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Journal of Global Antimicrobial Resistance

Naoko Chiba, Koichi Tanimoto, Junzo Hisatsune, Motoyuki Sugai, Keigo Shibayama, Haruo Watanabe, Haruyoshi Tomita
No abstract text is available yet for this article.
February 14, 2019: Journal of Global Antimicrobial Resistance
Cheng Shi, Jiaxing Chen, Bin Xiao, Xinyue Kang, Xingzhen Lao, Heng Zheng
OBJECTIVES: Human health is seriously threatened by metallo-beta-lactamase(MBL)-mediated bacterial resistance. Among them, the New Delhi metallo-beta-lactamase-1(NDM-1) has received great attention due to its extensive substrate specificity and high lateral gene transfer. Currently there is no inhibitor of NDM-1 available in clinical therapy, thus making an argent need for the research and development of novel NDM-1 inhibitors. METHODS: A natural compound library was screened to determine potential inhibitors of NDM-1 based on the crystal structure of NDM-1...
February 11, 2019: Journal of Global Antimicrobial Resistance
Paola Aparecida Alves Azevedo, João Pedro Rueda Furlan, Guilherme Bartolomeu Gonçalves, Carolina Nogueira Gomes, Rafael da Silva Goulart, Eliana Guedes Stehling, André Pitondo-Silva
OBJECTIVES: The present study aimed to characterize 48 Klebsiella pneumoniae isolated from outpatients with urinary tract infections (UTIs) in the micro-region of Ribeirão Preto, located in the Southeastern of Brazil. METHODS: Thee isolates were identified by conventional biochemical and phenotypic tests and confirmed as K. pneumoniae using MALDI-TOF VITEK® MS. Antimicrobial susceptibility testing were performed by disk diffusion method as recommended by the Clinical Laboratory Standards Institute using thirty-eight different antibiotic discs...
February 11, 2019: Journal of Global Antimicrobial Resistance
Sajjad Yazdansetad, Ehsan Najari, Ezzat Allah Ghaemi, Naemeh Javid, Ali Hashemi, Abdollah Ardebili
OBJECTIVES: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a serious challenge and poses a threat to public health worldwide. This study aimed to determine drug susceptibility of A. baumannii, and then, investigate oxacillinase-encoding determinants and their association with ISAba1 sequence in CRAB isolates. METHODS: This study was performed on A. baumannii isolates recovered from patients with burn wound infections during 2013. All isolates were evaluated for antimicrobial susceptibility by disc agar diffusion method...
February 11, 2019: Journal of Global Antimicrobial Resistance
Jun Sung Hong, Dokyun Kim, Eun-Jeong Yoon, Hyukmin Lee, Seok Hoon Jeong
BACKGROUND: The spread of carbapenemase-producing organisms (CPOs) has been continuously reported over the past decade. The rapid and accurate detection of carbapenemase production is essential for adequate infection control and appropriate antimicrobial treatment in clinical fields. We evaluated the performance of the newly developed PANA RealTyper™ CRE Kit (PANAGENE, Daejeon, Korea) for the detection of six common carbapenemase genes (blaKPC , blaGES , blaIMP , blaNDM , blaVIM , and blaOXA-48-like )...
February 11, 2019: Journal of Global Antimicrobial Resistance
Emi Tanaka, Naoki Hara, Takeaki Wajima, Shoko Ochiai, Shoji Seyama, Atsuko Shirai, Meiwa Shibata, Hiroyuki Shiro, Yoshiaki Natsume, Norihisa Noguchi
BACKGROUND: In Japan, usage of non-β-lactam agents has increased due to the prevalence of β-lactam resistant pathogens. This study aimed to clarify the recent trend of antimicrobial susceptibility and molecular epidemiological features in Haemophilus influenzae. METHODS: Fifty-seven H. influenzae isolated from a Japanese teaching hospital in 2017 were characterized, and the data were compared with those of a previous study. The MICs were determined using the broth dilution methods Genetic backgrounds were compared by Multilocus sequence typing...
February 9, 2019: Journal of Global Antimicrobial Resistance
Kageto Yamada, Ryoichi Saito, Saori Muto, Masakazu Sasaki, Hinako Murakami, Kotaro Aoki, Yoshikazu Ishii, Kazuhiro Tateda
OBJECTIVES: Campylobacter jejuni is one of the most common pathogens causing gastroenteritis. Because there is currently insufficient epidemiological information on the antimicrobial susceptibility and molecular characterization of clinical isolates of C. jejuni in Japan, we carried out antimicrobial susceptibility testing, and MLST of clinical C. jejuni isolates in Tokyo between 2000 and 2017. METHODS: Antimicrobial susceptibility to erythromycin and ciprofloxacin was tested in 430 clinical isolates of C...
February 9, 2019: Journal of Global Antimicrobial Resistance
Teresa Conceição, Hermínia de Lencastre, Marta Aires-de-Sousa
No abstract text is available yet for this article.
February 9, 2019: Journal of Global Antimicrobial Resistance
Acar Ali, Karaahmetoğlu Gökhan, Akalın Halis, Altay F Aybala
OBJECTIVES: This meta-analysis aimed to evaluate the current prevalence and trends over the past 10-years of antimicrobial resistance of Pseudomonas aeruginosa. Two researches independently searched two national (ULAKBİM, Türk Medline) and two international databases (PubMed, Web of Science) to identify studies on P. aeruginosa resistance to antimicrobials from 2007 to 2017. METHODS: Homogeneity across studies was assessed using a Cochrane's and total variability due to between study variations was reflected in the I2 index...
February 9, 2019: Journal of Global Antimicrobial Resistance
Ahmed El-Nawawy, Magdy A-F Ramadan, Manal A-M Antonios, Shams A-F Arafa, Eman Hamza
PURPOSE: Therapy of severe pneumonia is very challenging in view of the current widespread bacterial resistance to many antibiotics especially extended spectrum ß-lactams, carbapenems, and anti-pseudomonal drugs. The current study aimed at assessing antimicrobial sensitivity pattern and optimization of the antibiotic stewardship program applied in a university affiliated pediatric intensive care unit (PICU). SUBJECTS AND METHODS: This prospective cohort study included all patients aged 1 month to 12 years, admitted to the PICU with severe pneumonia episodes indicated for mechanical ventilation, and were followed up and investigated...
January 30, 2019: Journal of Global Antimicrobial Resistance
Chun-Zhen Hua, Hong-Jiao Wang, Zhe Zhang, Xiao-Fen Tao, Jian-Ping Li, Yu-Mei Mi, Lan-Fang Tang, Zhi-Min Chen
BACKGROUND AND OBJECTIVE: Macrolides are the recommended antibiotics for treating pertussis and preventing transmission. The causative bacterium, Bordetella pertussis, has high macrolide resistance and has recently circulated in China. The objective of the study was to find effective alternative antibiotics in therapy by assessing the in vitro activity and clinical efficacy of antibiotics against Bordetella pertussis. METHODS: Bordetella pertussis was confirmed by agglutination with specific antisera and mass spectrometry...
January 30, 2019: Journal of Global Antimicrobial Resistance
Ebrahim Kouhsari, Masoumeh Douraghi, Marcela Krutova, Hashem Fakhre Yaseri, Malihe Talebi, Zohreh Baseri, Vahid Moqarabzadeh, Mohammad Sholeh, Nour Amirmozafari
OBJECTIVES: Clostridium difficile is the main causative agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis (PMC). The accumulation of antimicrobial resistance in C. difficile strains can drive Clostridium difficile infection (CDI) epidemiology. This study was undertaken in order to evaluate the antimicrobial resistance patterns of toxigenic C. difficile isolates cultured from diarrhoeal stool samples of hospitalised patients with suspected CDI in three tertiary care hospitals in Tehran, Iran...
January 28, 2019: Journal of Global Antimicrobial Resistance
Pham Hong Nhung, Vu Ho Van, Nguyen Quoc Anh, Doan Mai Phuong
OBJECTIVES: Antimicrobial suceptibility pattern of clinical Burkholderia pseudomallei in Vietnam has not reported since the first publication in 2008. The present study aimed to determine the antimicrobial susceptibility pattern of B. pseudomallei isolated in a tertiary referral center in Hanoi from January 2012 to December 2017. METHODS: A total of 312 B. pseudomallei isolates obtained from meliodiosis patients admited in 2000-bed general hospital were analyzed by Etest method...
January 24, 2019: Journal of Global Antimicrobial Resistance
Edgarthe Priscilla Ngaiganam, Jean-Marc Rolain, Seydina M Diene
No abstract text is available yet for this article.
January 24, 2019: Journal of Global Antimicrobial Resistance
Pijush Kanti Pramanik, Md Nur Alam, Dibyapriya Roy Chowdhury, Tapati Chakraborti
Nowadays, drug resistance in parasites is considered to be one of the foremost concerns of health and disease management. It is interconnected around the world and undermining effectiveness of health of millions of people and threatens to grow worse. Unfortunately, it doesn't receive serious attention from every corner of the society. So, drug resistance in parasites gradually complicating and challenging the treatment processes of parasitic diseases. In this context, we have dedicated ourselves to review drug resistance incidences in Plasmodium, Leishmania, Trypanosoma, Entamoeba and Toxoplasma gondii...
January 24, 2019: Journal of Global Antimicrobial Resistance
Kald Beshir Tuem, Rahel Desta, Helen Bitew, Seid Ibrahim, Hailemichael Zeru Hishe
BACKGROUND: Urinary tract infections (UTIs) are considered to be one of the most common infections in humans. On the other side, studies showed that antibiotics are usually prescribed empirically before the laboratory results of urine culture are available. OBJECTIVE: The aim of the study was to assess the six years antibacterial resistance patterns of bacteria isolated from urine samples in Ayder Comprehensive Specialized Hospital (ACSH). METHODS: A retrospective study of culture results of UTIs was conducted in Ayder Comprehensive Specialized Hospital (ACSH) from January, 2012 to December 2017 GC...
January 24, 2019: Journal of Global Antimicrobial Resistance
João Pedro Rueda Furlan, Eliana Guedes Stehling
OBJECTIVES: The aim of this study was to report the draft genome sequence of a multidrug-resistant Escherichia coli obtained from a jaboticaba (Plinia cauliflora) culture soil in Brazil. METHODS: The whole genome was sequenced on an Illumina MiSeq Platform and was assembled using SPAdes v.3.9. All data analyses were performed using tools from the Center for Genomic Epidemiology and Geneious v.11.1.5 software. The genome was annotated using NCBI Prokaryotic Genome Annotation Pipeline v...
January 24, 2019: Journal of Global Antimicrobial Resistance
Reza Beigverdi, Leila Jabalameli, Fereshteh Jabalameli, Mohammad Emaneini
OBJECTIVES: Extended-spectrum β-lactamases- producing Klebsiella pneumonia (ESBL-KP) have emerged as an important pathogen causing severe infection thought the world. Infections due to ESBL-KP are associated with high morbidity and mortality, especially in developing countries such as Iran. The aim of current study was to assess the pooled prevalence of ESBL-KP with different gene variants in Iran. METHODS: A literature search of the Medline (via PubMed), Embase, Web of Science, and Iranian Database was carried out...
January 24, 2019: Journal of Global Antimicrobial Resistance
Masato Kawamura, Shigeru Fujimura, Koichi Tokuda, Tetsuji Aoyagi, Shiro Endo, Hajime Kanamori, Akira Watanabe, Mitsuo Kaku
OBJECTIVE: The aim of this study was to determine the mutant selection window (MSW) of various disinfectants against Staphylococcus aureus and Pseudomonas aeruginosa, to find out the tendency of these strains to acquire disinfectant resistance. METHODS: A total of 60 isolates of S. aureus consisting of 30 methicillin-resistant S. aureus (MRSA), 30 methicillin-susceptible S. aureus (MSSA), and 30 P. aeruginosa including 2 multi-drug resistance P. aeruginosa (MDRP) were collected in Japan...
January 23, 2019: Journal of Global Antimicrobial Resistance
Yuliya Bocharova, Tatiana Savinova, Dmitriy A Shagin, Andrey A Shelenkov, Nikolay A Mayanskiy, Igor V Chebotar
OBJECTIVES: Alteration of the porin-coding oprD gene by insertion sequences (ISs) is one of the mechanisms conferring carbapenem resistance in Pseudomonas aeruginosa. In this study, we described a carbapenem resistant clinical isolate P. aeruginosa 36-989 harboring a novel IS (ISPa195) in oprD. METHODS: Minimal inhibitory concentration (MIC) values were determined by broth microdilution. Carbapenemase activity was assessed using a MALDI-TOF MS-based assay of meropenem hydrolysis...
January 22, 2019: Journal of Global Antimicrobial Resistance
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