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Journals Frontiers in Cell and Developm...

Frontiers in Cell and Developmental Biology

https://read.qxmd.com/read/38544822/biophysical-interplay-between-extracellular-matrix-remodeling-and-hypoxia-signaling-in-regulating-cancer-metastasis
#1
REVIEW
Sun-Ah Lee, Gi-Ju Cho, Doyoung Kim, Dong-Hwee Kim
Mechanical properties of the tumor microenvironment play a critical role in cancer progression by activation of cancer mechano-responses. The biophysical interactions between cancer cells and their dynamic microenvironment are attributed to force-dependent alterations in molecular pathways that trigger the structural reorganization of intracellular organelles and their associated genetic modifications. Recent studies underscore the role of oxygen concentration in cancer metastasis. Suppressed oxygen levels promote the development of invasive phenotypes and aggressive proliferation of cancer cells, accompanied by remodeling of tumor microenvironment encompassing the modulation of physical settings of extracellular matrix...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38544821/micrornas-in-maxillofacial-bone-modeling-and-remodeling-implications-for-malocclusion-development-and-orthodontic-treatment
#2
REVIEW
Baike Chen, Yuxin Zhang, Ousheng Liu
Modeling and remodeling are essential processes in the development and refinement of maxillofacial bones. Dysregulated bone modeling during the developmental stage may lead to maxillofacial bone malformations and malocclusion. Bone remodeling under mechanical loading serves as the biological basis for orthodontic treatment. Although previous reviews have indicated the significance of microRNAs (miRNAs) in bone metabolism, their roles in orchestrating maxillofacial bone modeling and remodeling remain unclear...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38544820/oocyte-and-embryo-culture-under-oil-profoundly-alters-effective-concentrations-of-small-molecule-inhibitors
#3
JOURNAL ARTICLE
Gaudeline Rémillard-Labrosse, Sydney Cohen, Éliane Boucher, Kéryanne Gagnon, Filip Vasilev, Aleksandar I Mihajlović, Greg FitzHarris
Culture of oocytes and embryos in media under oil is a cornerstone of fertility treatment, and extensively employed in experimental investigation of early mammalian development. It has been noted anecdotally by some that certain small molecule inhibitors might lose activity in oil-covered culture systems, presumably by drug partitioning into the oil. Here we took a pseudo-pharmacological approach to appraise this formally using mouse oocytes and embryos. Using different culture dish designs with defined media:oil volume ratios, we show that the EC50 of the widely employed microtubule poison nocodazole shifts as a function of the media:oil ratio, such that nocodazole concentrations that prevent cell division in oil-free culture fail to in oil-covered media drops...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38544819/gene-expression-and-cellular-changes-in-injured-myocardium-of-ciona-intestinalis
#4
JOURNAL ARTICLE
Serenity Stokes, Pooja Pardhanani Palmer, Jeremy L Barth, Robert L Price, Bella G Parker, Heather J Evans Anderson
Ciona intestinalis is an invertebrate animal model system that is well characterized and has many advantages for the study of cardiovascular biology. The regulatory mechanisms of cardiac myocyte proliferation in Ciona are intriguing since regeneration of functional tissue has been demonstrated in other organs of Ciona in response to injury . To identify genes that are differentially expressed in response to Ciona cardiac injury, microarray analysis was conducted on RNA from adult Ciona hearts with normal or damaged myocardium...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38544818/early-onset-of-apc-c-activity-renders-sac-inefficient-in-mouse-embryos
#5
JOURNAL ARTICLE
Adela Horakova, Marketa Konecna, Lenka Radonova, Martin Anger
Control mechanisms of spindle assembly and chromosome segregation are vital for preventing aneuploidy during cell division. The mammalian germ cells and embryos are prone to chromosome segregation errors, and the resulting aneuploidy is a major cause of termination of development or severe developmental disorders. Here we focused on early mouse embryos, and using combination of methods involving microinjection, immunodetection and confocal live cell imaging, we concentrated on the Spindle Assembly Checkpoint (SAC) and Anaphase Promoting Complex/Cyclosome (APC/C)...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38544817/exploring-the-neuroprotective-activity-of-a-lignanamides-rich-extract-in-human-neuroblastoma-sh-sy5y-cells-under-dimethyl-sulfoxide-induced-stress
#6
JOURNAL ARTICLE
Marta Mallardo, Severina Pacifico, Simona Piccolella, Irene Di Meo, Maria Rosaria Rizzo, Aurora Daniele, Ersilia Nigro
Introduction: Dimethyl sulfoxide (DMSO) is widely used as a diluent and/or solvent for pharmacological compounds. Furthermore, DMSO crosses the blood-brain barrier acting on the nervous system. The natural compounds phenylamides and lignanamides (LnHS) have protective effects on neuronal health, being promising neuroprotective candidates. In this scenario, we evaluated the impact of DMSO and/or LnHS on SH-SY5Y and U-87 cells, taken as in vitro model of neurons and glia. Methods: Cells were treated with DMSO and/or LnHS at different doses and proliferation (MTT and trypan blue counting, colony forming ability, autophagy, oxidative stress (NO, ROS determination) and inflammatory (IL8, IL6, TNFα mRNA expression) response was evaluated...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38544816/multiplexing-of-tmt-labeling-reveals-folate-deficient-diet-specific-proteome-changes-in-ntds
#7
JOURNAL ARTICLE
Pei Pei, Jinying Shen, Xuejia He, Yubing Zeng, Ting Zhang, Shan Wang
Introduction: In the early stage of embryonic development, the neural tube (NT) cannot be closed properly due to some complex factors, including environmental factors, genetic factors, and the relationship between various factors, leading to the occurrence of neural tube defects (NTDs). Methods: In this study, we induced a mouse model of NTDs by feeding mice with a low-folate diet and intraperitoneally injecting them with 1.5 mg/kg methotrexate on E7.5. Fetal mice were achieved at E13.5, and we extracted proteins from brain tissues with trypsin digestion...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38533089/novel-lipid-mediator-7-s-14-r-docosahexaenoic-acid-biogenesis-and-harnessing-mesenchymal-stem-cells-to-ameliorate-diabetic-mellitus-and-retinal-pericyte-loss
#8
JOURNAL ARTICLE
Yan Lu, Haibin Tian, Hongying Peng, Quansheng Wang, Bruce A Bunnell, Nicolas G Bazan, Song Hong
Introduction: Stem cells can be used to treat diabetic mellitus and complications. ω3-docosahexaenoic acid (DHA) derived lipid mediators are inflammation-resolving and protective. This study found novel DHA-derived 7 S ,14 R -dihydroxy-4 Z ,8 E ,10 Z ,12 E ,16 Z ,19 Z -docosahexaenoic acid (7 S ,14 R -diHDHA), a maresin-1 stereoisomer biosynthesized by leukocytes and related enzymes. Moreover, 7 S ,14 R -diHDHA can enhance mesenchymal stem cell (MSC) functions in the amelioration of diabetic mellitus and retinal pericyte loss in diabetic db/db mice...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38533088/deficiency-of-mastl-a-mitotic-regulator-results-in-cell-detachment-from-developing-tissues-of-zebrafish-embryos
#9
JOURNAL ARTICLE
Hideko Utsumi, Taijiro Yabe, Sumito Koshida, Akira Yamashita, Shinji Takada
To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may cause such contacts to be temporarily weakened, risking improper development and maintenance of tissues. Despite such risks, tissues form properly during normal development. However, it is not well understood whether mitotic abnormalities affect tissue formation...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38533087/editorial-infectious-disease-agents-and-cancer
#10
EDITORIAL
Ana Igea, Océane C B Martin, Tomer Cooks, Ioannis S Pateras
No abstract text is available yet for this article.
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38533086/gene-networks-and-the-evolution-of-olfactory-organs-eyes-hair-cells-and-motoneurons-a-view-encompassing-lancelets-tunicates-and-vertebrates
#11
REVIEW
Bernd Fritzsch, Joel C Glover
Key developmental pathways and gene networks underlie the formation of sensory cell types and structures involved in chemosensation, vision and mechanosensation, and of the efferents these sensory inputs can activate. We describe similarities and differences in these pathways and gene networks in selected species of the three main chordate groups, lancelets, tunicates, and vertebrates, leading to divergent development of olfactory receptors, eyes, hair cells and motoneurons. The lack of appropriately posited expression of certain transcription factors in lancelets and tunicates prevents them from developing vertebrate-like olfactory receptors and eyes, although they generate alternative structures for chemosensation and vision...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38533085/membrane-trafficking-alterations-in-breast-cancer-progression
#12
REVIEW
Andreia Ferreira, Pedro Castanheira, Cristina Escrevente, Duarte C Barral, Teresa Barona
Breast cancer (BC) is the most common type of cancer in women, and remains one of the major causes of death in women worldwide. It is now well established that alterations in membrane trafficking are implicated in BC progression. Indeed, membrane trafficking pathways regulate BC cell proliferation, migration, invasion, and metastasis. The 22 members of the ADP-ribosylation factor (ARF) and the >60 members of the rat sarcoma (RAS)-related in brain (RAB) families of small GTP-binding proteins (GTPases), which belong to the RAS superfamily, are master regulators of membrane trafficking pathways...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38533084/forward-genetic-screen-using-a-gene-breaking-trap-approach-identifies-a-novel-role-of-grin2bb-associated-rna-transcript-grin2bbart-in-zebrafish-heart-function
#13
JOURNAL ARTICLE
Ramcharan Singh Angom, Adita Joshi, Ashok Patowary, Ambily Sivadas, Soundhar Ramasamy, Shamsudheen K V, Kriti Kaushik, Ankit Sabharwal, Mukesh Kumar Lalwani, Subburaj K, Naresh Singh, Vinod Scaria, Sridhar Sivasubbu
LncRNA-based control affects cardiac pathophysiologies like myocardial infarction, coronary artery disease, hypertrophy, and myotonic muscular dystrophy. This study used a gene-break transposon (GBT) to screen zebrafish ( Danio rerio ) for insertional mutagenesis. We identified three insertional mutants where the GBT captured a cardiac gene. One of the adult viable GBT mutants had bradycardia (heart arrhythmia) and enlarged cardiac chambers or hypertrophy; we named it "bigheart." Bigheart mutant insertion maps to grin2bb or N-methyl D-aspartate receptor (NMDAR2B) gene intron 2 in reverse orientation...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38529408/identification-of-testis-development-related-genes-by-combining-iso-seq-and-rna-seq-in-zeugodacus-tau
#14
JOURNAL ARTICLE
Peipei Liu, Ziniu Li, Qiuyuan Zhang, Jiao Qiao, Chenjun Zheng, Wenping Zheng, Hongyu Zhang
Introduction: Zeugodacus tau (Walker) is an invasive pest. An effective method to control this pest is the sterile insect technique (SIT). To better apply this technique, it is necessary to understand testis development progression. Methods: Differentially expressed genes (DEGs) during testis development were analyzed by PacBio Iso-Seq and RNA-seq. Results: RNA-Seq library of Z. tau testes on day 1, 6, and 11 post eclosion were constructed. We identified 755 and 865 differentially expressed genes in the comparisons of T6 (testes on day 6) vs...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38529407/direct-male-development-in-chromosomally-zz-zebrafish
#15
JOURNAL ARTICLE
Catherine A Wilson, Peter Batzel, John H Postlethwait
The genetics of sex determination varies across taxa, sometimes even within a species. Major domesticated strains of zebrafish ( Danio rerio ), including AB and TU, lack a strong genetic sex determining locus, but strains more recently derived from nature, like Nadia (NA), possess a ZZ male/ZW female chromosomal sex-determination system. AB fish pass through a juvenile ovary stage, forming oocytes that survive in fish that become females but die in fish that become males. To understand mechanisms of gonad development in NA zebrafish, we studied histology and single cell transcriptomics in developing ZZ and ZW fish...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38529406/the-epithelium-takes-the-stage-in-asthma-and-inflammatory-bowel-diseases
#16
REVIEW
Rocío López-Posadas, Dustin C Bagley, Carlos Pardo-Pastor, Elena Ortiz-Zapater
The epithelium is a dynamic barrier and the damage to this epithelial layer governs a variety of complex mechanisms involving not only epithelial cells but all resident tissue constituents, including immune and stroma cells. Traditionally, diseases characterized by a damaged epithelium have been considered "immunological diseases," and research efforts aimed at preventing and treating these diseases have primarily focused on immuno-centric therapeutic strategies, that often fail to halt or reverse the natural progression of the disease...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38529405/superior-migration-ability-of-umbilical-cord-derived-mesenchymal-stromal-cells-mscs-toward-activated-lymphocytes-in-comparison-with-those-of-bone-marrow-and-adipose-derived-mscs
#17
JOURNAL ARTICLE
Akiko Hori, Atsuko Takahashi, Yuta Miharu, Satoru Yamaguchi, Masatoshi Sugita, Takeo Mukai, Fumitaka Nagamura, Tokiko Nagamura-Inoue
Introduction: Mesenchymal stromal cells (MSCs) are activated upon inflammation and/or tissue damage and migrate to suppress inflammation and repair tissues. Migration is the first important step for MSCs to become functional; however, the migration potency of umbilical cord-derived MSCs (UC-MSCs) remains poorly understood. Thus, we aimed to assess the migration potency of UC-MSCs in comparison with those of bone marrow-derived MSCs (BM-MSCs) and adipose tissue-derived MSCs (AD-MSCs) and investigate the influence of chemotactic factors on the migration of these cells...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38523628/cellular-abundance-based-prognostic-model-associated-with-deregulated-gene-expression-of-leukemic-stem-cells-in-acute-myeloid-leukemia
#18
JOURNAL ARTICLE
Dong-Jin Han, Sunmin Kim, Seo-Young Lee, Su Jung Kang, Youngbeen Moon, Hoon Seok Kim, Myungshin Kim, Tae-Min Kim
Background: Previous studies have reported that genes highly expressed in leukemic stem cells (LSC) may dictate the survival probability of patients and expression-based cellular deconvolution may be informative in forecasting prognosis. However, whether the prognosis of acute myeloid leukemia (AML) can be predicted using gene expression and deconvoluted cellular abundances is debatable. Methods: Nine different cell-type abundances of a training set composed of the AML samples of 422 patients, were used to build a model for predicting prognosis by least absolute shrinkage and selection operator Cox regression...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38523627/communication-molecules-ncrnas-mediate-tumor-associated-macrophage-polarization-and-tumor-progression
#19
REVIEW
Min Yao, Xuhua Mao, Zherui Zhang, Feilun Cui, Shihe Shao, Boneng Mao
Non-coding RNAs play important roles in tumor cells and macrophages and participate in their communication as messengers. Non-coding RNAs have an impact in tumor cell proliferation, migration, and apoptosis, and they also regulate the differentiation and regulation of immune cells. In macrophages, they stimulate the polarization of macrophages into M1 or M2 by regulating proteins related to signaling pathways; in tumor cells, non-coding RNAs can enter macrophages through exosomes and affect the latter polarization...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38523626/editorial-rna-binding-proteins-in-cancer-advances-in-translational-research
#20
EDITORIAL
Caterina Mancarella, Nadine Bley, Luiz O F Penalva
No abstract text is available yet for this article.
2024: Frontiers in Cell and Developmental Biology
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