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Journals Journal of Global Antimicrobia...

Journal of Global Antimicrobial Resistance

https://read.qxmd.com/read/38408565/candida-glabrata-hospital-isolate-from-lebanon-reveals-micafungin-resistance-associated-with-increased-chitin-and-resistance-to-a-cell-surface-disrupting-agent
#1
JOURNAL ARTICLE
Nour Fattouh, Roy A Khalaf, Rola Husni
OBJECTIVES: The aim of this study was to identify the resistance mechanisms to micafungin and fluconazole in a clinical isolate of Candida glabrata. METHODS: The isolate was whole genome sequenced in order to identify amino acid changes in key proteins involved in antifungal resistance and the isolate was further characterized by pathogenicity related phenotypic assays that supported the sequencing results. RESULTS: Amino acid substitutions were detected in 8 out of 17 protein candidates...
February 24, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38408564/co-existence-of-bla-ndm-5-bla-ctx-m-15-bla-oxa-232-bla-shv-182-genes-in-multi-drug-resistant-k-pneumoniae-st437-carrying-ompk36-and-ompk37-porin-mutations-first-report-in-italy
#2
JOURNAL ARTICLE
S Di Marcantonio, M Perilli, G Alloggia, B Segatore, G Miconi, G Bruno, P Frascaria, A Piccirilli
OBJECTIVES: K. pneumoniae is a common cause of severe hospital-acquired infections. In the present study we have characterized the whole-genome of two K. pneumoniae ST437 belonging to the clonal complex CC258. METHODS: The whole-genome sequencing was performed by MiSeq Illumina, with a 2×300bp paired-end run. ResFinder 4.4.2 was used to detect acquired antimicrobial resistance genes (ARGs) and chromosomal mutations. Mobile genetic elements (plasmids and ISs) were identified by MobileElementFinder v1...
February 24, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38408563/coexistence-of-virulent-and-multidrug-resistant-plasmids-in-a-uropathogenic-escherichia-coli
#3
JOURNAL ARTICLE
Yongli Wu, Ziyao Li, Zichen Lei, Jiankang Zhao, Yulin Zhang, Xinmeng Liu, Yanning Hu, Feilong Zhang, Binghuai Lu
OBJECTIVES: The emergence of pathogens co-harboring multiple mobile resistance and virulence elements is of great concern in clinical settings. Herein, we report an O101: H10-ST167 Escherichia coli Hu106 strain isolated from the urinary tract of a female in China. METHODS: Antibiotic susceptibility testing was used to present the antimicrobial resistance spectrum. Whole-genome sequencing (WGS) and bioinformatic analysis were used to clarify the virulent and resistance mechanisms...
February 24, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38408562/genomic-insights-into-an-extensively-drug-resistant-and-hypervirulent-burkholderia-dolosa-n149-isolate-of-a-novel-sequence-type-st2237-from-a-vietnamese-patient-hospitalized-for-stroke
#4
JOURNAL ARTICLE
Nguyen Quang Huy, Nguyen Cam Linh, Nguyen Thai Son, Do Bich Ngoc, Tran Thi Thanh Tam, Le Thi Thu Hang, Bui Thanh Thuyet, Le Huu Song, Dong Van Quyen, Juliette Hayer, Anne-Laure Bañuls, Bui Tien Sy
OBJECTIVES: Burkholderia dolosa is a clinically important opportunistic pathogen in inpatients. Here we characterized an extensively drug-resistant and hypervirulent B. dolosa isolate from a patient hospitalized for stroke. METHODS: Resistance to 41 antibiotics was tested with the agar disc diffusion, minimum inhibitory concentration, or broth microdilution method. The complete genome was assembled using short-reads and long-reads and the hybrid de novo assembly method...
February 24, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38408561/hybrid-genome-assembly-of-colistin-resistant-mcr-1-5-producing-escherichia-coli-st354-reveals-phylogenomic-pattern-associated-with-urinary-tract-infections-in-brazil
#5
JOURNAL ARTICLE
Bruna Fuga, Fábio P Sellera, Fernanda Esposito, Quézia Moura, Marcelo Pillonetto, Nilton Lincopan
BACKGROUND: The rapid and global spread of Escherichia coli carrying mcr-type genes at the human-animal-environmental interface has become a serious global public health problem. OBJECTIVE: To perform a genomic investigation of a colistin-resistant E. coli strain (14005RM) causing urinary tract infection, using a hybrid de novo assembly of Illumina/Nanopore sequence data, presenting phylogenomic insights into relationship with mcr-1-positive strains circulating at the human-animal-environmental interface, in Brazil...
February 24, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38408560/co-existence-of-tmexcd2-toprj2-and-bla-ndm-1-on-a-single-plasmid-carried-by-raoultella-ornithinolytica-isolated-from-public-garbage-bins
#6
LETTER
Jie Li, Xiaoqian Long, Hui Lin, Caihong Song, Guoping Zhao, Biao Tang
No abstract text is available yet for this article.
February 24, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38342378/evaluation-of-clinical-and-microbiological-factors-related-to-mortality-in-patients-with-gram-negative-bacterial-infections-treated-with-ceftazidime-avibactam-a-prospective-multicentric-cohort-study
#7
JOURNAL ARTICLE
Beatriz Arns, Guilherme Geraldo Lovato Sório, Tarsila Vieceli, Dariane Pereira, Andrea Souza, Priscila Wink, Dariane Pereira, Julia Hoefel Paes, Leonardo David, Fernanda Barboza, Stella Hickmann, Gustavo Alves, Antônio Cândido Santos, Anelise da Rosa, Marcelle Alves, Cibele Magagnin, Eduardo Gomes, Alexandre Prehn Zavascki, Maria Helena Rigatto
OBJECTIVES: This study aimed to evaluate the clinical and microbiological risk factors associated with mortality in patients treated with ceftazidime-avibactam for carbapenem-resistant gram-negative bacterial infections. METHODS: This multicentric prospective cohort study included hospitalized adult patients with a microbiologically confirmed infection treated with ceftazidime-avibactam for ≥48 hours. The clinical and microbiological risk factors for 30-day mortality were evaluated using a Cox regression model...
February 9, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38336229/transferable-linezolid-resistance-genes-optra-and-poxta-in-enterococci-derived-from-livestock-compost-at-japanese-farms
#8
JOURNAL ARTICLE
Akira Fukuda, Chie Nakajima, Yasuhiko Suzuki, Masaru Usui
OBJECTIVES: Linezolid is a last-resort antimicrobial in human clinical settings to treat multidrug-resistant gram-positive bacterial infections. Mobile linezolid resistance genes (optrA, poxtA, and cfr) have been detected in various sources worldwide. However, the presence of linezolid-not-susceptible bacteria and mobile linezolid resistance genes in Japan remains uncertain. Therefore, we clarified the existence of linezolid-not-susceptible bacteria and mobile linezolid resistance genes in farm environments in Japan...
February 7, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38336228/in-vitro-activity-of-cefiderocol-against-gram-negative-pathogens-isolated-from-people-with-cystic-fibrosis-and-bronchiectasis
#9
JOURNAL ARTICLE
C S McLaughlin, J S Elborn, C M Longshaw, Tunney Mm
OBJECTIVES: Gram-negative pathogens causing respiratory infection in people with cystic fibrosis and bronchiectasis are becoming progressively more resistant to conventional antibiotics. Although cefiderocol is licensed for the treatment of infections due to Gram-negative organisms, there is limited data on the activity of cefiderocol against pathogens associated with chronic respiratory diseases. The aim of this study was to determine the susceptibility of Gram-negative pathogens from cystic fibrosis and bronchiectasis to cefiderocol and comparator antibiotics...
February 7, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38336227/global-distribution-of-heterogeneous-vancomycin-intermediate-staphylococcus-aureus-strains-1997-2021-a-systematic-review-and-meta-analysis
#10
JOURNAL ARTICLE
Masoud Keikha, Mohsen Karbalaei
BACKGROUND: Heterogeneous vancomycin-intermediate Staphylococcus aureus is considered as one of the main causes in treatment failure of vancomycin, which leads to poor clinical outcomes. Herein, we comprehensively evaluated characteristics such as global prevalence, trend, and genetic backgrounds of these strains. METHODS: In this study, we conducted a meta-analysis based on PRISMA checklist 2020. In the beginning, global databases were searched to achieve the studies related to the prevalence of hVISA in clinical isolates of methicillin-resistant Staphylococcus aureus...
February 7, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38331031/evaluation-of-antibiofilm-activity-of-cefiderocol-alone-and-in-combination-with-imipenem-against-pseudomonas-aeruginosa
#11
JOURNAL ARTICLE
Caterina Ferretti, Noemi Violeta Poma, Mariano Bernardo, Laura Rindi, Novella Cesta, Arianna Tavanti, Carlo Tascini, Mariagrazia Di Luca
OBJECTIVES;: The main aim of this study was to evaluate the antibiofilm activity of cefiderocol alone and in combination with imipenem versus sessile cells of Pseudomonas aeruginosa, assessing a potential synergistic bactericidal effect. METHODS;: Ten P. aeruginosa clinical isolates from infected implants and bloodstream were included in the study. Cefiderocol was tested alone and in combination with imipenem on 24 hour-old P. aeruginosa biofilm formed on porous glass beads. For each antibiotic formulation, minimum bactericidal biofilm concentration (MBBC), defined as the lowest concentration that determined a reduction of at least 3-log10 CFU/mL compared to the untreated control, was evaluated...
February 6, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38331030/in-vitro-antimicrobial-susceptibility-data-of-global-meropenem-resistant-acinetobacter-baumannii-isolates-causing-pneumonia-data-from-the-antimicrobial-testing-leadership-and-surveillance-program-2014-2021-and-re-estimations-of-susceptibility-breakpoints-and
#12
JOURNAL ARTICLE
Shun-Chung Hsueh, Yu-Tsung Huang, Wen-Chien Ko, I-Min Liu, Po-Chuen Hsieh, Shio-Shin Jean
OBJECTIVES: To evaluate the susceptibility of globally pneumonia-causing meropenem-resistant (MEM-R) Acinetobacter baumannii isolates against important antibiotics and estimate appropriate dosages of indicated antibiotics. METHODS: We extracted the 2014-2021 Antimicrobial Testing of Leadership Surveillance database regarding the susceptibility of MEM-R A. baumannii isolates causing pneumonia against important antibiotics. The susceptibility and carbapenemase-encoding gene (CPEG) data of pneumonia-causing MEM-R A...
February 6, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38331029/persistence-and-evolution-of-linezolid-and-methicillin-resistant-staphylococcus-epidermidis-st2-and-st5-clones-in-an-italian-hospital
#13
JOURNAL ARTICLE
Marzia Cinthi, Sonia Nina Coccitto, Antonella Pocognoli, Guido Zeni, Annarita Mazzariol, Alessandra Di Gregorio, Carla Vignaroli, Brenciani Andrea, Eleonora Giovanetti
BACKGROUND: Staphylococcus epidermidis is a member of the human skin microbiome. However, in recent decades multidrug-resistant and hospital-adapted S. epidermidis clones are increasingly involved in severe human infections associated to medical devices and in immunocompromisedpatients. In 2016, we reported that a linezolid- and methicillin-resistant S. epidermidis ST2 clone, bearing the G2576T mutation, was endemic in an Italian hospital since 2004. AIM: To retrospectively analyze 34 linezolid- and methicillin-resistant S...
February 6, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38325733/risk-factors-associated-with-mcr-1-colistin-resistance-gene-in-e-coli-broiler-samples-in-northern-jordan
#14
JOURNAL ARTICLE
Mohammad H Gharaibeh, Sahba Y Al Sheyab, Shawkat Q Lafi, Eman M Etoom
OBJECTIVES: The purpose of this study was to determine the prevalence of colistin-resistant E. coli carrying mcr-1, and to identify risk factors associated with mcr genes mediated resistance. METHODS: In total, 385 cloacal samples were collected from 125 broiler farms and a questionnaire containing information about each farm was designed and filled. RESULTS: Most of the antibiotics used in the disk diffusion method were highly resistant in all samples, with tetracycline and penicillin showing 100% and 99...
February 5, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38307252/a-clade-of-streptococcus-pneumoniae-clonal-complex-320-with-increased-tolerance-to-%C3%AE-lactam-antibiotics-in-a-chinese-metropolitan-city
#15
JOURNAL ARTICLE
Qiuwei Yi, Liqiang Li, Heping Wang, Chunqing Zhu, Yunsheng Chen, Liang Yang, Yuejie Zheng, Yonghong Yang, Yanmin Bao
OBJECTIVES: We characterized the population structure and features of clinical Streptococcus pneumoniae isolates associated with invasive pneumococcal disease (IPD) from 2009 to 2017 in a Chinese metropolitan city using a whole-genome sequencing approach. METHODS: Seventy-nine pneumococcal strains, including 60 serogroup-19 strains from children enduring IPD from a pediatric hospital in Shenzhen, were subjected to whole-genome sequencing. Population structure was characterized through phylogenetic analysis, sequence typing, serotyping, virulence factor and antimicrobial drug resistance (AMR) gene profiling, combining the publicly available related WGS data...
January 31, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38307251/diversity-of-staphylococcus-aureus-associated-with-mastitis-from-dairy-cows-in-rwanda
#16
JOURNAL ARTICLE
Helga Keinprecht, Emmanuel Irimaso, Adriana Cabal Rosel, Beatrix Stessl, Christophe Ntakirutimana, Lydia Marek, Otto W Fischer, Michael P Szostak, Jennifer Zöchbauer, Thomas Wittek, Elke Müller, Amelie Desvars-Larrive, Andrea T Feßler, Sascha D Braun, Stefan Schwarz, Joachim Spergser, Monika Ehling-Schulz, Stefan Monecke, Ralf Ehricht, Werner Ruppitsch, Tom Grunert, Igor Loncaric
OBJECTIVES: The objective of the present study was to examine the diversity of S. aureus from mastitis milk samples of cows in Rwanda. METHODS: A total of 1080 quarter milk samples from 279 dairy cows were collected in 80 different farms from all five provinces of Rwanda. In total, 135 S. aureus isolates were obtained and subjected to genotyping (spa typing, DNA microarray, whole-genome sequencing (WGS)), antimicrobial susceptibility testing (AST) and phenotypic profiling by Fourier Transform Infrared (FTIR) spectroscopy (including capsular serotyping)...
January 31, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38307250/evaluation-of-the-therapeutic-effect-of-a-novel-bacteriophage-in-the-healing-process-of-infected-wounds-with-klebsiella-pneumoniae-in-mice
#17
JOURNAL ARTICLE
Fatemeh Zeynali Kelishomi, Farhad Nikkhahi, Samira Amereh, Fatemeh Ghayyaz, Seyed Mahmoud Amin Marashi, Amir Javadi, Gholamhassan Shahbazi, Mohaddeseh Khakpoor
OBJECTIVE: Bacterial wound infections have recently become a threat to public health. The emergence of multidrug-resistant (MDR) strains of Klebsiella pneumoniae highlights the need for a new treatment method. The effectiveness of bacteriophages has been observed for several infections in animal models and human trials. In this study, we assessed the effectiveness of bacteriophages in the treatment of wound infections associated with MDR and biofilm-producing K. pneumoniae and compared its effectiveness with that of gentamicin...
January 31, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38307249/acquisition-of-a-stable-and-transferable-plasmid-co-harboring-hypervirulence-and-mdr-genes-with-low-fitness-cost-accelerating-the-dissemination-of-st11-kl64-cr-hvkp
#18
JOURNAL ARTICLE
Binghui Huo, DanDan Wei, QiSen Huang, Shanshan Huang, LinPing Fan, Ping Li, Jiehui Qiu, Qun Ren, ChunPing Wei, Yang Liu
OBJECTIVES: This study aimed to delineate the ability of a plasmid, pS130-4, which harbored both hypervirulence and multidrug resistance genes, to disseminate within Klebsiella pneumoniae, as well as its potential formation mechanism. METHODS: We employed whole-genome sequencing to decipher the genetic architecture of pS130-4. Its capability to conjugate and transfer was assessed through a series of experiments, including plasmid stability, competitive growth, and growth curve analysis...
January 31, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38295902/prevalence-and-molecular-characteristics-of-ceftazidime-avibactam-resistance-among-carbapenem-resistant-pseudomonas-aeruginosa-clinical-isolates
#19
JOURNAL ARTICLE
Yili Chen, Guoxiu Xiang, Pingjuan Liu, Xianling Zhou, Penghao Guo, Zhongwen Wu, Juhua Yang, Peisong Chen, Junqi Huang, Kang Liao
BACKGROUND: Resistance against ceftazidime-avibactam (CZA) in carbapenem-resistant Pseudomonas aeruginosa (CRPA) is emerging. This study was aimed at detecting the prevalence and molecular characteristics of CZA-resistant CRPA clinical isolates in Guangdong Province, China. METHODS: The antimicrobial susceptibility profile of these strains was determined. A subset of sixteen CZA-resistant CRPA isolates was analyzed by whole genome sequencing (WGS). Genetic surroundings of carbapenem resistance genes and pan-genome-wide association analysis were further studied...
January 29, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38280721/successful-spread-of-mcr-1-bearing-incx4-plasmids-is-associated-with-variant-in-replication-protein-of-incx4-plasmids
#20
JOURNAL ARTICLE
Lingxian Yi, Kaiyang Yu, Guolong Gao, Rongmin Zhang, Luchao Lv, Daojin Yu, Jun Yang, Jian-Hua Liu
IncX4 plasmids are one of the most epidemiologically successful vehicles for mcr-1 spread. Here we found that the IncX4 plasmids carried two different replication proteins encoded by genes pir-1 and pir-2, respectively, but mcr-1 was only carried by IncX4 plasmid encoding pir-1. The copy number of pir-2 encoding plasmids (3.15±0.9 copies) are higher than that of pir-1 encoding plasmids (0.85±0.5 copies). When mcr-1 was cloned into IncX4 plasmid encoding pir-2, the higher copy number of these plasmids resulted in increased expression of mcr-1 and a greater fitness burden on their host cells...
January 25, 2024: Journal of Global Antimicrobial Resistance
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