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JOURNAL ARTICLE
Mihaela Golic, Harald Aiff, Per-Ola Attman, Bernd Ramsauer, Staffan Schön, Steinn Steingrimsson, Jan Svedlund
BACKGROUND: Lithium is an essential psychopharmaceutical, yet side effects and concerns about severe renal function impairment limit its usage. AIMS: Our objectives were to quantify the occurrence of chronic kidney disease stage 4 or higher (CKD4 +) within a lithium-treated population, using age- and time-specific cumulative incidence and age-specific lifetime risk as measures of disease occurrence. Additionally, we aimed to investigate the association between the duration of lithium treatment and the risk of CKD4 + ...
December 9, 2023: International Journal of Bipolar Disorders
#2
JOURNAL ARTICLE
Alessandro Miola, Manuel Gardea-Reséndez, Javier Ortiz-Orendain, Nicolas A Nunez, Mete Ercis, Brandon J Coombes, Manuel Fuentes Salgado, Peggy M Gruhlke, Ian Michel, J Michael Bostwick, Alastair J McKean, Aysegul Ozerdem, Mark A Frye
BACKGROUND: Factors associated with suicide attempts during the antecedent illness trajectory of bipolar disorder (BD) and schizophrenia (SZ) are poorly understood. METHODS: Utilizing the Rochester Epidemiology Project, individuals born after 1985 in Olmsted County, MN, presented with first episode mania (FEM) or psychosis (FEP), subsequently diagnosed with BD or SZ were identified. Patient demographics, suicidal ideation with plan, self-harm, suicide attempts, psychiatric hospitalizations, substance use, and childhood adversities were quantified using the electronic health record...
December 8, 2023: International Journal of Bipolar Disorders
#3
REVIEW
Annakarina Mundorf, Jette Borawski, Sebastian Ocklenburg
BACKGROUND: Bipolar disorder (BD) is often seen as a bridge between schizophrenia and depression in terms of symptomatology and etiology. Interestingly, hemispheric asymmetries as well as behavioral lateralization are shifted towards a tendency of left-side or mixed-side bias in schizophrenia whereas no shift is observed in subjects with depression. Given the role of BD with both, (hypo)manic and depressive episodes, investigating hemispheric asymmetries in subjects with BD is an interesting objective...
December 1, 2023: International Journal of Bipolar Disorders
#4
JOURNAL ARTICLE
Essi Whaites Heinonen, Katarina Tötterman, Karin Bäck, Ihsan Sarman, Lisa Forsberg, Jenny Svedenkrans
BACKGROUND: Neonatal effects of late intrauterine and early postpartum exposure to lithium through mother's own milk are scarcely studied. It is unclear whether described symptoms in breastfed neonates are caused by placental lithium transfer or postnatal exposure to lithium through breastfeeding. We aimed to investigate lithium clearance and neonatal morbidity in breastfed infants with high versus low serum lithium concentrations at birth. METHODS: This retrospective study focused on breastfed infants to women treated with lithium during and after pregnancy, born between 2006 and 2021 in Stockholm, Sweden...
November 30, 2023: International Journal of Bipolar Disorders
#5
REVIEW
Michael Gitlin, Michael Bauer
For over half a century, it has been widely known that lithium is the most efficacious maintenance treatment for bipolar disorder. Despite thorough research on the long-term effects of lithium on renal function, a number of important questions relevant to clinical practice remain. The risk of polyuria, reflecting renal tubular dysfunction, is seen in a substantial proportion of patients treated with long term lithium therapy. The duration of lithium may be the most important risk factor for lithium-induced polyuria...
November 16, 2023: International Journal of Bipolar Disorders
#6
JOURNAL ARTICLE
Waldemar Greil, Mateo de Bardeci, Bruno Müller-Oerlinghausen, Nadja Nievergelt, Hans Stassen, Gregor Hasler, Andreas Erfurth, Katja Cattapan, Eckart Rüther, Johanna Seifert, Sermin Toto, Stefan Bleich, Georgios Schoretsanitis
BACKGROUND: The impact of long-term lithium treatment on weight gain has been a controversial topic with conflicting evidence. We aim to assess reporting of weight gain associated with lithium and other mood stabilizers compared to lamotrigine which is considered free of metabolic adverse drug reactions (ADRs). METHODS: We conducted a case/non-case pharmacovigilance study using data from the AMSP project (German: "Arzneimittelsicherheit in der Psychiatrie"; i.e...
October 15, 2023: International Journal of Bipolar Disorders
#7
JOURNAL ARTICLE
Gianluca Rosso, Giuseppe Maina, Elena Teobaldi, Ilaria Balbo, Gabriele Di Salvo, Francesca Montarolo, Nicola Rizzo Pesci, Filippo Tempia, Eriola Hoxha
BACKGROUND: The differential diagnosis of patients presenting for the first time with a depressive episode into unipolar disorder versus bipolar disorder is crucial to establish the correct pharmacological therapy (antidepressants vs mood stabilizers), but no biological markers are currently available. Several lines of evidence indicate an involvement of Glycogen Synthase Kinase-3 (GSK3) in the pathophysiology of depression. However, previous reports about GSK3 in peripheral blood were incomplete or inconsistent, so a specific marker is not yet available...
October 8, 2023: International Journal of Bipolar Disorders
#8
JOURNAL ARTICLE
Victória A Müller Ewald, Nicholas T Trapp, McCall E Sarrett, Benjamin D Pace, Linder Wendt, Jenny G Richards, Ilisa K Gala, Jacob N Miller, Jan R Wessel, Vincent A Magnotta, John A Wemmie, Aaron D Boes, Krystal L Parker
BACKGROUND: Widely reported by bipolar disorder (BD) patients, cognitive symptoms, including deficits in executive function, memory, attention, and timing are under-studied. Work suggests that individuals with BD show impairments in interval timing tasks, including supra-second, sub-second, and implicit motor timing compared to the neuronormative population. However, how time perception differs within individuals with BD based on disorder sub-type (BDI vs II), depressed mood, or antipsychotic medication-use has not been thoroughly investigated...
October 1, 2023: International Journal of Bipolar Disorders
#9
JOURNAL ARTICLE
Kamilla Woznica Miskowiak, Katrine Bang Hansen, Johanna Mariegaard, Lars Vedel Kessing
BACKGROUND: Childhood trauma (CT) are frequently reported by patients with bipolar disorder (BD), but it is unclear whether and how CT contribute to patients' cognitive and psychosocial impairments. We aimed to examine the impact of CT on cognition and psychosocial functioning in a large sample of 345 patients with BD and 183 healthy control participants (HC) using the Childhood Trauma Questionnaire, neurocognitive tests and ratings of mood symptoms and functioning. RESULTS: Patients showed broad cognitive impairments across memory, attention and executive function and functional disability despite being in partial or full remission and had higher levels of CT than HC...
September 20, 2023: International Journal of Bipolar Disorders
#10
REVIEW
Gin S Malhi, Erica Bell, Maedeh Jadidi, Michael Gitlin, Michael Bauer
For over half a century, it has been widely known that lithium is the most efficacious treatment for bipolar disorder. Yet, despite this, its prescription has consistently declined over this same period of time. A number of reasons for this apparent disparity between evidence and clinical practice have been proposed, including a lack of confidence amongst clinicians possibly because of an absence of training and lack of familiarity with the molecule. Simultaneously, competition has grown within the pharmacological armamentarium for bipolar disorder with newer treatments promoting an image of being safer and easier to prescribe primarily because of not necessitating plasma monitoring, which understandably is appealing to patients who then exercise their preferences accordingly...
August 26, 2023: International Journal of Bipolar Disorders
#11
LETTER
Gin S Malhi, Maedeh Jadidi, Erica Bell
No abstract text is available yet for this article.
August 26, 2023: International Journal of Bipolar Disorders
#12
JOURNAL ARTICLE
Andrew Nierenberg, Philip Lavin, Daniel C Javitt, Richard Shelton, Michael T Sapko, Sanjay Mathew, Robert E Besthof, Jonathan C Javitt
BACKGROUND: We tested the hypothesis that, after initial improvement with intravenous ketamine in patients with bipolar disorder (BD) with severe depression and acute suicidal thinking or behavior, a fixed-dose combination of oral D-cycloserine (DCS) and lurasidone (NRX-101) can maintain improvement more effectively than lurasidone alone. METHODS: This was a multi-center, double-blind, twostage, parallel randomized trial. Adult BD patients with depression and suicidal ideation or behavior were infused with ketamine or saline (Stage 1); those who improved were randomized to a fixed-dose combination of DCS and lurasidone vs...
August 13, 2023: International Journal of Bipolar Disorders
#13
JOURNAL ARTICLE
Craig Steel, Kim Wright, Guy M Goodwin, Judit Simon, Nicola Morant, Rod S Taylor, Michael Brown, Susie Jennings, Susie A Hales, Jemma Regan, Michaela Sibsey, Zoe Thomas, Lynette Meredith, Emily A Holmes
BACKGROUND: Intrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured psychological intervention developed to enable people to use the skills required to regulate the emotional impact of these images. METHODS: Participants aged 18 and over with a diagnosis of bipolar disorder and at least a mild level of anxiety were randomly assigned (1:1) to receive IBER plus treatment as usual (IBER + TAU) or treatment as usual alone (TAU)...
July 22, 2023: International Journal of Bipolar Disorders
#14
JOURNAL ARTICLE
Ryobu Tachi, Kazutaka Ohi, Daisuke Nishizawa, Midori Soda, Daisuke Fujikane, Junko Hasegawa, Ayumi Kuramitsu, Kentaro Takai, Yukimasa Muto, Shunsuke Sugiyama, Kiyoyuki Kitaichi, Ryota Hashimoto, Kazutaka Ikeda, Toshiki Shioiri
BACKGROUND: Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role. Some studies have investigated whether genetic variants in the mitochondrial chromosome are associated with BD and SZ. However, the genetic variants identified as being associated are not identical among studies, and the participants were limited to individuals of European ancestry. Here, we investigate associations of genome-wide genetic variants in the mitochondrial chromosome with BD, SZ, and PSY in a Japanese population...
July 21, 2023: International Journal of Bipolar Disorders
#15
JOURNAL ARTICLE
Giulio Emilio Brancati, Abraham Nunes, Katie Scott, Claire O'Donovan, Pablo Cervantes, Paul Grof, Martin Alda
BACKGROUND: The distinction between bipolar I and bipolar II disorder and its treatment implications have been a matter of ongoing debate. The aim of this study was to examine differences between patients with bipolar I and II disorders with particular emphasis on the early phases of the disorders. METHODS: 808 subjects diagnosed with bipolar I (N = 587) or bipolar II disorder (N = 221) according to DSM-IV criteria were recruited between April 1994 and March 2022 from tertiary-level mood disorder clinics...
July 14, 2023: International Journal of Bipolar Disorders
#16
JOURNAL ARTICLE
Noralie N Schonewille, Pleun A Terpstra, Maria E N van den Heuvel, Maria G Van Pampus, Odile A van den Heuvel, Birit F P Broekman
BACKGROUND: Lithium is the preferred treatment for pregnant women with bipolar disorders (BD), as it is most effective in preventing postpartum relapse. Although it has been prescribed during pregnancy for decades, the safety for neonates and obstetric outcomes are a topic of ongoing scientific debate as previous research has yielded contradicting outcomes. Our study aims to compare (re)admission rates and reasons for admissions in neonates born to women with bipolar disorders (BD) with and without lithium exposure...
July 14, 2023: International Journal of Bipolar Disorders
#17
JOURNAL ARTICLE
Danielle Hett, Isabel Morales-Muñoz, Buse Beril Durdurak, Max Carlish, Steven Marwaha
BACKGROUND: Evidence regarding the rate of relapse in people with bipolar disorder (BD), particularly from the UK, is lacking. This study aimed to evaluate the rate and associations of clinician-defined relapse over 5 years in a large sample of BD patients receiving routine care from a UK mental health service. METHOD: We utilised de-identified electronic health records to sample people with BD at baseline. Relapse was defined as either hospitalisation, or a referral to acute mental health crisis services, between June 2014 and June 2019...
June 30, 2023: International Journal of Bipolar Disorders
#18
JOURNAL ARTICLE
Michael Bauer, Tasha Glenn, Eric D Achtyes, Martin Alda, Esen Agaoglu, Kürsat Altınbaş, Ole A Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P Behere, Prakash B Behere, Habte Belete, Tilahun Belete, Gabriel Okawa Belizario, Frank Bellivier, Robert H Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Şule Bicakci, Harriet Birabwa-Oketcho, Thomas D Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y W Cheung, Silvia Chiesa, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Maria Del Zompo, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G Fiedorowicz, Kostas N Fountoulakis, Mark A Frye, Pierre A Geoffroy, Michael J Gitlin, Ana Gonzalez-Pinto, John F Gottlieb, Paul Grof, Bartholomeus C M Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T Isometsä, Maja Ivkovic, Sven Janno, Simon Johnsen, Flávio Kapczinski, Gregory N Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara König, Timur L Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landén, Erik R Larsen, Melanie Lenger, Rasmus W Licht, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Østergaard Madsen, Simone Alberte Kongstad A Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Julia Martini, Klaus Martiny, Yuki Mashima, Declan M McLoughlin, Ybe Meesters, Ingrid Melle, Fátima Meza-Urzúa, Pavol Mikolas, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A Mozzhegorov, Rodrigo Munoz, Starlin V Mythri, Fethi Nacef, Ravi K Nadella, Takako Nakanotani, René Ernst Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Johannes Petzold, Andrea Pfennig, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard J Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-Apha, Michaela Ratzenhofer, Maria Redahan, M S Reddy, Andreas Reif, Eva Z Reininghaus, Jenny Gringer Richards, Philipp Ritter, Janusz K Rybakowski, Leela Sathyaputri, Angela M Scippa, Christian Simhandl, Daniel Smith, José Smith, Paul W Stackhouse, Dan J Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E Vaaler, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H Young, Yosra Zgueb, Peter C Whybrow
BACKGROUND: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample...
June 22, 2023: International Journal of Bipolar Disorders
#19
JOURNAL ARTICLE
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J Baldessarini
BACKGROUND: Rapid-cycling (RC; ≥ 4 episodes/year) in bipolar disorder (BD) has been recognized since the 1970s and associated with inferior treatment response. However, associations of single years of RC with overall cycling rate, long-term morbidity, and diagnostic subtypes are not clear. RESULTS: We compared descriptive and clinical characteristics in 1261 BD patients with/without RC, based on history and prospective follow-up for several years...
June 4, 2023: International Journal of Bipolar Disorders
#20
JOURNAL ARTICLE
Diego Hidalgo-Mazzei, Tim Mantingh, Xavier Pérez de Mendiola, Ludovic Samalin, Juan Undurraga, Sergio Strejilevich, Emanuel Severus, Michael Bauer, Ana González-Pinto, Willem A Nolen, Allan H Young, Eduard Vieta
BACKGROUND: Lithium has long been considered the gold-standard pharmacological treatment for the maintenance treatment of bipolar disorders (BD) which is supported by a wide body of evidence. Prior research has shown a steady decline in lithium prescriptions during the last two decades. We aim to identify potential factors explaining this decline across the world with an anonymous worldwide survey developed by the International Society for Bipolar Disorders (ISBD) Task Force "Role of Lithium in Bipolar Disorders" and distributed by diverse academic and professional international channels...
May 27, 2023: International Journal of Bipolar Disorders
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