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International Journal of Bipolar Disorders

G Snijders, R Brouwer, S Kemner, F Bootsman, H A Drexhage, M H J Hillegers
BACKGROUND: In previous studies we found mild deficiencies of circulating T cells in patients with bipolar disorder (BD) and children at risk for BD, correlating to a higher inflammatory state. The genetic and environmental influences on these T cell deficiencies in association with BD development are unknown. OBJECTIVES: The aim is to quantify genetic and environmental factors that contribute to the association between the liability to develop BD and T cell deficiencies...
February 10, 2019: International Journal of Bipolar Disorders
Maria Faurholt-Jepsen, Mads Frost, Jonas Busk, Ellen Margrethe Christensen, Jakob E Bardram, Maj Vinberg, Lars Vedel Kessing
BACKGROUND: Mood instability in bipolar disorder is associated with a risk of relapse. This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously has been sparingly investigated. METHODS: Patients with bipolar disorder type I (n = 53) and type II (n = 31) used a daily smartphone-based self-monitoring system for 9 months. Data in the present reflect 15.975 observations of daily collected smartphone-based data on patient-evaluated mood...
February 1, 2019: International Journal of Bipolar Disorders
Kallia Apazoglou, Anne-Lise Küng, Paolo Cordera, Jean-Michel Aubry, Alexandre Dayer, Patrik Vuilleumier, Camille Piguet
INTRODUCTION: Mood disorder patients have a tendency to be more internally oriented, with difficulties in switching attentional focus, which might result in the generation of negative thoughts, such as rumination. The present study explored self-referential neural activity correlating with rumination tendency and attentional switching capacity in bipolar disorder. METHODS: Twenty euthymic bipolar patients and twenty matched healthy controls underwent a novel introspection task of switching between internally and externally focused attention during a word processing task, while their brain activity was assessed using functional MRI...
January 12, 2019: International Journal of Bipolar Disorders
P J J Goossens, T H Daggenvoorde, H G Groot Lipman, S Verhaeghe, A W M M Stevens
BACKGROUND: The progress and recovery of a patient with mania during hospitalization is differently seen by professionals working at an admission ward and by relatives of the patient. Professionals often indicate that the situation of the patient is improving while relatives estimate the improvement to be minimal in relation to the recovery of the patient. OBJECTIVE(S): To develop an intervention to give professionals at an admission ward an impression of the patient in a euthymic mood state to provide professionals with information to plan and conduct individualized patient centred care...
January 4, 2019: International Journal of Bipolar Disorders
Maria Faurholt-Jepsen, Emanuale Torri, Jesús Cobo, Daryoush Yazdanyar, Diego Palao, Narcis Cardoner, Olaf Andreatta, Oscar Mayora, Lars Vedel Kessing
BACKGROUND: The aims of the present multicenter pilot study were to examine the feasibility and usability of two different smartphone-based monitoring systems (the Pulso system and the Trilogis-Monsenso system) from two IT companies in patients with bipolar disorder, developed and selected to be testes as a part of a European Union funded Pre-Commercial Procurement (the NYMPHA-MD project). METHODS: Patients with bipolar disorder (ICD-10), > 18 years of age during a remitted, partial remitted or mild to moderate depressive state (HDRS-17 < 25) from Italy, Spain and Denmark were included...
January 4, 2019: International Journal of Bipolar Disorders
Eline M P Poels, Hilmar H Bijma, Megan Galbally, Veerle Bergink
Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse in bipolar disorder. However, lithium has also been associated with risks during pregnancy for both the mother and the unborn child. Recent large studies have confirmed the association between first trimester lithium exposure and an increased risk of congenital malformations. Importantly, the risk estimates from these studies are lower than previously reported. Tapering of lithium during the first trimester could be considered but should be weighed against the risks of relapse...
December 2, 2018: International Journal of Bipolar Disorders
Michael J Gitlin
The proper place and the optimal use of antidepressants in treating bipolar depression continues to be an area of great interest and greater controversy with passionate opinions more common than good studies. Even the handful of meta-analyses in the area disagree with each other. Overall, the evidence that antidepressants are effective in treating bipolar depression is weak. Additionally, many experts and clinicians worry greatly about the capacity of antidepressants to cause affective switching or mood destabilization...
December 1, 2018: International Journal of Bipolar Disorders
Paul Grof, Bruno Müller-Oerlinghausen
No abstract text is available yet for this article.
November 28, 2018: International Journal of Bipolar Disorders
René Breuer, Manuel Mattheisen, Josef Frank, Bertram Krumm, Jens Treutlein, Layla Kassem, Jana Strohmaier, Stefan Herms, Thomas W Mühleisen, Franziska Degenhardt, Sven Cichon, Markus M Nöthen, George Karypis, John Kelsoe, Tiffany Greenwood, Caroline Nievergelt, Paul Shilling, Tatyana Shekhtman, Howard Edenberg, David Craig, Szabolcs Szelinger, John Nurnberger, Elliot Gershon, Ney Alliey-Rodriguez, Peter Zandi, Fernando Goes, Nicholas Schork, Erin Smith, Daniel Koller, Peng Zhang, Judith Badner, Wade Berrettini, Cinnamon Bloss, William Byerley, William Coryell, Tatiana Foroud, Yirin Guo, Maria Hipolito, Brendan Keating, William Lawson, Chunyu Liu, Pamela Mahon, Melvin McInnis, Sarah Murray, Evaristus Nwulia, James Potash, John Rice, William Scheftner, Sebastian Zöllner, Francis J McMahon, Marcella Rietschel, Thomas G Schulze
BACKGROUND: Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other complex disorders, major breakthroughs in explaining the high heritability of BD through GWAS have remained elusive. To overcome this dilemma, genetic research into BD, has embraced a variety of strategies such as the formation of large consortia to increase sample size and sequencing approaches...
November 11, 2018: International Journal of Bipolar Disorders
Eva F Maassen, Barbara J Regeer, Eline J Regeer, Joske F G Bunders, Ralph W Kupka
BACKGROUND: In mental health care, clinical practice is often based on the best available research evidence. However, research findings are difficult to apply to clinical practice, resulting in an implementation gap. To bridge the gap between research and clinical practice, patients' perspectives should be used in health care and research. This study aimed to understand the challenges people with bipolar disorder (BD) experience and examine what these challenges imply for health care and research needs...
November 6, 2018: International Journal of Bipolar Disorders
Joannes W Renes, Eline J Regeer, Adriaan W Hoogendoorn, Willem A Nolen, Ralph W Kupka
BACKGROUND: Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities. AIMS: To study concordance with the Dutch guideline of various treatment modalities in outpatient treatment settings for patients with bipolar disorder and to identity factors associated with concordance. METHODS: A nationwide non-interventional study using psychiatrists' and patients' surveys...
October 20, 2018: International Journal of Bipolar Disorders
Doris Verwijmeren, Koen P Grootens
BACKGROUND: Shared decision making has been promoted as standard care, but there has been debate on the possible types. On the one hand, there is a more 'instrumental'/objective approach focused on the exchange of information, but an 'interpersonal'/subjective patient involvement has been suggested as well. In this study we aim to investigate this further by assessing both actual and perceived patient involvement in medical decisions. METHODS: Eighty-one consultations between patients with bipolar disorder and their clinicians were observed and scored using the OPTION scale...
October 4, 2018: International Journal of Bipolar Disorders
Ole Kristian Drange, Arne Einar Vaaler, Gunnar Morken, Ole Andreas Andreassen, Ulrik Fredrik Malt, Per Ivar Finseth
BACKGROUND: About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical condition (BD due to TBI). We investigated whether these patients have similar clinical characteristics as previously described in BD due to TBI (i.e. more aggression and irritability and an increased hypomania/mania:depression ratio) and other distinct clinical characteristics...
September 10, 2018: International Journal of Bipolar Disorders
Rita Bauer, Tasha Glenn, Sergio Strejilevich, Jörn Conell, Martin Alda, Raffaella Ardau, Bernhard T Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Angela M Paredes Castro, Eric Y W Cheung, Caterina Chillotti, Sabine Choppin, Alessandro Cuomo, Maria Del Zompo, Rodrigo Dias, Seetal Dodd, Anne Duffy, Bruno Etain, Andrea Fagiolini, Miryam Fernández Hernandez, Julie Garnham, John Geddes, Jonas Gildebro, Michael J Gitlin, Ana Gonzalez-Pinto, Guy M Goodwin, Paul Grof, Hirohiko Harima, Stefanie Hassel, Chantal Henry, Diego Hidalgo-Mazzei, Anne Hvenegaard Lund, Vaisnvy Kapur, Girish Kunigiri, Beny Lafer, Erik R Larsen, Ute Lewitzka, Rasmus W Licht, Blazej Misiak, Patryk Piotrowski, Ângela Miranda-Scippa, Scott Monteith, Rodrigo Munoz, Takako Nakanotani, René E Nielsen, Claire O'Donovan, Yasushi Okamura, Yamima Osher, Andreas Reif, Philipp Ritter, Janusz K Rybakowski, Kemal Sagduyu, Brett Sawchuk, Elon Schwartz, Claire Slaney, Ahmad H Sulaiman, Kirsi Suominen, Aleksandra Suwalska, Peter Tam, Yoshitaka Tatebayashi, Leonardo Tondo, Julia Veeh, Eduard Vieta, Maj Vinberg, Biju Viswanath, Mark Zetin, Peter C Whybrow, Michael Bauer
BACKGROUND: The world population is aging and the number of older adults with bipolar disorder is increasing. Digital technologies are viewed as a framework to improve care of older adults with bipolar disorder. This analysis quantifies Internet use by older adults with bipolar disorder as part of a larger survey project about information seeking. METHODS: A paper-based survey about information seeking by patients with bipolar disorder was developed and translated into 12 languages...
September 4, 2018: International Journal of Bipolar Disorders
Hari-Mandir K Khalsa, Ross J Baldessarini, Mauricio Tohen, Paola Salvatore
BACKGROUND: Aggression by patients with bipolar I disorder (BD-I) is not uncommon. Identifying potential risk factors early in the illness-course should inform clinical management and reduce risk. METHODS: In a study sample of 216 initially hospitalized, first-psychotic episode subjects diagnosed with DSM-IV-TR BD-I, we identified recent (within 1 month before hospitalization) aggression by ratings on the Brief Psychiatric Rating Scale-Expanded and review of detailed clinical research records...
August 11, 2018: International Journal of Bipolar Disorders
Luca Ambrosiani, Claudia Pisanu, Arianna Deidda, Caterina Chillotti, Maria Erminia Stochino, Alberto Bocchetta
BACKGROUND: Cancer had never been considered as a relevant problem in patients treated with lithium until 2015, when a document published by the European Medicine Agency concluded that long-term use of lithium might induce renal tumors. A few months later, we observed the case of a woman treated with lithium for 18 years who was diagnosed with both thyroid and renal tumors. METHODS: This study aimed to investigate the correlation between lithium treatment and thyroid or renal tumors...
August 6, 2018: International Journal of Bipolar Disorders
Douglass Godwin, Kathryn I Alpert, Lei Wang, Daniel Mamah
BACKGROUND: Schizophrenia shares some genetic risk and clinical symptoms with bipolar disorder. Clinical heterogeneity across subjects is thought to contribute to variable structural imaging findings across studies. The current study investigates cortical thickness in young adults diagnosed with schizophrenia or bipolar I disorder with a history of hyperthymic mania. We hypothesize that cortical thickness will be most similar between SCZ and the psychotic bipolar 1 disorder subtype. METHODS: Patients with schizophrenia (n = 52), psychotic bipolar I disorder (PBD; n = 49) and non-psychotic bipolar I disorder (NPBD; n = 24) and healthy controls (n = 40) were scanned in a 3T Trio MRI...
July 11, 2018: International Journal of Bipolar Disorders
John R Purcell, Monika Lohani, Christie Musket, Aleena C Hay, Derek M Isaacowitz, June Gruber
BACKGROUND: Bipolar disorder is associated with heightened and persistent positive emotion (Gruber in Curr Dir Psychol Sci 20:217-221, 2011; Johnson in Clin Psychol Rev 25:241-262, 2005). Yet little is known about information processing biases that may influence these patterns of emotion responding. METHODS: The current study adopted eye-tracking methodology as a continuous measure of sustained overt attention to monitor gaze preferences during passive viewing of positive, negative, and neutral standardized photo stimuli among remitted bipolar adults and healthy controls...
July 3, 2018: International Journal of Bipolar Disorders
Joseph R Calabrese, Na Jin, Brian Johnson, Pedro Such, Ross A Baker, Jessica Madera, Peter Hertel, Jocelyn Ottinger, Joan Amatniek, Hiroaki Kawasaki
BACKGROUND: The long-acting injectable antipsychotic aripiprazole once-monthly 400 mg (AOM 400) was recently approved for maintenance treatment of bipolar I disorder (BP-I). The purpose of this study was to evaluate the safety, tolerability, and efficacy of AOM 400 as long-term maintenance treatment for BP-I. METHODS: This open-label multicenter study evaluated the effectiveness of AOM 400 as maintenance treatment for BP-I by assessing safety and tolerability (primary objective) and efficacy (secondary objective)...
June 10, 2018: International Journal of Bipolar Disorders
Angèle P M Kerckhoffs, Erwin G T M Hartong, Koen P Grootens
BACKGROUND: Lithium is the treatment of choice for patients suffering from bipolar disorder (BD) but prolonged use induces renal dysfunction in at least 20% of patient. Intensive monitoring of kidney functioning helps to reveal early decline in renal failure. This study investigates the views and experiences of BD patients who have developed end-stage renal disease and were receiving renal replacement therapy. RESULTS: The patients overall reported not to have been offered alternative treatment options at the start of lithium therapy or when renal functions deteriorated...
June 2, 2018: International Journal of Bipolar Disorders
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