Journals International Journal of Bipol...

International Journal of Bipolar Disorders
Diego Hidalgo-Mazzei, Tim Mantingh, Xavier Pérez de Mendiola, Ludovic Samalin, Juan Undurraga, Sergio Strejilevich, Emanuel Severus, Michael Bauer, Ana González-Pinto, Willem A Nolen, Allan H Young, Eduard Vieta
BACKGROUND: Lithium has long been considered the gold-standard pharmacological treatment for the maintenance treatment of bipolar disorders (BD) which is supported by a wide body of evidence. Prior research has shown a steady decline in lithium prescriptions during the last two decades. We aim to identify potential factors explaining this decline across the world with an anonymous worldwide survey developed by the International Society for Bipolar Disorders (ISBD) Task Force "Role of Lithium in Bipolar Disorders" and distributed by diverse academic and professional international channels...
May 27, 2023: International Journal of Bipolar Disorders
Yijun Shao, Yan Cheng, Srikanth Gottipati, Qing Zeng-Treitler
BACKGROUND: Detecting prodromal symptoms of bipolar disorder (BD) has garnered significant attention in recent research, as early intervention could potentially improve therapeutic efficacy and improve patient outcomes. The heterogeneous nature of the prodromal phase in BD, however, poses considerable challenges for investigators. Our study aimed to identify distinct prodromal phenotypes or "fingerprints" in patients diagnosed with BD and subsequently examine correlations between these fingerprints and relevant clinical outcomes...
May 18, 2023: International Journal of Bipolar Disorders
Abigail Ortiz, Yunkyung Park, Christina Gonzalez-Torres, Martin Alda, Daniel M Blumberger, Rachael Burnett, M Ishrat Husain, Marcos Sanches, Benoit H Mulsant
BACKGROUND: Several studies have reported on the feasibility of electronic (e-)monitoring using computers or smartphones in patients with mental disorders, including bipolar disorder (BD). While studies on e-monitoring have examined the role of demographic factors, such as age, gender, or socioeconomic status and use of health apps, to our knowledge, no study has examined clinical characteristics that might impact adherence with e-monitoring in patients with BD. We analyzed adherence to e-monitoring in patients with BD who participated in an ongoing e-monitoring study and evaluated whether demographic and clinical factors would predict adherence...
May 17, 2023: International Journal of Bipolar Disorders
Kevin Li, Erica Richards, Fernando S Goes
BACKGROUND: Across clinical settings, black individuals are disproportionately less likely to be diagnosed with bipolar disorder compared to schizophrenia, a traditionally more severe and chronic disorder with lower expectations for remission. The causes of this disparity are likely multifactorial, ranging from the effects of implicit bias, to developmental and lifelong effects of structural racism, to differing cultural manifestations of psychiatric symptoms and distress. While prior studies examining differences have found a greater preponderance of specific psychotic symptoms (such as persecutory delusions and hallucinations) and a more dysphoric/mixed mania presentation in Black individuals, these studies have been limited by a lack of systematic phenotypic assessment and small sample sizes...
May 11, 2023: International Journal of Bipolar Disorders
C Marie-Claire, C Courtin, F Bellivier, S Gard, M Leboyer, J Scott, B Etain
BACKGROUND: Response to lithium (Li) is highly variable in bipolar disorders (BD). Despite decades of research, no clinical predictor(s) of response to Li prophylaxis have been consistently identified. Recently, we developed epigenetic Methylation Specific High-Resolution Melting (MS-HRM) assays able to discriminate good responders (GR) from non-responders (NR) to Li in individuals with BD type 1 (BD-I). This study examined whether a combination of clinical and epigenetic markers can distinguish NR from other types of Li responders...
April 29, 2023: International Journal of Bipolar Disorders
Diego J Martino, Marina P Valerio
No abstract text is available yet for this article.
April 28, 2023: International Journal of Bipolar Disorders
Beny Lafer, Cicera Claudinea Duarte, Julia Maria D'Andrea Greve, Paulo Roberto Dos Santos Silva, Karla Mathias de Almeida, Gabriel Okawa Belizario, Lucas Melo Neves
BACKGROUND: Physical exercise (PE) is a recommended lifestyle intervention for different mental disorders and has shown specific positive therapeutic effects in unipolar depressive disorder. Considering the similar symptomatology of the depressive phase in patients with bipolar disorder (BD) and unipolar depressive disorder, it is reasonable to suggest that PE may also be beneficial for bipolar depression. However, there is an absence of studies evaluating the antidepressant effect of a structured PE intervention in BD...
April 21, 2023: International Journal of Bipolar Disorders
J E Siegel-Ramsay, S J Sharp, C J Ulack, K S Chiang, T Lanza di Scalea, S O'Hara, K Carberry, S M Strakowski, J Suarez, E Teisberg, S Wallace, J R C Almeida
BACKGROUND: When assessing the value of an intervention in bipolar disorder, researchers and clinicians often focus on metrics that quantify improvements to core diagnostic symptoms (e.g., mania). Providers often overlook or misunderstand the impact of treatment on life quality and function. We wanted to better characterize the shared experiences and obstacles of bipolar disorder within the United States from the patient's perspective. METHODS: We recruited 24 individuals diagnosed with bipolar disorder and six caretakers supporting someone with the condition...
April 20, 2023: International Journal of Bipolar Disorders
Fumika Kondo, Jocelyne C Whitehead, Fernando Corbalán, Serge Beaulieu, Jorge L Armony
BACKGROUND: Bipolar disorder type-I (BD-I) patients are known to show emotion regulation abnormalities. In a previous fMRI study using an explicit emotion regulation paradigm, we compared responses from 19 BD-I patients and 17 matched healthy controls (HC). A standard general linear model-based univariate analysis revealed that BD patients showed increased activations in inferior frontal gyrus when instructed to decrease their emotional response as elicited by neutral images. We implemented multivariate pattern recognition analyses on the same data to examine if we could classify conditions within-group as well as HC versus BD...
March 25, 2023: International Journal of Bipolar Disorders
I Zorrilla, S Lopez-Zurbano, S Alberich, I Barbero, P Lopez-Pena, E García-Corres, J P Chart Pascual, J M Crespo, C de Dios, V Balanzá-Martínez, A Gonzalez-Pinto
BACKGROUND: Patients should get actively involved in the management of their illness. The aim of this study was to assess the influence of lifestyle factors, including sleep, diet, and physical activity, on lithium levels in patients with bipolar disorder. METHODS: A multicenter study was performed. In total, 157 lithium measurements were done biweekly in a sample of 65 patients (35 women) over 6 weeks. Lifestyle, based on total sleep hours and physical activity, was assessed by actigraphy...
March 16, 2023: International Journal of Bipolar Disorders
Tiffany Resendes, Lisa Serravalle, Vanessa Iacono, Mark A Ellenbogen
BACKGROUND: Offspring of parents with bipolar disorder (OBD) are at risk for developing mental disorders, and the literature suggests that parenting stress may represent an important risk factor linking parental psychopathology to offspring psychopathology. We aimed to investigate whether improvements in parenting stress mediated the relationship between participation in a prevention program and offspring internalizing and externalizing symptoms at follow-up. METHODS: Families having a parent with BD (N = 25) underwent a 12-week prevention program...
February 27, 2023: International Journal of Bipolar Disorders
Maryam Latifian, Kianoush Abdi, Ghoncheh Raheb, Sheikh Mohammed Shariful Islam, Rosa Alikhani
BACKGROUND: Stigma affects different life aspects in people living with bipolar disorder and their families. This study aimed to examining the experience of stigma and evaluating predictors, consequences and strategies to combat stigma in people with bipolar disorder and their families. METHODS: We conducted a systematic review according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) in 2022. We extensively reviewed six online databases (PubMed, Scopus, Medline, EMBASE, Web of Science and Google Scholar)...
February 20, 2023: International Journal of Bipolar Disorders
Delfina Janiri, Gaia Sampogna, Umberto Albert, Filippo Caraci, Giovanni Martinotti, Gianluca Serafini, Alfonso Tortorella, Alessandro Zuddas, Andrea Fiorillo, Gabriele Sani
BACKGROUND: Lithium is one of the most consistently effective treatment for mood disorders. However, patients may show a high level of heterogeneity in treatment response across the lifespan. In particular, the benefits of lithium use may vary in special clinical conditions. The aim of this study was to test this hypothesis by conducting an umbrella review on the efficacy and safety of lithium in childhood and adolescence, peripartum and old age. METHODS: We applied the Preferred Reporting Items for Systematic Reviews and Meta-analyses criteria (PRISMA) to identify systematic reviews/meta-analyses on the efficacy and/or safety of lithium in mood disorders in special clinical conditions: (i) childhood and adolescence; (ii) peripartum (pregnancy, postpartum and lactation); (iii) old age...
February 12, 2023: International Journal of Bipolar Disorders
Hernán Guillen-Burgos, Sergio Moreno-Lopez, Kaleb Acevedo-Vergara, Manuel Pérez-Florez, Catherine Pachón-Garcia, Juan Francisco Gálvez-Flórez
BACKGROUND: Bipolar disorder (BD) is higher in developing countries. Childhood trauma exposure is a common environmental risk factor in Colombia and might be associated with a more severe course of bipolar disorder in Low-Middle Income-Countries. We carried out the first case-control study in Colombia using a structural clinical interview and the Childhood Trauma Questionnaire-Short Form (CTQ-SF) to describe the prevalence and association between trauma exposure during childhood with a severe course of illness (early age onset, rapid cycling, ideation or suicide attempt, or ≥ 3 hospitalization) in a sample of BD patients...
February 10, 2023: International Journal of Bipolar Disorders
Brett D M Jones, Madeha Umer, Mary E Kittur, Ofer Finkelstein, Siqi Xue, Mikaela K Dimick, Abigail Ortiz, Benjamin I Goldstein, Benoit H Mulsant, Muhammad I Husain
BACKGROUND: Evidence-based psychotherapies available to treat patients with bipolar disorders (BD) are limited. Dialectical behavior therapy (DBT) may target several common symptoms of BD. We conducted a systematic review on the efficacy of DBT for mood symptoms in patients with BD. The systematic search used key words related to DBT and BD in Medline, Embase, PsycInfo, CINAHL, and Cochrane Library databases from 1980 to April 1st, 2022. We included studies that enrolled patients with a BD I or II diagnosis (DSM or ICD), age 12 and older who received a DBT-based intervention...
February 5, 2023: International Journal of Bipolar Disorders
Helle B Krogh, Maj Vinberg, Gitte Lee Mortensen, Ditte Skakke, Dorthe Nielsen, Annamaria Giraldi
BACKGROUND: Individuals with mental health disorders have a higher risk of sexual problems impacting intimate relations and quality of life. For individuals with bipolar disorder (BD) the mood shifts might to a particular degree affect their sexual function with possible hypersexual interest during manic episodes and low sexual interest during depressive episodes. The diagnosis is often given in late adolescence, which may impact sexual identity and development. Only a few studies have looked at BD and sexual life, with no qualitative research on the topic...
February 3, 2023: International Journal of Bipolar Disorders
Elise Boivin, Brendan Le Daré, Romain Bellay, Cécile Vigneau, Marion Mercerolle, Astrid Bacle
BACKGROUND: Lithium is well recognized as the first-line maintenance treatment for bipolar disorder (BD). However, besides therapeutic benefits attributed to lithium therapy, the associated side effects including endocrinological and renal disorders constitute important parameters in prescribing patterns and patient adherence. The objectives of this study is to (i) determine whether long-term lithium therapy is associated with a decrease in renal function, hyperparathyroidism and hypercalcemia and (ii) identify risk factors for lithium-induced chronic kidney disease (CKD)...
January 29, 2023: International Journal of Bipolar Disorders
Xinyue Jiang, Alysha A Sultan, Mikaela K Dimick, Clement C Zai, James L Kennedy, Bradley J MacIntosh, Benjamin I Goldstein
BACKGROUND: CACNA1C rs1006737 A allele, identified as a genetic risk variant for bipolar disorder (BD), is associated with anomalous functional connectivity in adults with and without BD. Studies have yet to investigate the association of CACNA1C rs1006737 with resting-state functional connectivity (rsFC) in youth BD. METHODS: Participants included 139 youth with BD-I, -II, or -not otherwise specified, ages 13-20 years, including 27 BD A-carriers, 41 BD non-carriers, 32 healthy controls (HC) A-carriers, and 39 HC non-carriers...
January 13, 2023: International Journal of Bipolar Disorders
Dung Ezekiel Jidong, M Ishrat Husain, Tarela J Ike, Nusrat Husain, Maigari Yusufu Taru, Nwoga Charles Nnaemeka, Christopher Francis, David B Jack, Shadrack B Mwankon, Siqi Xue, Juliet Y Pwajok, Pam P Nyam, Maisha Murshed
BACKGROUND: Bipolar Disorders (BDs) are chronic mental health disorders that often result in functional impairment and contribute significantly to the disability-adjusted life years (DALY). BDs are historically under-researched compared to other mental health disorders, especially in Sub-Saharan Africa and Nigeria. DESIGN: We adopted a mixed-methods design. Study 1 examined the public knowledge of BDs in relation to sociodemographic outcomes using quantitative data whilst Study 2 qualitatively assessed the lived experiences of patients with BDs, clinicians, and family caregivers...
January 7, 2023: International Journal of Bipolar Disorders
A Ratheesh, D Hett, J Ramain, E Wong, L Berk, P Conus, M A Fristad, T Goldstein, M Hillegers, S Jauhar, L V Kessing, D J Miklowitz, G Murray, J Scott, M Tohen, L N Yatham, A H Young, M Berk, S Marwaha
BACKGROUND: Given the likelihood of progressive illness in bipolar disorder (BD), it is important to understand the benefits and risks of interventions administered early in illness course. We conducted a systematic review of the effectiveness of interventions in the early course of BD I or II. METHODS: We completed a systematic search on MEDLINE, PsycINFO, EMBASE, the Cochrane Central Register of Controlled Trials, CINAHL and Google Scholar from 1/1/1979 till 14/9/2022...
January 3, 2023: International Journal of Bipolar Disorders
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