alanine substitutions (P405A; P531A) in the Oxygen-dependent degradation domain (HIF-2αdPA) in the NP tissue using an inducible, nucleus pulposus-specific K19CreERT allele to study HIF-2α function in the adult intervertebral disc. Expression of HIF-2α in NP impacted disc morphology, as evident from small but significantly higher scores of degeneration in NP of 24-month-old K19CreERT ; HIF-2αdPA (K19-dPA) mice...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38510178/editorial-coordinated-regulation-of-the-balance-between-stem-cell-self-renewal-and-differentiation
#27
EDITORIAL
Marco Tatullo
No abstract text is available yet for this article.
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38510177/interaction-between-immuno-stem-dual-lineages-in-jaw-bone-formation-and-injury-repair
#28
REVIEW
Ziyi Liu, Xutao Luo, Ruoshi Xu
The jawbone, a unique structure in the human body, undergoes faster remodeling than other bones due to the presence of stem cells and its distinct immune microenvironment. Long-term exposure of jawbones to an oral environment rich in microbes results in a complex immune balance, as shown by the higher proportion of activated macrophage in the jaw. Stem cells derived from the jawbone have a higher propensity to differentiate into osteoblasts than those derived from other bones. The unique immune microenvironment of the jaw also promotes osteogenic differentiation of jaw stem cells...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38510176/myc-there-is-more-to-it-than-cancer
#29
REVIEW
Mariano F Zacarías-Fluck, Laura Soucek, Jonathan R Whitfield
MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular proliferation, differentiation, metabolism, ribogenesis, and bone and vascular development. Over 4 decades of research and some 10,000 publications linking it to tumorigenesis (by searching PubMed for "MYC oncogene") have led to MYC becoming a most-wanted target for the treatment of cancer, where many of MYC's physiological functions become co-opted for tumour initiation and maintenance...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38505263/cell-type-specific-regulation-of-cftr-trafficking-on-the-verge-of-progress
#30
REVIEW
Carlos M Farinha, Lúcia Santos, João F Ferreira
Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein is a complex process that starts with its biosynthesis and folding in the endoplasmic reticulum. Exit from the endoplasmic reticulum (ER) is coupled with the acquisition of a compact structure that can be processed and traffic through the secretory pathway. Once reaching its final destination-the plasma membrane, CFTR stability is regulated through interaction with multiple protein partners that are involved in its post-translation modification, connecting the channel to several signaling pathways...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38505262/proton-sensing-ion-channels-gpcrs-and-calcium-signaling-regulated-by-them-implications-for-cancer
#31
REVIEW
Renhui Ji, Li Chang, Caiyan An, Junjing Zhang
Extracellular acidification of tumors is common. Through proton-sensing ion channels or proton-sensing G protein-coupled receptors (GPCRs), tumor cells sense extracellular acidification to stimulate a variety of intracellular signaling pathways including the calcium signaling, which consequently exerts global impacts on tumor cells. Proton-sensing ion channels, and proton-sensing GPCRs have natural advantages as drug targets of anticancer therapy. However, they and the calcium signaling regulated by them attracted limited attention as potential targets of anticancer drugs...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38505261/editorial-proteins-and-protein-complexes-underlying-mitochondrial-structure-function-and-metabolism-implications-in-diseases
#32
EDITORIAL
Mohammad Golam Sabbir, Nawab John Dar, Shahnawaz Ali Bhat, Hamad H Alanazi, Jeff Perry
No abstract text is available yet for this article.
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38505260/developmental-outcome-of-electroencephalographic-findings-in-syngap1-encephalopathy
#33
JOURNAL ARTICLE
Juliana Ribeiro-Constante, Alba Tristán-Noguero, Fernando Francisco Martínez Calvo, Salvador Ibañez-Mico, José Luis Peña Segura, José Miguel Ramos-Fernández, María Del Carmen Moyano Chicano, Rafael Camino León, Víctor Soto Insuga, Elena González Alguacil, Carlos Valera Dávila, Alberto Fernández-Jaén, Laura Plans, Ana Camacho, Nuria Visa-Reñé, María Del Pilar Martin-Tamayo Blázquez, Fernando Paredes-Carmona, Itxaso Marti-Carrera, Aránzazu Hernández-Fabián, Meritxell Tomas Davi, Merce Casadesus Sanchez, Laura Cuesta Herraiz, Patricia Fuentes Pita, Teresa Bermejo Gonzalez, Mar O'Callaghan, Federico Felipe Iglesias Santa Polonia, María Rosario Cazorla, María Teresa Ferrando Lucas, Antonio González-Meneses, Júlia Sala-Coromina, Alfons Macaya, Amaia Lasa-Aranzasti, Anna Ma Cueto-González, Francisca Valera Párraga, Jaume Campistol Plana, Mercedes Serrano, Xenia Alonso, Diego Del Castillo-Berges, Marc Schwartz-Palleja, Sofía Illescas, Alia Ramírez Camacho, Oscar Sans Capdevila, Angeles García-Cazorla, Àlex Bayés, Itziar Alonso-Colmenero
SYNGAP1 haploinsufficiency results in a developmental and epileptic encephalopathy (DEE) causing generalized epilepsies accompanied by a spectrum of neurodevelopmental symptoms. Concerning interictal epileptiform discharges (IEDs) in electroencephalograms (EEG), potential biomarkers have been postulated, including changes in background activity, fixation-off sensitivity (FOS) or eye closure sensitivity (ECS). In this study we clinically evaluate a new cohort of 36 SYNGAP1-DEE individuals. Standardized questionnaires were employed to collect clinical, electroencephalographic and genetic data...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38505259/roles-of-endogenous-retroviral-elements-in-the-establishment-and-maintenance-of-imprinted-gene-expression
#34
REVIEW
Sherry Fang, Kai-Wei Chang, Louis Lefebvre
DNA methylation (DNAme) has long been recognized as a host defense mechanism, both in the restriction modification systems of prokaryotes as well as in the transcriptional silencing of repetitive elements in mammals. When DNAme was shown to be implicated as a key epigenetic mechanism in the regulation of imprinted genes in mammals, a parallel with host defense mechanisms was drawn, suggesting perhaps a common evolutionary origin. Here we review recent work related to this hypothesis on two different aspects of the developmental imprinting cycle in mammals that has revealed unexpected roles for long terminal repeat (LTR) retroelements in imprinting, both canonical and noncanonical...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38505258/research-advances-of-polycomb-group-proteins-in-regulating-mammalian-development
#35
REVIEW
Yan Li, Yanxiang Mo, Chen Chen, Jin He, Zhiheng Guo
Polycomb group (PcG) proteins are a subset of epigenetic factors that are highly conserved throughout evolution. In mammals, PcG proteins can be classified into two muti-proteins complexes: Polycomb repressive complex 1 (PRC1) and PRC2. Increasing evidence has demonstrated that PcG complexes play critical roles in the regulation of gene expression, genomic imprinting, chromosome X-inactivation, and chromatin structure. Accordingly, the dysfunction of PcG proteins is tightly orchestrated with abnormal developmental processes...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38505257/primary-sarcopenia-is-associated-with-elevated-spontaneous-net-formation
#36
JOURNAL ARTICLE
Irina Balazs, Manuel Stelzer, Julia Traub, Angela Horvath, Nicole Feldbacher, Vanessa Stadlbauer
Introduction: Sarcopenia is a frequent complication of liver cirrhosis, but it can also occur independently as a result of any underlying cause. The immune system plays an important role in the pathogenesis of both liver cirrhosis and sarcopenia. Neutrophil function, including neutrophil extracellular trap (NET) formation, is linked to chronic inflammation; however, it has not been extensively studied in patients with sarcopenia. Here, we aim to study if main neutrophil functions, such as phagocytosis, reactive oxygen species (ROS) production, and NET formation, are altered in patients with sarcopenia with or without liver cirrhosis...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38500688/livestock-species-as-emerging-models-for-genomic-imprinting
#37
REVIEW
Jean-Noël Hubert, Mathilde Perret, Juliette Riquet, Julie Demars
Genomic imprinting is an epigenetically-regulated process of central importance in mammalian development and evolution. It involves multiple levels of regulation, with spatio-temporal heterogeneity, leading to the context-dependent and parent-of-origin specific expression of a small fraction of the genome. Genomic imprinting studies have therefore been essential to increase basic knowledge in functional genomics, evolution biology and developmental biology, as well as with regard to potential clinical and agrigenomic perspectives...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38500687/high-resolution-3d-ultrastructural-analysis-of-developing-mouse-neocortex-reveals-long-slender-processes-of-endothelial-cells-that-enter-neural-cells
#38
JOURNAL ARTICLE
Michaela Wilsch-Bräuninger, Jula Peters, Wieland B Huttner
The development of the neocortex involves an interplay between neural cells and the vasculature. However, little is known about this interplay at the ultrastructural level. To gain a 3D insight into the ultrastructure of the developing neocortex, we have analyzed the embryonic mouse neocortex by serial block-face scanning electron microscopy (SBF-SEM). In this study, we report a first set of findings that focus on the interaction of blood vessels, notably endothelial tip cells (ETCs), and the neural cells in this tissue...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38500686/comparison-of-three-dimensional-cell-culture-techniques-of-dedifferentiated-liposarcoma-and-their-integration-with-future-research
#39
JOURNAL ARTICLE
Sayumi Tahara, Soumya Sharma, Fernanda Costas Casal de Faria, Patricia Sarchet, Luisa Tomasello, Sydney Rentsch, Roma Karna, Federica Calore, Raphael E Pollock
Background: Dedifferentiated liposarcoma is a formidable sarcoma subtype due to its high local recurrence rate and resistance to medical treatment. While 2D cell cultures are still commonly used, 3D cell culture systems have emerged as a promising alternative, particularly scaffold-based techniques that enable the creation of 3D models with more accurate cell-stroma interactions. Objective: To investigate how 3D structures with or without the scaffold existence would affect liposarcoma cell lines growth morphologically and biologically...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38500685/cell-cell-interaction-in-the-pathogenesis-of-inherited-retinal-diseases
#40
REVIEW
Xue Du, Anna G Butler, Holly Y Chen
The retina is part of the central nervous system specialized for vision. Inherited retinal diseases (IRD) are a group of clinically and genetically heterogenous disorders that lead to progressive vision impairment or blindness. Although each disorder is rare, IRD accumulatively cause blindness in up to 5.5 million individuals worldwide. Currently, the pathophysiological mechanisms of IRD are not fully understood and there are limited treatment options available. Most IRD are caused by degeneration of light-sensitive photoreceptors...
2024: Frontiers in Cell and Developmental Biology
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